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The map label for this gene is mrdA [H]

Identifier: 119775720

GI number: 119775720

Start: 3095404

End: 3097236

Strand: Direct

Name: mrdA [H]

Synonym: Sama_2588

Alternate gene names: 119775720

Gene position: 3095404-3097236 (Clockwise)

Preceding gene: 119775719

Following gene: 119775721

Centisome position: 71.88

GC content: 54.99

Gene sequence:

>1833_bases
ATGCATGACCACGCCGCTGAGGCAGCATTGTTCAAGCGACGGGCGATATTTACCTTTCTCTGCGTGGTCGCACTTTTTGG
TGTACTCCTGACCAACCTGTATCACCTACAGGTCACCTCCTACGCAGACTACACCACCCGCTCCAATGACAACCGGATCC
GGGTAACACCGGTTGCCCCAAGCCGCGGCCTGATTTATGACCGCAATGGTGTGCTGCTTGCCGAAAACCAGCCGGTGTAT
TCTCTTGAGCTCATTCCCGAGAAGGTTAAAAACATCCCCCAGACGCTGACTCAACTCTCGACTGTGATACCGCTGAGTGA
AGAAGCCCAGGCCGAATTCCTCGAAGCCCTCAAATATCACCGCCGCTTTAAACCCCTTACGCTCAGGGATAACCTGACCG
AGGAAGAAGTGGCCGCGTTCAGCGTAAATCAGCATCAGTTTCCCGGCGTACGTGTCGAGGCAGGTCTGAAACGCTTCTAT
CCCCATGGTGAGCTTTTGACACACGTGCTGGGATTTGTGGGCAAAATCAACGCCAAAGACAGGACAGCACTGGAAAAGGC
TGACCGCTGGCCTGACTATGCCGCCAGTAAGGACATAGGCAAACAAGGTGTTGAAAAGTATTACGAAAACCTGCTTCACG
GCAAACCGGGGCACCTGGAAGAAGAGGTCAATAACCGTGGCCGCACCATTCGTACCCTGAAAACCGTACCGCCGGAGCCG
GGTCAGGATCTTTACCTGACGCTGGACATCAATCTGCAGAAAAAGGCCATGGAACTGCTGTCTGGGCGTCGTGGCACCAT
AGTAGCAATCGATCCCCGTGACGGTGGCATTATGGCGATGGTGTCGAGTCCGTCCTACGATCCCAACCTCTTTGTGCAAG
GGATCAGCTCCAAAGATTACAGCGCCCTGCTCAACGACAAGGCAAGGCCGCTGATTAACCGCGCAACTCAGGGGCTGTAC
GCCCCCGCCTCAACCATCAAACCCCATATGGCACTGATGGGACTTGAGGAGCAGGTCGTCACAGAGCGCACCCGCATCTG
GGATCCCGGGTACTGGCAAATGCCCGGCGTCGAGCGAAAATGGCGTGACTGGAAAAAATGGGGCCATGGCTACGTGGATG
TTTACCATGCCATTGTCGAGTCCTGCGATATCTTCTTTTACGACATGGTGCACAAGATGGGCATAGATAAGATTGCCGCC
TTTATGCATCAATTTGGCTTTGGTGAAAGTACCGGCGTGGATATCTTTGAAGAATCCGCCGGCATCATGCCGTCGTCCGA
TTGGAAACGTATCCGCCACAACCAGCCCTGGTATCCGGGTGATACCATTTCGGTGGGGATTGGCCAGGGCTACTGGACAG
CAACACCTATTCAACTGGCCAATGCCACGGCAATCCTGGCCAATCGTGGCAAGCGCTTTGTGCCACACCTGCTCAAGGCG
ATGAAAGACAACAGTGCCAAAATCGAGCGGCCGCCCGAAGAGATGCCCCCGGTGGCACTGAAGAATCCCCGCAACTGGGA
AATCATCAACGAAGCCATGCGGCAAACGGCCCATAAGTCGCGCTTTACCGATGCCACTTATACCGCCGCCATGAAAACAG
GTACCGCTCAGGTGTTTTCGGTGGCACAGGATGCCAAATACGACCACGACAAGGTGGCAGAGCACCTGAGAGACAACGCC
CTGATTGTGGCTTACGCCCCCTTTGAATCCCCCAAGATAGTATTGGCTGTGGTATTGGAGAACGCTGGTTGGGGCGGCGC
CAATGCCGGTCCTGTGGCACGCGCCATGCTGGATGAATTTATGCTCCATGAGCAGTGGAAGGTGCAACCATGA

Upstream 100 bases:

>100_bases
AGCATTAACAACAACCATCCTTATCACAGGGAATAGTGTGCCCTTGTCAGGCCGCTGATTGCACCGGAGACGTTGAGTGA
CACCAAGAAAACGGGTAGCC

Downstream 100 bases:

>100_bases
CAAGGGATCATGCCCGTAAGAATATCTGGCAACGGATGCACATCGACTTACCGCTTTTGCTCGGACTGCTGGCCATCATG
GGGTTTGGGCTGTTTGTTAT

Product: peptidoglycan glycosyltransferase

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 610; Mature: 610

Protein sequence:

>610_residues
MHDHAAEAALFKRRAIFTFLCVVALFGVLLTNLYHLQVTSYADYTTRSNDNRIRVTPVAPSRGLIYDRNGVLLAENQPVY
SLELIPEKVKNIPQTLTQLSTVIPLSEEAQAEFLEALKYHRRFKPLTLRDNLTEEEVAAFSVNQHQFPGVRVEAGLKRFY
PHGELLTHVLGFVGKINAKDRTALEKADRWPDYAASKDIGKQGVEKYYENLLHGKPGHLEEEVNNRGRTIRTLKTVPPEP
GQDLYLTLDINLQKKAMELLSGRRGTIVAIDPRDGGIMAMVSSPSYDPNLFVQGISSKDYSALLNDKARPLINRATQGLY
APASTIKPHMALMGLEEQVVTERTRIWDPGYWQMPGVERKWRDWKKWGHGYVDVYHAIVESCDIFFYDMVHKMGIDKIAA
FMHQFGFGESTGVDIFEESAGIMPSSDWKRIRHNQPWYPGDTISVGIGQGYWTATPIQLANATAILANRGKRFVPHLLKA
MKDNSAKIERPPEEMPPVALKNPRNWEIINEAMRQTAHKSRFTDATYTAAMKTGTAQVFSVAQDAKYDHDKVAEHLRDNA
LIVAYAPFESPKIVLAVVLENAGWGGANAGPVARAMLDEFMLHEQWKVQP

Sequences:

>Translated_610_residues
MHDHAAEAALFKRRAIFTFLCVVALFGVLLTNLYHLQVTSYADYTTRSNDNRIRVTPVAPSRGLIYDRNGVLLAENQPVY
SLELIPEKVKNIPQTLTQLSTVIPLSEEAQAEFLEALKYHRRFKPLTLRDNLTEEEVAAFSVNQHQFPGVRVEAGLKRFY
PHGELLTHVLGFVGKINAKDRTALEKADRWPDYAASKDIGKQGVEKYYENLLHGKPGHLEEEVNNRGRTIRTLKTVPPEP
GQDLYLTLDINLQKKAMELLSGRRGTIVAIDPRDGGIMAMVSSPSYDPNLFVQGISSKDYSALLNDKARPLINRATQGLY
APASTIKPHMALMGLEEQVVTERTRIWDPGYWQMPGVERKWRDWKKWGHGYVDVYHAIVESCDIFFYDMVHKMGIDKIAA
FMHQFGFGESTGVDIFEESAGIMPSSDWKRIRHNQPWYPGDTISVGIGQGYWTATPIQLANATAILANRGKRFVPHLLKA
MKDNSAKIERPPEEMPPVALKNPRNWEIINEAMRQTAHKSRFTDATYTAAMKTGTAQVFSVAQDAKYDHDKVAEHLRDNA
LIVAYAPFESPKIVLAVVLENAGWGGANAGPVARAMLDEFMLHEQWKVQP
>Mature_610_residues
MHDHAAEAALFKRRAIFTFLCVVALFGVLLTNLYHLQVTSYADYTTRSNDNRIRVTPVAPSRGLIYDRNGVLLAENQPVY
SLELIPEKVKNIPQTLTQLSTVIPLSEEAQAEFLEALKYHRRFKPLTLRDNLTEEEVAAFSVNQHQFPGVRVEAGLKRFY
PHGELLTHVLGFVGKINAKDRTALEKADRWPDYAASKDIGKQGVEKYYENLLHGKPGHLEEEVNNRGRTIRTLKTVPPEP
GQDLYLTLDINLQKKAMELLSGRRGTIVAIDPRDGGIMAMVSSPSYDPNLFVQGISSKDYSALLNDKARPLINRATQGLY
APASTIKPHMALMGLEEQVVTERTRIWDPGYWQMPGVERKWRDWKKWGHGYVDVYHAIVESCDIFFYDMVHKMGIDKIAA
FMHQFGFGESTGVDIFEESAGIMPSSDWKRIRHNQPWYPGDTISVGIGQGYWTATPIQLANATAILANRGKRFVPHLLKA
MKDNSAKIERPPEEMPPVALKNPRNWEIINEAMRQTAHKSRFTDATYTAAMKTGTAQVFSVAQDAKYDHDKVAEHLRDNA
LIVAYAPFESPKIVLAVVLENAGWGGANAGPVARAMLDEFMLHEQWKVQP

Specific function: Cell wall formation; PBP-2 is responsible for the determination of the rod shape of the cell. Its synthesize cross- linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=612, Percent_Identity=50.1633986928105, Blast_Score=644, Evalue=0.0,
Organism=Escherichia coli, GI1786272, Length=614, Percent_Identity=24.5928338762215, Blast_Score=122, Evalue=9e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460
- InterPro:   IPR017790 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 68760; Mature: 68760

Theoretical pI: Translated: 8.22; Mature: 8.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHDHAAEAALFKRRAIFTFLCVVALFGVLLTNLYHLQVTSYADYTTRSNDNRIRVTPVAP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCCCCCCEEEEEECCC
SRGLIYDRNGVLLAENQPVYSLELIPEKVKNIPQTLTQLSTVIPLSEEAQAEFLEALKYH
CCCEEECCCCEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
RRFKPLTLRDNLTEEEVAAFSVNQHQFPGVRVEAGLKRFYPHGELLTHVLGFVGKINAKD
HHCCCEEECCCCCHHHHHHEECCCCCCCCEEHHHHHHHHCCCHHHHHHHHHHHHCCCCCH
RTALEKADRWPDYAASKDIGKQGVEKYYENLLHGKPGHLEEEVNNRGRTIRTLKTVPPEP
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCEEEEEECCCCCC
GQDLYLTLDINLQKKAMELLSGRRGTIVAIDPRDGGIMAMVSSPSYDPNLFVQGISSKDY
CCCEEEEEECCCHHHHHHHHCCCCCCEEEECCCCCCEEEEECCCCCCCCEEEEECCCCHH
SALLNDKARPLINRATQGLYAPASTIKPHMALMGLEEQVVTERTRIWDPGYWQMPGVERK
HHHHCCCCHHHHHHHHCCCCCCHHHCCHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCHH
WRDWKKWGHGYVDVYHAIVESCDIFFYDMVHKMGIDKIAAFMHQFGFGESTGVDIFEESA
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCCHHHHCC
GIMPSSDWKRIRHNQPWYPGDTISVGIGQGYWTATPIQLANATAILANRGKRFVPHLLKA
CCCCCHHHHHHHCCCCCCCCCEEEEECCCCCEECCCHHHCCHHHHHHCCCCHHHHHHHHH
MKDNSAKIERPPEEMPPVALKNPRNWEIINEAMRQTAHKSRFTDATYTAAMKTGTAQVFS
HCCCCCCCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHH
VAQDAKYDHDKVAEHLRDNALIVAYAPFESPKIVLAVVLENAGWGGANAGPVARAMLDEF
HHHHCCCCHHHHHHHHCCCEEEEEECCCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHH
MLHEQWKVQP
HHHHHCCCCC
>Mature Secondary Structure
MHDHAAEAALFKRRAIFTFLCVVALFGVLLTNLYHLQVTSYADYTTRSNDNRIRVTPVAP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCCCCCCEEEEEECCC
SRGLIYDRNGVLLAENQPVYSLELIPEKVKNIPQTLTQLSTVIPLSEEAQAEFLEALKYH
CCCEEECCCCEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
RRFKPLTLRDNLTEEEVAAFSVNQHQFPGVRVEAGLKRFYPHGELLTHVLGFVGKINAKD
HHCCCEEECCCCCHHHHHHEECCCCCCCCEEHHHHHHHHCCCHHHHHHHHHHHHCCCCCH
RTALEKADRWPDYAASKDIGKQGVEKYYENLLHGKPGHLEEEVNNRGRTIRTLKTVPPEP
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCEEEEEECCCCCC
GQDLYLTLDINLQKKAMELLSGRRGTIVAIDPRDGGIMAMVSSPSYDPNLFVQGISSKDY
CCCEEEEEECCCHHHHHHHHCCCCCCEEEECCCCCCEEEEECCCCCCCCEEEEECCCCHH
SALLNDKARPLINRATQGLYAPASTIKPHMALMGLEEQVVTERTRIWDPGYWQMPGVERK
HHHHCCCCHHHHHHHHCCCCCCHHHCCHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCHH
WRDWKKWGHGYVDVYHAIVESCDIFFYDMVHKMGIDKIAAFMHQFGFGESTGVDIFEESA
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCCHHHHCC
GIMPSSDWKRIRHNQPWYPGDTISVGIGQGYWTATPIQLANATAILANRGKRFVPHLLKA
CCCCCHHHHHHHCCCCCCCCCEEEEECCCCCEECCCHHHCCHHHHHHCCCCHHHHHHHHH
MKDNSAKIERPPEEMPPVALKNPRNWEIINEAMRQTAHKSRFTDATYTAAMKTGTAQVFS
HCCCCCCCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHH
VAQDAKYDHDKVAEHLRDNALIVAYAPFESPKIVLAVVLENAGWGGANAGPVARAMLDEF
HHHHCCCCHHHHHHHHCCCEEEEEECCCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHH
MLHEQWKVQP
HHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]