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The map label for this gene is adhA [H]

Identifier: 119896403

GI number: 119896403

Start: 128838

End: 129824

Strand: Direct

Name: adhA [H]

Synonym: azo0111

Alternate gene names: 119896403

Gene position: 128838-129824 (Clockwise)

Preceding gene: 119896401

Following gene: 119896405

Centisome position: 2.94

GC content: 73.15

Gene sequence:

>987_bases
ATGCGCGCGATGGTGTTGGATACCCCCGGCCAGCCGCTGCGGCCCGCGGTGCTGCCGCAGCCGACGCCCGGCCCGGGCCA
GGTACTGCTGAAGGTGGAAGCCTGCGGCGTGTGTCGCACCGATCTGCACCTGGTCGACGGCGAATTGCCCGAGCCGCGCC
TGCCGGTGGTGCCGGGCCACGAGATCGTCGGCCGCGTCGTCGCCACCGGGCCCGGTGTCACCGCACTGCGCATCGGCCAG
CGCGCCGGCGTGCCGTGGCTGGGCTGGACCTGCGGCGAATGCAGCTATTGCCGCGGCGGCCACGAGAACCTGTGTGACGC
CGCACGCTTCACCGGCTACACGCTGGACGGCGGCTACGCGGAATACACCGTGGCCGACCAGCGTTACTGCTTTCCGCTGC
CCGACCCGCTGCCGGCGGTGGAACTGGCGCCGCTGCTGTGCGCCGGCCTGATCGGCTACCGCGCGCTGGCGATGGCGGGC
GACGCTGAGCGCATCGGCATCTACGGCTTCGGCGCCGCGGCCCACATCCTCGCCCAGGTGCTGGTGCATCAAGGGCGCGC
CTTCTATGCCTTCACCCGTCCGGGCGATCTCGCCGGCCAGGGCTTTGCCTGCCGTCTCGGTGCGGCCTGGGCCGGCGGCA
GCGACGAGGCGCCTGACCAGGCGCTGGACGCGGCGCTGATCTTCGCCCCCGCCGGCCCGCTGGTGCCGGCCGCGCTGCGG
GCGGTGCGCAAGGGCGGCACCGTGGTCTGCGCCGGCATCCACATGAGCGATATCCCCGCCTTCCCGTACGACATCCTGTG
GGGCGAGCGCGTGCTGCGGTCCGTCGCCAACCTCACCCGCGCGGACGGCGAACGCTTCCTCCGGATCGTGGCCGACAACC
CGGTGCGCAGCCACGTGCAGGTCTATCGGCTGGACCAGGCCAACGAAGCGCTGGACGCGCTGCGGCTGGGGCGGATCGAA
GGGGCGGCGGTGCTGGTGCCGGAGTGA

Upstream 100 bases:

>100_bases
ATGGCCGGTCGCCACTGCTTTCGCCAGCGCGATTGCTTGCCGCGGGGGTGTCGGCGGCGTAGCGTTGTTCTGGATCAGCC
AACGCAGCAAGGAGGACGCG

Downstream 100 bases:

>100_bases
GCTTCGCGCACCCGGCCTACAGCGCGGCGAGCTGCTCGCCGAGGTCGCGGCGCAGCCAGTCCACCAACACCCGCGTGCGG
GTCGGCAGCAAGCGGGCGTG

Product: putative alcohol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 328; Mature: 328

Protein sequence:

>328_residues
MRAMVLDTPGQPLRPAVLPQPTPGPGQVLLKVEACGVCRTDLHLVDGELPEPRLPVVPGHEIVGRVVATGPGVTALRIGQ
RAGVPWLGWTCGECSYCRGGHENLCDAARFTGYTLDGGYAEYTVADQRYCFPLPDPLPAVELAPLLCAGLIGYRALAMAG
DAERIGIYGFGAAAHILAQVLVHQGRAFYAFTRPGDLAGQGFACRLGAAWAGGSDEAPDQALDAALIFAPAGPLVPAALR
AVRKGGTVVCAGIHMSDIPAFPYDILWGERVLRSVANLTRADGERFLRIVADNPVRSHVQVYRLDQANEALDALRLGRIE
GAAVLVPE

Sequences:

>Translated_328_residues
MRAMVLDTPGQPLRPAVLPQPTPGPGQVLLKVEACGVCRTDLHLVDGELPEPRLPVVPGHEIVGRVVATGPGVTALRIGQ
RAGVPWLGWTCGECSYCRGGHENLCDAARFTGYTLDGGYAEYTVADQRYCFPLPDPLPAVELAPLLCAGLIGYRALAMAG
DAERIGIYGFGAAAHILAQVLVHQGRAFYAFTRPGDLAGQGFACRLGAAWAGGSDEAPDQALDAALIFAPAGPLVPAALR
AVRKGGTVVCAGIHMSDIPAFPYDILWGERVLRSVANLTRADGERFLRIVADNPVRSHVQVYRLDQANEALDALRLGRIE
GAAVLVPE
>Mature_328_residues
MRAMVLDTPGQPLRPAVLPQPTPGPGQVLLKVEACGVCRTDLHLVDGELPEPRLPVVPGHEIVGRVVATGPGVTALRIGQ
RAGVPWLGWTCGECSYCRGGHENLCDAARFTGYTLDGGYAEYTVADQRYCFPLPDPLPAVELAPLLCAGLIGYRALAMAG
DAERIGIYGFGAAAHILAQVLVHQGRAFYAFTRPGDLAGQGFACRLGAAWAGGSDEAPDQALDAALIFAPAGPLVPAALR
AVRKGGTVVCAGIHMSDIPAFPYDILWGERVLRSVANLTRADGERFLRIVADNPVRSHVQVYRLDQANEALDALRLGRIE
GAAVLVPE

Specific function: Preferred Specificity Is Towards 1-Propanol. [C]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI71743840, Length=182, Percent_Identity=29.1208791208791, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI262073058, Length=182, Percent_Identity=29.1208791208791, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI71565154, Length=110, Percent_Identity=36.3636363636364, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI4501933, Length=173, Percent_Identity=28.3236994219653, Blast_Score=66, Evalue=4e-11,
Organism=Escherichia coli, GI87081918, Length=321, Percent_Identity=32.398753894081, Blast_Score=129, Evalue=3e-31,
Organism=Escherichia coli, GI1786518, Length=333, Percent_Identity=29.7297297297297, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI87082401, Length=312, Percent_Identity=28.2051282051282, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1787863, Length=223, Percent_Identity=29.1479820627803, Blast_Score=91, Evalue=9e-20,
Organism=Escherichia coli, GI226510992, Length=292, Percent_Identity=26.7123287671233, Blast_Score=81, Evalue=7e-17,
Organism=Escherichia coli, GI1790045, Length=321, Percent_Identity=25.2336448598131, Blast_Score=78, Evalue=8e-16,
Organism=Escherichia coli, GI1786552, Length=110, Percent_Identity=44.5454545454545, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI87082125, Length=137, Percent_Identity=33.5766423357664, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1788073, Length=143, Percent_Identity=31.4685314685315, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1786825, Length=81, Percent_Identity=38.2716049382716, Blast_Score=65, Evalue=9e-12,
Organism=Escherichia coli, GI1788407, Length=182, Percent_Identity=30.2197802197802, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17562582, Length=337, Percent_Identity=27.299703264095, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17562584, Length=336, Percent_Identity=25.5952380952381, Blast_Score=113, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI71988145, Length=328, Percent_Identity=25.3048780487805, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17562876, Length=263, Percent_Identity=29.277566539924, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17562878, Length=129, Percent_Identity=35.6589147286822, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI25146526, Length=197, Percent_Identity=31.9796954314721, Blast_Score=71, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI71997431, Length=199, Percent_Identity=31.6582914572864, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6323961, Length=360, Percent_Identity=29.7222222222222, Blast_Score=132, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6324486, Length=341, Percent_Identity=29.6187683284457, Blast_Score=127, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6319621, Length=360, Percent_Identity=28.8888888888889, Blast_Score=126, Evalue=6e-30,
Organism=Saccharomyces cerevisiae, GI6323729, Length=342, Percent_Identity=28.6549707602339, Blast_Score=122, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6323980, Length=158, Percent_Identity=36.7088607594937, Blast_Score=104, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6319949, Length=301, Percent_Identity=27.2425249169435, Blast_Score=83, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6319258, Length=212, Percent_Identity=28.3018867924528, Blast_Score=74, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6319257, Length=205, Percent_Identity=29.7560975609756, Blast_Score=74, Evalue=3e-14,
Organism=Drosophila melanogaster, GI17737895, Length=195, Percent_Identity=27.6923076923077, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI17137530, Length=139, Percent_Identity=32.3741007194245, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI17737897, Length=139, Percent_Identity=33.0935251798561, Blast_Score=68, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR014187
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 34683; Mature: 34683

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAMVLDTPGQPLRPAVLPQPTPGPGQVLLKVEACGVCRTDLHLVDGELPEPRLPVVPGH
CCEEEECCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCEEEECCCCCCCCCCCCCCH
EIVGRVVATGPGVTALRIGQRAGVPWLGWTCGECSYCRGGHENLCDAARFTGYTLDGGYA
HHHHHHEECCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCEEECCCEE
EYTVADQRYCFPLPDPLPAVELAPLLCAGLIGYRALAMAGDAERIGIYGFGAAAHILAQV
EEEECCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHH
LVHQGRAFYAFTRPGDLAGQGFACRLGAAWAGGSDEAPDQALDAALIFAPAGPLVPAALR
HHHCCCEEEEEECCCCCCCCCEEEEECCEECCCCCCCCHHHHCEEEEEECCCCHHHHHHH
AVRKGGTVVCAGIHMSDIPAFPYDILWGERVLRSVANLTRADGERFLRIVADNPVRSHVQ
HHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHCEE
VYRLDQANEALDALRLGRIEGAAVLVPE
EEEECCHHHHHHHHHHCCCCCCEEEECC
>Mature Secondary Structure
MRAMVLDTPGQPLRPAVLPQPTPGPGQVLLKVEACGVCRTDLHLVDGELPEPRLPVVPGH
CCEEEECCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCEEEECCCCCCCCCCCCCCH
EIVGRVVATGPGVTALRIGQRAGVPWLGWTCGECSYCRGGHENLCDAARFTGYTLDGGYA
HHHHHHEECCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCEEECCCEE
EYTVADQRYCFPLPDPLPAVELAPLLCAGLIGYRALAMAGDAERIGIYGFGAAAHILAQV
EEEECCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHH
LVHQGRAFYAFTRPGDLAGQGFACRLGAAWAGGSDEAPDQALDAALIFAPAGPLVPAALR
HHHCCCEEEEEECCCCCCCCCEEEEECCEECCCCCCCCHHHHCEEEEEECCCCHHHHHHH
AVRKGGTVVCAGIHMSDIPAFPYDILWGERVLRSVANLTRADGERFLRIVADNPVRSHVQ
HHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHCEE
VYRLDQANEALDALRLGRIEGAAVLVPE
EEEECCHHHHHHHHHHCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]