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The map label for this gene is frdB [H]

Identifier: 119776351

GI number: 119776351

Start: 3811363

End: 3812091

Strand: Reverse

Name: frdB [H]

Synonym: Sama_3219

Alternate gene names: 119776351

Gene position: 3812091-3811363 (Counterclockwise)

Preceding gene: 119776352

Following gene: 119776350

Centisome position: 88.53

GC content: 55.97

Gene sequence:

>729_bases
ATGAGCGGCCGCATTCTGACATTCAATATTTTCCGTTTCGACCCACAGGACGCCGGTGATAAGCCCAAAATGGTCAAGTA
CCAGTTGGAAGAAACCAGTGGTATGACCGTGTTCATTGCTCTCAATAAGCTCCGTCAGGAGCAGGACCCGTCGCTGCAGT
TTGACTTTGTGTGCCGCGCTGGCATTTGTGGCAGCTGCGCCATGGTGATCAATGGTTTCCCCACATTGGCGTGCCGTACC
CTCACAGCAAAATACCCCAAGGGCGAAATCACTTTGATGCCGCTGCCGGGTTTTGAGCTGATTGGTGACCTGTCGGTAAA
CACGGGCAAGTTTATGCGTGAGCTGGCCGAGCGCTTGAAGCTGTGGCTGCACCCCAAGGGAGACGATCTCAACATCCATC
GTCTGGAAGACCCCATGGACCCACAGGAGGCCGCCAGGCTTTATGAACTGGAGCGCTGTGTGGAATGTGGTGTGTGTGTA
TCGGCCTGTGCCACCAAGCAGATGCGCGACACCTTTGTGGGCGCTGTGGGCATGATGAAGATTGCCCGCTTCGAGCTCGA
CAGCCGCGATGGCCGCAGCGCCGATGACTTCTACCATGTGATTGGCAATCAGGATGGGGTGTTTGGCTGTATGACCCTGC
TGGGCTGCCAGGACAATTGCCCCAAAGATTTGCCCCATATGCAGCAAATCGCCTATCTGCGCCGCAAGATGGCTTCGACC
CTGCTGTGA

Upstream 100 bases:

>100_bases
CACCGGCCAACGAACGCTTGGCCGACCGCCTCAATGGGCTGGTGAACATTGACACCGCAGCGAGCCCAACTACGCCCAAC
ATTGCCGGAGACGATAATTC

Downstream 100 bases:

>100_bases
TCTTTAGCTGACCCAAGTAGCCCGCGCCGGATATTCCCGCGCGGGCTTTGTTTTAAGGGGCATTTGGGGGTAGTGTTAGC
CGGTAAATATCAGGCGAGGA

Product: fumarate reductase iron-sulfur subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 242; Mature: 241

Protein sequence:

>242_residues
MSGRILTFNIFRFDPQDAGDKPKMVKYQLEETSGMTVFIALNKLRQEQDPSLQFDFVCRAGICGSCAMVINGFPTLACRT
LTAKYPKGEITLMPLPGFELIGDLSVNTGKFMRELAERLKLWLHPKGDDLNIHRLEDPMDPQEAARLYELERCVECGVCV
SACATKQMRDTFVGAVGMMKIARFELDSRDGRSADDFYHVIGNQDGVFGCMTLLGCQDNCPKDLPHMQQIAYLRRKMAST
LL

Sequences:

>Translated_242_residues
MSGRILTFNIFRFDPQDAGDKPKMVKYQLEETSGMTVFIALNKLRQEQDPSLQFDFVCRAGICGSCAMVINGFPTLACRT
LTAKYPKGEITLMPLPGFELIGDLSVNTGKFMRELAERLKLWLHPKGDDLNIHRLEDPMDPQEAARLYELERCVECGVCV
SACATKQMRDTFVGAVGMMKIARFELDSRDGRSADDFYHVIGNQDGVFGCMTLLGCQDNCPKDLPHMQQIAYLRRKMAST
LL
>Mature_241_residues
SGRILTFNIFRFDPQDAGDKPKMVKYQLEETSGMTVFIALNKLRQEQDPSLQFDFVCRAGICGSCAMVINGFPTLACRTL
TAKYPKGEITLMPLPGFELIGDLSVNTGKFMRELAERLKLWLHPKGDDLNIHRLEDPMDPQEAARLYELERCVECGVCVS
ACATKQMRDTFVGAVGMMKIARFELDSRDGRSADDFYHVIGNQDGVFGCMTLLGCQDNCPKDLPHMQQIAYLRRKMASTL
L

Specific function: The fumarate reductase enzyme complex is required for fumarate respiration using formate or sulfide as electron donor [H]

COG id: COG0479

COG function: function code C; Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 4Fe-4S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI115387094, Length=240, Percent_Identity=32.5, Blast_Score=117, Evalue=7e-27,
Organism=Escherichia coli, GI1786943, Length=234, Percent_Identity=34.1880341880342, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1790596, Length=219, Percent_Identity=26.4840182648402, Blast_Score=102, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17533915, Length=234, Percent_Identity=31.1965811965812, Blast_Score=119, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6322987, Length=240, Percent_Identity=29.1666666666667, Blast_Score=111, Evalue=8e-26,
Organism=Drosophila melanogaster, GI17137106, Length=244, Percent_Identity=30.7377049180328, Blast_Score=119, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24643156, Length=234, Percent_Identity=29.0598290598291, Blast_Score=107, Evalue=8e-24,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006058
- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012675
- InterPro:   IPR001041
- InterPro:   IPR012285
- InterPro:   IPR009051
- InterPro:   IPR004489 [H]

Pfam domain/function: NA

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 27206; Mature: 27075

Theoretical pI: Translated: 6.49; Mature: 6.49

Prosite motif: PS00197 2FE2S_FER_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.5 %Cys     (Translated Protein)
5.4 %Met     (Translated Protein)
9.9 %Cys+Met (Translated Protein)
4.6 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
9.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGRILTFNIFRFDPQDAGDKPKMVKYQLEETSGMTVFIALNKLRQEQDPSLQFDFVCRA
CCCCEEEEEEEEECCCCCCCCCCEEEEEEECCCCCEEEEEEHHHHHCCCCCCEEEEEECC
GICGSCAMVINGFPTLACRTLTAKYPKGEITLMPLPGFELIGDLSVNTGKFMRELAERLK
CCCCHHHHHHCCCCHHHHHHHHCCCCCCCEEEEECCCHHHEECCCCCHHHHHHHHHHHHH
LWLHPKGDDLNIHRLEDPMDPQEAARLYELERCVECGVCVSACATKQMRDTFVGAVGMMK
EEECCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IARFELDSRDGRSADDFYHVIGNQDGVFGCMTLLGCQDNCPKDLPHMQQIAYLRRKMAST
HHHHHCCCCCCCCHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHH
LL
CC
>Mature Secondary Structure 
SGRILTFNIFRFDPQDAGDKPKMVKYQLEETSGMTVFIALNKLRQEQDPSLQFDFVCRA
CCCEEEEEEEEECCCCCCCCCCEEEEEEECCCCCEEEEEEHHHHHCCCCCCEEEEEECC
GICGSCAMVINGFPTLACRTLTAKYPKGEITLMPLPGFELIGDLSVNTGKFMRELAERLK
CCCCHHHHHHCCCCHHHHHHHHCCCCCCCEEEEECCCHHHEECCCCCHHHHHHHHHHHHH
LWLHPKGDDLNIHRLEDPMDPQEAARLYELERCVECGVCVSACATKQMRDTFVGAVGMMK
EEECCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IARFELDSRDGRSADDFYHVIGNQDGVFGCMTLLGCQDNCPKDLPHMQQIAYLRRKMAST
HHHHHCCCCCCCCHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHH
LL
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2244791; 9492313; 14500908; 10586875; 11248702 [H]