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The map label for this gene is vipA [H]

Identifier: 119775395

GI number: 119775395

Start: 2723235

End: 2724512

Strand: Reverse

Name: vipA [H]

Synonym: Sama_2260

Alternate gene names: 119775395

Gene position: 2724512-2723235 (Counterclockwise)

Preceding gene: 119775396

Following gene: 119775394

Centisome position: 63.27

GC content: 37.17

Gene sequence:

>1278_bases
ATGATGTCGTTGAAAGAATTAAAAATAGGCGTTATTGGCTTAGGTTACGTTGGTCTCCCTTTGGCCGTTGAGTTTGGCAA
AAAATATCCAACATTGGGATTTGATATTAATGAACTACGTGTAAGAGAGTTAAGTCAGGGGAGAGATGCGACACTTGAAT
GTACTGCAGAAGAATTGTCAGAAGCGAGTCTATTAAAGTATACATCTACTTTGGAAGACATTAAAGACTGCAATTTCTAT
ATAGTTACAGTGCCAACACCCATCGATGAAAGTAATGCACCAGATTTGACTCCATTAAAAAAGGCATCCGAGGCGTTAGG
TAAGGTCATTTCGCTTGATGATATCGTGGTTTTTGAGTCTACAGTCTATCCAGGTGCAACAGAGGAATATTGTATTCCTA
TAATTGAACGTGTTTCTAATTTGATGTTTAATCGTGATTTTTATGCTGGTTATAGCCCAGAACGAATTAATCCAGGTGAT
AAGGTAAATCGTTTAACAACCATTGTGAAAATTACTTCAGGGTCCACTCCAGAAGTGGCGGACTTTGTCGATGCAGTTTA
TTCATCAATTGTTAGTGCGGGAACTCATAAAGCATCTTCGATAAAAGTTGCGGAGGCTGCCAAGGTTATTGAAAACACTC
AGAGAGATCTGAATATTGCAGTGATTAACGAATTTGCAAAAATATTCAACCGCTTAAAAATTGACACAGAAGAAGTTTTA
AAGGCTGCTGGTACTAAATGGAATTTTTTGCACTTTAAACCAGGCTTGGTTGGTGGGCACTGCATAAGTGTAGACCCATA
TTATTTAACCCATAAAGCGAAAGAGGTTGGTTATTCTCCTGAAGTGATATTGGCTGGGCGTAGAATAAACGACGGTATGG
GAAGCTATGTAGCTACCCAGATGGTTAAAAAATTAGCCAGTAAAAAAATACACATAGACGAAGCTAACGTACTAATAATG
GGCTTTACATTTAAAGGTGATTGTCCAGATGTACGTAATACCAAGGTTATTGAAATAGTTAAAGAACTCAAAAGTTTCAA
TATTAACGTTGATGTCTATGATTCTTGGGCAAATCCAGACGAAGTAGAACATGAGTATGGTATTAAGATGATTTCTGAGC
TCTTTAATGGATACTATGATGGCATTATTGTTGCGGTTGATCACTCAGAGTTTAAACAGATGGGTATTCAAAAAGTACGA
CTTTTAGGTAGGCCTAATCATGTGGTGTACGATGTAAAATACGTATTTGGTTTGAATGATTCAGATATCCGTTTGTAA

Upstream 100 bases:

>100_bases
TTAGCTTATCAACATATGAGTGTTGCCCATAACCCTTATGGAGATGGGAAAGCGTGTCACAGAATTCTTAAAGCATTAAT
TTAGTAATAGGTCATTAGAT

Downstream 100 bases:

>100_bases
AAGGAAATGACAATGAAAAACTTTGCATTAATCGGTGCTGCAGGATACATCGCACCTCGTCACTTACGAGCAATTAAAGA
TACGGGTAATAATTTGGTTG

Product: UDP-glucose/GDP-mannose dehydrogenase

Products: UDP-N-acetyl-D-mannosaminuronic-acid; NADH; Proton [C]

Alternate protein names: NA

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
MMSLKELKIGVIGLGYVGLPLAVEFGKKYPTLGFDINELRVRELSQGRDATLECTAEELSEASLLKYTSTLEDIKDCNFY
IVTVPTPIDESNAPDLTPLKKASEALGKVISLDDIVVFESTVYPGATEEYCIPIIERVSNLMFNRDFYAGYSPERINPGD
KVNRLTTIVKITSGSTPEVADFVDAVYSSIVSAGTHKASSIKVAEAAKVIENTQRDLNIAVINEFAKIFNRLKIDTEEVL
KAAGTKWNFLHFKPGLVGGHCISVDPYYLTHKAKEVGYSPEVILAGRRINDGMGSYVATQMVKKLASKKIHIDEANVLIM
GFTFKGDCPDVRNTKVIEIVKELKSFNINVDVYDSWANPDEVEHEYGIKMISELFNGYYDGIIVAVDHSEFKQMGIQKVR
LLGRPNHVVYDVKYVFGLNDSDIRL

Sequences:

>Translated_425_residues
MMSLKELKIGVIGLGYVGLPLAVEFGKKYPTLGFDINELRVRELSQGRDATLECTAEELSEASLLKYTSTLEDIKDCNFY
IVTVPTPIDESNAPDLTPLKKASEALGKVISLDDIVVFESTVYPGATEEYCIPIIERVSNLMFNRDFYAGYSPERINPGD
KVNRLTTIVKITSGSTPEVADFVDAVYSSIVSAGTHKASSIKVAEAAKVIENTQRDLNIAVINEFAKIFNRLKIDTEEVL
KAAGTKWNFLHFKPGLVGGHCISVDPYYLTHKAKEVGYSPEVILAGRRINDGMGSYVATQMVKKLASKKIHIDEANVLIM
GFTFKGDCPDVRNTKVIEIVKELKSFNINVDVYDSWANPDEVEHEYGIKMISELFNGYYDGIIVAVDHSEFKQMGIQKVR
LLGRPNHVVYDVKYVFGLNDSDIRL
>Mature_425_residues
MMSLKELKIGVIGLGYVGLPLAVEFGKKYPTLGFDINELRVRELSQGRDATLECTAEELSEASLLKYTSTLEDIKDCNFY
IVTVPTPIDESNAPDLTPLKKASEALGKVISLDDIVVFESTVYPGATEEYCIPIIERVSNLMFNRDFYAGYSPERINPGD
KVNRLTTIVKITSGSTPEVADFVDAVYSSIVSAGTHKASSIKVAEAAKVIENTQRDLNIAVINEFAKIFNRLKIDTEEVL
KAAGTKWNFLHFKPGLVGGHCISVDPYYLTHKAKEVGYSPEVILAGRRINDGMGSYVATQMVKKLASKKIHIDEANVLIM
GFTFKGDCPDVRNTKVIEIVKELKSFNINVDVYDSWANPDEVEHEYGIKMISELFNGYYDGIIVAVDHSEFKQMGIQKVR
LLGRPNHVVYDVKYVFGLNDSDIRL

Specific function: Catalyzes The Oxidation Of Udp-Mannac To Udp-N- Acetylmannosaminuronic Acid (Udp-Mannaca). [C]

COG id: COG0677

COG function: function code M; UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI48994968, Length=413, Percent_Identity=26.8765133171913, Blast_Score=140, Evalue=1e-34,
Organism=Drosophila melanogaster, GI17136908, Length=378, Percent_Identity=22.7513227513227, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 47290; Mature: 47290

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMSLKELKIGVIGLGYVGLPLAVEFGKKYPTLGFDINELRVRELSQGRDATLECTAEELS
CCCHHHEEEEEEEECCCCCHHHEECCCCCCCCCCCHHHHHHHHHHCCCCCEEEECHHHHH
EASLLKYTSTLEDIKDCNFYIVTVPTPIDESNAPDLTPLKKASEALGKVISLDDIVVFES
HHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEC
TVYPGATEEYCIPIIERVSNLMFNRDFYAGYSPERINPGDKVNRLTTIVKITSGSTPEVA
CCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHEEEEEEEECCCCCHHH
DFVDAVYSSIVSAGTHKASSIKVAEAAKVIENTQRDLNIAVINEFAKIFNRLKIDTEEVL
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHH
KAAGTKWNFLHFKPGLVGGHCISVDPYYLTHKAKEVGYSPEVILAGRRINDGMGSYVATQ
HHCCCCEEEEEECCCCCCCEEEEECCCEEECHHHHCCCCCCEEEECCCCCCCCHHHHHHH
MVKKLASKKIHIDEANVLIMGFTFKGDCPDVRNTKVIEIVKELKSFNINVDVYDSWANPD
HHHHHHHCEEEEECCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCH
EVEHEYGIKMISELFNGYYDGIIVAVDHSEFKQMGIQKVRLLGRPNHVVYDVKYVFGLND
HHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHCCCCEEEEEEEEEEECCC
SDIRL
CCCCC
>Mature Secondary Structure
MMSLKELKIGVIGLGYVGLPLAVEFGKKYPTLGFDINELRVRELSQGRDATLECTAEELS
CCCHHHEEEEEEEECCCCCHHHEECCCCCCCCCCCHHHHHHHHHHCCCCCEEEECHHHHH
EASLLKYTSTLEDIKDCNFYIVTVPTPIDESNAPDLTPLKKASEALGKVISLDDIVVFES
HHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEC
TVYPGATEEYCIPIIERVSNLMFNRDFYAGYSPERINPGDKVNRLTTIVKITSGSTPEVA
CCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHEEEEEEEECCCCCHHH
DFVDAVYSSIVSAGTHKASSIKVAEAAKVIENTQRDLNIAVINEFAKIFNRLKIDTEEVL
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHH
KAAGTKWNFLHFKPGLVGGHCISVDPYYLTHKAKEVGYSPEVILAGRRINDGMGSYVATQ
HHCCCCEEEEEECCCCCCCEEEEECCCEEECHHHHCCCCCCEEEECCCCCCCCHHHHHHH
MVKKLASKKIHIDEANVLIMGFTFKGDCPDVRNTKVIEIVKELKSFNINVDVYDSWANPD
HHHHHHHCEEEEECCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCH
EVEHEYGIKMISELFNGYYDGIIVAVDHSEFKQMGIQKVRLLGRPNHVVYDVKYVFGLND
HHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHCCCCEEEEEEEEEEECCC
SDIRL
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-mannosamine; NAD [C]

Specific reaction: UDP-N-acetyl-D-mannosamine + NAD = UDP-N-acetyl-D-mannosaminuronic-acid + NADH + Proton [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8248629; 8331073; 11677608; 12644504 [H]