Click here to switch to the map view.

The map label for this gene is guaA

Identifier: 119775492

GI number: 119775492

Start: 2832531

End: 2834108

Strand: Reverse

Name: guaA

Synonym: Sama_2358

Alternate gene names: 119775492

Gene position: 2834108-2832531 (Counterclockwise)

Preceding gene: 119775493

Following gene: 119775490

Centisome position: 65.82

GC content: 56.65

Gene sequence:

>1578_bases
ATGAGCAACATTCATGAGCACAAGATACTTATTCTGGATTTCGGCTCTCAGTACACTCAGCTGATCGCCCGCCGTATTCG
TGAAATCGGCGTGTACTGCGAACTCTGGGCCTGGGATGTGACCGAAGCGCAAATCCGTGAATTTGCCCCTAACGGTATTG
TTCTGGCCGGTGGTCCCGAGTCGGTAACCGAAGATAACTCTCCCCGCGCTCCCGAGTACGTGTTCGACGCCGGTGTGCCT
GTGCTGGGGATTTGCTACGGCATGCAGACCATGAGCGAGCAGCTGGGCGGTAAGGTTATTCAGGGTGTTGGCGAGCGTGA
GTTCGGTTATGCCCAGGTGGAAGTACTCACCGACAGCGCACTGCTGCGTCATATCGAAGACGGTATCTCTGATGCCGGCA
AGCCAGTGCTGGACGTATGGATGAGCCACGGCGACAAGGTGTCTGCCATTCCTGAAGGCTTTGTGGCCGTTGCCAAGACT
GAAACCTGTCCGTTTGCCGTGATGGCCAACGAAGACAAGAAGTTTTACGGCGTACAGTTCCACCCTGAAGTGACCCACAC
CCGTCAGGGCAAGCGCATGCTCGAACACTTTGTGATGGACATCTGTGGCTGTGACAACAAATGGCAGCCAGCCTCCATCA
TCGAAGACGCCGTTGAGCGCATCAAAGCCCAGGTGGGTGACGATGAAGTGATCCTCGGCCTCTCAGGCGGTGTGGATTCA
TCCGTGACTGCCATGCTGCTGCACCGTGCCATCGGCGAGCGCCTGACCTGTGTGTTCGTTGACAACGGCCTTTTGCGTCT
CAATGAAGCCAAGCAGGTACTGGAAATGTTCGGTGACCACTTTGGTCTCAACATCGTCCACGTGGATGCCGAAAACCGCT
TCCTCGAAGCGCTCAAGGGCGAAAACGACCCAGAAGCCAAGCGTAAGATCATTGGCCGCGTATTCGTGGAAATCTTCGAC
GAAGAAGCCTCCAAGTGTGTTAACGCCAAGTGGCTGGCTCAGGGCACCATTTACCCTGACGTGATTGAATCTGCAGGCAG
CGCCACCGGCAAGGCCCATGTGATCAAGTCACATCACAACGTGGGCGGTCTGCCGGATGACATGGAGCTGGGCTTGGTTG
AGCCACTGCGGGAACTCTTCAAAGACGAAGTACGTAAGATTGGTCTGGAACTCGGCCTGCCTTACGACATGCTCTATCGC
CACCCATTCCCAGGCCCGGGCCTTGGGGTGCGTGTACTGGGCGAAGTGAAGAAAGAGTACTGCGACCTTTTGCGCCGCGC
TGATGCCATCTTCATCGAAGAGCTGCACCGCGCCGATCTGTACAACAAGGTCAGCCAGGCGTTCACCGTGTTCCTGCCGG
TTCGCAGTGTGGGCGTGATGGGCGATGGCCGTAAGTACGACTGGGTTGTGTCGCTGCGCGCCGTCGAAACCATCGACTTT
ATGACTGCACACTGGGCGCACCTGCCATATGATTTCCTTGGCCGCGTTTCCAACCGCATCATCAACGAAGTCGACGGCAT
CTCCCGCGTGGTGTATGACATCTCCGGCAAGCCACCTGCCACCATCGAGTGGGAATAA

Upstream 100 bases:

>100_bases
TGATTGAAAAGGGCGGCTGCGTGTCGCCCTTGCTGTACCTGATGTCCGGTGCTCTTCTGCACCGGAATAAGATAAATGCC
AAATGAGATAAAGGTTTTCC

Downstream 100 bases:

>100_bases
GCCTGAGGCTTATCTGGGCTAACCCTCTAAAAAGGCGCTTCGGCGCCTTTTTTATTTGAACTCTAATCAAGCTTCCTACT
TTGGGTTTTGTTGATGATTT

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase

Number of amino acids: Translated: 525; Mature: 524

Protein sequence:

>525_residues
MSNIHEHKILILDFGSQYTQLIARRIREIGVYCELWAWDVTEAQIREFAPNGIVLAGGPESVTEDNSPRAPEYVFDAGVP
VLGICYGMQTMSEQLGGKVIQGVGEREFGYAQVEVLTDSALLRHIEDGISDAGKPVLDVWMSHGDKVSAIPEGFVAVAKT
ETCPFAVMANEDKKFYGVQFHPEVTHTRQGKRMLEHFVMDICGCDNKWQPASIIEDAVERIKAQVGDDEVILGLSGGVDS
SVTAMLLHRAIGERLTCVFVDNGLLRLNEAKQVLEMFGDHFGLNIVHVDAENRFLEALKGENDPEAKRKIIGRVFVEIFD
EEASKCVNAKWLAQGTIYPDVIESAGSATGKAHVIKSHHNVGGLPDDMELGLVEPLRELFKDEVRKIGLELGLPYDMLYR
HPFPGPGLGVRVLGEVKKEYCDLLRRADAIFIEELHRADLYNKVSQAFTVFLPVRSVGVMGDGRKYDWVVSLRAVETIDF
MTAHWAHLPYDFLGRVSNRIINEVDGISRVVYDISGKPPATIEWE

Sequences:

>Translated_525_residues
MSNIHEHKILILDFGSQYTQLIARRIREIGVYCELWAWDVTEAQIREFAPNGIVLAGGPESVTEDNSPRAPEYVFDAGVP
VLGICYGMQTMSEQLGGKVIQGVGEREFGYAQVEVLTDSALLRHIEDGISDAGKPVLDVWMSHGDKVSAIPEGFVAVAKT
ETCPFAVMANEDKKFYGVQFHPEVTHTRQGKRMLEHFVMDICGCDNKWQPASIIEDAVERIKAQVGDDEVILGLSGGVDS
SVTAMLLHRAIGERLTCVFVDNGLLRLNEAKQVLEMFGDHFGLNIVHVDAENRFLEALKGENDPEAKRKIIGRVFVEIFD
EEASKCVNAKWLAQGTIYPDVIESAGSATGKAHVIKSHHNVGGLPDDMELGLVEPLRELFKDEVRKIGLELGLPYDMLYR
HPFPGPGLGVRVLGEVKKEYCDLLRRADAIFIEELHRADLYNKVSQAFTVFLPVRSVGVMGDGRKYDWVVSLRAVETIDF
MTAHWAHLPYDFLGRVSNRIINEVDGISRVVYDISGKPPATIEWE
>Mature_524_residues
SNIHEHKILILDFGSQYTQLIARRIREIGVYCELWAWDVTEAQIREFAPNGIVLAGGPESVTEDNSPRAPEYVFDAGVPV
LGICYGMQTMSEQLGGKVIQGVGEREFGYAQVEVLTDSALLRHIEDGISDAGKPVLDVWMSHGDKVSAIPEGFVAVAKTE
TCPFAVMANEDKKFYGVQFHPEVTHTRQGKRMLEHFVMDICGCDNKWQPASIIEDAVERIKAQVGDDEVILGLSGGVDSS
VTAMLLHRAIGERLTCVFVDNGLLRLNEAKQVLEMFGDHFGLNIVHVDAENRFLEALKGENDPEAKRKIIGRVFVEIFDE
EASKCVNAKWLAQGTIYPDVIESAGSATGKAHVIKSHHNVGGLPDDMELGLVEPLRELFKDEVRKIGLELGLPYDMLYRH
PFPGPGLGVRVLGEVKKEYCDLLRRADAIFIEELHRADLYNKVSQAFTVFLPVRSVGVMGDGRKYDWVVSLRAVETIDFM
TAHWAHLPYDFLGRVSNRIINEVDGISRVVYDISGKPPATIEWE

Specific function: Catalyzes the synthesis of GMP from XMP

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain

Homologues:

Organism=Homo sapiens, GI4504035, Length=568, Percent_Identity=35.7394366197183, Blast_Score=292, Evalue=6e-79,
Organism=Escherichia coli, GI1788854, Length=523, Percent_Identity=84.321223709369, Blast_Score=929, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71992710, Length=580, Percent_Identity=34.8275862068965, Blast_Score=281, Evalue=6e-76,
Organism=Caenorhabditis elegans, GI133901714, Length=580, Percent_Identity=34.8275862068965, Blast_Score=281, Evalue=6e-76,
Organism=Caenorhabditis elegans, GI71992717, Length=580, Percent_Identity=34.8275862068965, Blast_Score=281, Evalue=6e-76,
Organism=Saccharomyces cerevisiae, GI6323873, Length=523, Percent_Identity=49.5219885277247, Blast_Score=526, Evalue=1e-150,
Organism=Drosophila melanogaster, GI281365319, Length=565, Percent_Identity=34.5132743362832, Blast_Score=278, Evalue=9e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GUAA_SHEAM (A1S856)

Other databases:

- EMBL:   CP000507
- RefSeq:   YP_928232.1
- ProteinModelPortal:   A1S856
- SMR:   A1S856
- STRING:   A1S856
- GeneID:   4604607
- GenomeReviews:   CP000507_GR
- KEGG:   saz:Sama_2358
- NMPDR:   fig|326297.7.peg.2208
- eggNOG:   COG0519
- HOGENOM:   HBG391775
- OMA:   MKLVEPL
- PhylomeDB:   A1S856
- ProtClustDB:   PRK00074
- HAMAP:   MF_00344
- InterPro:   IPR006220
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PRINTS:   PR00097
- PRINTS:   PR00096
- TIGRFAMs:   TIGR00884
- TIGRFAMs:   TIGR00888

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase

EC number: =6.3.5.2

Molecular weight: Translated: 58462; Mature: 58330

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: PS51273 GATASE_TYPE_1; PS00442 GATASE_TYPE_I

Important sites: ACT_SITE 85-85 ACT_SITE 181-181 ACT_SITE 183-183

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNIHEHKILILDFGSQYTQLIARRIREIGVYCELWAWDVTEAQIREFAPNGIVLAGGPE
CCCCCCCEEEEEECCCHHHHHHHHHHHHHCCEEEEEECCCCHHHHHHCCCCCEEEECCCC
SVTEDNSPRAPEYVFDAGVPVLGICYGMQTMSEQLGGKVIQGVGEREFGYAQVEVLTDSA
CCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCEEEEEEHHHH
LLRHIEDGISDAGKPVLDVWMSHGDKVSAIPEGFVAVAKTETCPFAVMANEDKKFYGVQF
HHHHHHHHHHHCCCHHHHHHHHCCCEEECCCCCCEEEEECCCCCEEEEECCCCEEEEEEE
HPEVTHTRQGKRMLEHFVMDICGCDNKWQPASIIEDAVERIKAQVGDDEVILGLSGGVDS
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCH
SVTAMLLHRAIGERLTCVFVDNGLLRLNEAKQVLEMFGDHFGLNIVHVDAENRFLEALKG
HHHHHHHHHHHCCCEEEEEECCCCEEEHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHCC
ENDPEAKRKIIGRVFVEIFDEEASKCVNAKWLAQGTIYPDVIESAGSATGKAHVIKSHHN
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHCCCCCCCEEEEECCCC
VGGLPDDMELGLVEPLRELFKDEVRKIGLELGLPYDMLYRHPFPGPGLGVRVLGEVKKEY
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCHHHHHHHHHHH
CDLLRRADAIFIEELHRADLYNKVSQAFTVFLPVRSVGVMGDGRKYDWVVSLRAVETIDF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEHHHCCCCCCCCCEEEEEEEHHHHHHHH
MTAHWAHLPYDFLGRVSNRIINEVDGISRVVYDISGKPPATIEWE
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCEECC
>Mature Secondary Structure 
SNIHEHKILILDFGSQYTQLIARRIREIGVYCELWAWDVTEAQIREFAPNGIVLAGGPE
CCCCCCEEEEEECCCHHHHHHHHHHHHHCCEEEEEECCCCHHHHHHCCCCCEEEECCCC
SVTEDNSPRAPEYVFDAGVPVLGICYGMQTMSEQLGGKVIQGVGEREFGYAQVEVLTDSA
CCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCEEEEEEHHHH
LLRHIEDGISDAGKPVLDVWMSHGDKVSAIPEGFVAVAKTETCPFAVMANEDKKFYGVQF
HHHHHHHHHHHCCCHHHHHHHHCCCEEECCCCCCEEEEECCCCCEEEEECCCCEEEEEEE
HPEVTHTRQGKRMLEHFVMDICGCDNKWQPASIIEDAVERIKAQVGDDEVILGLSGGVDS
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCH
SVTAMLLHRAIGERLTCVFVDNGLLRLNEAKQVLEMFGDHFGLNIVHVDAENRFLEALKG
HHHHHHHHHHHCCCEEEEEECCCCEEEHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHCC
ENDPEAKRKIIGRVFVEIFDEEASKCVNAKWLAQGTIYPDVIESAGSATGKAHVIKSHHN
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHCCCCCCCEEEEECCCC
VGGLPDDMELGLVEPLRELFKDEVRKIGLELGLPYDMLYRHPFPGPGLGVRVLGEVKKEY
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCHHHHHHHHHHH
CDLLRRADAIFIEELHRADLYNKVSQAFTVFLPVRSVGVMGDGRKYDWVVSLRAVETIDF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEHHHCCCCCCCCCEEEEEEEHHHHHHHH
MTAHWAHLPYDFLGRVSNRIINEVDGISRVVYDISGKPPATIEWE
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA