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The map label for this gene is fadI

Identifier: 119775303

GI number: 119775303

Start: 2622849

End: 2624159

Strand: Reverse

Name: fadI

Synonym: Sama_2168

Alternate gene names: 119775303

Gene position: 2624159-2622849 (Counterclockwise)

Preceding gene: 119775321

Following gene: 119775302

Centisome position: 60.94

GC content: 55.53

Gene sequence:

>1311_bases
ATGAGTGACAGACAACAGGTAACCAATGCCAGAGGCGAGCGTATTGCCATCGTCTCGGGCCTGAGAACCCCTTTTGCCAA
GCAGGCGACTGCATTCCATGGGGTTTCAGCCCTGGACATGGGCAAGATGGTGGTGAACGAACTCTTAAGCCGCAGCGAGC
TTGATCCCAAGCTGGTTGAACAGCTGGTCTATGGCCAGGTAGTACAAATGCCGGCTGCGCCGAACATTGCCCGCGAAATC
GTGTTGGGTACCGGCATGAATGTGGCTACCGATGCTTACAGCGTTACCCGCGCCTGTGCCACCAGTTTCCAATCAACAGT
CAACATCGCCGAAAGCATCATGACCGGCAATATTGAAATTGGTATTGCCGGTGGCGCTGACTCTTCTTCTGTATTGCCTA
TCGGAGTGTCCAAAAAACTGGCCCATGCCCTGGTTGACCTGACCAAGGCCAGAACATTTGGTCAGAAACTGGCAATTTTT
AGACGCCTGGGTATCAAAGACCTGCTGCCAGTGCCGCCTGCGGTGGCCGAATACTCCACTGGCCTTTCCATGGGGCAGAC
GGCTGAACAGATGGCCAAGACTCACGGTATCAGCCGTGCGGATCAGGACGCTATGGCGCACCGCTCTCACACCCTTGCCG
CCCAAACCTGGGCCTCCGGCGTGATGAAAAACGAAGTAATGGTGGCCCACGTGCCGCCATACAACCAGTTCATTGAAAAA
GACAACAATATCCGCGAAAGCTCGGATCTGGCATCGTACGCCAAGCTGCGTCCGGTGTTTGACCGCAAGCACGGCAGCGT
CACTGCCGCCAACAGTACACCTTTGACCGACGGTGCCTCAGCACTCTTGCTGATGAGCGAAGGTCGTGCCAAGGCGCTGG
GGTACACCCCAATCGGTTACATCAAGAGTTATGCCTTTGCCGCCATCGATGTGTGGGAAGACATGTTGATGGGGCCTTCC
TATGCCACGCCCATGGCGCTTAAGCGTGCCGGTATGCAGCTTGAAGACCTGACGCTGATTGAAATGCATGAAGCCTTTGC
GGCTCAGGCTCTTGCCAATATGAAGATGTTTGCATCCAAGAAGTTTGCCGAAGAAAAGCTTGGTCAAAATCGTGCGATCG
GTGAAATCGACATGAGCAAATTCAACGTGCTGGGTGGCTCCCTGGCCTATGGCCATCCCTTTGCGGCAACCGGCGCCCGT
TTGATTACCCAGATGTGTAACGAGCTTAAGCGACGCGGCGGCGGTGTGGGTCTGACTACCGCCTGTGCGGCTGGTGGTCT
GGGTGCGGCAATGATCCTGGAAGTGGAGTAA

Upstream 100 bases:

>100_bases
GGTCACACTTTTAATGGTCAGACCTGTTGAGTCGTCAGGTCAGCAAGGAAACAGCAGCAGACGGACAGCGGCCGGATGCG
GAGAATAAAGAGGGTGACAA

Downstream 100 bases:

>100_bases
CAGACAATGGAAAAGACTTTTAGCCTAAGCCGCCGTGACGACGGCATCGCGCTGCTGACCATGGATGTGCCCGGTGAAAC
CATGAACACCCTGAAGGCGC

Product: 3-ketoacyl-CoA thiolase

Products: NA

Alternate protein names: ACSs; Acetyl-CoA acyltransferase; Acyl-CoA ligase; Beta-ketothiolase; Fatty acid oxidation complex subunit beta

Number of amino acids: Translated: 436; Mature: 435

Protein sequence:

>436_residues
MSDRQQVTNARGERIAIVSGLRTPFAKQATAFHGVSALDMGKMVVNELLSRSELDPKLVEQLVYGQVVQMPAAPNIAREI
VLGTGMNVATDAYSVTRACATSFQSTVNIAESIMTGNIEIGIAGGADSSSVLPIGVSKKLAHALVDLTKARTFGQKLAIF
RRLGIKDLLPVPPAVAEYSTGLSMGQTAEQMAKTHGISRADQDAMAHRSHTLAAQTWASGVMKNEVMVAHVPPYNQFIEK
DNNIRESSDLASYAKLRPVFDRKHGSVTAANSTPLTDGASALLLMSEGRAKALGYTPIGYIKSYAFAAIDVWEDMLMGPS
YATPMALKRAGMQLEDLTLIEMHEAFAAQALANMKMFASKKFAEEKLGQNRAIGEIDMSKFNVLGGSLAYGHPFAATGAR
LITQMCNELKRRGGGVGLTTACAAGGLGAAMILEVE

Sequences:

>Translated_436_residues
MSDRQQVTNARGERIAIVSGLRTPFAKQATAFHGVSALDMGKMVVNELLSRSELDPKLVEQLVYGQVVQMPAAPNIAREI
VLGTGMNVATDAYSVTRACATSFQSTVNIAESIMTGNIEIGIAGGADSSSVLPIGVSKKLAHALVDLTKARTFGQKLAIF
RRLGIKDLLPVPPAVAEYSTGLSMGQTAEQMAKTHGISRADQDAMAHRSHTLAAQTWASGVMKNEVMVAHVPPYNQFIEK
DNNIRESSDLASYAKLRPVFDRKHGSVTAANSTPLTDGASALLLMSEGRAKALGYTPIGYIKSYAFAAIDVWEDMLMGPS
YATPMALKRAGMQLEDLTLIEMHEAFAAQALANMKMFASKKFAEEKLGQNRAIGEIDMSKFNVLGGSLAYGHPFAATGAR
LITQMCNELKRRGGGVGLTTACAAGGLGAAMILEVE
>Mature_435_residues
SDRQQVTNARGERIAIVSGLRTPFAKQATAFHGVSALDMGKMVVNELLSRSELDPKLVEQLVYGQVVQMPAAPNIAREIV
LGTGMNVATDAYSVTRACATSFQSTVNIAESIMTGNIEIGIAGGADSSSVLPIGVSKKLAHALVDLTKARTFGQKLAIFR
RLGIKDLLPVPPAVAEYSTGLSMGQTAEQMAKTHGISRADQDAMAHRSHTLAAQTWASGVMKNEVMVAHVPPYNQFIEKD
NNIRESSDLASYAKLRPVFDRKHGSVTAANSTPLTDGASALLLMSEGRAKALGYTPIGYIKSYAFAAIDVWEDMLMGPSY
ATPMALKRAGMQLEDLTLIEMHEAFAAQALANMKMFASKKFAEEKLGQNRAIGEIDMSKFNVLGGSLAYGHPFAATGARL
ITQMCNELKRRGGGVGLTTACAAGGLGAAMILEVE

Specific function: Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family

Homologues:

Organism=Homo sapiens, GI4504327, Length=420, Percent_Identity=40, Blast_Score=326, Evalue=2e-89,
Organism=Homo sapiens, GI4557237, Length=434, Percent_Identity=29.2626728110599, Blast_Score=193, Evalue=3e-49,
Organism=Homo sapiens, GI167614485, Length=427, Percent_Identity=31.8501170960187, Blast_Score=189, Evalue=7e-48,
Organism=Homo sapiens, GI4501853, Length=430, Percent_Identity=30.4651162790698, Blast_Score=181, Evalue=1e-45,
Organism=Homo sapiens, GI148539872, Length=438, Percent_Identity=29.4520547945205, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI194353979, Length=258, Percent_Identity=27.1317829457364, Blast_Score=81, Evalue=2e-15,
Organism=Escherichia coli, GI1788683, Length=426, Percent_Identity=71.5962441314554, Blast_Score=632, Evalue=0.0,
Organism=Escherichia coli, GI87082165, Length=426, Percent_Identity=32.6291079812207, Blast_Score=194, Evalue=1e-50,
Organism=Escherichia coli, GI1788554, Length=425, Percent_Identity=33.6470588235294, Blast_Score=189, Evalue=3e-49,
Organism=Escherichia coli, GI48994986, Length=428, Percent_Identity=33.1775700934579, Blast_Score=185, Evalue=4e-48,
Organism=Escherichia coli, GI1787663, Length=424, Percent_Identity=31.8396226415094, Blast_Score=170, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI17551802, Length=421, Percent_Identity=38.479809976247, Blast_Score=285, Evalue=4e-77,
Organism=Caenorhabditis elegans, GI133906874, Length=426, Percent_Identity=32.3943661971831, Blast_Score=190, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI25147385, Length=421, Percent_Identity=27.790973871734, Blast_Score=161, Evalue=8e-40,
Organism=Caenorhabditis elegans, GI17535921, Length=426, Percent_Identity=26.9953051643192, Blast_Score=149, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI17535917, Length=427, Percent_Identity=21.5456674473068, Blast_Score=87, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6325229, Length=432, Percent_Identity=28.4722222222222, Blast_Score=169, Evalue=5e-43,
Organism=Saccharomyces cerevisiae, GI6322031, Length=444, Percent_Identity=28.8288288288288, Blast_Score=158, Evalue=2e-39,
Organism=Drosophila melanogaster, GI17137578, Length=429, Percent_Identity=40.7925407925408, Blast_Score=324, Evalue=6e-89,
Organism=Drosophila melanogaster, GI24655093, Length=424, Percent_Identity=28.3018867924528, Blast_Score=164, Evalue=9e-41,
Organism=Drosophila melanogaster, GI24640423, Length=424, Percent_Identity=26.1792452830189, Blast_Score=160, Evalue=1e-39,
Organism=Drosophila melanogaster, GI17648125, Length=429, Percent_Identity=28.4382284382284, Blast_Score=152, Evalue=6e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FADI_SHEAM (A1S7L7)

Other databases:

- EMBL:   CP000507
- RefSeq:   YP_928043.1
- ProteinModelPortal:   A1S7L7
- SMR:   A1S7L7
- STRING:   A1S7L7
- GeneID:   4604418
- GenomeReviews:   CP000507_GR
- KEGG:   saz:Sama_2168
- NMPDR:   fig|326297.7.peg.2036
- eggNOG:   COG0183
- HOGENOM:   HBG370930
- OMA:   RDEVMTA
- PhylomeDB:   A1S7L7
- ProtClustDB:   PRK08963
- GO:   GO:0005737
- HAMAP:   MF_01618
- InterPro:   IPR012806
- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616
- Gene3D:   G3DSA:3.40.47.10
- PANTHER:   PTHR18919
- PIRSF:   PIRSF000429
- TIGRFAMs:   TIGR01930
- TIGRFAMs:   TIGR02446

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N; SSF53901 Thiolase-like

EC number: =2.3.1.16

Molecular weight: Translated: 46443; Mature: 46312

Theoretical pI: Translated: 8.73; Mature: 8.73

Prosite motif: PS00098 THIOLASE_1; PS00737 THIOLASE_2; PS00099 THIOLASE_3

Important sites: ACT_SITE 99-99 ACT_SITE 392-392 ACT_SITE 422-422

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDRQQVTNARGERIAIVSGLRTPFAKQATAFHGVSALDMGKMVVNELLSRSELDPKLVE
CCCHHHHHHCCCCEEEEEECCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHH
QLVYGQVVQMPAAPNIAREIVLGTGMNVATDAYSVTRACATSFQSTVNIAESIMTGNIEI
HHHHHHHHCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
GIAGGADSSSVLPIGVSKKLAHALVDLTKARTFGQKLAIFRRLGIKDLLPVPPAVAEYST
EEECCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCHHHHHHC
GLSMGQTAEQMAKTHGISRADQDAMAHRSHTLAAQTWASGVMKNEVMVAHVPPYNQFIEK
CCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHC
DNNIRESSDLASYAKLRPVFDRKHGSVTAANSTPLTDGASALLLMSEGRAKALGYTPIGY
CCCCCHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCEEEEEECCCCCCCCCCCHHH
IKSYAFAAIDVWEDMLMGPSYATPMALKRAGMQLEDLTLIEMHEAFAAQALANMKMFASK
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
KFAEEKLGQNRAIGEIDMSKFNVLGGSLAYGHPFAATGARLITQMCNELKRRGGGVGLTT
HHHHHHHCCCCCCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHH
ACAAGGLGAAMILEVE
HHHCCCCCEEEEEEEC
>Mature Secondary Structure 
SDRQQVTNARGERIAIVSGLRTPFAKQATAFHGVSALDMGKMVVNELLSRSELDPKLVE
CCHHHHHHCCCCEEEEEECCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHH
QLVYGQVVQMPAAPNIAREIVLGTGMNVATDAYSVTRACATSFQSTVNIAESIMTGNIEI
HHHHHHHHCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
GIAGGADSSSVLPIGVSKKLAHALVDLTKARTFGQKLAIFRRLGIKDLLPVPPAVAEYST
EEECCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCHHHHHHC
GLSMGQTAEQMAKTHGISRADQDAMAHRSHTLAAQTWASGVMKNEVMVAHVPPYNQFIEK
CCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHC
DNNIRESSDLASYAKLRPVFDRKHGSVTAANSTPLTDGASALLLMSEGRAKALGYTPIGY
CCCCCHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCEEEEEECCCCCCCCCCCHHH
IKSYAFAAIDVWEDMLMGPSYATPMALKRAGMQLEDLTLIEMHEAFAAQALANMKMFASK
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
KFAEEKLGQNRAIGEIDMSKFNVLGGSLAYGHPFAATGARLITQMCNELKRRGGGVGLTT
HHHHHHHCCCCCCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHH
ACAAGGLGAAMILEVE
HHHCCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA