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The map label for this gene is cpxR [H]

Identifier: 119776564

GI number: 119776564

Start: 4061772

End: 4062458

Strand: Direct

Name: cpxR [H]

Synonym: Sama_3432

Alternate gene names: 119776564

Gene position: 4061772-4062458 (Clockwise)

Preceding gene: 119776559

Following gene: 119776565

Centisome position: 94.33

GC content: 55.46

Gene sequence:

>687_bases
ATGAATCACTTGTTGCTTGTTGATGACGATCCAGGTTTGTCTGAGCTGTTAAAAGAATTACTGGAGCTGGAAGGCTTTGT
CCTCACCCTCGCCCACGATGGCGCCGAAGGACTCAGCAAGGCCGTCAGCAGCCACTTTGACCTCATTCTGCTGGATGTGA
TGCTGCCTAAATTGAATGGCTTTGAAGTGCTTAAACAGCTGCGTAACCACAAACAAACGCCGGTGCTTATGCTCACCGCC
CGCGGTGATGATATCGACCGGGTCGTGGGGCTTGAAATCGGCGCCGATGACTATCTGCCCAAGCCCTTCAACGACCGCGA
GTTGGTGGCCCGCATTCGTGCCATTTTGCGCCGGGCTCAGCCGGGCACACCACAGAGTCAGCCACCGGAAGAGATACAAC
TTGGTGACCTGAAATTAGATCCCAGCCGCCAGGAAGCCTGGTGCGCCCAGAGCCTTATCAATCTCACAGGTACCGAATTT
GCCCTGCTGCTGCAGCTGGCTTCACAGGCAGGCGAACTGGTGAGTAAAGAAACCCTGAGTGAAACCGTGCTCGGCAAGCG
CCTGATGCCCTTTGACCGCAGCCTGGATATGCACCTGTCGAACCTGCGCAAGAAGTTGCCCGAGCGCAGCGATGGTCGCC
CCAGGGTAAAAACCATCCGTGGTAAGGGATATATCTGGCTGAAATGA

Upstream 100 bases:

>100_bases
TAAAGATCGGCGCCGCCTGCTTCTTTACACAGACTTACAAAGGTAAAACACCCATTGACGTACGGCTGGTTATACTGGGA
GTCCTGATCCCGGAGGTTAA

Downstream 100 bases:

>100_bases
ACACCCAAACCCTGCCCAATCGCCTCTTTATCAAACTGCTGCTCGGTTTCTGGCTATGCAGCTCTGTGGTGCTGGTTGCC
GTAGGCAGCCTGCCACTGCT

Product: response regulator receiver protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 228; Mature: 228

Protein sequence:

>228_residues
MNHLLLVDDDPGLSELLKELLELEGFVLTLAHDGAEGLSKAVSSHFDLILLDVMLPKLNGFEVLKQLRNHKQTPVLMLTA
RGDDIDRVVGLEIGADDYLPKPFNDRELVARIRAILRRAQPGTPQSQPPEEIQLGDLKLDPSRQEAWCAQSLINLTGTEF
ALLLQLASQAGELVSKETLSETVLGKRLMPFDRSLDMHLSNLRKKLPERSDGRPRVKTIRGKGYIWLK

Sequences:

>Translated_228_residues
MNHLLLVDDDPGLSELLKELLELEGFVLTLAHDGAEGLSKAVSSHFDLILLDVMLPKLNGFEVLKQLRNHKQTPVLMLTA
RGDDIDRVVGLEIGADDYLPKPFNDRELVARIRAILRRAQPGTPQSQPPEEIQLGDLKLDPSRQEAWCAQSLINLTGTEF
ALLLQLASQAGELVSKETLSETVLGKRLMPFDRSLDMHLSNLRKKLPERSDGRPRVKTIRGKGYIWLK
>Mature_228_residues
MNHLLLVDDDPGLSELLKELLELEGFVLTLAHDGAEGLSKAVSSHFDLILLDVMLPKLNGFEVLKQLRNHKQTPVLMLTA
RGDDIDRVVGLEIGADDYLPKPFNDRELVARIRAILRRAQPGTPQSQPPEEIQLGDLKLDPSRQEAWCAQSLINLTGTEF
ALLLQLASQAGELVSKETLSETVLGKRLMPFDRSLDMHLSNLRKKLPERSDGRPRVKTIRGKGYIWLK

Specific function: Member of the two-component regulatory system CpxA/CpxR. This system combats a variety of extracytoplasmic protein-mediated toxicities. It performs this function by increasing the synthesis of the periplasmic protease, DegP as well as that of CpxP protein

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=59.2105263157895, Blast_Score=243, Evalue=7e-66,
Organism=Escherichia coli, GI1789809, Length=231, Percent_Identity=40.2597402597403, Blast_Score=150, Evalue=6e-38,
Organism=Escherichia coli, GI1788394, Length=223, Percent_Identity=36.322869955157, Blast_Score=145, Evalue=2e-36,
Organism=Escherichia coli, GI1790860, Length=223, Percent_Identity=39.0134529147982, Blast_Score=141, Evalue=3e-35,
Organism=Escherichia coli, GI1786599, Length=224, Percent_Identity=38.3928571428571, Blast_Score=140, Evalue=6e-35,
Organism=Escherichia coli, GI1786784, Length=224, Percent_Identity=37.0535714285714, Blast_Score=134, Evalue=6e-33,
Organism=Escherichia coli, GI87082012, Length=225, Percent_Identity=36, Blast_Score=132, Evalue=1e-32,
Organism=Escherichia coli, GI1790552, Length=226, Percent_Identity=37.1681415929204, Blast_Score=130, Evalue=9e-32,
Organism=Escherichia coli, GI1790863, Length=232, Percent_Identity=32.3275862068966, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1786911, Length=228, Percent_Identity=33.3333333333333, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI1789402, Length=222, Percent_Identity=33.7837837837838, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1787229, Length=213, Percent_Identity=33.8028169014084, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI145693140, Length=233, Percent_Identity=30.9012875536481, Blast_Score=108, Evalue=4e-25,
Organism=Escherichia coli, GI1787375, Length=227, Percent_Identity=30.3964757709251, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1788550, Length=109, Percent_Identity=34.8623853211009, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1790299, Length=132, Percent_Identity=34.8484848484849, Blast_Score=74, Evalue=8e-15,
Organism=Escherichia coli, GI1790437, Length=175, Percent_Identity=29.1428571428571, Blast_Score=64, Evalue=7e-12,
Organism=Escherichia coli, GI1789149, Length=147, Percent_Identity=29.2517006802721, Blast_Score=64, Evalue=8e-12,
Organism=Escherichia coli, GI1788905, Length=122, Percent_Identity=35.2459016393443, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25542; Mature: 25542

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNHLLLVDDDPGLSELLKELLELEGFVLTLAHDGAEGLSKAVSSHFDLILLDVMLPKLNG
CCCEEEEECCCCHHHHHHHHHHHCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCH
FEVLKQLRNHKQTPVLMLTARGDDIDRVVGLEIGADDYLPKPFNDRELVARIRAILRRAQ
HHHHHHHHCCCCCCEEEEEECCCCCHHEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCC
PGTPQSQPPEEIQLGDLKLDPSRQEAWCAQSLINLTGTEFALLLQLASQAGELVSKETLS
CCCCCCCCCCCCEECCEEECCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
ETVLGKRLMPFDRSLDMHLSNLRKKLPERSDGRPRVKTIRGKGYIWLK
HHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCEEEEECCEEEEEC
>Mature Secondary Structure
MNHLLLVDDDPGLSELLKELLELEGFVLTLAHDGAEGLSKAVSSHFDLILLDVMLPKLNG
CCCEEEEECCCCHHHHHHHHHHHCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCH
FEVLKQLRNHKQTPVLMLTARGDDIDRVVGLEIGADDYLPKPFNDRELVARIRAILRRAQ
HHHHHHHHCCCCCCEEEEEECCCCCHHEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCC
PGTPQSQPPEEIQLGDLKLDPSRQEAWCAQSLINLTGTEFALLLQLASQAGELVSKETLS
CCCCCCCCCCCCEECCEEECCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
ETVLGKRLMPFDRSLDMHLSNLRKKLPERSDGRPRVKTIRGKGYIWLK
HHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCEEEEECCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]