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The map label for this gene is mucD1 [H]

Identifier: 119896384

GI number: 119896384

Start: 108207

End: 109646

Strand: Reverse

Name: mucD1 [H]

Synonym: azo0092

Alternate gene names: 119896384

Gene position: 109646-108207 (Counterclockwise)

Preceding gene: 119896385

Following gene: 119896382

Centisome position: 2.51

GC content: 69.65

Gene sequence:

>1440_bases
ATGCGCCACCCGCTTGCCGTGACCGCCCTTGCGCTCAGCCTCGCCGGCTGGATTCCCGCCGCTTCGCTGTCCTCCTCCGC
CCACGCCGCGCTGTTCGGTGACAGTTCGCCCGCCTCCAATCGCTATGGTCTGCCGGACTTCGGCGATCTGGTCGAGCAGG
TCGGCCCGGCGGTGGTCAACATCAGCGTGGTACAGCAGCAAGCCGGCGGCGACGGCGGGCTGGCCAACGATCCCTTCTAC
GACTTCCTGCGCCGCTTCGGCGTACCCACGCCGGAGATGCCCGGCCAGGGCGCGCCGCGGATCAGCCGCGGCATCGGCTC
GGGCTTCATCGTCAGCGCCGACGGCTATGTGCTGACCAACGCCCACGTGGTGGGCGAGTCCGGGGCCGAAGTCACGGTCA
CGCTGGTGGACAAGCGTGAATTCAAAGCCAGGGTGGTGGGGACGGACAAACGCACCGACGTCGCGGTGATCAAGATCGAC
GCGCGCAACCTGCCGACGGTGAAGATCGGCGATGCCGAACGCTCGCGCGTCGGCGAATGGGTGATCGCGGTCGGCTCGCC
CTTCGGCTTCGATCACTCGGTGACCGCCGGCATCATCTCCGCCAAGGCGCGGCGGTTGCCCGACGAGAACTACGTGCCTT
TCCTGCAGACCGACGTCGCGATCAACCCCGGCAACTCGGGCGGGCCGCTGTTCAACCTGGGCGGCGAGGTCATCGGCATC
AACTCTCAGATCTACTCGCGTTCGGGCGGCTTCATGGGGATCTCGTTCGCAATCCCGATCGACGTCGCGATGAAGGTCAA
GGACCAGCTGGTGACGCATGGCCGGGTGCAGCGCGGCCGCCTCGGCATCGCCATCCAGGGCGTGGACAAGGAGCTGGCGC
AGTCCTTTGGCCTGCCCGACGCGCGCGGCGCGCTGGTCGCCAATGTGGAACCGGACAGCGCCGCGGACAAGGCGGGCGTC
AAGGCGGGCGACGTGGTGCTGGCAGTGGATGGAACGCGGATCAACGATTCAGCCGACCTGCCGCGCATCATCGGCGACAA
GCGCCCGGGCACCCGGGTACGGCTGGAAGTGTGGCGCGACGGCCGCAGCCGCGAGGTGAGCGCGACGCTGGACGAACTGG
GTGCCGAAACCGCCGCGGCGGCGCCCGCGCGCCCCGGCCGGGGCGAGAGCACCGGCGGCAAGCTCGGCCTCACGGCACGG
CCGCTCAGCAGCCAGGAAGCCGCCCAGCTCGGCATCAACGGCGGGCTGGTGGTCGAAGCCGCCAGCGGTCCGGCGGCCAA
GGCCGGGCTGGAGCGCGGTGACATCGTGCTGGCGATCAACAACCAGCCGGTCACTACGGTCGCCCAGTTCCGCCAGTTGG
CGGAAAAGGCGGGCAACCGCTTTGCGCTGCTGGTCCAGCGCGGCAGCGCCCGCATCTTCGTGCCGGTACGGCTGGACTGA

Upstream 100 bases:

>100_bases
GCCCCGATCTATGCCGGGCTTGCGTCCGGGAACGCACGGCCCGGCCGCGGCGTCCACCCACGCATCCCGTCCCACACGTT
TCCGCCACAGGATACCGTCC

Downstream 100 bases:

>100_bases
GCCCCGCCTAGACGCGGAAGCGCGACACCGAATCCTGCAGGCGCGCCGCGAGCTGCTCCAGCTCGCGCGCGGCCGCCACG
GTCTCCTCGATTGCGGCGTT

Product: serine protease MucD

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 479; Mature: 479

Protein sequence:

>479_residues
MRHPLAVTALALSLAGWIPAASLSSSAHAALFGDSSPASNRYGLPDFGDLVEQVGPAVVNISVVQQQAGGDGGLANDPFY
DFLRRFGVPTPEMPGQGAPRISRGIGSGFIVSADGYVLTNAHVVGESGAEVTVTLVDKREFKARVVGTDKRTDVAVIKID
ARNLPTVKIGDAERSRVGEWVIAVGSPFGFDHSVTAGIISAKARRLPDENYVPFLQTDVAINPGNSGGPLFNLGGEVIGI
NSQIYSRSGGFMGISFAIPIDVAMKVKDQLVTHGRVQRGRLGIAIQGVDKELAQSFGLPDARGALVANVEPDSAADKAGV
KAGDVVLAVDGTRINDSADLPRIIGDKRPGTRVRLEVWRDGRSREVSATLDELGAETAAAAPARPGRGESTGGKLGLTAR
PLSSQEAAQLGINGGLVVEAASGPAAKAGLERGDIVLAINNQPVTTVAQFRQLAEKAGNRFALLVQRGSARIFVPVRLD

Sequences:

>Translated_479_residues
MRHPLAVTALALSLAGWIPAASLSSSAHAALFGDSSPASNRYGLPDFGDLVEQVGPAVVNISVVQQQAGGDGGLANDPFY
DFLRRFGVPTPEMPGQGAPRISRGIGSGFIVSADGYVLTNAHVVGESGAEVTVTLVDKREFKARVVGTDKRTDVAVIKID
ARNLPTVKIGDAERSRVGEWVIAVGSPFGFDHSVTAGIISAKARRLPDENYVPFLQTDVAINPGNSGGPLFNLGGEVIGI
NSQIYSRSGGFMGISFAIPIDVAMKVKDQLVTHGRVQRGRLGIAIQGVDKELAQSFGLPDARGALVANVEPDSAADKAGV
KAGDVVLAVDGTRINDSADLPRIIGDKRPGTRVRLEVWRDGRSREVSATLDELGAETAAAAPARPGRGESTGGKLGLTAR
PLSSQEAAQLGINGGLVVEAASGPAAKAGLERGDIVLAINNQPVTTVAQFRQLAEKAGNRFALLVQRGSARIFVPVRLD
>Mature_479_residues
MRHPLAVTALALSLAGWIPAASLSSSAHAALFGDSSPASNRYGLPDFGDLVEQVGPAVVNISVVQQQAGGDGGLANDPFY
DFLRRFGVPTPEMPGQGAPRISRGIGSGFIVSADGYVLTNAHVVGESGAEVTVTLVDKREFKARVVGTDKRTDVAVIKID
ARNLPTVKIGDAERSRVGEWVIAVGSPFGFDHSVTAGIISAKARRLPDENYVPFLQTDVAINPGNSGGPLFNLGGEVIGI
NSQIYSRSGGFMGISFAIPIDVAMKVKDQLVTHGRVQRGRLGIAIQGVDKELAQSFGLPDARGALVANVEPDSAADKAGV
KAGDVVLAVDGTRINDSADLPRIIGDKRPGTRVRLEVWRDGRSREVSATLDELGAETAAAAPARPGRGESTGGKLGLTAR
PLSSQEAAQLGINGGLVVEAASGPAAKAGLERGDIVLAINNQPVTTVAQFRQLAEKAGNRFALLVQRGSARIFVPVRLD

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=341, Percent_Identity=34.6041055718475, Blast_Score=158, Evalue=1e-38,
Organism=Homo sapiens, GI22129776, Length=370, Percent_Identity=32.972972972973, Blast_Score=149, Evalue=7e-36,
Organism=Homo sapiens, GI24308541, Length=254, Percent_Identity=36.6141732283465, Blast_Score=134, Evalue=3e-31,
Organism=Homo sapiens, GI7019477, Length=312, Percent_Identity=34.6153846153846, Blast_Score=132, Evalue=7e-31,
Organism=Escherichia coli, GI1786356, Length=472, Percent_Identity=35.1694915254237, Blast_Score=256, Evalue=3e-69,
Organism=Escherichia coli, GI1789629, Length=475, Percent_Identity=35.7894736842105, Blast_Score=254, Evalue=9e-69,
Organism=Escherichia coli, GI1789630, Length=278, Percent_Identity=37.410071942446, Blast_Score=169, Evalue=3e-43,
Organism=Drosophila melanogaster, GI24646839, Length=265, Percent_Identity=36.6037735849057, Blast_Score=140, Evalue=1e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 49863; Mature: 49863

Theoretical pI: Translated: 8.81; Mature: 8.81

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
0.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRHPLAVTALALSLAGWIPAASLSSSAHAALFGDSSPASNRYGLPDFGDLVEQVGPAVVN
CCCCHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHCCEEEE
ISVVQQQAGGDGGLANDPFYDFLRRFGVPTPEMPGQGAPRISRGIGSGFIVSADGYVLTN
EEEEEECCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHCCCCCEEEECCCEEEEE
AHVVGESGAEVTVTLVDKREFKARVVGTDKRTDVAVIKIDARNLPTVKIGDAERSRVGEW
EEEECCCCCEEEEEEEECCCCEEEEECCCCCCEEEEEEEECCCCCEEEECCCHHHCCCEE
VIAVGSPFGFDHSVTAGIISAKARRLPDENYVPFLQTDVAINPGNSGGPLFNLGGEVIGI
EEEECCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCCCEEECCCEEEEE
NSQIYSRSGGFMGISFAIPIDVAMKVKDQLVTHGRVQRGRLGIAIQGVDKELAQSFGLPD
CHHEEECCCCEEEEEEEECEEEEHHHHHHHHHCCCCCCCEEEEEEECCCHHHHHHCCCCC
ARGALVANVEPDSAADKAGVKAGDVVLAVDGTRINDSADLPRIIGDKRPGTRVRLEVWRD
CCCCEEEECCCCCCHHHCCCCCCCEEEEECCCEECCCCCCCHHHCCCCCCCEEEEEEECC
GRSREVSATLDELGAETAAAAPARPGRGESTGGKLGLTARPLSSQEAAQLGINGGLVVEA
CCCCCHHHHHHHHCCHHHCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHCCCCCEEEEE
ASGPAAKAGLERGDIVLAINNQPVTTVAQFRQLAEKAGNRFALLVQRGSARIFVPVRLD
CCCCHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCEEEEEEEECCCEEEEEEEEC
>Mature Secondary Structure
MRHPLAVTALALSLAGWIPAASLSSSAHAALFGDSSPASNRYGLPDFGDLVEQVGPAVVN
CCCCHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHCCEEEE
ISVVQQQAGGDGGLANDPFYDFLRRFGVPTPEMPGQGAPRISRGIGSGFIVSADGYVLTN
EEEEEECCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHCCCCCEEEECCCEEEEE
AHVVGESGAEVTVTLVDKREFKARVVGTDKRTDVAVIKIDARNLPTVKIGDAERSRVGEW
EEEECCCCCEEEEEEEECCCCEEEEECCCCCCEEEEEEEECCCCCEEEECCCHHHCCCEE
VIAVGSPFGFDHSVTAGIISAKARRLPDENYVPFLQTDVAINPGNSGGPLFNLGGEVIGI
EEEECCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCCCEEECCCEEEEE
NSQIYSRSGGFMGISFAIPIDVAMKVKDQLVTHGRVQRGRLGIAIQGVDKELAQSFGLPD
CHHEEECCCCEEEEEEEECEEEEHHHHHHHHHCCCCCCCEEEEEEECCCHHHHHHCCCCC
ARGALVANVEPDSAADKAGVKAGDVVLAVDGTRINDSADLPRIIGDKRPGTRVRLEVWRD
CCCCEEEECCCCCCHHHCCCCCCCEEEEECCCEECCCCCCCHHHCCCCCCCEEEEEEECC
GRSREVSATLDELGAETAAAAPARPGRGESTGGKLGLTARPLSSQEAAQLGINGGLVVEA
CCCCCHHHHHHHHCCHHHCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHCCCCCEEEEE
ASGPAAKAGLERGDIVLAINNQPVTTVAQFRQLAEKAGNRFALLVQRGSARIFVPVRLD
CCCCHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCEEEEEEEECCCEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7861951 [H]