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The map label for this gene is frdA [H]

Identifier: 119776352

GI number: 119776352

Start: 3812088

End: 3814127

Strand: Reverse

Name: frdA [H]

Synonym: Sama_3220

Alternate gene names: 119776352

Gene position: 3814127-3812088 (Counterclockwise)

Preceding gene: 119776353

Following gene: 119776351

Centisome position: 88.57

GC content: 59.41

Gene sequence:

>2040_bases
GTGAAACTCATTTATACAGACTGTCTTGTGGTGGGCGCGGGCCTTGCGGGTCTCAGGGTTGCCATTGCCGCCAAAGAAAG
GGGCCACGATACCTTGGTGTTATCCCTCATTCCGGCCAAACGCAGCCATTCGGCGGCGGCACAGGGCGGTATGCAGGCGA
GCCTGGGGAATACGGTCAAGGGCCTTGGCGATAATGAAGATGTGCACTTTCAGGACACGGTAAAGGGCTCAGACTGGGGC
TGCGACCAAACCGTGGCGCGCATGTTTGCCCACTGTGCCCCCAAGGCGGTGCGGGAGCTGGCCAACTGGGGCGTGCCCTG
GACCCGGGTGACCAAGGGCCCCCGTGAAGTGGTGGTAAATGCCGAGCGCATCACCATCGAAGAAGCCGAAGCCGCCCATG
GACTGATTAACGCCCGCGATTTTGGTGGCACCAAAAAATGGCGCACCTGCTACACAGCCGACGGCACCGGCCACTCGCTC
TTGTATGCGGTGGATAACAAGGCCATTTCCCTTGGCATTCCAGTCCATGAGCGGGTAGAAGCCCTGTCGATTATTCACGA
TGGCGAGCGCTGCCACGGTGTAGTGGCTCGCTGCCTTATCACAGGTGAACTGCGCGCCTATATCGGCAAGTCCACTACCA
TAGCCACCGGTGGCTATGGCCGTATTTATGAGGTGTCCACCAACGCCATCATCTGTGAGGGTGTAGGTCAGGCACTGGCG
CTGGAGACCGGCGTCGCCACCCTTGGCAACATGGAAGCGGTGCAGTTTCACCCCACCGCCATTGTGCCCGTGGGGATCCT
CACTACCGAAGGTTGCCGCGGTGACGGTGGTTTGCTGCGTGACAAAGACGGCTACCGCTTTATGCCGGACTATGAGCCGG
AGAAAAAAGAGCTCGCCTCCCGCGACGTGGTGTCGCGCCGCATGACAGAGCATATGCGCAAGGGCAAGGGCGTCGACAGC
CCATACGGCCCGCACCTGTGGCTGGATATCACCCTGCTGGGTCGCAAACACATAGAAACCAACCTGCGGGAAGTGAAAGA
AATCTGCGAAAACTTCCTCGGCATTGACCCCGCCAAGGATTGGATCCCGGTGCGTCCGACCCAGCACTACTCCATGGGCG
GTATCCGCACCACGCCAACCGGTGAGAGCCCGCAGCTCAAGGGCCTGTTTGCCGTGGGAGAGGCCGCCTGCTGGGATATG
CACGGTTTTAACCGCCTCGGGGGTAACTCGCTCGCTGAAACCGTGGTGGGCGGCATGATCATCGGCAAATACGTAGCGGA
CTTTTGTGACGATAACGATTTGGTGCTGGATACCGGCCTGGCCAAACGTTATGTGGACAAGGTGCGCACCGAAATCGATG
AGTTGATTGAAGGCAAGGGTACTGAGAACCCCTGGGAGCTCAAGTCTGCGATGCAGCGGGTGATGATGGACTATGTGGGC
ATTTTCCGTAATGGCCCCGAACTCAATGAAGCAGTAAAACAGCTTAAGGCGTTGCTGGCACGCTCAGTTAATCTGGGTGT
GAGCTGTAAAAAACGCCATGCCAACCCCGAACTGGTAGAAGCGCTGCGGGTACGCCGCATGCTGAAAGTAGCGCTCACCG
TGGCCTGCGGCGCCGCGGCCCGCACCGAGAGCCGTGGTGCCCACGCCCGGGAAGACTTCCCACAGCGCAACGACAAAGAC
TGGCTGTGCCGCACCCTGGCAAGCTGGCCCGACGCCAATGCCCTGGAACCCACACTCAGCTACGAGCCATTGGATGTAAT
GAAGATGGAGCTACCGCCGGGCTATCGAGGTTATGGTGCAGACAATGCCATTGCTCACCCGGACACCGCCAAACGCGAGG
CCGAAATTGCTGAACTGCTTGCTGCCCTTGGCCCCAATGCCAGCCGAGAGGCAATCCAGCAGGCTCTGATGCCCTTTGAG
TTACCCGAATCACTGACACCGGCCAACGAACGCTTGGCCGACCGCCTCAATGGGCTGGTGAACATTGACACCGCAGCGAG
CCCAACTACGCCCAACATTGCCGGAGACGATAATTCATGA

Upstream 100 bases:

>100_bases
TTCCCCATACTCCCGTGTAATTCATGAATATTGTTAAAAATAAGGCGGATAACAACCGCTGCTTACGCTGTACTTTGCAA
AAGTGTGCCAAGGAGTAAAC

Downstream 100 bases:

>100_bases
GCGGCCGCATTCTGACATTCAATATTTTCCGTTTCGACCCACAGGACGCCGGTGATAAGCCCAAAATGGTCAAGTACCAG
TTGGAAGAAACCAGTGGTAT

Product: fumarate reductase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 679; Mature: 679

Protein sequence:

>679_residues
MKLIYTDCLVVGAGLAGLRVAIAAKERGHDTLVLSLIPAKRSHSAAAQGGMQASLGNTVKGLGDNEDVHFQDTVKGSDWG
CDQTVARMFAHCAPKAVRELANWGVPWTRVTKGPREVVVNAERITIEEAEAAHGLINARDFGGTKKWRTCYTADGTGHSL
LYAVDNKAISLGIPVHERVEALSIIHDGERCHGVVARCLITGELRAYIGKSTTIATGGYGRIYEVSTNAIICEGVGQALA
LETGVATLGNMEAVQFHPTAIVPVGILTTEGCRGDGGLLRDKDGYRFMPDYEPEKKELASRDVVSRRMTEHMRKGKGVDS
PYGPHLWLDITLLGRKHIETNLREVKEICENFLGIDPAKDWIPVRPTQHYSMGGIRTTPTGESPQLKGLFAVGEAACWDM
HGFNRLGGNSLAETVVGGMIIGKYVADFCDDNDLVLDTGLAKRYVDKVRTEIDELIEGKGTENPWELKSAMQRVMMDYVG
IFRNGPELNEAVKQLKALLARSVNLGVSCKKRHANPELVEALRVRRMLKVALTVACGAAARTESRGAHAREDFPQRNDKD
WLCRTLASWPDANALEPTLSYEPLDVMKMELPPGYRGYGADNAIAHPDTAKREAEIAELLAALGPNASREAIQQALMPFE
LPESLTPANERLADRLNGLVNIDTAASPTTPNIAGDDNS

Sequences:

>Translated_679_residues
MKLIYTDCLVVGAGLAGLRVAIAAKERGHDTLVLSLIPAKRSHSAAAQGGMQASLGNTVKGLGDNEDVHFQDTVKGSDWG
CDQTVARMFAHCAPKAVRELANWGVPWTRVTKGPREVVVNAERITIEEAEAAHGLINARDFGGTKKWRTCYTADGTGHSL
LYAVDNKAISLGIPVHERVEALSIIHDGERCHGVVARCLITGELRAYIGKSTTIATGGYGRIYEVSTNAIICEGVGQALA
LETGVATLGNMEAVQFHPTAIVPVGILTTEGCRGDGGLLRDKDGYRFMPDYEPEKKELASRDVVSRRMTEHMRKGKGVDS
PYGPHLWLDITLLGRKHIETNLREVKEICENFLGIDPAKDWIPVRPTQHYSMGGIRTTPTGESPQLKGLFAVGEAACWDM
HGFNRLGGNSLAETVVGGMIIGKYVADFCDDNDLVLDTGLAKRYVDKVRTEIDELIEGKGTENPWELKSAMQRVMMDYVG
IFRNGPELNEAVKQLKALLARSVNLGVSCKKRHANPELVEALRVRRMLKVALTVACGAAARTESRGAHAREDFPQRNDKD
WLCRTLASWPDANALEPTLSYEPLDVMKMELPPGYRGYGADNAIAHPDTAKREAEIAELLAALGPNASREAIQQALMPFE
LPESLTPANERLADRLNGLVNIDTAASPTTPNIAGDDNS
>Mature_679_residues
MKLIYTDCLVVGAGLAGLRVAIAAKERGHDTLVLSLIPAKRSHSAAAQGGMQASLGNTVKGLGDNEDVHFQDTVKGSDWG
CDQTVARMFAHCAPKAVRELANWGVPWTRVTKGPREVVVNAERITIEEAEAAHGLINARDFGGTKKWRTCYTADGTGHSL
LYAVDNKAISLGIPVHERVEALSIIHDGERCHGVVARCLITGELRAYIGKSTTIATGGYGRIYEVSTNAIICEGVGQALA
LETGVATLGNMEAVQFHPTAIVPVGILTTEGCRGDGGLLRDKDGYRFMPDYEPEKKELASRDVVSRRMTEHMRKGKGVDS
PYGPHLWLDITLLGRKHIETNLREVKEICENFLGIDPAKDWIPVRPTQHYSMGGIRTTPTGESPQLKGLFAVGEAACWDM
HGFNRLGGNSLAETVVGGMIIGKYVADFCDDNDLVLDTGLAKRYVDKVRTEIDELIEGKGTENPWELKSAMQRVMMDYVG
IFRNGPELNEAVKQLKALLARSVNLGVSCKKRHANPELVEALRVRRMLKVALTVACGAAARTESRGAHAREDFPQRNDKD
WLCRTLASWPDANALEPTLSYEPLDVMKMELPPGYRGYGADNAIAHPDTAKREAEIAELLAALGPNASREAIQQALMPFE
LPESLTPANERLADRLNGLVNIDTAASPTTPNIAGDDNS

Specific function: The fumarate reductase enzyme complex is required for fumarate respiration using formate or sulfide as electron donor [H]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=605, Percent_Identity=35.8677685950413, Blast_Score=319, Evalue=5e-87,
Organism=Escherichia coli, GI1786942, Length=603, Percent_Identity=36.4842454394693, Blast_Score=334, Evalue=9e-93,
Organism=Escherichia coli, GI1790597, Length=588, Percent_Identity=35.8843537414966, Blast_Score=310, Evalue=2e-85,
Organism=Escherichia coli, GI1788928, Length=561, Percent_Identity=28.8770053475936, Blast_Score=172, Evalue=8e-44,
Organism=Caenorhabditis elegans, GI17505833, Length=545, Percent_Identity=38.5321100917431, Blast_Score=323, Evalue=2e-88,
Organism=Caenorhabditis elegans, GI17550100, Length=551, Percent_Identity=38.2940108892922, Blast_Score=313, Evalue=2e-85,
Organism=Saccharomyces cerevisiae, GI6322701, Length=619, Percent_Identity=37.3182552504039, Blast_Score=330, Evalue=3e-91,
Organism=Saccharomyces cerevisiae, GI6322416, Length=610, Percent_Identity=37.2131147540984, Blast_Score=323, Evalue=6e-89,
Organism=Drosophila melanogaster, GI17137288, Length=603, Percent_Identity=35.9867330016584, Blast_Score=315, Evalue=7e-86,
Organism=Drosophila melanogaster, GI24655642, Length=603, Percent_Identity=35.9867330016584, Blast_Score=315, Evalue=7e-86,
Organism=Drosophila melanogaster, GI24655647, Length=603, Percent_Identity=35.9867330016584, Blast_Score=315, Evalue=7e-86,
Organism=Drosophila melanogaster, GI24663005, Length=556, Percent_Identity=33.6330935251799, Blast_Score=264, Evalue=1e-70,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 73799; Mature: 73799

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLIYTDCLVVGAGLAGLRVAIAAKERGHDTLVLSLIPAKRSHSAAAQGGMQASLGNTVK
CEEEEEHHHHHHCCHHHHEEEEEECCCCCCEEEEEEECCCCCCHHHHHCCCHHHCCCHHC
GLGDNEDVHFQDTVKGSDWGCDQTVARMFAHCAPKAVRELANWGVPWTRVTKGPREVVVN
CCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHCHHHHHHHHHCCCCHHHHCCCCHHEEEE
AERITIEEAEAAHGLINARDFGGTKKWRTCYTADGTGHSLLYAVDNKAISLGIPVHERVE
CHHEEEEHHHHHHCCCCCCCCCCCCCCCEEEECCCCCCEEEEEECCCEEEECCCHHHHHH
ALSIIHDGERCHGVVARCLITGELRAYIGKSTTIATGGYGRIYEVSTNAIICEGVGQALA
HHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCEEEEEECCEEEECCCCCHHH
LETGVATLGNMEAVQFHPTAIVPVGILTTEGCRGDGGLLRDKDGYRFMPDYEPEKKELAS
HHHHHHHHCCCCEEEECCCEEEEEEEEEECCCCCCCCCCCCCCCCEECCCCCCHHHHHHH
RDVVSRRMTEHMRKGKGVDSPYGPHLWLDITLLGRKHIETNLREVKEICENFLGIDPAKD
HHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCC
WIPVRPTQHYSMGGIRTTPTGESPQLKGLFAVGEAACWDMHGFNRLGGNSLAETVVGGMI
CCCCCCCCCCCCCCEEECCCCCCCCCCEEEEECCHHHHCCCCCHHCCCHHHHHHHHHHHH
IGKYVADFCDDNDLVLDTGLAKRYVDKVRTEIDELIEGKGTENPWELKSAMQRVMMDYVG
HHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
IFRNGPELNEAVKQLKALLARSVNLGVSCKKRHANPELVEALRVRRMLKVALTVACGAAA
HHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHH
RTESRGAHAREDFPQRNDKDWLCRTLASWPDANALEPTLSYEPLDVMKMELPPGYRGYGA
CCCCCCCCCHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCC
DNAIAHPDTAKREAEIAELLAALGPNASREAIQQALMPFELPESLTPANERLADRLNGLV
CCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCEE
NIDTAASPTTPNIAGDDNS
EECCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKLIYTDCLVVGAGLAGLRVAIAAKERGHDTLVLSLIPAKRSHSAAAQGGMQASLGNTVK
CEEEEEHHHHHHCCHHHHEEEEEECCCCCCEEEEEEECCCCCCHHHHHCCCHHHCCCHHC
GLGDNEDVHFQDTVKGSDWGCDQTVARMFAHCAPKAVRELANWGVPWTRVTKGPREVVVN
CCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHCHHHHHHHHHCCCCHHHHCCCCHHEEEE
AERITIEEAEAAHGLINARDFGGTKKWRTCYTADGTGHSLLYAVDNKAISLGIPVHERVE
CHHEEEEHHHHHHCCCCCCCCCCCCCCCEEEECCCCCCEEEEEECCCEEEECCCHHHHHH
ALSIIHDGERCHGVVARCLITGELRAYIGKSTTIATGGYGRIYEVSTNAIICEGVGQALA
HHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCEEEEEECCEEEECCCCCHHH
LETGVATLGNMEAVQFHPTAIVPVGILTTEGCRGDGGLLRDKDGYRFMPDYEPEKKELAS
HHHHHHHHCCCCEEEECCCEEEEEEEEEECCCCCCCCCCCCCCCCEECCCCCCHHHHHHH
RDVVSRRMTEHMRKGKGVDSPYGPHLWLDITLLGRKHIETNLREVKEICENFLGIDPAKD
HHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCC
WIPVRPTQHYSMGGIRTTPTGESPQLKGLFAVGEAACWDMHGFNRLGGNSLAETVVGGMI
CCCCCCCCCCCCCCEEECCCCCCCCCCEEEEECCHHHHCCCCCHHCCCHHHHHHHHHHHH
IGKYVADFCDDNDLVLDTGLAKRYVDKVRTEIDELIEGKGTENPWELKSAMQRVMMDYVG
HHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
IFRNGPELNEAVKQLKALLARSVNLGVSCKKRHANPELVEALRVRRMLKVALTVACGAAA
HHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHH
RTESRGAHAREDFPQRNDKDWLCRTLASWPDANALEPTLSYEPLDVMKMELPPGYRGYGA
CCCCCCCCCHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCC
DNAIAHPDTAKREAEIAELLAALGPNASREAIQQALMPFELPESLTPANERLADRLNGLV
CCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCEE
NIDTAASPTTPNIAGDDNS
EECCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2244791; 9492313; 14500908; 3609021; 10586875; 11248702 [H]