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The map label for this gene is menB [H]

Identifier: 119776767

GI number: 119776767

Start: 4284569

End: 4285471

Strand: Direct

Name: menB [H]

Synonym: Sama_3635

Alternate gene names: 119776767

Gene position: 4284569-4285471 (Clockwise)

Preceding gene: 119776766

Following gene: 119776768

Centisome position: 99.5

GC content: 55.04

Gene sequence:

>903_bases
ATGACCAAAAAAGTTTCTGATAACTTTGATCCAGATCTCTGGACAGAAGTACCAGGTTTTGCATTCGACGACATCACCTA
CCACAGGGCCAAGGATCAGGGCACGGTACGTATCGCATTTAACCGTCCTGACTGCCTCAACGCCTTTCGCCCCAAAACCG
TTGATGAACTCTACACCGCCCTTGACCACGCCCGCCAATGGTCAGACGTTGGCTGTGTGCTGCTGACCGGCAACGGCCCC
TCTGCCAAAGGCCAATATTCGTTTTCCTCCGGTGGCGACCAGCGTATTCGTGGTAAAGACGGCTACAAATACGAAGGCGA
AGAAGCAGGCAAGGCCGATGTGGCCCGCATGGGCAGGTTGCACATTCTGGAAGTGCAGCGACTTATCCGCTTTATGCCCA
AGGTGGTGATTGCCGTTGTCCCCGGCTGGGCCGTGGGGGGAGGTCATAGCCTGCATGTGGTGTGTGACCTGACTCTGGCC
TCAAAGGAACACGCGGTATTTAAACAAACCGACCCGGATGTGGCCAGCTTTGACTCTGGTTACGGCAGTGCCTATCTCGC
CAAGATGGTGGGGCAAAAACGCGCCCGGGAAATCTTCTTCCTCGGCTTTAACTACAGTGCCGATGAAGCGGTCGCCATGG
GCATGGTCAATCGCAGTATTCCCCATGCCGAGCTGGAAACCGAAGCATTACGCTGGGCCAAAGAGATCAATTCCAAATCT
CCCACCGCCATGCGCATGCTCAAATACGGCTTCAACCTGCCAGATGACGGCCTGGTTGGTCAGCAACTGTTTGCCGGAGA
GGCCACCCGCCTTGCCTATGGTACAGATGAAGCACGTGAAGGCCGTGATGCCTTTTTGGAGAAACGGGATCAGGATTACA
GCCATTTCCCCTGGCACTACTAA

Upstream 100 bases:

>100_bases
CTTTTGTCGGCCACCCCATGGCTTTTACCTTAAAGCATTGACCCTAAATCAACTTGAGCCTAGCCTGTGGCAACTAATCT
GAACATAGGCAGGCTCAGTC

Downstream 100 bases:

>100_bases
TTCCTGAGGCCACCAGCAAAAGACGCAGCAAAATCTGCGTCTTTTGTCTTAATCGGCTGCCTCGTTTACCTCAATTGAAC
AATTCTACTTTACACGTAAG

Product: naphthoate synthase

Products: NA

Alternate protein names: DHNA-CoA synthase [H]

Number of amino acids: Translated: 300; Mature: 299

Protein sequence:

>300_residues
MTKKVSDNFDPDLWTEVPGFAFDDITYHRAKDQGTVRIAFNRPDCLNAFRPKTVDELYTALDHARQWSDVGCVLLTGNGP
SAKGQYSFSSGGDQRIRGKDGYKYEGEEAGKADVARMGRLHILEVQRLIRFMPKVVIAVVPGWAVGGGHSLHVVCDLTLA
SKEHAVFKQTDPDVASFDSGYGSAYLAKMVGQKRAREIFFLGFNYSADEAVAMGMVNRSIPHAELETEALRWAKEINSKS
PTAMRMLKYGFNLPDDGLVGQQLFAGEATRLAYGTDEAREGRDAFLEKRDQDYSHFPWHY

Sequences:

>Translated_300_residues
MTKKVSDNFDPDLWTEVPGFAFDDITYHRAKDQGTVRIAFNRPDCLNAFRPKTVDELYTALDHARQWSDVGCVLLTGNGP
SAKGQYSFSSGGDQRIRGKDGYKYEGEEAGKADVARMGRLHILEVQRLIRFMPKVVIAVVPGWAVGGGHSLHVVCDLTLA
SKEHAVFKQTDPDVASFDSGYGSAYLAKMVGQKRAREIFFLGFNYSADEAVAMGMVNRSIPHAELETEALRWAKEINSKS
PTAMRMLKYGFNLPDDGLVGQQLFAGEATRLAYGTDEAREGRDAFLEKRDQDYSHFPWHY
>Mature_299_residues
TKKVSDNFDPDLWTEVPGFAFDDITYHRAKDQGTVRIAFNRPDCLNAFRPKTVDELYTALDHARQWSDVGCVLLTGNGPS
AKGQYSFSSGGDQRIRGKDGYKYEGEEAGKADVARMGRLHILEVQRLIRFMPKVVIAVVPGWAVGGGHSLHVVCDLTLAS
KEHAVFKQTDPDVASFDSGYGSAYLAKMVGQKRAREIFFLGFNYSADEAVAMGMVNRSIPHAELETEALRWAKEINSKSP
TAMRMLKYGFNLPDDGLVGQQLFAGEATRLAYGTDEAREGRDAFLEKRDQDYSHFPWHY

Specific function: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA) [H]

COG id: COG0447

COG function: function code H; Dihydroxynaphthoic acid synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=279, Percent_Identity=29.3906810035842, Blast_Score=99, Evalue=7e-21,
Organism=Homo sapiens, GI31542718, Length=272, Percent_Identity=29.7794117647059, Blast_Score=89, Evalue=7e-18,
Organism=Homo sapiens, GI70995211, Length=256, Percent_Identity=28.125, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1788597, Length=275, Percent_Identity=46.9090909090909, Blast_Score=245, Evalue=2e-66,
Organism=Escherichia coli, GI87082183, Length=265, Percent_Identity=26.0377358490566, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1787659, Length=273, Percent_Identity=26.007326007326, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI221142681, Length=270, Percent_Identity=25.9259259259259, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1787660, Length=266, Percent_Identity=26.6917293233083, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17554946, Length=264, Percent_Identity=26.5151515151515, Blast_Score=87, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI25145438, Length=280, Percent_Identity=27.1428571428571, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17540714, Length=223, Percent_Identity=26.9058295964126, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI20129971, Length=264, Percent_Identity=26.5151515151515, Blast_Score=88, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24653477, Length=264, Percent_Identity=26.5151515151515, Blast_Score=88, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR010198 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.1.3.36 [H]

Molecular weight: Translated: 33502; Mature: 33371

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKKVSDNFDPDLWTEVPGFAFDDITYHRAKDQGTVRIAFNRPDCLNAFRPKTVDELYTA
CCCCCCCCCCCCHHHCCCCCEECCCEEEECCCCCEEEEEECCCHHHHCCCCCCHHHHHHH
LDHARQWSDVGCVLLTGNGPSAKGQYSFSSGGDQRIRGKDGYKYEGEEAGKADVARMGRL
HHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCHHHHHHHCCH
HILEVQRLIRFMPKVVIAVVPGWAVGGGHSLHVVCDLTLASKEHAVFKQTDPDVASFDSG
HHHHHHHHHHHHHHHHHHCCCCCEECCCCEEEEEEEEEECCCCCCEEECCCCCHHHCCCC
YGSAYLAKMVGQKRAREIFFLGFNYSADEAVAMGMVNRSIPHAELETEALRWAKEINSKS
CCHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCC
PTAMRMLKYGFNLPDDGLVGQQLFAGEATRLAYGTDEAREGRDAFLEKRDQDYSHFPWHY
HHHHHHHHHCCCCCCCCCCCHHHHCCCCCEEEECCCHHHCHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
TKKVSDNFDPDLWTEVPGFAFDDITYHRAKDQGTVRIAFNRPDCLNAFRPKTVDELYTA
CCCCCCCCCCCHHHCCCCCEECCCEEEECCCCCEEEEEECCCHHHHCCCCCCHHHHHHH
LDHARQWSDVGCVLLTGNGPSAKGQYSFSSGGDQRIRGKDGYKYEGEEAGKADVARMGRL
HHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCHHHHHHHCCH
HILEVQRLIRFMPKVVIAVVPGWAVGGGHSLHVVCDLTLASKEHAVFKQTDPDVASFDSG
HHHHHHHHHHHHHHHHHHCCCCCEECCCCEEEEEEEEEECCCCCCEEECCCCCHHHCCCC
YGSAYLAKMVGQKRAREIFFLGFNYSADEAVAMGMVNRSIPHAELETEALRWAKEINSKS
CCHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCC
PTAMRMLKYGFNLPDDGLVGQQLFAGEATRLAYGTDEAREGRDAFLEKRDQDYSHFPWHY
HHHHHHHHHCCCCCCCCCCCHHHHCCCCCEEEECCCHHHCHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]