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The map label for this gene is mtr [H]

Identifier: 119776611

GI number: 119776611

Start: 4109766

End: 4111022

Strand: Reverse

Name: mtr [H]

Synonym: Sama_3479

Alternate gene names: 119776611

Gene position: 4111022-4109766 (Counterclockwise)

Preceding gene: 119776612

Following gene: 119776609

Centisome position: 95.47

GC content: 55.05

Gene sequence:

>1257_bases
ATGGCTAACCACATGAATGCCGCCAGGCATCCGGTCAAAACTCCATCGCTGCTGGGTGGCGCCATGATTATCGCCGGTAC
TACGGTGGGAGCAGGAATGTTTTCCCTGCCTGTGGTGGGCGCCGGCATGTGGTTTGGCTATTCGCTGCTGCTGATGGTGG
CGATTTGGCTGTGCATGTTGTTGTCGGGATTACTGCTGCTGGAAACTAACCTGAGGTTCGAGCCGGGTGCCAGCTTTGAT
ACCCTTACCCGCGACAGCTTGGGACGCTTTGGCCGTATCGTCAACGGGCTCTCCATTGCCTTCGTGCTCTATATCCTGAC
ATACGCCTATATCAGTGGTGGTGGCTCCATCGTGAATCACAGCCTGTCGGGAATGGGCATCAGCCTGCCACAAAGTGTGG
CTGGGTTGGTGTTTGCTGCGGTATTGGCGGCCATCGTTATGATAAGTACCAAAGCGGTGGACAGAATCACCACCATTATG
CTGGGTGGCATGATAATGACCTTCTTCCTGGCGGTCGGAAACCTACTGATTGAGGTGCAGCCGAGCAATTTATTCTCGCC
CGATGGCGAAGCCCGCTTTGCCCCGTTTTTGTGGGCAGCAATTCCCTTCGGGCTGGCGAGTTTTGGCTACCACGGCAACG
TGCCTTCTCTGGTGAAATACTACGGTAAAAATCCGTCCGTCATCATTAAGGCGATTTGTATCGGCACCTTTATCGCACTG
GTGATTTATGTGTGCTGGCTGCTGGCTGCCATGGGCAATCTGCCGCGCAGTCAGTTCAGTGATATCATAGCTCAGGGTGG
CAACATGGGCGTGTTGGTGTCGGCCCTGTCGGAGGTCATGGCCAACGACTGGCTCGGCAAAATGCTGACCCTGTTTGCCA
ACCTTGCTGTAGCCTCTTCATTCCTTGGCGTGACCCTGGGATTGTTTGACTATCTGGCAGACCTCTTTGGTTTTGCCGAT
GACGCTAAAGGGCGTTTTAAGACCGCTGCCGTCACTTTCTTGCCGCCGACCTTGTTGGGGCTGCTGTTTCCCGACGGCTT
TTTGGTCGCCATCGGCTTTGCTGCGCTGGCGGCTACCGTTTGGACCCTGCTTGTACCCGGAGTCATGGCGTTGAAGCTCA
GAAAGCAGCAACCGGACTACCCCGGTTTCAGGGTGCCAGGTGGCGCTGGTGTTATCTATCTGGTGATAAGTTTCGGTATT
CTGACGGCAGCTTGCCATCTGCTCGCAATGGCTGAGCTGTTACCTGTATACCGTTAA

Upstream 100 bases:

>100_bases
GCGACAAGGTGCGTAAAATCCGTGATCATGCCAACGGGCTCCTCAGAAGCTCAGTGCGTCAGACCATTATTGAGACGCTG
AATCAGGAGCAGGACGACTG

Downstream 100 bases:

>100_bases
AGGATACTGCCATGCCTTTGCTTGACAAAGGCATGGATTTCAGTAATTTATAACGCGTAAAAGGCGGGTGTAGTTCAATG
GTAGAACGGCAGCTTCCCAA

Product: aromatic amino acid transport protein

Products: Indole [Cytoplasm]; L-tryptophan [Cytoplasm]; Proton [Cytoplasm] [C]

Alternate protein names: Tryptophan permease [H]

Number of amino acids: Translated: 418; Mature: 417

Protein sequence:

>418_residues
MANHMNAARHPVKTPSLLGGAMIIAGTTVGAGMFSLPVVGAGMWFGYSLLLMVAIWLCMLLSGLLLLETNLRFEPGASFD
TLTRDSLGRFGRIVNGLSIAFVLYILTYAYISGGGSIVNHSLSGMGISLPQSVAGLVFAAVLAAIVMISTKAVDRITTIM
LGGMIMTFFLAVGNLLIEVQPSNLFSPDGEARFAPFLWAAIPFGLASFGYHGNVPSLVKYYGKNPSVIIKAICIGTFIAL
VIYVCWLLAAMGNLPRSQFSDIIAQGGNMGVLVSALSEVMANDWLGKMLTLFANLAVASSFLGVTLGLFDYLADLFGFAD
DAKGRFKTAAVTFLPPTLLGLLFPDGFLVAIGFAALAATVWTLLVPGVMALKLRKQQPDYPGFRVPGGAGVIYLVISFGI
LTAACHLLAMAELLPVYR

Sequences:

>Translated_418_residues
MANHMNAARHPVKTPSLLGGAMIIAGTTVGAGMFSLPVVGAGMWFGYSLLLMVAIWLCMLLSGLLLLETNLRFEPGASFD
TLTRDSLGRFGRIVNGLSIAFVLYILTYAYISGGGSIVNHSLSGMGISLPQSVAGLVFAAVLAAIVMISTKAVDRITTIM
LGGMIMTFFLAVGNLLIEVQPSNLFSPDGEARFAPFLWAAIPFGLASFGYHGNVPSLVKYYGKNPSVIIKAICIGTFIAL
VIYVCWLLAAMGNLPRSQFSDIIAQGGNMGVLVSALSEVMANDWLGKMLTLFANLAVASSFLGVTLGLFDYLADLFGFAD
DAKGRFKTAAVTFLPPTLLGLLFPDGFLVAIGFAALAATVWTLLVPGVMALKLRKQQPDYPGFRVPGGAGVIYLVISFGI
LTAACHLLAMAELLPVYR
>Mature_417_residues
ANHMNAARHPVKTPSLLGGAMIIAGTTVGAGMFSLPVVGAGMWFGYSLLLMVAIWLCMLLSGLLLLETNLRFEPGASFDT
LTRDSLGRFGRIVNGLSIAFVLYILTYAYISGGGSIVNHSLSGMGISLPQSVAGLVFAAVLAAIVMISTKAVDRITTIML
GGMIMTFFLAVGNLLIEVQPSNLFSPDGEARFAPFLWAAIPFGLASFGYHGNVPSLVKYYGKNPSVIIKAICIGTFIALV
IYVCWLLAAMGNLPRSQFSDIIAQGGNMGVLVSALSEVMANDWLGKMLTLFANLAVASSFLGVTLGLFDYLADLFGFADD
AKGRFKTAAVTFLPPTLLGLLFPDGFLVAIGFAALAATVWTLLVPGVMALKLRKQQPDYPGFRVPGGAGVIYLVISFGIL
TAACHLLAMAELLPVYR

Specific function: Involved in transporting tryptophan across the cytoplasmic membrane [H]

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. Mtr/TnaB/TyrP permease subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789552, Length=406, Percent_Identity=55.9113300492611, Blast_Score=414, Evalue=1e-117,
Organism=Escherichia coli, GI1790145, Length=409, Percent_Identity=44.2542787286064, Blast_Score=328, Evalue=4e-91,
Organism=Escherichia coli, GI1788218, Length=399, Percent_Identity=37.0927318295739, Blast_Score=239, Evalue=3e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002091
- InterPro:   IPR013061
- InterPro:   IPR013059
- InterPro:   IPR018227 [H]

Pfam domain/function: PF03222 Trp_Tyr_perm [H]

EC number: NA

Molecular weight: Translated: 44242; Mature: 44111

Theoretical pI: Translated: 8.82; Mature: 8.82

Prosite motif: PS00189 LIPOYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHCCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ANHMNAARHPVKTPSLLGGAMIIAGTTVGAGMFSLPVVGAGMWFGYSLLLMVAIWLCML
CCCCCHHCCCCCCCHHHCCHHEEECCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSGLLLLETNLRFEPGASFDTLTRDSLGRFGRIVNGLSIAFVLYILTYAYISGGGSIVNH
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHC
SLSGMGISLPQSVAGLVFAAVLAAIVMISTKAVDRITTIMLGGMIMTFFLAVGNLLIEVQ
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEC
PSNLFSPDGEARFAPFLWAAIPFGLASFGYHGNVPSLVKYYGKNPSVIIKAICIGTFIAL
CCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHH
VIYVCWLLAAMGNLPRSQFSDIIAQGGNMGVLVSALSEVMANDWLGKMLTLFANLAVASS
HHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLGVTLGLFDYLADLFGFADDAKGRFKTAAVTFLPPTLLGLLFPDGFLVAIGFAALAATV
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHEEHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
WTLLVPGVMALKLRKQQPDYPGFRVPGGAGVIYLVISFGILTAACHLLAMAELLPVYR
HHHHHHHHHHHHHHHCCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Indole [Periplasm]; L-tryptophan [Periplasm]; Proton [Periplasm] [C]

Specific reaction: Proton [Periplasm] + indole [Periplasm] = Proton [Cytoplasm] + indole [Cytoplasm] L-tryptophan [Periplasm] + Proton [Periplasm] = L-tryptophan [Cytoplasm] + Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1987112; 2061290; 9278503; 1904443; 7814318 [H]