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The map label for this gene is fkpA [H]

Identifier: 119775827

GI number: 119775827

Start: 3222217

End: 3222984

Strand: Direct

Name: fkpA [H]

Synonym: Sama_2695

Alternate gene names: 119775827

Gene position: 3222217-3222984 (Clockwise)

Preceding gene: 119775826

Following gene: 119775828

Centisome position: 74.83

GC content: 52.47

Gene sequence:

>768_bases
GTGAGCCACTATACACATCAAAAGTTCGTCCTTCCGCTACTGACTGCGACGTTACTCATGGGTTGCGAACCCACAGTTCA
ATCCCCTCCCCCCGCACAAAATGCCATCACAGCCAATGCCGAAACAGCGCAATCGGCAACGGTCGAAAAGTCCTATGCTG
TGGGATCCCAATTCGGCAACTTTGCCCGGGAGTACCTTAAAGCACAGGCTGAGATCAATGAGCCGCTCGATGAAGCCATT
ATCATCGCGGCCTTTGGCGATGCACTGCGTGATAAGGCCAGCATGGATCACGAGGTTGCAGGGAAGCTAGTCAGTGAAAT
GCGTCTGGCGACCCAAAAACGACGCGCCGAGCAATTCAAGGCACAGCAGCTGGCAAGTAACAGTTCTTTTTTGGTGGAAA
ACGGCAAAAAACCTGGGGTGACCACCACAGAATCAGGATTGCAATACGAGGTACTGACCCTGGGAACAGGCCCAAAGCCG
GGCCCAAAAGATATAGTAAGCGTGCATTACGAGGGACAGCTTATCGATGGCAAGGTGTTCGACAGTTCTTTTAAACGCAA
CGCTCCAGCCACTTTTTCACTCGACCAGGTCATCAAAGGCTGGACCGAAGGGCTGCAGTTAATGCCTGTGGGCAGCAAGT
TCCGCCTTACCCTGCCCCATGATTTGGGATATGGCAGTCGTGGTGCTTTGGGCGGAGAAATCCCACCCTTTGCTACCCTG
GAATTCGTCATTGAGCTGTTGGATATCCAAACCCCTACGGACAAATAA

Upstream 100 bases:

>100_bases
GCTCATAATCGCTTGTACAAAGGCGCACAATTTATGCGTTGAGTCTGTAAATCCGTAACCGTTAGTATGAGTTCTTTTAC
AAAGATGTTACGGAGTCCAG

Downstream 100 bases:

>100_bases
CCCAGAAATCATGTACCCGACCATGCCGCAGCAGAGACTTCTGACCAGCGGTTTTGACCCGACTCTTTTGTCGGGTCGAC
ATCATAGTATCCCGCTTCCA

Product: periplasmic peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 255; Mature: 254

Protein sequence:

>255_residues
MSHYTHQKFVLPLLTATLLMGCEPTVQSPPPAQNAITANAETAQSATVEKSYAVGSQFGNFAREYLKAQAEINEPLDEAI
IIAAFGDALRDKASMDHEVAGKLVSEMRLATQKRRAEQFKAQQLASNSSFLVENGKKPGVTTTESGLQYEVLTLGTGPKP
GPKDIVSVHYEGQLIDGKVFDSSFKRNAPATFSLDQVIKGWTEGLQLMPVGSKFRLTLPHDLGYGSRGALGGEIPPFATL
EFVIELLDIQTPTDK

Sequences:

>Translated_255_residues
MSHYTHQKFVLPLLTATLLMGCEPTVQSPPPAQNAITANAETAQSATVEKSYAVGSQFGNFAREYLKAQAEINEPLDEAI
IIAAFGDALRDKASMDHEVAGKLVSEMRLATQKRRAEQFKAQQLASNSSFLVENGKKPGVTTTESGLQYEVLTLGTGPKP
GPKDIVSVHYEGQLIDGKVFDSSFKRNAPATFSLDQVIKGWTEGLQLMPVGSKFRLTLPHDLGYGSRGALGGEIPPFATL
EFVIELLDIQTPTDK
>Mature_254_residues
SHYTHQKFVLPLLTATLLMGCEPTVQSPPPAQNAITANAETAQSATVEKSYAVGSQFGNFAREYLKAQAEINEPLDEAII
IAAFGDALRDKASMDHEVAGKLVSEMRLATQKRRAEQFKAQQLASNSSFLVENGKKPGVTTTESGLQYEVLTLGTGPKPG
PKDIVSVHYEGQLIDGKVFDSSFKRNAPATFSLDQVIKGWTEGLQLMPVGSKFRLTLPHDLGYGSRGALGGEIPPFATLE
FVIELLDIQTPTDK

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. FkpA probably acts in the folding of extracytoplasmic proteins [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI206725530, Length=93, Percent_Identity=50.5376344086022, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI17149844, Length=93, Percent_Identity=50.5376344086022, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI17149842, Length=93, Percent_Identity=50.5376344086022, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI17149836, Length=110, Percent_Identity=46.3636363636364, Blast_Score=81, Evalue=9e-16,
Organism=Homo sapiens, GI4503725, Length=110, Percent_Identity=46.3636363636364, Blast_Score=81, Evalue=9e-16,
Organism=Homo sapiens, GI224809329, Length=103, Percent_Identity=46.6019417475728, Blast_Score=74, Evalue=9e-14,
Organism=Homo sapiens, GI224809327, Length=103, Percent_Identity=46.6019417475728, Blast_Score=74, Evalue=9e-14,
Organism=Homo sapiens, GI4758384, Length=103, Percent_Identity=46.6019417475728, Blast_Score=74, Evalue=9e-14,
Organism=Homo sapiens, GI4503727, Length=154, Percent_Identity=36.3636363636364, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI4758380, Length=110, Percent_Identity=42.7272727272727, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI224809331, Length=89, Percent_Identity=49.438202247191, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI8923659, Length=93, Percent_Identity=46.2365591397849, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI192448443, Length=119, Percent_Identity=36.1344537815126, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI33469985, Length=93, Percent_Identity=41.9354838709677, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI4503729, Length=99, Percent_Identity=41.4141414141414, Blast_Score=65, Evalue=6e-11,
Organism=Escherichia coli, GI87082390, Length=202, Percent_Identity=44.5544554455446, Blast_Score=150, Evalue=6e-38,
Organism=Escherichia coli, GI1789745, Length=203, Percent_Identity=38.9162561576355, Blast_Score=129, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17540882, Length=88, Percent_Identity=50, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71993519, Length=110, Percent_Identity=42.7272727272727, Blast_Score=71, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6320727, Length=96, Percent_Identity=47.9166666666667, Blast_Score=83, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6324194, Length=112, Percent_Identity=41.9642857142857, Blast_Score=77, Evalue=2e-15,
Organism=Drosophila melanogaster, GI281363946, Length=89, Percent_Identity=56.1797752808989, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI17352457, Length=89, Percent_Identity=56.1797752808989, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24655568, Length=97, Percent_Identity=47.4226804123711, Blast_Score=78, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24583150, Length=107, Percent_Identity=42.0560747663551, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI21356629, Length=89, Percent_Identity=51.685393258427, Blast_Score=72, Evalue=4e-13,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179
- InterPro:   IPR000774 [H]

Pfam domain/function: PF00254 FKBP_C; PF01346 FKBP_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 27610; Mature: 27478

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHYTHQKFVLPLLTATLLMGCEPTVQSPPPAQNAITANAETAQSATVEKSYAVGSQFGN
CCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHH
FAREYLKAQAEINEPLDEAIIIAAFGDALRDKASMDHEVAGKLVSEMRLATQKRRAEQFK
HHHHHHHHHHHHCCCHHHEEEEEHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
AQQLASNSSFLVENGKKPGVTTTESGLQYEVLTLGTGPKPGPKDIVSVHYEGQLIDGKVF
HHHHHCCCCEEEECCCCCCCCCCCCCCEEEEEEECCCCCCCCHHEEEEEECCEEECCHHH
DSSFKRNAPATFSLDQVIKGWTEGLQLMPVGSKFRLTLPHDLGYGSRGALGGEIPPFATL
HHHHHCCCCCCCCHHHHHHHHHCCEEEEECCCEEEEECCCCCCCCCCCCCCCCCCCHHHH
EFVIELLDIQTPTDK
HHHHHHHHCCCCCCC
>Mature Secondary Structure 
SHYTHQKFVLPLLTATLLMGCEPTVQSPPPAQNAITANAETAQSATVEKSYAVGSQFGN
CCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHH
FAREYLKAQAEINEPLDEAIIIAAFGDALRDKASMDHEVAGKLVSEMRLATQKRRAEQFK
HHHHHHHHHHHHCCCHHHEEEEEHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
AQQLASNSSFLVENGKKPGVTTTESGLQYEVLTLGTGPKPGPKDIVSVHYEGQLIDGKVF
HHHHHCCCCEEEECCCCCCCCCCCCCCEEEEEEECCCCCCCCHHEEEEEECCEEECCHHH
DSSFKRNAPATFSLDQVIKGWTEGLQLMPVGSKFRLTLPHDLGYGSRGALGGEIPPFATL
HHHHHCCCCCCCCHHHHHHHHHCCEEEEECCCEEEEECCCCCCCCCCCCCCCCCCCHHHH
EFVIELLDIQTPTDK
HHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9171380 [H]