Click here to switch to the map view.

The map label for this gene is mepA [H]

Identifier: 119775579

GI number: 119775579

Start: 2942391

End: 2943722

Strand: Reverse

Name: mepA [H]

Synonym: Sama_2445

Alternate gene names: 119775579

Gene position: 2943722-2942391 (Counterclockwise)

Preceding gene: 119775580

Following gene: 119775578

Centisome position: 68.36

GC content: 55.26

Gene sequence:

>1332_bases
ATGAACCATACCCAAGCGATGCTGGAAGCGCCTGTTTCAAGGCTCTTTTGGCGCTACACCCTGCCAACCATAGCGTCCAT
GCTGGTTACCGGTATTTATGTCACCATCGATGGCATGTTCGTCGGGCATTTTCTTGGTGAAACCGGCCTTGCGGGCATTA
TGCTGGCTTATCCGGTGGGCGCCCTGCTGTATGCCGTCGGTGCCCTGATTGGCATGGGGGCCGGCGCTTTGGTATCCATC
AAGTTGGGTGAAGGCAAAACGGCCAAGGCAAGGGAGCTCCTTGGGAATGCGTTCAGCCTTGTGCTCTTGTCGGCGCTGTT
TTTTACCCTGGTGGGTTCAGTCAGTGCCAGGCATATCCTTATCTGGCTCGGCGCCGAAGGGGAGGTGCTGGAAAGTGCCC
ATGACTACCTGTTCTGGTACTTTGCGCTTTGCATTTTCCCATTGATTTCCATGGCGTTTTCAACCCTGCTTCGCAATGAC
GGCAAACCCGCTTTTGTGACCTGGGTGCTGATTGCCGGTGGGGTGATTAATACCCTGCTGGATTACCTCTTTATCGTGGT
GTGGGACTTTGGCCTGGCCGGTGCGTCTGTGGCGACCATGCTGTCTCAGGCTGTCACTGGCCTCTTGTGTTTGCAGCATT
TCTTCAGTGGCAAAACAGCGCTGCGAATCGATTTTGAGCAGATGCGGCTTAAATTGGACAACTGCCTGAATATTTCCCGG
GTGGGGCTGCCAAGCCTGCTGATGAACCTGTATCTCTCTATCGTGCTCACGCTGCACAACACTGCGCTCTTGTGGGTGGG
AACGCCGCTGCACGTGGCTGCTTACGGGGTGGTGAGTTACACCGAAGCGTTTTTCTATCTGATTTTTGAGGGCATAGCCC
TTGGCTCTCAACCTGTCCTCAGCTTTAACGCCGGTGCCGGCCGCATGGACAGGGTTCGCCAGACCCGTAATCTGGCGATG
GCGGTGACCTTGCTGACAGCGGGGCTTGGCTTGCTGTTTATTTACGGCAGACCCGAGTGGGCCCTCTACATTTTTGCCGG
CGATAATCCGGTGTTAAGCCCGGTAGCCATTGAGGGAATGCGGCTCTATTTTTGGGGGTTACCCTTTGAGGGCCTGATTT
TGGTGGGCGCGAGCTTTTTCCAGGCCATCAACAAGCCAAGAGAAGCCTCCATTCTGACCGGCACCAAATTGCTGTTGATA
GCGGCGGTGATATACAGCTTTGCCTGGCTGTTTGGTGTCCCCGGTGTCTGGGTGTCGCTGGCCTGTGTCAGCAGCGTTCT
TACCTTGTGGATGGTGTACAGCCTGGTCAGGATAGACAGTCAGTCCATGTGA

Upstream 100 bases:

>100_bases
CACAAATCTGGGTTACGGGCACTGGCCGGGCGGGGGAGAACTGGCTACAATCGGCCTTCCTGTGTTTAAAATAAAAATCA
AAAAGTTCAAAATAAAAAAC

Downstream 100 bases:

>100_bases
AACCGCGGTAGTTGTTAATTGGTGGTGGTTGGTCGCTGGCGGAGATTGTGGTAGTTTCCAATATTGTGTTGTGGTGAAAC
AGATAAAAGGAAATTATAAC

Product: multi anti extrusion protein MatE

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 443; Mature: 443

Protein sequence:

>443_residues
MNHTQAMLEAPVSRLFWRYTLPTIASMLVTGIYVTIDGMFVGHFLGETGLAGIMLAYPVGALLYAVGALIGMGAGALVSI
KLGEGKTAKARELLGNAFSLVLLSALFFTLVGSVSARHILIWLGAEGEVLESAHDYLFWYFALCIFPLISMAFSTLLRND
GKPAFVTWVLIAGGVINTLLDYLFIVVWDFGLAGASVATMLSQAVTGLLCLQHFFSGKTALRIDFEQMRLKLDNCLNISR
VGLPSLLMNLYLSIVLTLHNTALLWVGTPLHVAAYGVVSYTEAFFYLIFEGIALGSQPVLSFNAGAGRMDRVRQTRNLAM
AVTLLTAGLGLLFIYGRPEWALYIFAGDNPVLSPVAIEGMRLYFWGLPFEGLILVGASFFQAINKPREASILTGTKLLLI
AAVIYSFAWLFGVPGVWVSLACVSSVLTLWMVYSLVRIDSQSM

Sequences:

>Translated_443_residues
MNHTQAMLEAPVSRLFWRYTLPTIASMLVTGIYVTIDGMFVGHFLGETGLAGIMLAYPVGALLYAVGALIGMGAGALVSI
KLGEGKTAKARELLGNAFSLVLLSALFFTLVGSVSARHILIWLGAEGEVLESAHDYLFWYFALCIFPLISMAFSTLLRND
GKPAFVTWVLIAGGVINTLLDYLFIVVWDFGLAGASVATMLSQAVTGLLCLQHFFSGKTALRIDFEQMRLKLDNCLNISR
VGLPSLLMNLYLSIVLTLHNTALLWVGTPLHVAAYGVVSYTEAFFYLIFEGIALGSQPVLSFNAGAGRMDRVRQTRNLAM
AVTLLTAGLGLLFIYGRPEWALYIFAGDNPVLSPVAIEGMRLYFWGLPFEGLILVGASFFQAINKPREASILTGTKLLLI
AAVIYSFAWLFGVPGVWVSLACVSSVLTLWMVYSLVRIDSQSM
>Mature_443_residues
MNHTQAMLEAPVSRLFWRYTLPTIASMLVTGIYVTIDGMFVGHFLGETGLAGIMLAYPVGALLYAVGALIGMGAGALVSI
KLGEGKTAKARELLGNAFSLVLLSALFFTLVGSVSARHILIWLGAEGEVLESAHDYLFWYFALCIFPLISMAFSTLLRND
GKPAFVTWVLIAGGVINTLLDYLFIVVWDFGLAGASVATMLSQAVTGLLCLQHFFSGKTALRIDFEQMRLKLDNCLNISR
VGLPSLLMNLYLSIVLTLHNTALLWVGTPLHVAAYGVVSYTEAFFYLIFEGIALGSQPVLSFNAGAGRMDRVRQTRNLAM
AVTLLTAGLGLLFIYGRPEWALYIFAGDNPVLSPVAIEGMRLYFWGLPFEGLILVGASFFQAINKPREASILTGTKLLLI
AAVIYSFAWLFGVPGVWVSLACVSSVLTLWMVYSLVRIDSQSM

Specific function: Multidrug resistance efflux protein [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528
- InterPro:   IPR015522 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 48190; Mature: 48190

Theoretical pI: Translated: 7.57; Mature: 7.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNHTQAMLEAPVSRLFWRYTLPTIASMLVTGIYVTIDGMFVGHFLGETGLAGIMLAYPVG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEHHHHHHHHCCCCHHHHHHHHHHH
ALLYAVGALIGMGAGALVSIKLGEGKTAKARELLGNAFSLVLLSALFFTLVGSVSARHIL
HHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
IWLGAEGEVLESAHDYLFWYFALCIFPLISMAFSTLLRNDGKPAFVTWVLIAGGVINTLL
EEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
DYLFIVVWDFGLAGASVATMLSQAVTGLLCLQHFFSGKTALRIDFEQMRLKLDNCLNISR
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHCCCCHH
VGLPSLLMNLYLSIVLTLHNTALLWVGTPLHVAAYGVVSYTEAFFYLIFEGIALGSQPVL
CCHHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCE
SFNAGAGRMDRVRQTRNLAMAVTLLTAGLGLLFIYGRPEWALYIFAGDNPVLSPVAIEGM
EECCCCCHHHHHHHHHHHHHHHHHHHHCHHEEEEEECCCEEEEEEECCCCCCCHHHHCCE
RLYFWGLPFEGLILVGASFFQAINKPREASILTGTKLLLIAAVIYSFAWLFGVPGVWVSL
EEEEECCCHHHHHHHHHHHHHHHCCCCCCHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHH
ACVSSVLTLWMVYSLVRIDSQSM
HHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNHTQAMLEAPVSRLFWRYTLPTIASMLVTGIYVTIDGMFVGHFLGETGLAGIMLAYPVG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEHHHHHHHHCCCCHHHHHHHHHHH
ALLYAVGALIGMGAGALVSIKLGEGKTAKARELLGNAFSLVLLSALFFTLVGSVSARHIL
HHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
IWLGAEGEVLESAHDYLFWYFALCIFPLISMAFSTLLRNDGKPAFVTWVLIAGGVINTLL
EEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
DYLFIVVWDFGLAGASVATMLSQAVTGLLCLQHFFSGKTALRIDFEQMRLKLDNCLNISR
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHCCCCHH
VGLPSLLMNLYLSIVLTLHNTALLWVGTPLHVAAYGVVSYTEAFFYLIFEGIALGSQPVL
CCHHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCE
SFNAGAGRMDRVRQTRNLAMAVTLLTAGLGLLFIYGRPEWALYIFAGDNPVLSPVAIEGM
EECCCCCHHHHHHHHHHHHHHHHHHHHCHHEEEEEECCCEEEEEEECCCCCCCHHHHCCE
RLYFWGLPFEGLILVGASFFQAINKPREASILTGTKLLLIAAVIYSFAWLFGVPGVWVSL
EEEEECCCHHHHHHHHHHHHHHHCCCCCCHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHH
ACVSSVLTLWMVYSLVRIDSQSM
HHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA