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The map label for this gene is lexA

Identifier: 119776613

GI number: 119776613

Start: 4113597

End: 4114220

Strand: Direct

Name: lexA

Synonym: Sama_3481

Alternate gene names: 119776613

Gene position: 4113597-4114220 (Clockwise)

Preceding gene: 119776610

Following gene: 119776614

Centisome position: 95.53

GC content: 56.41

Gene sequence:

>624_bases
ATGAGACCGCTCACGCCTCGCCAGGCCGAGATCCTGGACCTAATCAAACGCAACATCGCCGAAACCGGCATGCCCCCAAC
GCGGGCAGAAATTGCATCCAGACTCGGCTTTAAAAGTGCTAATGCCGCCGAGGAGCATCTTAAAGCGCTCGCCAAAAAGG
GCTGCATTGAGATTATGCCCGGCACCTCGCGAGGTATCAGGCTGGCGGGTGATGAGTTGGAAGATCAGCCAGACCCGGGT
TTGCCCTTGATAGGTCAGGTGGCTGCCGGTGAACCCATTCTCGCCCAAGAGCATGTTGAGCAGTATTATCAGGTCGATCC
TGCCATGTTCCGCCCCCATGCCGATTTTCTGCTGCGGGTTCGCGGCGACAGTATGAAAGACATAGGTATTCTCGACGGCG
ACCTGCTGGCGGTGCACAAGATGAACCAGGCCCGTAATGGCCAGGTGGTGGTTGCCAGGGTGGAAGACGATGTCACGGTA
AAACGCTTCGAGAAGCAAGGCAATGTGGTGTACCTACACGCAGAGAACGAGGCATTCGCTCCTATCAGAGTGGATCTTGC
CAACCAGAGTCTCACCATCGAGGGCTTGGCTGTGGGCGTTATCCGTAATGGAGACTGGCTATGA

Upstream 100 bases:

>100_bases
GCCGCAGCCATTAGCCAATAATCTGAAAAATGGTTAATACTTGCGCTGATTAAAATACTGTATATACTGACAGTAACTGT
ATAGAAAAACAGGAATGACC

Downstream 100 bases:

>100_bases
ACAAGCTGATTGGTAACGCACCCCGTCATCCAGGTTTATGGACAGATTCCGCAGCCAAAGACGTTTGCCCCACATCGCAG
GTGATTACCCAAAGCACTCA

Product: LexA repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 207; Mature: 207

Protein sequence:

>207_residues
MRPLTPRQAEILDLIKRNIAETGMPPTRAEIASRLGFKSANAAEEHLKALAKKGCIEIMPGTSRGIRLAGDELEDQPDPG
LPLIGQVAAGEPILAQEHVEQYYQVDPAMFRPHADFLLRVRGDSMKDIGILDGDLLAVHKMNQARNGQVVVARVEDDVTV
KRFEKQGNVVYLHAENEAFAPIRVDLANQSLTIEGLAVGVIRNGDWL

Sequences:

>Translated_207_residues
MRPLTPRQAEILDLIKRNIAETGMPPTRAEIASRLGFKSANAAEEHLKALAKKGCIEIMPGTSRGIRLAGDELEDQPDPG
LPLIGQVAAGEPILAQEHVEQYYQVDPAMFRPHADFLLRVRGDSMKDIGILDGDLLAVHKMNQARNGQVVVARVEDDVTV
KRFEKQGNVVYLHAENEAFAPIRVDLANQSLTIEGLAVGVIRNGDWL
>Mature_207_residues
MRPLTPRQAEILDLIKRNIAETGMPPTRAEIASRLGFKSANAAEEHLKALAKKGCIEIMPGTSRGIRLAGDELEDQPDPG
LPLIGQVAAGEPILAQEHVEQYYQVDPAMFRPHADFLLRVRGDSMKDIGILDGDLLAVHKMNQARNGQVVVARVEDDVTV
KRFEKQGNVVYLHAENEAFAPIRVDLANQSLTIEGLAVGVIRNGDWL

Specific function: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, recA interacts with lexA causing an autocatalytic cleavage which disrupts the DNA-binding part of lexA, lea

COG id: COG1974

COG function: function code KT; SOS-response transcriptional repressors (RecA-mediated autopeptidases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S24 family

Homologues:

Organism=Escherichia coli, GI1790476, Length=207, Percent_Identity=70.048309178744, Blast_Score=292, Evalue=1e-80,
Organism=Escherichia coli, GI1787431, Length=124, Percent_Identity=33.0645161290323, Blast_Score=62, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LEXA_SHEAM (A1SBC7)

Other databases:

- EMBL:   CP000507
- RefSeq:   YP_929353.1
- ProteinModelPortal:   A1SBC7
- SMR:   A1SBC7
- STRING:   A1SBC7
- MEROPS:   S24.001
- GeneID:   4605728
- GenomeReviews:   CP000507_GR
- KEGG:   saz:Sama_3481
- NMPDR:   fig|326297.7.peg.3280
- eggNOG:   COG1974
- HOGENOM:   HBG679610
- OMA:   IAENPDF
- PhylomeDB:   A1SBC7
- ProtClustDB:   PRK00215
- GO:   GO:0006508
- GO:   GO:0006350
- HAMAP:   MF_00015
- InterPro:   IPR006199
- InterPro:   IPR006200
- InterPro:   IPR006197
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056
- InterPro:   IPR011991
- Gene3D:   G3DSA:2.10.109.10
- Gene3D:   G3DSA:1.10.10.10
- PRINTS:   PR00726
- TIGRFAMs:   TIGR00498

Pfam domain/function: PF01726 LexA_DNA_bind; PF00717 Peptidase_S24; SSF51306 Pept_S24_S26_C

EC number: =3.4.21.88

Molecular weight: Translated: 22732; Mature: 22732

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: NA

Important sites: ACT_SITE 124-124 ACT_SITE 161-161

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPLTPRQAEILDLIKRNIAETGMPPTRAEIASRLGFKSANAAEEHLKALAKKGCIEIMP
CCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHCCCEEECC
GTSRGIRLAGDELEDQPDPGLPLIGQVAAGEPILAQEHVEQYYQVDPAMFRPHADFLLRV
CCCCCEEEECCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHCCHHHCCCCCEEEEEE
RGDSMKDIGILDGDLLAVHKMNQARNGQVVVARVEDDVTVKRFEKQGNVVYLHAENEAFA
CCCCCCCCCCCCCCEEEEEHHCCCCCCCEEEEEECCCCCHHHHHCCCCEEEEEECCCCCC
PIRVDLANQSLTIEGLAVGVIRNGDWL
EEEEEECCCEEEEEEEEEEEEECCCCC
>Mature Secondary Structure
MRPLTPRQAEILDLIKRNIAETGMPPTRAEIASRLGFKSANAAEEHLKALAKKGCIEIMP
CCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHCCCEEECC
GTSRGIRLAGDELEDQPDPGLPLIGQVAAGEPILAQEHVEQYYQVDPAMFRPHADFLLRV
CCCCCEEEECCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHCCHHHCCCCCEEEEEE
RGDSMKDIGILDGDLLAVHKMNQARNGQVVVARVEDDVTVKRFEKQGNVVYLHAENEAFA
CCCCCCCCCCCCCCEEEEEHHCCCCCCCEEEEEECCCCCHHHHHCCCCEEEEEECCCCCC
PIRVDLANQSLTIEGLAVGVIRNGDWL
EEEEEECCCEEEEEEEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA