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The map label for this gene is sufS [H]

Identifier: 119775909

GI number: 119775909

Start: 3319713

End: 3320942

Strand: Direct

Name: sufS [H]

Synonym: Sama_2777

Alternate gene names: 119775909

Gene position: 3319713-3320942 (Clockwise)

Preceding gene: 119775908

Following gene: 119775910

Centisome position: 77.09

GC content: 60.0

Gene sequence:

>1230_bases
ATGAACATTTCCAGCCTTCGTAACCAGTTCCCTGCACTTGACCAACACATTGGCGACTATCCGCTGGTGTATCTGGACAC
AGCCGCCACCAGTCAAAAGCCCCGGCAGGTTCTGGATGCCATGGCGCACTTTCTGACCACAGACAACGCCAACGTGCACC
GCGCCGCCCATACCCTGTCGGGCCGCGCCACCGCAAGTTACGAAGCCGTGCGGGATAAACTCAAAGCCTTTGTCCATGCC
GGCCGCCGGGAAGAAATTATCTTCACCCACGGCACCACAGAGGCCATCAATCTGGTGGCCAATGGGCTTAAACACCGCCT
TAATTCCGGCGATGTCATCCTGGTAGACAGCGCCGCCCACCATGCCAATCTGGTGCCCTGGCAGCAGCTTGCCGCGCAAA
CCGGTGCCAGGGTGGAAGCCATTCCCCTGACGGCAGAACTGCGTTTGGATACCGCCGCCTTCGAAGCACAGCTCGAAGCA
GGCGCCGCCCTGGTGGCGCTCGGTCATGTATCCAACGTGCTGGGCACAGTGAATGACGTCAACACACTCTGCGCCATGGC
CCGCGCCAAAGGTGCCCTCACGCTGGTGGACGGTGCTCAGGCCGTGGCCCACCAGCGGGTGGATGTGACCGATATCGGCT
GCGACTTTTATGTGTTCTCCGGCCACAAGATGTATGGGCCCGATGGCGTGGGTGTGCTCTATGGCCGCTATGAGGTGCTC
GATACCCTTACGCCGCTTCTCACAGGTGGCGAGATGATAAAGACGGTAAGCTTTACCGGCACCGAATTTGGCGAGCTGCC
AAACCGGCTTGAGGCCGGCACGCCGCCTATCGTCTCTGTCATCGGGCTTGGGGCCGCCATCGACTTTATCAATAGCCTCG
ACAGGCAAGCAGTACTGGCCCACGAGCATGACCTTATGGCCCGGCTGCGTGCCGGGCTTGAGGCGGTGTTGCAAATCCGC
ATTCACAGCCCGCGCGATGCTGCGGGGGCTGCCCCCAACAGCGGCGCCATCGCCTTCAACCTGGGGGATGAACATCATCA
GGATGTAGGTATCTTGTTGGATCAACAGGGAATTGCAGTTCGCTGCGGCCATCATTGCGCCATGCCGCTGATGAGTCTGA
TGGGCGTAAAAGGCTGCTGCCGTGCTTCCATCGGCCTTTACACCAGCCCGGATGATATCGACCGTTTTCTCGCCGCCGTC
AAAGAAGCGGCCGAACTCTTATGCCCATGA

Upstream 100 bases:

>100_bases
GTCAATTCCTGTTTCAATCCCGGCGCGGCCTTGCAATGGCCGCGCAAATCCTTAAAGATCGACTCAATCCCTTTTCGGCT
ATTGCTTTGACAGCGTTTTA

Downstream 100 bases:

>100_bases
TCTGCTGCGAGGAAACCATGGAACTACGTCCCACCCCCACCGACTTTTTAAGCCGCCATCACAGCAGCAGTGCCCCGCTC
GCGCAGCTGGTTAATCAGGT

Product: aminotransferase, class V

Products: NA

Alternate protein names: Selenocysteine beta-lyase; SCL; Selenocysteine lyase; Selenocysteine reductase [H]

Number of amino acids: Translated: 409; Mature: 409

Protein sequence:

>409_residues
MNISSLRNQFPALDQHIGDYPLVYLDTAATSQKPRQVLDAMAHFLTTDNANVHRAAHTLSGRATASYEAVRDKLKAFVHA
GRREEIIFTHGTTEAINLVANGLKHRLNSGDVILVDSAAHHANLVPWQQLAAQTGARVEAIPLTAELRLDTAAFEAQLEA
GAALVALGHVSNVLGTVNDVNTLCAMARAKGALTLVDGAQAVAHQRVDVTDIGCDFYVFSGHKMYGPDGVGVLYGRYEVL
DTLTPLLTGGEMIKTVSFTGTEFGELPNRLEAGTPPIVSVIGLGAAIDFINSLDRQAVLAHEHDLMARLRAGLEAVLQIR
IHSPRDAAGAAPNSGAIAFNLGDEHHQDVGILLDQQGIAVRCGHHCAMPLMSLMGVKGCCRASIGLYTSPDDIDRFLAAV
KEAAELLCP

Sequences:

>Translated_409_residues
MNISSLRNQFPALDQHIGDYPLVYLDTAATSQKPRQVLDAMAHFLTTDNANVHRAAHTLSGRATASYEAVRDKLKAFVHA
GRREEIIFTHGTTEAINLVANGLKHRLNSGDVILVDSAAHHANLVPWQQLAAQTGARVEAIPLTAELRLDTAAFEAQLEA
GAALVALGHVSNVLGTVNDVNTLCAMARAKGALTLVDGAQAVAHQRVDVTDIGCDFYVFSGHKMYGPDGVGVLYGRYEVL
DTLTPLLTGGEMIKTVSFTGTEFGELPNRLEAGTPPIVSVIGLGAAIDFINSLDRQAVLAHEHDLMARLRAGLEAVLQIR
IHSPRDAAGAAPNSGAIAFNLGDEHHQDVGILLDQQGIAVRCGHHCAMPLMSLMGVKGCCRASIGLYTSPDDIDRFLAAV
KEAAELLCP
>Mature_409_residues
MNISSLRNQFPALDQHIGDYPLVYLDTAATSQKPRQVLDAMAHFLTTDNANVHRAAHTLSGRATASYEAVRDKLKAFVHA
GRREEIIFTHGTTEAINLVANGLKHRLNSGDVILVDSAAHHANLVPWQQLAAQTGARVEAIPLTAELRLDTAAFEAQLEA
GAALVALGHVSNVLGTVNDVNTLCAMARAKGALTLVDGAQAVAHQRVDVTDIGCDFYVFSGHKMYGPDGVGVLYGRYEVL
DTLTPLLTGGEMIKTVSFTGTEFGELPNRLEAGTPPIVSVIGLGAAIDFINSLDRQAVLAHEHDLMARLRAGLEAVLQIR
IHSPRDAAGAAPNSGAIAFNLGDEHHQDVGILLDQQGIAVRCGHHCAMPLMSLMGVKGCCRASIGLYTSPDDIDRFLAAV
KEAAELLCP

Specific function: Cysteine desulfurases mobilize the sulfur from L- cysteine to yield L-alanine, an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Component of the suf operon, which is activated and required under speci

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=291, Percent_Identity=28.1786941580756, Blast_Score=112, Evalue=7e-25,
Organism=Homo sapiens, GI156713448, Length=428, Percent_Identity=24.5327102803738, Blast_Score=79, Evalue=7e-15,
Organism=Escherichia coli, GI1787970, Length=409, Percent_Identity=43.7652811735941, Blast_Score=348, Evalue=4e-97,
Organism=Escherichia coli, GI1789175, Length=408, Percent_Identity=40.6862745098039, Blast_Score=293, Evalue=1e-80,
Organism=Escherichia coli, GI48994898, Length=395, Percent_Identity=26.3291139240506, Blast_Score=123, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI25143064, Length=265, Percent_Identity=29.0566037735849, Blast_Score=108, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI193211090, Length=426, Percent_Identity=22.7699530516432, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6319831, Length=398, Percent_Identity=24.3718592964824, Blast_Score=105, Evalue=1e-23,
Organism=Drosophila melanogaster, GI20129463, Length=400, Percent_Identity=26, Blast_Score=119, Evalue=4e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010970
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7; =4.4.1.16 [H]

Molecular weight: Translated: 43561; Mature: 43561

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNISSLRNQFPALDQHIGDYPLVYLDTAATSQKPRQVLDAMAHFLTTDNANVHRAAHTLS
CCHHHHHHHCCCHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHC
GRATASYEAVRDKLKAFVHAGRREEIIFTHGTTEAINLVANGLKHRLNSGDVILVDSAAH
CCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCCEEEEECCCC
HANLVPWQQLAAQTGARVEAIPLTAELRLDTAAFEAQLEAGAALVALGHVSNVLGTVNDV
CCCCCCHHHHHHHCCCCEEEEEEEEEEEECHHHHHHHHHCCHHEEEHHHHHHHHHHHHHH
NTLCAMARAKGALTLVDGAQAVAHQRVDVTDIGCDFYVFSGHKMYGPDGVGVLYGRYEVL
HHHHHHHHCCCCEEEECCHHHHHHCCCCEEECCCEEEEEECCEEECCCCCEEEEHHHHHH
DTLTPLLTGGEMIKTVSFTGTEFGELPNRLEAGTPPIVSVIGLGAAIDFINSLDRQAVLA
HHHHHHHCCCHHEEEEEECCCHHHHCCCHHCCCCCHHHHHHHHHHHHHHHHHHCHHHHHH
HEHDLMARLRAGLEAVLQIRIHSPRDAAGAAPNSGAIAFNLGDEHHQDVGILLDQQGIAV
HHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCCCEEEEECCCCCCCCCEEEEECCCCEE
RCGHHCAMPLMSLMGVKGCCRASIGLYTSPDDIDRFLAAVKEAAELLCP
ECCCHHHHHHHHHHCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNISSLRNQFPALDQHIGDYPLVYLDTAATSQKPRQVLDAMAHFLTTDNANVHRAAHTLS
CCHHHHHHHCCCHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHC
GRATASYEAVRDKLKAFVHAGRREEIIFTHGTTEAINLVANGLKHRLNSGDVILVDSAAH
CCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCCEEEEECCCC
HANLVPWQQLAAQTGARVEAIPLTAELRLDTAAFEAQLEAGAALVALGHVSNVLGTVNDV
CCCCCCHHHHHHHCCCCEEEEEEEEEEEECHHHHHHHHHCCHHEEEHHHHHHHHHHHHHH
NTLCAMARAKGALTLVDGAQAVAHQRVDVTDIGCDFYVFSGHKMYGPDGVGVLYGRYEVL
HHHHHHHHCCCCEEEECCHHHHHHCCCCEEECCCEEEEEECCEEECCCCCEEEEHHHHHH
DTLTPLLTGGEMIKTVSFTGTEFGELPNRLEAGTPPIVSVIGLGAAIDFINSLDRQAVLA
HHHHHHHCCCHHEEEEEECCCHHHHCCCHHCCCCCHHHHHHHHHHHHHHHHHHCHHHHHH
HEHDLMARLRAGLEAVLQIRIHSPRDAAGAAPNSGAIAFNLGDEHHQDVGILLDQQGIAV
HHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCCCEEEEECCCCCCCCCEEEEECCCCEE
RCGHHCAMPLMSLMGVKGCCRASIGLYTSPDDIDRFLAAVKEAAELLCP
ECCCHHHHHHHHHHCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA