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The map label for this gene is guaB [H]

Identifier: 119775493

GI number: 119775493

Start: 2834206

End: 2835672

Strand: Reverse

Name: guaB [H]

Synonym: Sama_2359

Alternate gene names: 119775493

Gene position: 2835672-2834206 (Counterclockwise)

Preceding gene: 119775495

Following gene: 119775492

Centisome position: 65.85

GC content: 56.51

Gene sequence:

>1467_bases
ATGCTACGTTTAATCAAAGAAGCGCTGACTTTTGACGATGTGTTACTGGTCCCTGCGCACTCAACCGTCCTCCCTAATAC
CGCAATCCTCAAGACTCGACTGACTCAAAAAATCGAGCTCAACATTCCTCTGGTGTCTGCCGCCATGGATACCGTCACTG
AAGCCCGTTTGGCAATTGCCATGGCTCAGGAAGGTGGTTTGGGCTTTATTCATAAAAACATGAGCATCGAGGCCCAGGCT
GAAGAAGTCCGCAAGGTTAAAATCTACGAAGCCGGTGTGGTACAGGACCCTGTGACTGTAACTCCGGGCACCACCTTGGC
TGAGCTGCGTAAGCTCACCGAGCGTAACGGCTTTGCCGGTTACCCCGTGGTGAACGAAGCCAACGAGCTGGTAGGCATCA
TCACTGGCCGTGACGTACGCTTTGTGACCGACTGGTCCAAAACCGTGCAGGAAGTGATGACCCCGAAAGAACGTCTGGTG
ACGGTTCCTGAAGGCACTAAGCTGGAAGACGTGCAAAAGCTGATGCACACCAACCGTATCGAAAAGGTACTGGTAGTAGA
CGACAGCTTCTGCCTTAAAGGTCTTATCACTGTTAAAGACTTCGAAAAAGCTGAACGTAAGCCAAACGCCTGTAAAGACG
AGCTGGGTCGCCTGCGTGTGGGCGCCGCTGTAGGTGCCGGTGCTGGCAACGAAGAGCGTGTTGATGCCCTGGTGAAAGCC
GGTGTGGACGTACTGCTTATCGACTCATCCCATGGTCACTCCGAAGGCGTGTTGCAGCGTATCCGCGACACCCGCGCCAA
GTATCCAGACTTGCAAATTATCGGTGGTAACGTGGCCACAGCTGAAGGCGCACTGGCGCTGGTTGAAGCCGGTGTAAACG
CAGTGAAAGTGGGTATCGGCCCCGGCTCTATCTGTACCACCCGTATCGTTACCGGTGTGGGCGTACCACAAATCACAGCC
GTGTCCGATGCCGCAGCTGCCGTTAAGCACCTGAATGTACCCGTGATTGCCGACGGCGGTATCCGCTTCTCCGGTGACCT
TGCCAAGGCGCTGGCTGCCGGTGCATCGTGCATTATGGCCGGCTCCATGTTTGCCGGTACCGACGAAGCCCCGGGTGAAA
CCGAGCTGTATCAGGGCCGCGCTTACAAGTCTTACCGCGGCATGGGTTCCCTTGGCGCCATGAGCCAGGGTTCATCCGAC
CGTTACTTCCAGAGCGATAACGCCGCCGACAAGCTGGTGCCCGAGGGTATCGAAGGTCGTGTGCCATACAAGGGCAAGCT
CAAGGAAATCATTCACCAGCACATGGGCGGCCTGCGCTCCTGTATGGGCCTCACCGGCTGCGCCACCATCAAAGAATTGG
GTGAGAAGGCCCAGTTCGTGAAGGTGACCTCTGCCGGTATGGGCGAGTCCCACGTGCACGATGTGACCATCACCAAAGAA
GCCCCGAACTACCGTACCGGCGGCTGA

Upstream 100 bases:

>100_bases
TAATTTTTCACAATTTTGCATTTACCGACCCTCACTTGCAAGGTATAATGCCGCCGCAATATTTCACCTCTACTTATCCT
ACCCAAGGGGAGATGTTGCA

Downstream 100 bases:

>100_bases
TTGAAAAGGGCGGCTGCGTGTCGCCCTTGCTGTACCTGATGTCCGGTGCTCTTCTGCACCGGAATAAGATAAATGCCAAA
TGAGATAAAGGTTTTCCATG

Product: inosine 5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 488; Mature: 488

Protein sequence:

>488_residues
MLRLIKEALTFDDVLLVPAHSTVLPNTAILKTRLTQKIELNIPLVSAAMDTVTEARLAIAMAQEGGLGFIHKNMSIEAQA
EEVRKVKIYEAGVVQDPVTVTPGTTLAELRKLTERNGFAGYPVVNEANELVGIITGRDVRFVTDWSKTVQEVMTPKERLV
TVPEGTKLEDVQKLMHTNRIEKVLVVDDSFCLKGLITVKDFEKAERKPNACKDELGRLRVGAAVGAGAGNEERVDALVKA
GVDVLLIDSSHGHSEGVLQRIRDTRAKYPDLQIIGGNVATAEGALALVEAGVNAVKVGIGPGSICTTRIVTGVGVPQITA
VSDAAAAVKHLNVPVIADGGIRFSGDLAKALAAGASCIMAGSMFAGTDEAPGETELYQGRAYKSYRGMGSLGAMSQGSSD
RYFQSDNAADKLVPEGIEGRVPYKGKLKEIIHQHMGGLRSCMGLTGCATIKELGEKAQFVKVTSAGMGESHVHDVTITKE
APNYRTGG

Sequences:

>Translated_488_residues
MLRLIKEALTFDDVLLVPAHSTVLPNTAILKTRLTQKIELNIPLVSAAMDTVTEARLAIAMAQEGGLGFIHKNMSIEAQA
EEVRKVKIYEAGVVQDPVTVTPGTTLAELRKLTERNGFAGYPVVNEANELVGIITGRDVRFVTDWSKTVQEVMTPKERLV
TVPEGTKLEDVQKLMHTNRIEKVLVVDDSFCLKGLITVKDFEKAERKPNACKDELGRLRVGAAVGAGAGNEERVDALVKA
GVDVLLIDSSHGHSEGVLQRIRDTRAKYPDLQIIGGNVATAEGALALVEAGVNAVKVGIGPGSICTTRIVTGVGVPQITA
VSDAAAAVKHLNVPVIADGGIRFSGDLAKALAAGASCIMAGSMFAGTDEAPGETELYQGRAYKSYRGMGSLGAMSQGSSD
RYFQSDNAADKLVPEGIEGRVPYKGKLKEIIHQHMGGLRSCMGLTGCATIKELGEKAQFVKVTSAGMGESHVHDVTITKE
APNYRTGG
>Mature_488_residues
MLRLIKEALTFDDVLLVPAHSTVLPNTAILKTRLTQKIELNIPLVSAAMDTVTEARLAIAMAQEGGLGFIHKNMSIEAQA
EEVRKVKIYEAGVVQDPVTVTPGTTLAELRKLTERNGFAGYPVVNEANELVGIITGRDVRFVTDWSKTVQEVMTPKERLV
TVPEGTKLEDVQKLMHTNRIEKVLVVDDSFCLKGLITVKDFEKAERKPNACKDELGRLRVGAAVGAGAGNEERVDALVKA
GVDVLLIDSSHGHSEGVLQRIRDTRAKYPDLQIIGGNVATAEGALALVEAGVNAVKVGIGPGSICTTRIVTGVGVPQITA
VSDAAAAVKHLNVPVIADGGIRFSGDLAKALAAGASCIMAGSMFAGTDEAPGETELYQGRAYKSYRGMGSLGAMSQGSSD
RYFQSDNAADKLVPEGIEGRVPYKGKLKEIIHQHMGGLRSCMGLTGCATIKELGEKAQFVKVTSAGMGESHVHDVTITKE
APNYRTGG

