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The map label for this gene is fhs

Identifier: 119776278

GI number: 119776278

Start: 3733497

End: 3735179

Strand: Reverse

Name: fhs

Synonym: Sama_3146

Alternate gene names: 119776278

Gene position: 3735179-3733497 (Counterclockwise)

Preceding gene: 119776280

Following gene: 119776276

Centisome position: 86.74

GC content: 59.71

Gene sequence:

>1683_bases
ATGTTGACTGATATGGAAATTTCCCGGCAGGCCAATGTACGCCCCATAGGCTGGATTGCCGATGACTTTGGTCTTGGCAA
GCATTTGTGGCGGGAGGCCGGTCATGCCATGGCCAAAATCAGCCTTGAAGCCGCCCGCGCGCCTTTGCGTGGCAAGCTGG
TTATAGTCACCGCCGTCACACCCACTCCCCATGGCGAAGGTAAAACCGTGACCACCATAGGGCTCACCCAGGGGCTGCAT
CTGCTGGGGCACAAGGCTTGTGCCTGTATCCGTCAGCCCAGTCTCGGCCCTGTTTTCGGGGTTAAAGGCGGCGCCGCCGG
TGGGGGATATGCCCAGGTGGTGCCCATGGAGGTGATGAACCTGCATATGACCGGTGACATCCATGCCGTCACCAGTGCCC
ATAACCTGGCTGCCGCCGCCATCGATGCCCGCCTGTTTCATGAAACCCGTCTGGGGTGTGAATCGTTCAGCGCCAAAACG
GGATTACCGGCGCTGAATATCGACCCCGAGCGCATTCTCTGGCGCCGGGTGGTGGACCACAACGATCGCAGCCTGCGCCA
GATTGAACTTGGTCTTGGGGATAACAATGGTCCGGTTCACGGCGGGGGCTTTGATATCACGGCGGCCTCTGAACTCATGG
CCATTCTGGCCCTGTGCGAAAACATCGCCGATATGCGTGCCCGGATCGGGCGGGTTATTCTGGCCATGAGCCGGGACGGT
AAACCCATCAGTGCCGATGATCTCGGTGTGGCCGGTGCCATGACCGCCATCATGCGTGATGCCATCGAACCGACGTTGAT
GCAAACCCTGAGCGGGGCACCCTGCCTGGTTCATGCGGGCCCCTTTGCCAATATCGCCCATGGCAACTCTTCCATTATCG
CCGACCGGGTGGCCCTGGCACACCACGACTACGTGGTGACAGAGGGGGGATTTGGCTCCGACATGGGCTTTGAAAAGTTC
TGCAACATCAAGAGCCGCGCCTCGGGCATTGCCCCTTCCGCCGCCGTGTTGGTGGTGACCTTAAGGGCGCTTAAGGCCAA
CTCAGGCGTGGAAGGCGACGACAGAGCGCGTCTGGAAGCCGGCTTTGCCAACCTGCACTGGCACATGCAAAACGTGATGG
GCTATGGCCTGCCGTTGGTGGTGGCCATCAATCGATTCCCCGACGATGCGATGGCCGAACTGGACTGGCTCAAAGAACGT
TGCCTTGAAGAAGGGGCCTTTGGCTGCGAAATCAGCGATGCCTTCAGCCACGGTGCCGAGGGCGCTCGGGCGCTGGCCAC
TGCAGTCGCCCGTGCCTGCGATGCGCCGGTAAACTTTGAGTATCTCTATGACGACGAGATGGACTTTGGTGCCCGCCTGA
TGACCCTGGCAGAGCGTTATGGTGCGGCAGGCGTAAGTCTGTCTGAGGACGCGCGTCGGGATCTGGCGATGATTACCGAG
CTTGGGATGGACAAATTGCCCCTGTGCATGGCCAAAACCCCTTTGTCCATCAGCCATGATCCTTCGCTCAAAGGAGCCCC
CAGTGGCTTTGAGCTGCCTGTGGTCGGCTTACGTTTGAGTGCCGGTGCGGGCTTTATTACTGTGCTCACAGGCAAGGTGA
TGACCATGCCGGGGTTGGGGCTCCTGCCCGGCTATCTGAATATCGACATCAATGACAAGGGCGAAATAATCGGCCTGGGA
TGA

Upstream 100 bases:

>100_bases
TCTTTAGCCCGGGTCTTTGGCTTAGGCTGTGTTGAGCCAGGACCCGCCACAGGGTCTCACAATAACAATCACAAGCATAC
CCTACAGCGAGAACTCCACT

Downstream 100 bases:

>100_bases
TGGATGCAGATGAGTGACAAGAAAGGCACCCTCGGGTGCCTTTCTGTTTTCAGCGATTTGCTGTGGTCAAGCGCGATAGA
AGTGCACATCCCGCTGCGGG

Product: formate--tetrahydrofolate ligase

Products: NA

Alternate protein names: Formyltetrahydrofolate synthetase; FHS; FTHFS

Number of amino acids: Translated: 560; Mature: 560

Protein sequence:

>560_residues
MLTDMEISRQANVRPIGWIADDFGLGKHLWREAGHAMAKISLEAARAPLRGKLVIVTAVTPTPHGEGKTVTTIGLTQGLH
LLGHKACACIRQPSLGPVFGVKGGAAGGGYAQVVPMEVMNLHMTGDIHAVTSAHNLAAAAIDARLFHETRLGCESFSAKT
GLPALNIDPERILWRRVVDHNDRSLRQIELGLGDNNGPVHGGGFDITAASELMAILALCENIADMRARIGRVILAMSRDG
KPISADDLGVAGAMTAIMRDAIEPTLMQTLSGAPCLVHAGPFANIAHGNSSIIADRVALAHHDYVVTEGGFGSDMGFEKF
CNIKSRASGIAPSAAVLVVTLRALKANSGVEGDDRARLEAGFANLHWHMQNVMGYGLPLVVAINRFPDDAMAELDWLKER
CLEEGAFGCEISDAFSHGAEGARALATAVARACDAPVNFEYLYDDEMDFGARLMTLAERYGAAGVSLSEDARRDLAMITE
LGMDKLPLCMAKTPLSISHDPSLKGAPSGFELPVVGLRLSAGAGFITVLTGKVMTMPGLGLLPGYLNIDINDKGEIIGLG

Sequences:

>Translated_560_residues
MLTDMEISRQANVRPIGWIADDFGLGKHLWREAGHAMAKISLEAARAPLRGKLVIVTAVTPTPHGEGKTVTTIGLTQGLH
LLGHKACACIRQPSLGPVFGVKGGAAGGGYAQVVPMEVMNLHMTGDIHAVTSAHNLAAAAIDARLFHETRLGCESFSAKT
GLPALNIDPERILWRRVVDHNDRSLRQIELGLGDNNGPVHGGGFDITAASELMAILALCENIADMRARIGRVILAMSRDG
KPISADDLGVAGAMTAIMRDAIEPTLMQTLSGAPCLVHAGPFANIAHGNSSIIADRVALAHHDYVVTEGGFGSDMGFEKF
CNIKSRASGIAPSAAVLVVTLRALKANSGVEGDDRARLEAGFANLHWHMQNVMGYGLPLVVAINRFPDDAMAELDWLKER
CLEEGAFGCEISDAFSHGAEGARALATAVARACDAPVNFEYLYDDEMDFGARLMTLAERYGAAGVSLSEDARRDLAMITE
LGMDKLPLCMAKTPLSISHDPSLKGAPSGFELPVVGLRLSAGAGFITVLTGKVMTMPGLGLLPGYLNIDINDKGEIIGLG
>Mature_560_residues
MLTDMEISRQANVRPIGWIADDFGLGKHLWREAGHAMAKISLEAARAPLRGKLVIVTAVTPTPHGEGKTVTTIGLTQGLH
LLGHKACACIRQPSLGPVFGVKGGAAGGGYAQVVPMEVMNLHMTGDIHAVTSAHNLAAAAIDARLFHETRLGCESFSAKT
GLPALNIDPERILWRRVVDHNDRSLRQIELGLGDNNGPVHGGGFDITAASELMAILALCENIADMRARIGRVILAMSRDG
KPISADDLGVAGAMTAIMRDAIEPTLMQTLSGAPCLVHAGPFANIAHGNSSIIADRVALAHHDYVVTEGGFGSDMGFEKF
CNIKSRASGIAPSAAVLVVTLRALKANSGVEGDDRARLEAGFANLHWHMQNVMGYGLPLVVAINRFPDDAMAELDWLKER
CLEEGAFGCEISDAFSHGAEGARALATAVARACDAPVNFEYLYDDEMDFGARLMTLAERYGAAGVSLSEDARRDLAMITE
LGMDKLPLCMAKTPLSISHDPSLKGAPSGFELPVVGLRLSAGAGFITVLTGKVMTMPGLGLLPGYLNIDINDKGEIIGLG

Specific function: Unknown

COG id: COG2759

COG function: function code F; Formyltetrahydrofolate synthetase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the formate--tetrahydrofolate ligase family

Homologues:

Organism=Homo sapiens, GI222136639, Length=616, Percent_Identity=45.2922077922078, Blast_Score=475, Evalue=1e-134,
Organism=Homo sapiens, GI36796743, Length=614, Percent_Identity=44.6254071661238, Blast_Score=445, Evalue=1e-125,
Organism=Homo sapiens, GI310124614, Length=81, Percent_Identity=45.679012345679, Blast_Score=72, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17568737, Length=618, Percent_Identity=45.9546925566343, Blast_Score=471, Evalue=1e-133,
Organism=Caenorhabditis elegans, GI17568739, Length=618, Percent_Identity=45.9546925566343, Blast_Score=471, Evalue=1e-133,
Organism=Saccharomyces cerevisiae, GI6321643, Length=624, Percent_Identity=43.75, Blast_Score=464, Evalue=1e-131,
Organism=Saccharomyces cerevisiae, GI6319558, Length=629, Percent_Identity=42.2893481717011, Blast_Score=447, Evalue=1e-126,
Organism=Drosophila melanogaster, GI24645718, Length=618, Percent_Identity=43.042071197411, Blast_Score=418, Evalue=1e-117,
Organism=Drosophila melanogaster, GI17137370, Length=618, Percent_Identity=43.042071197411, Blast_Score=418, Evalue=1e-117,
Organism=Drosophila melanogaster, GI62472483, Length=618, Percent_Identity=43.042071197411, Blast_Score=417, Evalue=1e-117,
Organism=Drosophila melanogaster, GI45551871, Length=618, Percent_Identity=43.042071197411, Blast_Score=417, Evalue=1e-117,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FTHS_SHEAM (A1SAE2)

Other databases:

- EMBL:   CP000507
- RefSeq:   YP_929018.1
- STRING:   A1SAE2
- GeneID:   4605393
- GenomeReviews:   CP000507_GR
- KEGG:   saz:Sama_3146
- NMPDR:   fig|326297.7.peg.2959
- eggNOG:   COG2759
- HOGENOM:   HBG677721
- OMA:   EIMAVLC
- PhylomeDB:   A1SAE2
- ProtClustDB:   PRK13506
- HAMAP:   MF_01543
- InterPro:   IPR000559
- InterPro:   IPR020628

Pfam domain/function: PF01268 FTHFS

EC number: =6.3.4.3

Molecular weight: Translated: 59202; Mature: 59202

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: PS00721 FTHFS_1; PS00722 FTHFS_2; PS00584 PFKB_KINASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTDMEISRQANVRPIGWIADDFGLGKHLWREAGHAMAKISLEAARAPLRGKLVIVTAVT
CCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHCHHHEEEEHHHHCCCCCCCEEEEEEEC
PTPHGEGKTVTTIGLTQGLHLLGHKACACIRQPSLGPVFGVKGGAAGGGYAQVVPMEVMN
CCCCCCCCEEEEEEHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCEEEEEEEHEE
LHMTGDIHAVTSAHNLAAAAIDARLFHETRLGCESFSAKTGLPALNIDPERILWRRVVDH
EEECCCEEEECCHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCHHHHHHHHHHCC
NDRSLRQIELGLGDNNGPVHGGGFDITAASELMAILALCENIADMRARIGRVILAMSRDG
CCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCC
KPISADDLGVAGAMTAIMRDAIEPTLMQTLSGAPCLVHAGPFANIAHGNSSIIADRVALA
CCCCCCCCCHHHHHHHHHHHHCCHHHHHHCCCCCEEEECCCCCEECCCCCCHHHHHHHHH
HHDYVVTEGGFGSDMGFEKFCNIKSRASGIAPSAAVLVVTLRALKANSGVEGDDRARLEA
CCCEEEECCCCCCCCCHHHHHCHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHH
GFANLHWHMQNVMGYGLPLVVAINRFPDDAMAELDWLKERCLEEGAFGCEISDAFSHGAE
CHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCEEHHHHHCCCC
GARALATAVARACDAPVNFEYLYDDEMDFGARLMTLAERYGAAGVSLSEDARRDLAMITE
HHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
LGMDKLPLCMAKTPLSISHDPSLKGAPSGFELPVVGLRLSAGAGFITVLTGKVMTMPGLG
CCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCEEEEEECCEEECCCCC
LLPGYLNIDINDKGEIIGLG
CCCCEEEEEECCCCCEEECC
>Mature Secondary Structure
MLTDMEISRQANVRPIGWIADDFGLGKHLWREAGHAMAKISLEAARAPLRGKLVIVTAVT
CCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHCHHHEEEEHHHHCCCCCCCEEEEEEEC
PTPHGEGKTVTTIGLTQGLHLLGHKACACIRQPSLGPVFGVKGGAAGGGYAQVVPMEVMN
CCCCCCCCEEEEEEHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCEEEEEEEHEE
LHMTGDIHAVTSAHNLAAAAIDARLFHETRLGCESFSAKTGLPALNIDPERILWRRVVDH
EEECCCEEEECCHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCHHHHHHHHHHCC
NDRSLRQIELGLGDNNGPVHGGGFDITAASELMAILALCENIADMRARIGRVILAMSRDG
CCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCC
KPISADDLGVAGAMTAIMRDAIEPTLMQTLSGAPCLVHAGPFANIAHGNSSIIADRVALA
CCCCCCCCCHHHHHHHHHHHHCCHHHHHHCCCCCEEEECCCCCEECCCCCCHHHHHHHHH
HHDYVVTEGGFGSDMGFEKFCNIKSRASGIAPSAAVLVVTLRALKANSGVEGDDRARLEA
CCCEEEECCCCCCCCCHHHHHCHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHH
GFANLHWHMQNVMGYGLPLVVAINRFPDDAMAELDWLKERCLEEGAFGCEISDAFSHGAE
CHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCEEHHHHHCCCC
GARALATAVARACDAPVNFEYLYDDEMDFGARLMTLAERYGAAGVSLSEDARRDLAMITE
HHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
LGMDKLPLCMAKTPLSISHDPSLKGAPSGFELPVVGLRLSAGAGFITVLTGKVMTMPGLG
CCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCEEEEEECCEEECCCCC
LLPGYLNIDINDKGEIIGLG
CCCCEEEEEECCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA