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The map label for this gene is accC [H]

Identifier: 119776328

GI number: 119776328

Start: 3787677

End: 3789041

Strand: Direct

Name: accC [H]

Synonym: Sama_3196

Alternate gene names: 119776328

Gene position: 3787677-3789041 (Clockwise)

Preceding gene: 119776327

Following gene: 119776332

Centisome position: 87.96

GC content: 60.0

Gene sequence:

>1365_bases
ATGCCGACTGAGGCCCGCTTTAAACGGGTACTGGTGGCCAATCGCGGTGAAATCGCGGTACGCATTATCCGCGCCTGCCA
TCAACTGGGGCTGGAAACCGTTGCCATCTATTCCAGCGCCGACAAGGGCGCGCTGCACACCCTGCTGGCAACCCACTGCC
TGTGCATAGGCCCAGCGGCGGCCAAAGACAGCTACCTCAATATCAATGCCATATTGGAAGCCGCCAAACTCACGGCCGCC
GATGCCATACACCCGGGTTATGGCTTTTTGGCCGAGCGGGCCGGGTTTGCCCGGGCAGTGACAGAGGCGGGCCTGGTGTT
TCTGGGGCCTGATGCCGATACCATAGCCACCATGGGCGATAAGGTCAGCGCCATCAAATCCATCAAGGCCGTGGGCATTC
CTACGCTGCCGGGCTCAGATGGGGCGCTGAATGATGACATGAACGCTGTTGAGGCCCTCGCCACCGACATAGGTTATCCG
GTGCTTATCAAGGCCAGTGCCGGCGGAGGTGGCCGGGGGATGCGCCGGGTCGACTCGGCAGACGAGCTGGCATCAGCCAT
TGCCCTTACCCGCAGCGAAGCCCTGGCGGCCTTTGGCGACAACACCGTCTATCTGGAGAAATTCCTCACGCATCCACGCC
ATATCGAGTTTCAGATGCTGGCCGATGGCGAAGCTGCGCTGTGTCTCGGTGAGCGGGACTGCTCCGCCCAGCGCCGTCAT
CAAAAGCTGATTGAAGAGGCGCCGGCACTCGGAATTGCCCGAGAGAAAATACGGGAGATGGCCGATATCTGTGAGGCCGC
CTGTCGGCGTCTCGGGTACCGAGGAGTGGGCACCTTTGAGTTTCTCTATCAGGACGGCGCCTTTTTCTTTATCGAAATGA
ACACCCGTATTCAGGTTGAGCACACAGTCACCGAGATGGTGACCGGGCTGGATCTCATTGCCTGGCAGCTGAAAGTGGCC
CTGGGACACCCTCTGCCACCAAGGCCTCAGGTACAGGGTCATGCAATCGAGTGTCGCATCAATGCCGAAGCCCCCCAAAG
CCAGTTGCCTTCACCTGGGGTAATAACCCAGCTCAGGGTGCCAGGCGGCCCAGGGGTTCGGTGGGACTCCTATCTCTTCC
CCGGGGCAATGGTACCTGCCTTTTACGACTCGCTGATTGGCAAACTCATCTGCCACGGCGTCACCCGCGAAGAGGCCACG
GCGCGCCTGCGGCAGGCACTGACAGAGCTTGAAATTCAAGGGATCGCCATCAATAAGTCCCTGCACCTGCAACTCATTGC
ATGTGACGCATTCCAGCCCTGGCAGCGTGACATTCATTTTGTTGATGCACTCTCAGCGCCAGGTGTCGGGCAGGCGCACC
TGTGA

Upstream 100 bases:

>100_bases
ATGAACCAAATAGCCGCCGACCGCGCCGGGACAGTGAAAGCGATTCTGGTAGAAAACGGCACCGCTGTGGAGTTTGACCA
ACCCCTGTTTGTGATTGGTG

Downstream 100 bases:

>100_bases
CCACAGCTGCTCACTGAGTACATCGCCCCTGTGCCATTCTCCCTGCTCAACCCATTGCACCAGGGCGTCGCCCACGGCGG
GATAACGCACCGGCTCAGGG

Product: acetyl-CoA carboxylase, biotin carboxylase

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 454; Mature: 453

Protein sequence:

>454_residues
MPTEARFKRVLVANRGEIAVRIIRACHQLGLETVAIYSSADKGALHTLLATHCLCIGPAAAKDSYLNINAILEAAKLTAA
DAIHPGYGFLAERAGFARAVTEAGLVFLGPDADTIATMGDKVSAIKSIKAVGIPTLPGSDGALNDDMNAVEALATDIGYP
VLIKASAGGGGRGMRRVDSADELASAIALTRSEALAAFGDNTVYLEKFLTHPRHIEFQMLADGEAALCLGERDCSAQRRH
QKLIEEAPALGIAREKIREMADICEAACRRLGYRGVGTFEFLYQDGAFFFIEMNTRIQVEHTVTEMVTGLDLIAWQLKVA
LGHPLPPRPQVQGHAIECRINAEAPQSQLPSPGVITQLRVPGGPGVRWDSYLFPGAMVPAFYDSLIGKLICHGVTREEAT
ARLRQALTELEIQGIAINKSLHLQLIACDAFQPWQRDIHFVDALSAPGVGQAHL

Sequences:

>Translated_454_residues
MPTEARFKRVLVANRGEIAVRIIRACHQLGLETVAIYSSADKGALHTLLATHCLCIGPAAAKDSYLNINAILEAAKLTAA
DAIHPGYGFLAERAGFARAVTEAGLVFLGPDADTIATMGDKVSAIKSIKAVGIPTLPGSDGALNDDMNAVEALATDIGYP
VLIKASAGGGGRGMRRVDSADELASAIALTRSEALAAFGDNTVYLEKFLTHPRHIEFQMLADGEAALCLGERDCSAQRRH
QKLIEEAPALGIAREKIREMADICEAACRRLGYRGVGTFEFLYQDGAFFFIEMNTRIQVEHTVTEMVTGLDLIAWQLKVA
LGHPLPPRPQVQGHAIECRINAEAPQSQLPSPGVITQLRVPGGPGVRWDSYLFPGAMVPAFYDSLIGKLICHGVTREEAT
ARLRQALTELEIQGIAINKSLHLQLIACDAFQPWQRDIHFVDALSAPGVGQAHL
>Mature_453_residues
PTEARFKRVLVANRGEIAVRIIRACHQLGLETVAIYSSADKGALHTLLATHCLCIGPAAAKDSYLNINAILEAAKLTAAD
AIHPGYGFLAERAGFARAVTEAGLVFLGPDADTIATMGDKVSAIKSIKAVGIPTLPGSDGALNDDMNAVEALATDIGYPV
LIKASAGGGGRGMRRVDSADELASAIALTRSEALAAFGDNTVYLEKFLTHPRHIEFQMLADGEAALCLGERDCSAQRRHQ
KLIEEAPALGIAREKIREMADICEAACRRLGYRGVGTFEFLYQDGAFFFIEMNTRIQVEHTVTEMVTGLDLIAWQLKVAL
GHPLPPRPQVQGHAIECRINAEAPQSQLPSPGVITQLRVPGGPGVRWDSYLFPGAMVPAFYDSLIGKLICHGVTREEATA
RLRQALTELEIQGIAINKSLHLQLIACDAFQPWQRDIHFVDALSAPGVGQAHL

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI65506442, Length=438, Percent_Identity=45.4337899543379, Blast_Score=363, Evalue=1e-100,
Organism=Homo sapiens, GI295821183, Length=438, Percent_Identity=45.4337899543379, Blast_Score=363, Evalue=1e-100,
Organism=Homo sapiens, GI189095269, Length=433, Percent_Identity=45.4965357967667, Blast_Score=359, Evalue=3e-99,
Organism=Homo sapiens, GI116805327, Length=440, Percent_Identity=41.1363636363636, Blast_Score=335, Evalue=4e-92,
Organism=Homo sapiens, GI106049528, Length=447, Percent_Identity=42.2818791946309, Blast_Score=318, Evalue=8e-87,
Organism=Homo sapiens, GI106049295, Length=447, Percent_Identity=42.2818791946309, Blast_Score=318, Evalue=8e-87,
Organism=Homo sapiens, GI106049292, Length=447, Percent_Identity=42.2818791946309, Blast_Score=318, Evalue=8e-87,
Organism=Homo sapiens, GI38679977, Length=509, Percent_Identity=31.434184675835, Blast_Score=219, Evalue=5e-57,
Organism=Homo sapiens, GI38679967, Length=509, Percent_Identity=31.434184675835, Blast_Score=219, Evalue=5e-57,
Organism=Homo sapiens, GI38679960, Length=509, Percent_Identity=31.434184675835, Blast_Score=219, Evalue=5e-57,
Organism=Homo sapiens, GI38679971, Length=509, Percent_Identity=31.434184675835, Blast_Score=219, Evalue=6e-57,
Organism=Homo sapiens, GI38679974, Length=509, Percent_Identity=31.434184675835, Blast_Score=218, Evalue=6e-57,
Organism=Homo sapiens, GI134142062, Length=512, Percent_Identity=31.25, Blast_Score=211, Evalue=1e-54,
Organism=Escherichia coli, GI1789654, Length=438, Percent_Identity=56.62100456621, Blast_Score=495, Evalue=1e-141,
Organism=Caenorhabditis elegans, GI17567343, Length=438, Percent_Identity=42.2374429223744, Blast_Score=331, Evalue=4e-91,
Organism=Caenorhabditis elegans, GI17562816, Length=453, Percent_Identity=43.2671081677704, Blast_Score=316, Evalue=1e-86,
Organism=Caenorhabditis elegans, GI71987519, Length=431, Percent_Identity=41.0672853828306, Blast_Score=311, Evalue=5e-85,
Organism=Caenorhabditis elegans, GI133931226, Length=495, Percent_Identity=28.2828282828283, Blast_Score=192, Evalue=4e-49,
Organism=Caenorhabditis elegans, GI71997168, Length=411, Percent_Identity=30.4136253041363, Blast_Score=182, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI71997163, Length=411, Percent_Identity=30.4136253041363, Blast_Score=182, Evalue=3e-46,
Organism=Saccharomyces cerevisiae, GI6319685, Length=433, Percent_Identity=39.7228637413395, Blast_Score=320, Evalue=2e-88,
Organism=Saccharomyces cerevisiae, GI6319695, Length=450, Percent_Identity=40.8888888888889, Blast_Score=299, Evalue=7e-82,
Organism=Saccharomyces cerevisiae, GI6321376, Length=439, Percent_Identity=41.9134396355353, Blast_Score=289, Evalue=6e-79,
Organism=Saccharomyces cerevisiae, GI6323863, Length=412, Percent_Identity=34.7087378640777, Blast_Score=202, Evalue=1e-52,
Organism=Saccharomyces cerevisiae, GI6324343, Length=479, Percent_Identity=29.4363256784969, Blast_Score=196, Evalue=5e-51,
Organism=Drosophila melanogaster, GI24651757, Length=442, Percent_Identity=41.1764705882353, Blast_Score=332, Evalue=2e-91,
Organism=Drosophila melanogaster, GI281363050, Length=446, Percent_Identity=41.2556053811659, Blast_Score=318, Evalue=5e-87,
Organism=Drosophila melanogaster, GI24652224, Length=446, Percent_Identity=41.2556053811659, Blast_Score=318, Evalue=5e-87,
Organism=Drosophila melanogaster, GI24652222, Length=446, Percent_Identity=41.2556053811659, Blast_Score=318, Evalue=5e-87,
Organism=Drosophila melanogaster, GI24652220, Length=446, Percent_Identity=41.2556053811659, Blast_Score=318, Evalue=5e-87,
Organism=Drosophila melanogaster, GI24652218, Length=446, Percent_Identity=41.2556053811659, Blast_Score=318, Evalue=5e-87,
Organism=Drosophila melanogaster, GI24652212, Length=446, Percent_Identity=41.2556053811659, Blast_Score=318, Evalue=6e-87,
Organism=Drosophila melanogaster, GI24652210, Length=446, Percent_Identity=41.2556053811659, Blast_Score=318, Evalue=6e-87,
Organism=Drosophila melanogaster, GI24652214, Length=446, Percent_Identity=41.2556053811659, Blast_Score=318, Evalue=6e-87,
Organism=Drosophila melanogaster, GI19921944, Length=446, Percent_Identity=41.2556053811659, Blast_Score=318, Evalue=6e-87,
Organism=Drosophila melanogaster, GI24652216, Length=446, Percent_Identity=41.2556053811659, Blast_Score=318, Evalue=6e-87,
Organism=Drosophila melanogaster, GI24651759, Length=406, Percent_Identity=40.64039408867, Blast_Score=293, Evalue=1e-79,
Organism=Drosophila melanogaster, GI161076409, Length=503, Percent_Identity=31.013916500994, Blast_Score=210, Evalue=2e-54,
Organism=Drosophila melanogaster, GI161076407, Length=503, Percent_Identity=31.013916500994, Blast_Score=210, Evalue=2e-54,
Organism=Drosophila melanogaster, GI24586460, Length=503, Percent_Identity=31.013916500994, Blast_Score=210, Evalue=2e-54,
Organism=Drosophila melanogaster, GI24586458, Length=503, Percent_Identity=31.013916500994, Blast_Score=209, Evalue=2e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 48798; Mature: 48667

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTEARFKRVLVANRGEIAVRIIRACHQLGLETVAIYSSADKGALHTLLATHCLCIGPAA
CCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCC
AKDSYLNINAILEAAKLTAADAIHPGYGFLAERAGFARAVTEAGLVFLGPDADTIATMGD
CCCCEEEHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCEEEECCCCHHHHHCCH
KVSAIKSIKAVGIPTLPGSDGALNDDMNAVEALATDIGYPVLIKASAGGGGRGMRRVDSA
HHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCH
DELASAIALTRSEALAAFGDNTVYLEKFLTHPRHIEFQMLADGEAALCLGERDCSAQRRH
HHHHHHHHHHHHHHHHHCCCCEEEHHHHHCCCCCEEEEEEECCCEEEEECCCCCHHHHHH
QKLIEEAPALGIAREKIREMADICEAACRRLGYRGVGTFEFLYQDGAFFFIEMNTRIQVE
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCEEEEEECCEEEEH
HTVTEMVTGLDLIAWQLKVALGHPLPPRPQVQGHAIECRINAEAPQSQLPSPGVITQLRV
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCHHHCCCCCCEEEEEC
PGGPGVRWDSYLFPGAMVPAFYDSLIGKLICHGVTREEATARLRQALTELEIQGIAINKS
CCCCCCCCCCEECCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHEEEEEEECCC
LHLQLIACDAFQPWQRDIHFVDALSAPGVGQAHL
EEEEEEEECCCCCHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
PTEARFKRVLVANRGEIAVRIIRACHQLGLETVAIYSSADKGALHTLLATHCLCIGPAA
CCHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCC
AKDSYLNINAILEAAKLTAADAIHPGYGFLAERAGFARAVTEAGLVFLGPDADTIATMGD
CCCCEEEHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCEEEECCCCHHHHHCCH
KVSAIKSIKAVGIPTLPGSDGALNDDMNAVEALATDIGYPVLIKASAGGGGRGMRRVDSA
HHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCH
DELASAIALTRSEALAAFGDNTVYLEKFLTHPRHIEFQMLADGEAALCLGERDCSAQRRH
HHHHHHHHHHHHHHHHHCCCCEEEHHHHHCCCCCEEEEEEECCCEEEEECCCCCHHHHHH
QKLIEEAPALGIAREKIREMADICEAACRRLGYRGVGTFEFLYQDGAFFFIEMNTRIQVE
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCEEEEEECCEEEEH
HTVTEMVTGLDLIAWQLKVALGHPLPPRPQVQGHAIECRINAEAPQSQLPSPGVITQLRV
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCHHHCCCCCCEEEEEC
PGGPGVRWDSYLFPGAMVPAFYDSLIGKLICHGVTREEATARLRQALTELEIQGIAINKS
CCCCCCCCCCEECCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHEEEEEEECCC
LHLQLIACDAFQPWQRDIHFVDALSAPGVGQAHL
EEEEEEEECCCCCHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]