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The map label for this gene is wecB [H]

Identifier: 119775396

GI number: 119775396

Start: 2724529

End: 2725650

Strand: Reverse

Name: wecB [H]

Synonym: Sama_2261

Alternate gene names: 119775396

Gene position: 2725650-2724529 (Counterclockwise)

Preceding gene: 119775397

Following gene: 119775395

Centisome position: 63.3

GC content: 40.91

Gene sequence:

>1122_bases
ATGGCAAAAAAGAAAGTGCTTACTGTTTTTGGTACACGTCCTGAAGCAATTAAAATGGCCCCTCTGGTTAATGCTTTAGC
ATCCGATGACCGTTTTGAAGCAAAGTGTTGCGTAACAGCTCAACACAGGGAAATGCTCGATCAAGTACTAGAATTATTTG
AAATAACACCAGATTATGATCTTGATTTGATGAAAGCAGGGCAGACACTTAATGAAGTCACCGCCGGTATTATTCAAAAA
TTAAAACCAGTCCTTCAAGAATTTAAGCCAGATGTCGTGCTTGTGCATGGTGATACAGCAACGACTTTCGCTGCGAGCCT
TGCTGCTTACTATGAACAGATTGCAGTAGGACATGTAGAAGCAGGTCTGCGCACTGGCAACATCTACTCGCCTTGGCCAG
AAGAAGCAAACCGTCGCTTAACGGGAGTGCTGACTAAATATCATTTTGCGCCAACAGAAACATCGAAGCAGAATCTTCTA
AAAGAAAACTTTGAACCAAGCAATATCATTGTCACAGGTAATACTGTTATCGATGCGTTATTGATGGTGAAAGAAAAAAT
TGACTCAGACACAGACCTTAACCACACGATAGCTGAACAGTTCCCTTTCATAGATGAAAACAAGAAGCTGATCTTGGTTA
CTGGTCATCGTAGGGAAAGTTTTGGTGGTGGATTTGAGCGTATTTGCGAAGCATTGGCAACTGTCGCGAGAATGCATTCT
GACGTACAAATCCTATACCCAGTGCATTTGAACCCCAATGTAAGAGAACCAGTAAATCGTATTTTGGGGGATATAGATAA
TATTTTTTTGATCGAACCTCAACAATATCTTCCTTTCATTTACCTCATGGACAAGGCGTATATCATTCTTACGGATTCTG
GTGGAATACAGGAAGAAGCGCCATCTTTAGGTAAGCCTGTATTAGTTATGAGAGATGCAACTGAGCGTCCTGAAGCCGTA
GAGGCTGGTACAGTTAAGTTGGTTGGTACAGATGTCAAACGAATAGTCTCAAGCTTGAATGAATTATTGTGTGATGATTT
AGCTTATCAACATATGAGTGTTGCCCATAACCCTTATGGAGATGGGAAAGCGTGTCACAGAATTCTTAAAGCATTAATTT
AG

Upstream 100 bases:

>100_bases
AATGAACCAAAATAATCTCAGCCGAATTTGAAAGTTTAAAATTTCAAACAGGTAATATAGGTGTTTAATTTTAGGTAAAA
CGAAAAAAAGGTCATAAGTA

Downstream 100 bases:

>100_bases
TAATAGGTCATTAGATATGATGTCGTTGAAAGAATTAAAAATAGGCGTTATTGGCTTAGGTTACGTTGGTCTCCCTTTGG
CCGTTGAGTTTGGCAAAAAA

Product: UDP-N-acetylglucosamine 2-epimerase

Products: NA

Alternate protein names: UDP-GlcNAc-2-epimerase [H]

Number of amino acids: Translated: 373; Mature: 372

Protein sequence:

>373_residues
MAKKKVLTVFGTRPEAIKMAPLVNALASDDRFEAKCCVTAQHREMLDQVLELFEITPDYDLDLMKAGQTLNEVTAGIIQK
LKPVLQEFKPDVVLVHGDTATTFAASLAAYYEQIAVGHVEAGLRTGNIYSPWPEEANRRLTGVLTKYHFAPTETSKQNLL
KENFEPSNIIVTGNTVIDALLMVKEKIDSDTDLNHTIAEQFPFIDENKKLILVTGHRRESFGGGFERICEALATVARMHS
DVQILYPVHLNPNVREPVNRILGDIDNIFLIEPQQYLPFIYLMDKAYIILTDSGGIQEEAPSLGKPVLVMRDATERPEAV
EAGTVKLVGTDVKRIVSSLNELLCDDLAYQHMSVAHNPYGDGKACHRILKALI

Sequences:

>Translated_373_residues
MAKKKVLTVFGTRPEAIKMAPLVNALASDDRFEAKCCVTAQHREMLDQVLELFEITPDYDLDLMKAGQTLNEVTAGIIQK
LKPVLQEFKPDVVLVHGDTATTFAASLAAYYEQIAVGHVEAGLRTGNIYSPWPEEANRRLTGVLTKYHFAPTETSKQNLL
KENFEPSNIIVTGNTVIDALLMVKEKIDSDTDLNHTIAEQFPFIDENKKLILVTGHRRESFGGGFERICEALATVARMHS
DVQILYPVHLNPNVREPVNRILGDIDNIFLIEPQQYLPFIYLMDKAYIILTDSGGIQEEAPSLGKPVLVMRDATERPEAV
EAGTVKLVGTDVKRIVSSLNELLCDDLAYQHMSVAHNPYGDGKACHRILKALI
>Mature_372_residues
AKKKVLTVFGTRPEAIKMAPLVNALASDDRFEAKCCVTAQHREMLDQVLELFEITPDYDLDLMKAGQTLNEVTAGIIQKL
KPVLQEFKPDVVLVHGDTATTFAASLAAYYEQIAVGHVEAGLRTGNIYSPWPEEANRRLTGVLTKYHFAPTETSKQNLLK
ENFEPSNIIVTGNTVIDALLMVKEKIDSDTDLNHTIAEQFPFIDENKKLILVTGHRRESFGGGFERICEALATVARMHSD
VQILYPVHLNPNVREPVNRILGDIDNIFLIEPQQYLPFIYLMDKAYIILTDSGGIQEEAPSLGKPVLVMRDATERPEAVE
AGTVKLVGTDVKRIVSSLNELLCDDLAYQHMSVAHNPYGDGKACHRILKALI

Specific function: Catalyzes the reversible epimerization at C-2 of UDP-N- acetylglucosamine (UDP-GlcNAc) and thereby provides bacteria with UDP-N-acetylmannosamine (UDP-ManNAc), the activated donor of ManNAc residues [H]

COG id: COG0381

COG function: function code M; UDP-N-acetylglucosamine 2-epimerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-N-acetylglucosamine 2-epimerase family [H]

Homologues:

Organism=Escherichia coli, GI48994967, Length=368, Percent_Identity=71.4673913043478, Blast_Score=539, Evalue=1e-154,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003331 [H]

Pfam domain/function: PF02350 Epimerase_2 [H]

EC number: =5.1.3.14 [H]

Molecular weight: Translated: 41509; Mature: 41378

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKKKVLTVFGTRPEAIKMAPLVNALASDDRFEAKCCVTAQHREMLDQVLELFEITPDYD
CCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHCCCCCC
LDLMKAGQTLNEVTAGIIQKLKPVLQEFKPDVVLVHGDTATTFAASLAAYYEQIAVGHVE
HHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHH
AGLRTGNIYSPWPEEANRRLTGVLTKYHFAPTETSKQNLLKENFEPSNIIVTGNTVIDAL
HCCEECCCCCCCCHHHCCHHHHHHHHEECCCCCCHHHHHHHHCCCCCEEEEECHHHHHHH
LMVKEKIDSDTDLNHTIAEQFPFIDENKKLILVTGHRRESFGGGFERICEALATVARMHS
HHHHHHCCCCCCCCHHHHHHCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCC
DVQILYPVHLNPNVREPVNRILGDIDNIFLIEPQQYLPFIYLMDKAYIILTDSGGIQEEA
CCEEEEEEECCCCHHHHHHHHHCCCCCEEEECCHHHCCEEEEECCEEEEEECCCCCCCCC
PSLGKPVLVMRDATERPEAVEAGTVKLVGTDVKRIVSSLNELLCDDLAYQHMSVAHNPYG
CCCCCCEEEEECCCCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
DGKACHRILKALI
CCHHHHHHHHHHC
>Mature Secondary Structure 
AKKKVLTVFGTRPEAIKMAPLVNALASDDRFEAKCCVTAQHREMLDQVLELFEITPDYD
CCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHCCCCCC
LDLMKAGQTLNEVTAGIIQKLKPVLQEFKPDVVLVHGDTATTFAASLAAYYEQIAVGHVE
HHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHH
AGLRTGNIYSPWPEEANRRLTGVLTKYHFAPTETSKQNLLKENFEPSNIIVTGNTVIDAL
HCCEECCCCCCCCHHHCCHHHHHHHHEECCCCCCHHHHHHHHCCCCCEEEEECHHHHHHH
LMVKEKIDSDTDLNHTIAEQFPFIDENKKLILVTGHRRESFGGGFERICEALATVARMHS
HHHHHHCCCCCCCCHHHHHHCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCC
DVQILYPVHLNPNVREPVNRILGDIDNIFLIEPQQYLPFIYLMDKAYIILTDSGGIQEEA
CCEEEEEEECCCCHHHHHHHHHCCCCCEEEECCHHHCCEEEEECCEEEEEECCCCCCCCC
PSLGKPVLVMRDATERPEAVEAGTVKLVGTDVKRIVSSLNELLCDDLAYQHMSVAHNPYG
CCCCCCEEEEECCCCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
DGKACHRILKALI
CCHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]