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The map label for this gene is ilvC

Identifier: 119776414

GI number: 119776414

Start: 3899079

End: 3900560

Strand: Reverse

Name: ilvC

Synonym: Sama_3282

Alternate gene names: 119776414

Gene position: 3900560-3899079 (Counterclockwise)

Preceding gene: 119776416

Following gene: 119776413

Centisome position: 90.58

GC content: 54.25

Gene sequence:

>1482_bases
ATGGCTAACTACTTTAACTCATTGAATTTACGGCAGCAGCTGGCGCAGTTGAGTCAGTGTCGTTTTATGGATCGCAGCGA
GTTTGAAAATGGCTGTGACTACATCAAGGGCTGGAATATCGTTATCCTCGGCTGTGGCGCCCAAGGCCTGAACCAGGGTC
TGAACATGCGCGACTCCGGCCTGAATATCTCCTATGCCCTGCGCGCTGAGGCTATTGCTGAAAAGCGTGCTTCCTGGAAG
AAGGCCACCGACAACGGTTTTACCGTAGGTACCTTTGAAGAGCTGATCCCACAGGCGGATCTGGTACTGAACCTGACGCC
GGACAAGCAGCACTCCAACGTGGTTAACACCGTAATGCCGCTGATGAAGCAGGGCGCGACCCTGTCATACTCCCACGGTT
TCAACATAGTTGAAGAAGGCATGCAGGTTCGCCCCGATATCACCGTCATCATGGTGGCGCCCAAGTGCCCTGGCACCGAA
GTGCGTGAAGAATACAAGCGCGGTTTCGGTGTACCAACCCTGATTGCGGTTCACCCAGAGAACGATCCACGCGGTGATGG
CCTAGAGATTGCCAAGGCCTATGCCAGTGCCACCGGCGGCGACCGTGCCGGTGTACTACACTCTTCGTTTATCGCCGAAG
TAAAATCGGATCTGATGGGCGAGCAGACCATCCTGTGTGGCATGTTGCAAACCTCAGCCATCCTCGGCTACGAGAAAATG
GTGGCCGACGGTGTTGAGCCTGGCTATGCCGCCAAGCTTATCCAGCAGGGGCTGGAGACCATCACCGAAGCGCTCAAGCA
GGGCGGCATTACCAATATGATGGATCGCCTGTCCAACCCAGCCAAGATTAAAGCCTTTGATATGGCTGAAGAATTGAAAG
GCATTCTGGCACCTCTGTTCGAGAAGCACATGGATGACATCATCAGCGGCGAATTCTCCCGCACCATGATGGCAGACTGG
GCCAACGACGATGCCAATCTGCTGCGCTGGCGCGCCGAAACCAACGAGACTGCCTTTGAGAATGCGCCAAGCAGCAATGA
GCACATCGACGAACAGACTTACTTCGACAAGGGCATCTTCCTGGTTGCCATGATCAAGGCCGGTGTTGAGCTGGCATTCG
ATACCATGGTTGACGCCGGAATCATCGAAGAATCAGCCTATTATGAGTCGCTGCACGAAACACCGCTTATCGCCAACACC
ATCGCCCGTAAGCGTCTGTACGAGATGAATGTGGTGATTTCAGATACCGCCGAATATGGCTGCTATCTGTTCAACCATGC
CGCCGTACCTCTGCTGCGCGACTATGTGAAATCCATGTCGGCCGAGTATTTGGGTGGTGGGCTGAAAGACAGCAGCAACG
CCGTGGATAACGTGCGTTTGATTGAAGTGAATCAAGCCATCCGCAACACCGCCGTTGAGTTTATCGGCGAAGAGCTGCGT
GGCTACATGAAAGACATGAAGCGCATCAGCGCTGCCCAGTAA

Upstream 100 bases:

>100_bases
CTATCTCTGTTCTATAGTGAGTTCAATCACAATCGGTTGATGATATTAAGGTCACACTGATTGTTTGAACCCAATTGACG
AAGGATAAGTGGTATTCACT

Downstream 100 bases:

>100_bases
CAGGGGCACCACGCCGGGCCGTTCAAGGAGCCAGCGACCCGGCTGCAACAAATGCAATACTGCAACAGTTGTGTTGAGTA
GTCACAACTGCGGCAAGGTC

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase

Number of amino acids: Translated: 493; Mature: 492

Protein sequence:

>493_residues
MANYFNSLNLRQQLAQLSQCRFMDRSEFENGCDYIKGWNIVILGCGAQGLNQGLNMRDSGLNISYALRAEAIAEKRASWK
KATDNGFTVGTFEELIPQADLVLNLTPDKQHSNVVNTVMPLMKQGATLSYSHGFNIVEEGMQVRPDITVIMVAPKCPGTE
VREEYKRGFGVPTLIAVHPENDPRGDGLEIAKAYASATGGDRAGVLHSSFIAEVKSDLMGEQTILCGMLQTSAILGYEKM
VADGVEPGYAAKLIQQGLETITEALKQGGITNMMDRLSNPAKIKAFDMAEELKGILAPLFEKHMDDIISGEFSRTMMADW
ANDDANLLRWRAETNETAFENAPSSNEHIDEQTYFDKGIFLVAMIKAGVELAFDTMVDAGIIEESAYYESLHETPLIANT
IARKRLYEMNVVISDTAEYGCYLFNHAAVPLLRDYVKSMSAEYLGGGLKDSSNAVDNVRLIEVNQAIRNTAVEFIGEELR
GYMKDMKRISAAQ

Sequences:

>Translated_493_residues
MANYFNSLNLRQQLAQLSQCRFMDRSEFENGCDYIKGWNIVILGCGAQGLNQGLNMRDSGLNISYALRAEAIAEKRASWK
KATDNGFTVGTFEELIPQADLVLNLTPDKQHSNVVNTVMPLMKQGATLSYSHGFNIVEEGMQVRPDITVIMVAPKCPGTE
VREEYKRGFGVPTLIAVHPENDPRGDGLEIAKAYASATGGDRAGVLHSSFIAEVKSDLMGEQTILCGMLQTSAILGYEKM
VADGVEPGYAAKLIQQGLETITEALKQGGITNMMDRLSNPAKIKAFDMAEELKGILAPLFEKHMDDIISGEFSRTMMADW
ANDDANLLRWRAETNETAFENAPSSNEHIDEQTYFDKGIFLVAMIKAGVELAFDTMVDAGIIEESAYYESLHETPLIANT
IARKRLYEMNVVISDTAEYGCYLFNHAAVPLLRDYVKSMSAEYLGGGLKDSSNAVDNVRLIEVNQAIRNTAVEFIGEELR
GYMKDMKRISAAQ
>Mature_492_residues
ANYFNSLNLRQQLAQLSQCRFMDRSEFENGCDYIKGWNIVILGCGAQGLNQGLNMRDSGLNISYALRAEAIAEKRASWKK
ATDNGFTVGTFEELIPQADLVLNLTPDKQHSNVVNTVMPLMKQGATLSYSHGFNIVEEGMQVRPDITVIMVAPKCPGTEV
REEYKRGFGVPTLIAVHPENDPRGDGLEIAKAYASATGGDRAGVLHSSFIAEVKSDLMGEQTILCGMLQTSAILGYEKMV
ADGVEPGYAAKLIQQGLETITEALKQGGITNMMDRLSNPAKIKAFDMAEELKGILAPLFEKHMDDIISGEFSRTMMADWA
NDDANLLRWRAETNETAFENAPSSNEHIDEQTYFDKGIFLVAMIKAGVELAFDTMVDAGIIEESAYYESLHETPLIANTI
ARKRLYEMNVVISDTAEYGCYLFNHAAVPLLRDYVKSMSAEYLGGGLKDSSNAVDNVRLIEVNQAIRNTAVEFIGEELRG
YMKDMKRISAAQ

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family

Homologues:

Organism=Escherichia coli, GI1790210, Length=492, Percent_Identity=73.3739837398374, Blast_Score=747, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6323387, Length=290, Percent_Identity=32.7586206896552, Blast_Score=121, Evalue=3e-28,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ILVC_SHEAM (A1SAS8)

Other databases:

- EMBL:   CP000507
- RefSeq:   YP_929154.1
- ProteinModelPortal:   A1SAS8
- SMR:   A1SAS8
- STRING:   A1SAS8
- GeneID:   4605529
- GenomeReviews:   CP000507_GR
- KEGG:   saz:Sama_3282
- NMPDR:   fig|326297.7.peg.3092
- eggNOG:   COG0059
- HOGENOM:   HBG297205
- OMA:   EKHMDDI
- PhylomeDB:   A1SAS8
- ProtClustDB:   PRK05225
- HAMAP:   MF_00435
- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116
- InterPro:   IPR014359
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR21371
- PIRSF:   PIRSF000116
- TIGRFAMs:   TIGR00465

Pfam domain/function: PF01450 IlvC; PF07991 IlvN; SSF48179 6DGDH_C_like

EC number: =1.1.1.86

Molecular weight: Translated: 54432; Mature: 54300

Theoretical pI: Translated: 4.61; Mature: 4.61

Prosite motif: NA

Important sites: ACT_SITE 132-132

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANYFNSLNLRQQLAQLSQCRFMDRSEFENGCDYIKGWNIVILGCGAQGLNQGLNMRDSG
CCCCHHCCHHHHHHHHHHHHHCCCHHHHHHCCHHHCCCCEEEEECCCHHHHCCCCCCCCC
LNISYALRAEAIAEKRASWKKATDNGFTVGTFEELIPQADLVLNLTPDKQHSNVVNTVMP
CCEEEHHHHHHHHHHHHHHHCCCCCCCEECCHHHHCCCCCEEEECCCCCHHHHHHHHHHH
LMKQGATLSYSHGFNIVEEGMQVRPDITVIMVAPKCPGTEVREEYKRGFGVPTLIAVHPE
HHHCCCEEEECCCCHHHHCCCCCCCCEEEEEECCCCCCHHHHHHHHHCCCCCEEEEECCC
NDPRGDGLEIAKAYASATGGDRAGVLHSSFIAEVKSDLMGEQTILCGMLQTSAILGYEKM
CCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
VADGVEPGYAAKLIQQGLETITEALKQGGITNMMDRLSNPAKIKAFDMAEELKGILAPLF
HHCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHH
EKHMDDIISGEFSRTMMADWANDDANLLRWRAETNETAFENAPSSNEHIDEQTYFDKGIF
HHHHHHHHCCCHHHHHHHHCCCCCHHHEEEECCCCCCHHCCCCCCCCCCCHHHHHHCHHH
LVAMIKAGVELAFDTMVDAGIIEESAYYESLHETPLIANTIARKRLYEMNVVISDTAEYG
HHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHEEEEECCHHHC
CYLFNHAAVPLLRDYVKSMSAEYLGGGLKDSSNAVDNVRLIEVNQAIRNTAVEFIGEELR
EEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHH
GYMKDMKRISAAQ
HHHHHHHHHHCCC
>Mature Secondary Structure 
ANYFNSLNLRQQLAQLSQCRFMDRSEFENGCDYIKGWNIVILGCGAQGLNQGLNMRDSG
CCCHHCCHHHHHHHHHHHHHCCCHHHHHHCCHHHCCCCEEEEECCCHHHHCCCCCCCCC
LNISYALRAEAIAEKRASWKKATDNGFTVGTFEELIPQADLVLNLTPDKQHSNVVNTVMP
CCEEEHHHHHHHHHHHHHHHCCCCCCCEECCHHHHCCCCCEEEECCCCCHHHHHHHHHHH
LMKQGATLSYSHGFNIVEEGMQVRPDITVIMVAPKCPGTEVREEYKRGFGVPTLIAVHPE
HHHCCCEEEECCCCHHHHCCCCCCCCEEEEEECCCCCCHHHHHHHHHCCCCCEEEEECCC
NDPRGDGLEIAKAYASATGGDRAGVLHSSFIAEVKSDLMGEQTILCGMLQTSAILGYEKM
CCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
VADGVEPGYAAKLIQQGLETITEALKQGGITNMMDRLSNPAKIKAFDMAEELKGILAPLF
HHCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHH
EKHMDDIISGEFSRTMMADWANDDANLLRWRAETNETAFENAPSSNEHIDEQTYFDKGIF
HHHHHHHHCCCHHHHHHHHCCCCCHHHEEEECCCCCCHHCCCCCCCCCCCHHHHHHCHHH
LVAMIKAGVELAFDTMVDAGIIEESAYYESLHETPLIANTIARKRLYEMNVVISDTAEYG
HHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHEEEEECCHHHC
CYLFNHAAVPLLRDYVKSMSAEYLGGGLKDSSNAVDNVRLIEVNQAIRNTAVEFIGEELR
EEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHH
GYMKDMKRISAAQ
HHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA