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The map label for this gene is cpxA [H]

Identifier: 119776565

GI number: 119776565

Start: 4062455

End: 4063816

Strand: Direct

Name: cpxA [H]

Synonym: Sama_3433

Alternate gene names: 119776565

Gene position: 4062455-4063816 (Clockwise)

Preceding gene: 119776564

Following gene: 119776567

Centisome position: 94.34

GC content: 59.62

Gene sequence:

>1362_bases
ATGAACACCCAAACCCTGCCCAATCGCCTCTTTATCAAACTGCTGCTCGGTTTCTGGCTATGCAGCTCTGTGGTGCTGGT
TGCCGTAGGCAGCCTGCCACTGCTGCAACAGCAGCGGGAATCCACCCCCATTCCCAAAGAGCTGCAACAGACTCTGGATA
AGATTGCCAGGGCGATTGAGCGGGAGCCTGAACTGATGGAGCCAGAGCGGATGCGGCGCTGGGAGCGCTCGCGTCACGCC
GACGGCAAGCCCATGCGGGTATTTATCACCAATGAGGAAGGCCGCATTCTCGGCGAGCGCCAACCCCGCTCTCTGCGTAA
ATTTATCCTGCTCGCCGAAGAAGCCGAGCGCCCCATCATGTATCAGTTCCGCGATGAAATGGTGTTTGGCCCCAAGGAGT
TCCATGTCGATGGTAAGGAATACCACCTCTATGGCCGGGTGCCAGGGCAGCATCCACGGCCACTGTTCCTGTTTTTTATC
GAGCACAAGTTGCTGACACTGGGGCTCGCGGTGTTGGTCTCGGGGCTCTTGTGCGGCCTGCTGGCATGGCACCTTGGCAG
GCCCCTTAAGATGTTGAAACAAAGCGCCGATGCCTTGGCACGGGGCAACCTTGGCAGCCGGGTCGATGAAGCCACCCTGA
ATCGCCGGGATGAGTTGGGCCAGCTGGGCCATGCCTTCAACGCCATGGCCGAAGCCATTGAGCAGCAGGTCAACAATCAG
CAGCGACTGATGGGGGACATCAGCCACGAGCTGCGCACCCCCCTGACCCGGCTGCAGCTGGCGCTGGCATTGGCACGCAA
GCGAGGTCAGGACAGTAATGAGCTAAACCGTATTGCCCACGAGGCCGAGCAGCTCGATGCCCTGATAGCCGAGCTGTTGA
CTCTCTCCCGGGTGACCATGGGCGCCACCGAGGCCAAAGTTGACATCGAACTTGCCGAGACCCTCGGCCAGGTATTGGAT
GATGCGGAGTTTGAAGCCAGCGAATGCGGCAAGCATCTGGCCATTGAAATGGACGACAACCTGCTGTTAAGCCACACCCC
CAAGTTATTGGCACGGGCGGTGGAAAATTTGCTGCGTAACGCCATCCGCTACGCCAGGCTGCAGGTCAGTCTGACTGTGA
CAGACACTCAGGACCGCATTGAAATTCAAATTTGTGATGATGGCCCCGGCGTGGCTGACGCCGAACTCGAAGCCATCTTC
CGTCCTTTCTATCGCACCGATAAGTCCCGCGAGCGTGAGAGCGGCGGTTGGGGGCTTGGCCTCGCCATTACCGCGGCGGC
CATCGAAGCCCAGGGCGGCAGCATCAGCGCCCAAAACAGGCCAACCGGCGGCCTGTGCGTAACGATTTGCTTGCCGCGTT
AA

Upstream 100 bases:

>100_bases
TGGATATGCACCTGTCGAACCTGCGCAAGAAGTTGCCCGAGCGCAGCGATGGTCGCCCCAGGGTAAAAACCATCCGTGGT
AAGGGATATATCTGGCTGAA

Downstream 100 bases:

>100_bases
CTTTCTGAACTTGCGTCCGACAATCGGCTGTGCCTTTGGTGTTGCGGCTAACTGTCGGTACGCTTAAGACTGCGGTAAAT
CAGGTTGCGGCTTACCCCAA

Product: sensor protein CpxA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 453; Mature: 453

Protein sequence:

>453_residues
MNTQTLPNRLFIKLLLGFWLCSSVVLVAVGSLPLLQQQRESTPIPKELQQTLDKIARAIEREPELMEPERMRRWERSRHA
DGKPMRVFITNEEGRILGERQPRSLRKFILLAEEAERPIMYQFRDEMVFGPKEFHVDGKEYHLYGRVPGQHPRPLFLFFI
EHKLLTLGLAVLVSGLLCGLLAWHLGRPLKMLKQSADALARGNLGSRVDEATLNRRDELGQLGHAFNAMAEAIEQQVNNQ
QRLMGDISHELRTPLTRLQLALALARKRGQDSNELNRIAHEAEQLDALIAELLTLSRVTMGATEAKVDIELAETLGQVLD
DAEFEASECGKHLAIEMDDNLLLSHTPKLLARAVENLLRNAIRYARLQVSLTVTDTQDRIEIQICDDGPGVADAELEAIF
RPFYRTDKSRERESGGWGLGLAITAAAIEAQGGSISAQNRPTGGLCVTICLPR

Sequences:

>Translated_453_residues
MNTQTLPNRLFIKLLLGFWLCSSVVLVAVGSLPLLQQQRESTPIPKELQQTLDKIARAIEREPELMEPERMRRWERSRHA
DGKPMRVFITNEEGRILGERQPRSLRKFILLAEEAERPIMYQFRDEMVFGPKEFHVDGKEYHLYGRVPGQHPRPLFLFFI
EHKLLTLGLAVLVSGLLCGLLAWHLGRPLKMLKQSADALARGNLGSRVDEATLNRRDELGQLGHAFNAMAEAIEQQVNNQ
QRLMGDISHELRTPLTRLQLALALARKRGQDSNELNRIAHEAEQLDALIAELLTLSRVTMGATEAKVDIELAETLGQVLD
DAEFEASECGKHLAIEMDDNLLLSHTPKLLARAVENLLRNAIRYARLQVSLTVTDTQDRIEIQICDDGPGVADAELEAIF
RPFYRTDKSRERESGGWGLGLAITAAAIEAQGGSISAQNRPTGGLCVTICLPR
>Mature_453_residues
MNTQTLPNRLFIKLLLGFWLCSSVVLVAVGSLPLLQQQRESTPIPKELQQTLDKIARAIEREPELMEPERMRRWERSRHA
DGKPMRVFITNEEGRILGERQPRSLRKFILLAEEAERPIMYQFRDEMVFGPKEFHVDGKEYHLYGRVPGQHPRPLFLFFI
EHKLLTLGLAVLVSGLLCGLLAWHLGRPLKMLKQSADALARGNLGSRVDEATLNRRDELGQLGHAFNAMAEAIEQQVNNQ
QRLMGDISHELRTPLTRLQLALALARKRGQDSNELNRIAHEAEQLDALIAELLTLSRVTMGATEAKVDIELAETLGQVLD
DAEFEASECGKHLAIEMDDNLLLSHTPKLLARAVENLLRNAIRYARLQVSLTVTDTQDRIEIQICDDGPGVADAELEAIF
RPFYRTDKSRERESGGWGLGLAITAAAIEAQGGSISAQNRPTGGLCVTICLPR

Specific function: This protein is involved in several diverse cellular processes, such as the functioning of acetohydroxyacid synthetase I, in the biosynthesis of isoleucine and valine, the TraJ protein activation activity for tra gene expression in F plasmid, and the synt

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790346, Length=454, Percent_Identity=37.8854625550661, Blast_Score=225, Evalue=5e-60,
Organism=Escherichia coli, GI1787894, Length=334, Percent_Identity=31.7365269461078, Blast_Score=134, Evalue=2e-32,
Organism=Escherichia coli, GI1788393, Length=282, Percent_Identity=34.7517730496454, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI1786783, Length=300, Percent_Identity=31, Blast_Score=112, Evalue=7e-26,
Organism=Escherichia coli, GI1789808, Length=302, Percent_Identity=29.8013245033113, Blast_Score=108, Evalue=6e-25,
Organism=Escherichia coli, GI1786912, Length=228, Percent_Identity=31.5789473684211, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1786600, Length=222, Percent_Identity=27.4774774774775, Blast_Score=93, Evalue=4e-20,
Organism=Escherichia coli, GI1788279, Length=274, Percent_Identity=30.2919708029197, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1789149, Length=325, Percent_Identity=27.0769230769231, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1790436, Length=247, Percent_Identity=27.1255060728745, Blast_Score=79, Evalue=9e-16,
Organism=Escherichia coli, GI145693157, Length=250, Percent_Identity=26, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI87081816, Length=341, Percent_Identity=25.2199413489736, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1788713, Length=239, Percent_Identity=26.7782426778243, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI87082128, Length=298, Percent_Identity=22.8187919463087, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI1790861, Length=301, Percent_Identity=23.5880398671096, Blast_Score=63, Evalue=4e-11,
Organism=Escherichia coli, GI1788549, Length=223, Percent_Identity=30.0448430493274, Blast_Score=62, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 50844; Mature: 50844

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTQTLPNRLFIKLLLGFWLCSSVVLVAVGSLPLLQQQRESTPIPKELQQTLDKIARAIE
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHH
REPELMEPERMRRWERSRHADGKPMRVFITNEEGRILGERQPRSLRKFILLAEEAERPIM
CCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCH
YQFRDEMVFGPKEFHVDGKEYHLYGRVPGQHPRPLFLFFIEHKLLTLGLAVLVSGLLCGL
HHHHHHHCCCCHHEECCCCEEEEEECCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHH
LAWHLGRPLKMLKQSADALARGNLGSRVDEATLNRRDELGQLGHAFNAMAEAIEQQVNNQ
HHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHH
QRLMGDISHELRTPLTRLQLALALARKRGQDSNELNRIAHEAEQLDALIAELLTLSRVTM
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GATEAKVDIELAETLGQVLDDAEFEASECGKHLAIEMDDNLLLSHTPKLLARAVENLLRN
CCCHHHHHHHHHHHHHHHHCCCCCCHHHCCCEEEEEECCCEEECCCHHHHHHHHHHHHHH
AIRYARLQVSLTVTDTQDRIEIQICDDGPGVADAELEAIFRPFYRTDKSRERESGGWGLG
HHHHHEEEEEEEEECCCCEEEEEEECCCCCCCHHHHHHHHHHHHHCCCHHHHCCCCCCHH
LAITAAAIEAQGGSISAQNRPTGGLCVTICLPR
HHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCC
>Mature Secondary Structure
MNTQTLPNRLFIKLLLGFWLCSSVVLVAVGSLPLLQQQRESTPIPKELQQTLDKIARAIE
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHH
REPELMEPERMRRWERSRHADGKPMRVFITNEEGRILGERQPRSLRKFILLAEEAERPIM
CCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCH
YQFRDEMVFGPKEFHVDGKEYHLYGRVPGQHPRPLFLFFIEHKLLTLGLAVLVSGLLCGL
HHHHHHHCCCCHHEECCCCEEEEEECCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHH
LAWHLGRPLKMLKQSADALARGNLGSRVDEATLNRRDELGQLGHAFNAMAEAIEQQVNNQ
HHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHH
QRLMGDISHELRTPLTRLQLALALARKRGQDSNELNRIAHEAEQLDALIAELLTLSRVTM
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GATEAKVDIELAETLGQVLDDAEFEASECGKHLAIEMDDNLLLSHTPKLLARAVENLLRN
CCCHHHHHHHHHHHHHHHHCCCCCCHHHCCCEEEEEECCCEEECCCHHHHHHHHHHHHHH
AIRYARLQVSLTVTDTQDRIEIQICDDGPGVADAELEAIFRPFYRTDKSRERESGGWGLG
HHHHHEEEEEEEEECCCCEEEEEEECCCCCCCHHHHHHHHHHHHHCCCHHHHCCCCCCHH
LAITAAAIEAQGGSISAQNRPTGGLCVTICLPR
HHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]