Click here to switch to the map view.

The map label for this gene is accB [H]

Identifier: 119776327

GI number: 119776327

Start: 3787259

End: 3787687

Strand: Direct

Name: accB [H]

Synonym: Sama_3195

Alternate gene names: 119776327

Gene position: 3787259-3787687 (Clockwise)

Preceding gene: 119776326

Following gene: 119776328

Centisome position: 87.95

GC content: 57.11

Gene sequence:

>429_bases
ATGGCGATGGATCTGCGAAAAATCAAAAAGCTGATCGAGCTGGTACAGGAGTCCGGCATCAATGAGCTGGAAGTGAAAGA
AGGCGAAGAGTCGGTGCGCATCATCCGCCATGGCAATCTGCCACCGCAGACGGTAATCACTGAGATCAGCCCCAAGGCAA
CCAGCAGCGTTCAGGCCCATGAAGCAGGCCACAGAGTGCTCTCCCCCATGGTGGGCACCTTTTACCGCGCTCCCAGCCCC
GAAGCCCGTCCTTTTGTGGAGCTGGGCACAGAGGTGGCCGTGGGCGATACCCTCGCGGTGATTGAAGCCATGAAAATGAT
GAACCAAATAGCCGCCGACCGCGCCGGGACAGTGAAAGCGATTCTGGTAGAAAACGGCACCGCTGTGGAGTTTGACCAAC
CCCTGTTTGTGATTGGTGATGCCGACTGA

Upstream 100 bases:

>100_bases
ATTTTTCCGATAAGGCCGTTGGCGTGATCCTGGGTCTGGGTCCCAAAGGCTACTCGCTGGCACTCGAAGCGGCAGCGGAG
CGGTTGAAAGGGAGCAACTG

Downstream 100 bases:

>100_bases
GGCCCGCTTTAAACGGGTACTGGTGGCCAATCGCGGTGAAATCGCGGTACGCATTATCCGCGCCTGCCATCAACTGGGGC
TGGAAACCGTTGCCATCTAT

Product: acetyl-CoA carboxylase, biotin carboxyl carrier protein

Products: Malonyl-CoA; malonyl-CoA; phosphate; ADP [C]

Alternate protein names: BCCP [H]

Number of amino acids: Translated: 142; Mature: 141

Protein sequence:

>142_residues
MAMDLRKIKKLIELVQESGINELEVKEGEESVRIIRHGNLPPQTVITEISPKATSSVQAHEAGHRVLSPMVGTFYRAPSP
EARPFVELGTEVAVGDTLAVIEAMKMMNQIAADRAGTVKAILVENGTAVEFDQPLFVIGDAD

Sequences:

>Translated_142_residues
MAMDLRKIKKLIELVQESGINELEVKEGEESVRIIRHGNLPPQTVITEISPKATSSVQAHEAGHRVLSPMVGTFYRAPSP
EARPFVELGTEVAVGDTLAVIEAMKMMNQIAADRAGTVKAILVENGTAVEFDQPLFVIGDAD
>Mature_141_residues
AMDLRKIKKLIELVQESGINELEVKEGEESVRIIRHGNLPPQTVITEISPKATSSVQAHEAGHRVLSPMVGTFYRAPSPE
ARPFVELGTEVAVGDTLAVIEAMKMMNQIAADRAGTVKAILVENGTAVEFDQPLFVIGDAD

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0511

COG function: function code I; Biotin carboxyl carrier protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotinyl-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789653, Length=157, Percent_Identity=56.0509554140127, Blast_Score=160, Evalue=3e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001249
- InterPro:   IPR001882
- InterPro:   IPR000089
- InterPro:   IPR011053 [H]

Pfam domain/function: PF00364 Biotin_lipoyl [H]

EC number: NA

Molecular weight: Translated: 15379; Mature: 15248

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: PS50968 BIOTINYL_LIPOYL ; PS00188 BIOTIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAMDLRKIKKLIELVQESGINELEVKEGEESVRIIRHGNLPPQTVITEISPKATSSVQAH
CCCCHHHHHHHHHHHHHCCCCEEEECCCCCCEEEEECCCCCHHHHEECCCCCCCCCHHHH
EAGHRVLSPMVGTFYRAPSPEARPFVELGTEVAVGDTLAVIEAMKMMNQIAADRAGTVKA
HHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEE
ILVENGTAVEFDQPLFVIGDAD
EEEECCCEEEECCCEEEEECCC
>Mature Secondary Structure 
AMDLRKIKKLIELVQESGINELEVKEGEESVRIIRHGNLPPQTVITEISPKATSSVQAH
CCCHHHHHHHHHHHHHCCCCEEEECCCCCCEEEEECCCCCHHHHEECCCCCCCCCHHHH
EAGHRVLSPMVGTFYRAPSPEARPFVELGTEVAVGDTLAVIEAMKMMNQIAADRAGTVKA
HHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEE
ILVENGTAVEFDQPLFVIGDAD
EEEECCCEEEECCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Acetyl-CoA; HCO3-; Proton; acetyl-CoA; ATP [C]

Specific reaction: acetyl-CoA = malonyl-CoA HCO3- + Proton + acetyl-CoA + ATP = malonyl-CoA + phosphate + ADP [C]

General reaction: Ligases; Forming Carbon-Carbon Bonds; acetyl-CoA carboxylase Reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]