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI66933016, Length=483, Percent_Identity=41.407867494824, Blast_Score=335, Evalue=5e-92,
Organism=Homo sapiens, GI217035146, Length=452, Percent_Identity=41.5929203539823, Blast_Score=332, Evalue=4e-91,
Organism=Homo sapiens, GI34328928, Length=452, Percent_Identity=41.5929203539823, Blast_Score=332, Evalue=6e-91,
Organism=Homo sapiens, GI34328930, Length=452, Percent_Identity=41.5929203539823, Blast_Score=332, Evalue=7e-91,
Organism=Homo sapiens, GI156616279, Length=452, Percent_Identity=41.5929203539823, Blast_Score=331, Evalue=8e-91,
Organism=Homo sapiens, GI217035152, Length=446, Percent_Identity=41.7040358744395, Blast_Score=325, Evalue=5e-89,
Organism=Homo sapiens, GI217035148, Length=452, Percent_Identity=40.4867256637168, Blast_Score=318, Evalue=1e-86,
Organism=Homo sapiens, GI217035150, Length=452, Percent_Identity=38.0530973451327, Blast_Score=290, Evalue=2e-78,
Organism=Homo sapiens, GI156104880, Length=246, Percent_Identity=38.2113821138211, Blast_Score=165, Evalue=9e-41,
Organism=Homo sapiens, GI50541956, Length=247, Percent_Identity=37.246963562753, Blast_Score=162, Evalue=6e-40,
Organism=Homo sapiens, GI50541954, Length=247, Percent_Identity=37.246963562753, Blast_Score=162, Evalue=6e-40,
Organism=Homo sapiens, GI50541952, Length=247, Percent_Identity=37.246963562753, Blast_Score=162, Evalue=6e-40,
Organism=Homo sapiens, GI50541948, Length=247, Percent_Identity=37.246963562753, Blast_Score=162, Evalue=6e-40,
Organism=Escherichia coli, GI1788855, Length=487, Percent_Identity=80.4928131416838, Blast_Score=738, Evalue=0.0,
Organism=Escherichia coli, GI1786293, Length=221, Percent_Identity=35.7466063348416, Blast_Score=139, Evalue=5e-34,
Organism=Caenorhabditis elegans, GI71994385, Length=475, Percent_Identity=35.1578947368421, Blast_Score=254, Evalue=7e-68,
Organism=Caenorhabditis elegans, GI71994389, Length=422, Percent_Identity=37.2037914691943, Blast_Score=246, Evalue=3e-65,
Organism=Caenorhabditis elegans, GI17560440, Length=238, Percent_Identity=37.3949579831933, Blast_Score=158, Evalue=6e-39,
Organism=Saccharomyces cerevisiae, GI6323585, Length=483, Percent_Identity=39.3374741200828, Blast_Score=329, Evalue=6e-91,
Organism=Saccharomyces cerevisiae, GI6322012, Length=486, Percent_Identity=38.8888888888889, Blast_Score=327, Evalue=3e-90,
Organism=Saccharomyces cerevisiae, GI6323464, Length=482, Percent_Identity=39.4190871369295, Blast_Score=320, Evalue=4e-88,
Organism=Saccharomyces cerevisiae, GI6319352, Length=342, Percent_Identity=40.3508771929825, Blast_Score=251, Evalue=2e-67,
Organism=Saccharomyces cerevisiae, GI6319353, Length=122, Percent_Identity=39.344262295082, Blast_Score=77, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24641071, Length=483, Percent_Identity=39.1304347826087, Blast_Score=317, Evalue=1e-86,
Organism=Drosophila melanogaster, GI24641073, Length=483, Percent_Identity=39.1304347826087, Blast_Score=317, Evalue=1e-86,
Organism=Drosophila melanogaster, GI28571163, Length=441, Percent_Identity=39.6825396825397, Blast_Score=290, Evalue=2e-78,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 51823; Mature: 51823

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRLIKEALTFDDVLLVPAHSTVLPNTAILKTRLTQKIELNIPLVSAAMDTVTEARLAIA
CHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHEE
MAQEGGLGFIHKNMSIEAQAEEVRKVKIYEAGVVQDPVTVTPGTTLAELRKLTERNGFAG
EECCCCEEEEECCCCCEECHHHHHEEEEEECCCCCCCEEECCCCHHHHHHHHHHCCCCCC
YPVVNEANELVGIITGRDVRFVTDWSKTVQEVMTPKERLVTVPEGTKLEDVQKLMHTNRI
CCCCCCCCCEEEEEECCCEEEEECHHHHHHHHHCCHHHEEECCCCCCHHHHHHHHHHCCC
EKVLVVDDSFCLKGLITVKDFEKAERKPNACKDELGRLRVGAAVGAGAGNEERVDALVKA
CEEEEECCCHHHHCEEEHHHHHHHHCCCCHHHHHHCCEEECCEECCCCCCHHHHHHHHHC
GVDVLLIDSSHGHSEGVLQRIRDTRAKYPDLQIIGGNVATAEGALALVEAGVNAVKVGIG
CCCEEEEECCCCCHHHHHHHHHHHHCCCCCEEEECCCEECCCCHHHHHHCCCCEEEEECC
PGSICTTRIVTGVGVPQITAVSDAAAAVKHLNVPVIADGGIRFSGDLAKALAAGASCIMA
CCCHHHHHHHHCCCCCCEEEHHHHHHHHHHCCCCEEECCCEEECHHHHHHHHCCCHHEEE
GSMFAGTDEAPGETELYQGRAYKSYRGMGSLGAMSQGSSDRYFQSDNAADKLVPEGIEGR
CCEECCCCCCCCCCHHHCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCC
VPYKGKLKEIIHQHMGGLRSCMGLTGCATIKELGEKAQFVKVTSAGMGESHVHDVTITKE
CCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCEEEEEECCCCCCCCEEEEEEECC
APNYRTGG
CCCCCCCC
>Mature Secondary Structure
MLRLIKEALTFDDVLLVPAHSTVLPNTAILKTRLTQKIELNIPLVSAAMDTVTEARLAIA
CHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHEE
MAQEGGLGFIHKNMSIEAQAEEVRKVKIYEAGVVQDPVTVTPGTTLAELRKLTERNGFAG
EECCCCEEEEECCCCCEECHHHHHEEEEEECCCCCCCEEECCCCHHHHHHHHHHCCCCCC
YPVVNEANELVGIITGRDVRFVTDWSKTVQEVMTPKERLVTVPEGTKLEDVQKLMHTNRI
CCCCCCCCCEEEEEECCCEEEEECHHHHHHHHHCCHHHEEECCCCCCHHHHHHHHHHCCC
EKVLVVDDSFCLKGLITVKDFEKAERKPNACKDELGRLRVGAAVGAGAGNEERVDALVKA
CEEEEECCCHHHHCEEEHHHHHHHHCCCCHHHHHHCCEEECCEECCCCCCHHHHHHHHHC
GVDVLLIDSSHGHSEGVLQRIRDTRAKYPDLQIIGGNVATAEGALALVEAGVNAVKVGIG
CCCEEEEECCCCCHHHHHHHHHHHHCCCCCEEEECCCEECCCCHHHHHHCCCCEEEEECC
PGSICTTRIVTGVGVPQITAVSDAAAAVKHLNVPVIADGGIRFSGDLAKALAAGASCIMA
CCCHHHHHHHHCCCCCCEEEHHHHHHHHHHCCCCEEECCCEEECHHHHHHHHCCCHHEEE
GSMFAGTDEAPGETELYQGRAYKSYRGMGSLGAMSQGSSDRYFQSDNAADKLVPEGIEGR
CCEECCCCCCCCCCHHHCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCC
VPYKGKLKEIIHQHMGGLRSCMGLTGCATIKELGEKAQFVKVTSAGMGESHVHDVTITKE
CCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCEEEEEECCCCCCCCEEEEEEECC
APNYRTGG
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]