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The map label for this gene is rot [H]

Identifier: 119775833

GI number: 119775833

Start: 3232313

End: 3232876

Strand: Direct

Name: rot [H]

Synonym: Sama_2701

Alternate gene names: 119775833

Gene position: 3232313-3232876 (Clockwise)

Preceding gene: 119775832

Following gene: 119775836

Centisome position: 75.06

GC content: 51.77

Gene sequence:

>564_bases
ATGCAACTCGCCCACCAGCACCATTCATTTCGGCTGTTACTGCCCTTAATGACACTTTGTCTCGCCCTGATTGGCACAGG
GGTGAAGGCAGAAAATCTTGTCACCATAGAAACCAGTCTGGGTGACATGACCTTTGAGTTTTTCCCCAATGAAGCGCCAA
GGACAGTCGCCAACTTTCAACGACTCGCTCAAAGCGGTTGGTACGAAGGCAAGTCCTTTTATCGGGTCGTCAAGGGGCAT
GTTATTCAGGCAGGCAGCCTGGATGAAAACACAGAGCCCAGGGTGGAAGCCGAGTTCAACCAGCATCCCCACATCAAAGG
CACCCTGGGGCTTGCCCGGGACGAAGACCCCAACTCAGGCTCCACGGAATTTTACATCTGCCATGAAGCGAGGCCACACC
TGGATGGCCGCTATACCGTGTTTGGCCAACTGGTTGAGGGCGAAGCCGTACTCGATGCCATCGCCAATCAGGAAGTGATT
GAAAAATATTATGATGAAGACAAAAAAATCGCCTTCCACGAGCCCAAAACGCCTGTGTTAATCAAGGCCATACGTCTGCA
TTAA

Upstream 100 bases:

>100_bases
AGATTAGCAGGGGAAGGCCGAAGCACTGCCGGGATTAGTGTTTGAATTTCTCACCAATCTCTGTAGCTTAGAACGCACTG
TTCCCCAACTGGCCCCAGCT

Downstream 100 bases:

>100_bases
CCCAGATAAGTTCGCTCCTGATGTAAGACATGGCACCAGGCTCGCCCGATTGTGCAACGTTAGTCAAAGCCTCGCCGAAG
AGGCCTGAGGTATAACAGAC

Product: peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 187; Mature: 187

Protein sequence:

>187_residues
MQLAHQHHSFRLLLPLMTLCLALIGTGVKAENLVTIETSLGDMTFEFFPNEAPRTVANFQRLAQSGWYEGKSFYRVVKGH
VIQAGSLDENTEPRVEAEFNQHPHIKGTLGLARDEDPNSGSTEFYICHEARPHLDGRYTVFGQLVEGEAVLDAIANQEVI
EKYYDEDKKIAFHEPKTPVLIKAIRLH

Sequences:

>Translated_187_residues
MQLAHQHHSFRLLLPLMTLCLALIGTGVKAENLVTIETSLGDMTFEFFPNEAPRTVANFQRLAQSGWYEGKSFYRVVKGH
VIQAGSLDENTEPRVEAEFNQHPHIKGTLGLARDEDPNSGSTEFYICHEARPHLDGRYTVFGQLVEGEAVLDAIANQEVI
EKYYDEDKKIAFHEPKTPVLIKAIRLH
>Mature_187_residues
MQLAHQHHSFRLLLPLMTLCLALIGTGVKAENLVTIETSLGDMTFEFFPNEAPRTVANFQRLAQSGWYEGKSFYRVVKGH
VIQAGSLDENTEPRVEAEFNQHPHIKGTLGLARDEDPNSGSTEFYICHEARPHLDGRYTVFGQLVEGEAVLDAIANQEVI
EKYYDEDKKIAFHEPKTPVLIKAIRLH

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI19557636, Length=163, Percent_Identity=31.2883435582822, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI24308049, Length=140, Percent_Identity=32.1428571428571, Blast_Score=74, Evalue=9e-14,
Organism=Homo sapiens, GI7706339, Length=137, Percent_Identity=30.6569343065693, Blast_Score=71, Evalue=5e-13,
Organism=Homo sapiens, GI22547215, Length=142, Percent_Identity=30.9859154929577, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI22547212, Length=142, Percent_Identity=30.9859154929577, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI7657473, Length=142, Percent_Identity=30.9859154929577, Blast_Score=66, Evalue=2e-11,
Organism=Escherichia coli, GI1789763, Length=162, Percent_Identity=30.8641975308642, Blast_Score=72, Evalue=2e-14,
Organism=Escherichia coli, GI1786736, Length=168, Percent_Identity=28.5714285714286, Blast_Score=69, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71980590, Length=140, Percent_Identity=30, Blast_Score=70, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI71980594, Length=140, Percent_Identity=30, Blast_Score=70, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17539496, Length=129, Percent_Identity=31.0077519379845, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17506311, Length=138, Percent_Identity=30.4347826086957, Blast_Score=67, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6323562, Length=129, Percent_Identity=30.2325581395349, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24652460, Length=148, Percent_Identity=32.4324324324324, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI19922376, Length=146, Percent_Identity=30.1369863013699, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI19922912, Length=155, Percent_Identity=32.258064516129, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI17986117, Length=138, Percent_Identity=31.1594202898551, Blast_Score=67, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 21129; Mature: 21129

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLAHQHHSFRLLLPLMTLCLALIGTGVKAENLVTIETSLGDMTFEFFPNEAPRTVANFQ
CCCCCCCCCEEHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCEEEEECCCCCCHHHHHHH
RLAQSGWYEGKSFYRVVKGHVIQAGSLDENTEPRVEAEFNQHPHIKGTLGLARDEDPNSG
HHHHCCCCCCHHHHHHHHCCEEECCCCCCCCCCCEEECCCCCCCCEEEECCCCCCCCCCC
STEFYICHEARPHLDGRYTVFGQLVEGEAVLDAIANQEVIEKYYDEDKKIAFHEPKTPVL
CEEEEEEECCCCCCCCCEEEEEEECCCHHHHHHHCCHHHHHHHHCCCCEEEEECCCCCEE
IKAIRLH
EEEEECC
>Mature Secondary Structure
MQLAHQHHSFRLLLPLMTLCLALIGTGVKAENLVTIETSLGDMTFEFFPNEAPRTVANFQ
CCCCCCCCCEEHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCEEEEECCCCCCHHHHHHH
RLAQSGWYEGKSFYRVVKGHVIQAGSLDENTEPRVEAEFNQHPHIKGTLGLARDEDPNSG
HHHHCCCCCCHHHHHHHHCCEEECCCCCCCCCCCEEECCCCCCCCEEEECCCCCCCCCCC
STEFYICHEARPHLDGRYTVFGQLVEGEAVLDAIANQEVIEKYYDEDKKIAFHEPKTPVL
CEEEEEEECCCCCCCCCEEEEEEECCCHHHHHHHCCHHHHHHHHCCCCEEEEECCCCCEE
IKAIRLH
EEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA