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The map label for this gene is lysA [H]

Identifier: 119776382

GI number: 119776382

Start: 3844347

End: 3845591

Strand: Reverse

Name: lysA [H]

Synonym: Sama_3250

Alternate gene names: 119776382

Gene position: 3845591-3844347 (Counterclockwise)

Preceding gene: 119776383

Following gene: 119776381

Centisome position: 89.3

GC content: 57.67

Gene sequence:

>1245_bases
TTGGATCATTTTCTCTATCGTGAAGAGCGGCTGTTTGCCGAAGAGTGCGATGTGGCAGGTCTCGCAGCCGAACATGGCAC
GCCCCTGTACGTTTATTCCCGTGCCACCCTCGAACGCCACTGGCACGCCTTCGATGGTGCTGTAGCGAGCCATCCACACC
TGATTTGCTATGCGGTAAAAGCTAACTCCAACCTGGCGGTGCTCAATGTGCTGGCCCGGCTTGGCAGTGGTTTCGACATC
GTCTCCGGTGGTGAACTTAGCCGCGTGCTCGAAGCCGGCGGTGACCCAGCCAAAGTCGTATTTTCCGGGGTGGGCAAAAC
CGTGGCCGAGATGGAGCTGGCGCTCAATACCGGCATTATGTGCTTTAACCTGGAATCCGGCGCCGAGCTTGAGCTCCTGA
ATGAAGTGGCTGGTCGTCTTGGCAAGGTGGCGCCAGTGTCGCTGCGTGTTAACCCCGATGTGGACGCAGGTACCCATCCT
TATATTTCTACCGGCCTGAAAGAAAACAAATTCGGTATTCCCATGGAGGAGGCGGAGGCCCTGTTTGCCCGCGCCGCCGC
GTTGCCGAATCTGGCAGTGAAGGGGGTGGATTGTCACATTGGTTCGCAGCTGACCGAACTCAAGCCCTTCCTCGATGCCA
TGGACCGCATGCTGGCGTTGATTGACCGTCTGGCAGAGCAGGGCATTGTGATTGAACACTTCGATGTAGGTGGCGGCCTT
GGTGTGACCTACAACGGTGAAACCCCGCCGCATCCGGATGTGTATGCCGCTGCGATTCTTGAGAAGCTCAATGGCCGCCC
GCTTAAGCTGATTTTCGAGCCCGGCCGTGCCATTGCCGCCAACGCCGGTATCTTTGTTACTCAGGTGCTTTACACCAAGG
ATAATGGCGACAAACGCTTTGTGATTGTCGATGGCGCCATGAATGACCTTATCCGCCCGTCGCTTTACGGCGCCTGGCAA
AACATCATTCCTGCAGTCAAAACCAATGAGCCGACTACCCGCTGTGACGTGGTTGGCCCTGTGTGTGAGACCGGTGATTT
CCTCGGTAAAGACCGTGAGTTGGCGGCGGGCAGTGGCGATCTTCTGGTGGTACGCAGCGCCGGTGCCTACGGTTTTACCA
TGGCGTCGAACTACAATACCCGCCCCCGCGCCGCTGAGCTGATGGTCGATGGCGACAAGGCGTATGTGGTGCGCGAGCGG
GAAAAACTCAGTCAGCTCTGGCAAGGAGAGCAACTCCTGCCGTAA

Upstream 100 bases:

>100_bases
AGACACCGCCTGCTCCCGATAATCAGGCCCAGCAACCGGCAGCGCCAGTGGCAGCCGATACTCCCAGCACCGATGCGCGC
AAACAATAAGGACCTCTATC

Downstream 100 bases:

>100_bases
ACTGGGGAAAGTACCCGATTTTTGGGCGCCGGAGCACTGGCCCGGCGCTAAGGAAGCATAGCTTGATCCACTTCACCAAG
ATGCATGGTCTGGGCAACGA

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 414; Mature: 414

Protein sequence:

>414_residues
MDHFLYREERLFAEECDVAGLAAEHGTPLYVYSRATLERHWHAFDGAVASHPHLICYAVKANSNLAVLNVLARLGSGFDI
VSGGELSRVLEAGGDPAKVVFSGVGKTVAEMELALNTGIMCFNLESGAELELLNEVAGRLGKVAPVSLRVNPDVDAGTHP
YISTGLKENKFGIPMEEAEALFARAAALPNLAVKGVDCHIGSQLTELKPFLDAMDRMLALIDRLAEQGIVIEHFDVGGGL
GVTYNGETPPHPDVYAAAILEKLNGRPLKLIFEPGRAIAANAGIFVTQVLYTKDNGDKRFVIVDGAMNDLIRPSLYGAWQ
NIIPAVKTNEPTTRCDVVGPVCETGDFLGKDRELAAGSGDLLVVRSAGAYGFTMASNYNTRPRAAELMVDGDKAYVVRER
EKLSQLWQGEQLLP

Sequences:

>Translated_414_residues
MDHFLYREERLFAEECDVAGLAAEHGTPLYVYSRATLERHWHAFDGAVASHPHLICYAVKANSNLAVLNVLARLGSGFDI
VSGGELSRVLEAGGDPAKVVFSGVGKTVAEMELALNTGIMCFNLESGAELELLNEVAGRLGKVAPVSLRVNPDVDAGTHP
YISTGLKENKFGIPMEEAEALFARAAALPNLAVKGVDCHIGSQLTELKPFLDAMDRMLALIDRLAEQGIVIEHFDVGGGL
GVTYNGETPPHPDVYAAAILEKLNGRPLKLIFEPGRAIAANAGIFVTQVLYTKDNGDKRFVIVDGAMNDLIRPSLYGAWQ
NIIPAVKTNEPTTRCDVVGPVCETGDFLGKDRELAAGSGDLLVVRSAGAYGFTMASNYNTRPRAAELMVDGDKAYVVRER
EKLSQLWQGEQLLP
>Mature_414_residues
MDHFLYREERLFAEECDVAGLAAEHGTPLYVYSRATLERHWHAFDGAVASHPHLICYAVKANSNLAVLNVLARLGSGFDI
VSGGELSRVLEAGGDPAKVVFSGVGKTVAEMELALNTGIMCFNLESGAELELLNEVAGRLGKVAPVSLRVNPDVDAGTHP
YISTGLKENKFGIPMEEAEALFARAAALPNLAVKGVDCHIGSQLTELKPFLDAMDRMLALIDRLAEQGIVIEHFDVGGGL
GVTYNGETPPHPDVYAAAILEKLNGRPLKLIFEPGRAIAANAGIFVTQVLYTKDNGDKRFVIVDGAMNDLIRPSLYGAWQ
NIIPAVKTNEPTTRCDVVGPVCETGDFLGKDRELAAGSGDLLVVRSAGAYGFTMASNYNTRPRAAELMVDGDKAYVVRER
EKLSQLWQGEQLLP

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=361, Percent_Identity=26.0387811634349, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI22538418, Length=359, Percent_Identity=26.4623955431755, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI21361583, Length=359, Percent_Identity=26.4623955431755, Blast_Score=84, Evalue=3e-16,
Organism=Escherichia coli, GI1789203, Length=436, Percent_Identity=31.1926605504587, Blast_Score=169, Evalue=3e-43,
Organism=Escherichia coli, GI1789307, Length=308, Percent_Identity=25.6493506493506, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17562780, Length=361, Percent_Identity=23.2686980609418, Blast_Score=73, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6322664, Length=364, Percent_Identity=25.5494505494505, Blast_Score=78, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 44617; Mature: 44617

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDHFLYREERLFAEECDVAGLAAEHGTPLYVYSRATLERHWHAFDGAVASHPHLICYAVK
CCCCHHHHHHHHHHHCCCCEEECCCCCEEEEEECHHHHHHHHHHCCCCCCCCEEEEEEEE
ANSNLAVLNVLARLGSGFDIVSGGELSRVLEAGGDPAKVVFSGVGKTVAEMELALNTGIM
CCCCHHHHHHHHHHCCCCEEECCCHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHCCCEE
CFNLESGAELELLNEVAGRLGKVAPVSLRVNPDVDAGTHPYISTGLKENKFGIPMEEAEA
EEECCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHCCCCCCCCCCCHHHHHH
LFARAAALPNLAVKGVDCHIGSQLTELKPFLDAMDRMLALIDRLAEQGIVIEHFDVGGGL
HHHHHHCCCCCEEECCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCE
GVTYNGETPPHPDVYAAAILEKLNGRPLKLIFEPGRAIAANAGIFVTQVLYTKDNGDKRF
EEEECCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCEEEECCCEEEEEEEEEECCCCEEE
VIVDGAMNDLIRPSLYGAWQNIIPAVKTNEPTTRCDVVGPVCETGDFLGKDRELAAGSGD
EEECCCHHHHHCHHHHHHHHHHCCCCCCCCCCCEEEECCCHHCCCCCCCCCCEECCCCCC
LLVVRSAGAYGFTMASNYNTRPRAAELMVDGDKAYVVREREKLSQLWQGEQLLP
EEEEEECCCCEEEEECCCCCCCCEEEEEECCCCEEEEECHHHHHHHHCCCCCCC
>Mature Secondary Structure
MDHFLYREERLFAEECDVAGLAAEHGTPLYVYSRATLERHWHAFDGAVASHPHLICYAVK
CCCCHHHHHHHHHHHCCCCEEECCCCCEEEEEECHHHHHHHHHHCCCCCCCCEEEEEEEE
ANSNLAVLNVLARLGSGFDIVSGGELSRVLEAGGDPAKVVFSGVGKTVAEMELALNTGIM
CCCCHHHHHHHHHHCCCCEEECCCHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHCCCEE
CFNLESGAELELLNEVAGRLGKVAPVSLRVNPDVDAGTHPYISTGLKENKFGIPMEEAEA
EEECCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHCCCCCCCCCCCHHHHHH
LFARAAALPNLAVKGVDCHIGSQLTELKPFLDAMDRMLALIDRLAEQGIVIEHFDVGGGL
HHHHHHCCCCCEEECCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCE
GVTYNGETPPHPDVYAAAILEKLNGRPLKLIFEPGRAIAANAGIFVTQVLYTKDNGDKRF
EEEECCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCEEEECCCEEEEEEEEEECCCCEEE
VIVDGAMNDLIRPSLYGAWQNIIPAVKTNEPTTRCDVVGPVCETGDFLGKDRELAAGSGD
EEECCCHHHHHCHHHHHHHHHHCCCCCCCCCCCEEEECCCHHCCCCCCCCCCEECCCCCC
LLVVRSAGAYGFTMASNYNTRPRAAELMVDGDKAYVVREREKLSQLWQGEQLLP
EEEEEECCCCEEEEECCCCCCCCEEEEEECCCCEEEEECHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]