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The map label for this gene is ytfL [H]

Identifier: 119776416

GI number: 119776416

Start: 3901708

End: 3903018

Strand: Reverse

Name: ytfL [H]

Synonym: Sama_3284

Alternate gene names: 119776416

Gene position: 3903018-3901708 (Counterclockwise)

Preceding gene: 119776418

Following gene: 119776414

Centisome position: 90.64

GC content: 52.63

Gene sequence:

>1311_bases
ATGAGTTTCTTCGAAAATAGTTTGATTATTCTGATGCTTATCGGCATCAGTTGTTTTTTTTCCATGTCGGAAATCGCCCT
GGCGGCCTCCCGTAAAATTCGGCTGCGACAGTTGGCCGATGAAGGCAATGAGCGGGCCCGAAAAGTACTTGAGCTGCAGG
CTCATCCCGGCAGCTTCTTTACCGTGGTGCAAATAGGCCTCAATGCGGTGGCCATCATGGGCGGTATCGTGGGGGAGTCG
GCTTTTACCCCCCATATCATGGCCTTGCTGGATGGTATAGTGCCAGCTAAGTGGCTGGGCCAGTTCAGTTTTATCTTGTC
TTTTATGCTGGTGACCAGCCTGTTTATTTTGCTGGCAGATCTAATGCCAAAGCGTATCGCCATGGCTATGCCAGAGCGTG
TTGCTGTGTCATTGGTGGGGGCCATGGGCCTGTGCATTACCGTGCTGCGCCCCCTGGTGTGGGTGTTCAATGGCCTCGCC
AATGGTTTGTTCCGTATGCTGCGGATCCCCACAGAGCGTAACGATGCCATCACAGAGGATGACATTTACGCGGTGATGGA
TGCCGGTGCTGAAGCCGGTGTTATCGACAAGGGCGAACAGCAGATGATGGAGAACGTGTTTGAAATGCAAAGCGTTCCTG
TGACCTCAGCCATGACACCAAGGGAAAGCCTGGTGTTCTTTCTGCAAAGCGACACCGAAGAAGACATCAAGCGTAAAATC
GCCGCCGACCCCCACAGCCAGTTTCTGCTCTGTGATGGCCAGCTGGATGCCATCAAGGGCTATGTGGACTCCAAGGATTT
GCTTATCAAGGTGATAAGCGGTCAGGCATTAAACCTGAAAGACCCATCACTGGTACAAACCTGCCCCATTATCCCGGATA
CCCTGAGCCTGTCTGAGGCGCTGGATTACTTCCGTAACAACAGGGTCGACTTTGCAGTTGTGCTCAATGAGTATGCGTTG
GTGCTGGGGGTGGTGACCTTTAACGATCTGCAAAGCGCTGTGATGGGGACCTGGTCGCTGGCCGAAGGTGAAGAACAAAT
TGTGGCCCGGGATCCTTCGTCCTGGCTGGTGGATGGGGTAACGCCTATTACCGATGTGATGCGTGCCTTTGGCATCGACA
GTTTTCCCCAGAGCCAGAACTATGAAACCATCGCAGGTTTCATTATGTTTATGCTGCGTAAAATCCCCCGCCGTACCGAC
TTTGTGGTCTATGCCGGTTACAAATTTGAAGTGGTCGATATCGACTCATACAAGGTGGATCAGCTGCTGGTGACCAAGGT
GGAGTTGCCACCCGGTGCTGAGGATCAGTAA

Upstream 100 bases:

>100_bases
GTATATAATAGCTTAAACATAACTCCCCTCCGGCTTTAGCCGCACCCCTGAGTATAGCAAGATATCTGCGTATTGCCTCA
GTTGCAGGACGGATTGAAAA

Downstream 100 bases:

>100_bases
CGACCAACATGAAAAAAGGCCGCATTAAGCGGCCTTTTTCGTTGGGGTTCAACTTAATAGTCAATGCACGCGAGAAAGGC
AGCAATCAGCGGGTCGTCCC

Product: hemolysin

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 436; Mature: 435

Protein sequence:

>436_residues
MSFFENSLIILMLIGISCFFSMSEIALAASRKIRLRQLADEGNERARKVLELQAHPGSFFTVVQIGLNAVAIMGGIVGES
AFTPHIMALLDGIVPAKWLGQFSFILSFMLVTSLFILLADLMPKRIAMAMPERVAVSLVGAMGLCITVLRPLVWVFNGLA
NGLFRMLRIPTERNDAITEDDIYAVMDAGAEAGVIDKGEQQMMENVFEMQSVPVTSAMTPRESLVFFLQSDTEEDIKRKI
AADPHSQFLLCDGQLDAIKGYVDSKDLLIKVISGQALNLKDPSLVQTCPIIPDTLSLSEALDYFRNNRVDFAVVLNEYAL
VLGVVTFNDLQSAVMGTWSLAEGEEQIVARDPSSWLVDGVTPITDVMRAFGIDSFPQSQNYETIAGFIMFMLRKIPRRTD
FVVYAGYKFEVVDIDSYKVDQLLVTKVELPPGAEDQ

Sequences:

>Translated_436_residues
MSFFENSLIILMLIGISCFFSMSEIALAASRKIRLRQLADEGNERARKVLELQAHPGSFFTVVQIGLNAVAIMGGIVGES
AFTPHIMALLDGIVPAKWLGQFSFILSFMLVTSLFILLADLMPKRIAMAMPERVAVSLVGAMGLCITVLRPLVWVFNGLA
NGLFRMLRIPTERNDAITEDDIYAVMDAGAEAGVIDKGEQQMMENVFEMQSVPVTSAMTPRESLVFFLQSDTEEDIKRKI
AADPHSQFLLCDGQLDAIKGYVDSKDLLIKVISGQALNLKDPSLVQTCPIIPDTLSLSEALDYFRNNRVDFAVVLNEYAL
VLGVVTFNDLQSAVMGTWSLAEGEEQIVARDPSSWLVDGVTPITDVMRAFGIDSFPQSQNYETIAGFIMFMLRKIPRRTD
FVVYAGYKFEVVDIDSYKVDQLLVTKVELPPGAEDQ
>Mature_435_residues
SFFENSLIILMLIGISCFFSMSEIALAASRKIRLRQLADEGNERARKVLELQAHPGSFFTVVQIGLNAVAIMGGIVGESA
FTPHIMALLDGIVPAKWLGQFSFILSFMLVTSLFILLADLMPKRIAMAMPERVAVSLVGAMGLCITVLRPLVWVFNGLAN
GLFRMLRIPTERNDAITEDDIYAVMDAGAEAGVIDKGEQQMMENVFEMQSVPVTSAMTPRESLVFFLQSDTEEDIKRKIA
ADPHSQFLLCDGQLDAIKGYVDSKDLLIKVISGQALNLKDPSLVQTCPIIPDTLSLSEALDYFRNNRVDFAVVLNEYALV
LGVVTFNDLQSAVMGTWSLAEGEEQIVARDPSSWLVDGVTPITDVMRAFGIDSFPQSQNYETIAGFIMFMLRKIPRRTDF
VVYAGYKFEVVDIDSYKVDQLLVTKVELPPGAEDQ

Specific function: Unknown

COG id: COG1253

COG function: function code R; Hemolysins and related proteins containing CBS domains

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI310128564, Length=383, Percent_Identity=25.5874673629243, Blast_Score=160, Evalue=3e-39,
Organism=Escherichia coli, GI1790664, Length=421, Percent_Identity=58.1947743467934, Blast_Score=504, Evalue=1e-144,
Organism=Escherichia coli, GI145693175, Length=418, Percent_Identity=23.444976076555, Blast_Score=126, Evalue=2e-30,
Organism=Escherichia coli, GI87082033, Length=267, Percent_Identity=29.2134831460674, Blast_Score=111, Evalue=8e-26,
Organism=Escherichia coli, GI1788119, Length=271, Percent_Identity=26.5682656826568, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1786879, Length=269, Percent_Identity=25.2788104089219, Blast_Score=81, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016169
- InterPro:   IPR000644
- InterPro:   IPR002550
- InterPro:   IPR005170 [H]

Pfam domain/function: PF00571 CBS; PF03471 CorC_HlyC; PF01595 DUF21 [H]

EC number: NA

Molecular weight: Translated: 48237; Mature: 48106

Theoretical pI: Translated: 4.38; Mature: 4.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFFENSLIILMLIGISCFFSMSEIALAASRKIRLRQLADEGNERARKVLELQAHPGSFF
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCEE
TVVQIGLNAVAIMGGIVGESAFTPHIMALLDGIVPAKWLGQFSFILSFMLVTSLFILLAD
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LMPKRIAMAMPERVAVSLVGAMGLCITVLRPLVWVFNGLANGLFRMLRIPTERNDAITED
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
DIYAVMDAGAEAGVIDKGEQQMMENVFEMQSVPVTSAMTPRESLVFFLQSDTEEDIKRKI
CHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHEEEEEECCCHHHHHHHH
AADPHSQFLLCDGQLDAIKGYVDSKDLLIKVISGQALNLKDPSLVQTCPIIPDTLSLSEA
CCCCCCCEEEECCCHHHHHCCCCCHHHEEEEECCCEECCCCCCHHHCCCCCCCCCCHHHH
LDYFRNNRVDFAVVLNEYALVLGVVTFNDLQSAVMGTWSLAEGEEQIVARDPSSWLVDGV
HHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHEEECCCCHHHCCC
TPITDVMRAFGIDSFPQSQNYETIAGFIMFMLRKIPRRTDFVVYAGYKFEVVDIDSYKVD
CHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEECEEEEEEECCCCCCC
QLLVTKVELPPGAEDQ
CEEEEEEECCCCCCCC
>Mature Secondary Structure 
SFFENSLIILMLIGISCFFSMSEIALAASRKIRLRQLADEGNERARKVLELQAHPGSFF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCEE
TVVQIGLNAVAIMGGIVGESAFTPHIMALLDGIVPAKWLGQFSFILSFMLVTSLFILLAD
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LMPKRIAMAMPERVAVSLVGAMGLCITVLRPLVWVFNGLANGLFRMLRIPTERNDAITED
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
DIYAVMDAGAEAGVIDKGEQQMMENVFEMQSVPVTSAMTPRESLVFFLQSDTEEDIKRKI
CHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHEEEEEECCCHHHHHHHH
AADPHSQFLLCDGQLDAIKGYVDSKDLLIKVISGQALNLKDPSLVQTCPIIPDTLSLSEA
CCCCCCCEEEECCCHHHHHCCCCCHHHEEEEECCCEECCCCCCHHHCCCCCCCCCCHHHH
LDYFRNNRVDFAVVLNEYALVLGVVTFNDLQSAVMGTWSLAEGEEQIVARDPSSWLVDGV
HHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHEEECCCCHHHCCC
TPITDVMRAFGIDSFPQSQNYETIAGFIMFMLRKIPRRTDFVVYAGYKFEVVDIDSYKVD
CHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEECEEEEEEECCCCCCC
QLLVTKVELPPGAEDQ
CEEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]