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The map label for this gene is fabB [H]

Identifier: 119775289

GI number: 119775289

Start: 2602880

End: 2604091

Strand: Reverse

Name: fabB [H]

Synonym: Sama_2154

Alternate gene names: 119775289

Gene position: 2604091-2602880 (Counterclockwise)

Preceding gene: 119775291

Following gene: 119775288

Centisome position: 60.47

GC content: 54.7

Gene sequence:

>1212_bases
ATGAAAAGAGTCGTTATCACCGGCATTGGCATCGTTTCCAGTATCGGTAACAACAAACAAGAAGTGACCGAATCACTCAA
GGCCGGACGCAGCGGTATTACCCATTCCGCTCAGTTTGAAGAGATGCAGCTTCGCAGCCACGTGTGGGGCGATATCAAGC
TGGATCCCGCTGAGCACATCGACAGAAAAGCGCTGCGCTTCATGGGCGATGCAGCCGCCTATGCTTACCTCGCCATGCAG
GAAGCCATCAGCGATGCCAACCTGACTGAAGAGCAGTATTCCAACCCACGTGTGGGCCTGGTTGTGGGTACCGGCGGTGC
CTCTTCTTCTAACCAGGTACAGGCTGCCGACACGCTGCGTGAAAAGGGTGTTAAGCGCGTAGGCCCTTACATTGTGCCTC
GCATCATGGCATCTACTGCCTCTGCATGTTTGGCAACTCCTTTCAAAATCAAGGGCTTTAACTACTCCATCAGTTCTGCC
TGCGCCACCTCTGCTCACTGTATCGGTCATGCTGCCGAGCTTATCCAAATGGGTAAACAGGACATGGTATTTGCCGGCGG
CGCCGAAGAGCTGGATTGGACACTCACAATGGGCTTTGACGCCATGGGCGCACTGTCTACCAAGTACAATGAGACCCCTG
AAAAAGCCTCACGTACCTACGATGCTGACCGTGATGGTTTCGTTATCTCCGGTGGCGGCGGTATCGTGATTGTGGAAGAG
CTGGAACATGCTCTTGCACGCGGCGCCAAGATTTATGCTGAAGTTATCGGTTACGGTGCTTCTTCAGATGGTTACGACAT
GGTTGCCCCAAGTGGTGAAGGCGCCATGCGCTGCATGCAGATGGCGCTGACCGATGTGGATACCCCAATCGACTACATCA
ACACCCACGGTACTTCTACCCCAGTGGGTGACGTGCGCGAGCTGGAAGCCATTCGTGAAGTCTTTAAAGACCAGGTTCCG
CCAATCGCCTCCACCAAATCGCTGACGGGCCATGCCCTGGGCGCTGCCGGTGTGCACGAAGCCATCTACAGCCTGCTGAT
GATGGAAAATGGCTTTATTGCCGCTTCTGCCAACGTGGAAAACGTTGACCCTCAGGCTGCAGATATGCCAATCGTGACAC
AGTGCCGCGATGCTGAGCTCACCACAGTGATGAGCAACAGCTTCGGTTTTGGTGGCACCAACGCCACGCTGGTGATGCGT
AAGTACCGCTAA

Upstream 100 bases:

>100_bases
TTTACCGCCCTTTATGGAAAGCTGACCACTTAAAAGCGCCAAAGGGGATACTATTGGCGCACTAAAATTGGTACTCCCAG
TACGGAATGGATAGTAAAAC

Downstream 100 bases:

>100_bases
GCGGCTCGATAATCTCATTTGCGACCACAGTTTTCGCAAAATCAAAAGGGAAGCCAGGCTTCCCTTTTTTATTGTCTGTT
ACAATCCGCCCCAATCGCCA

Product: 3-oxoacyl-(acyl-carrier-protein) synthase I

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase I; Beta-ketoacyl-ACP synthase I; KAS I [H]

Number of amino acids: Translated: 403; Mature: 403

Protein sequence:

>403_residues
MKRVVITGIGIVSSIGNNKQEVTESLKAGRSGITHSAQFEEMQLRSHVWGDIKLDPAEHIDRKALRFMGDAAAYAYLAMQ
EAISDANLTEEQYSNPRVGLVVGTGGASSSNQVQAADTLREKGVKRVGPYIVPRIMASTASACLATPFKIKGFNYSISSA
CATSAHCIGHAAELIQMGKQDMVFAGGAEELDWTLTMGFDAMGALSTKYNETPEKASRTYDADRDGFVISGGGGIVIVEE
LEHALARGAKIYAEVIGYGASSDGYDMVAPSGEGAMRCMQMALTDVDTPIDYINTHGTSTPVGDVRELEAIREVFKDQVP
PIASTKSLTGHALGAAGVHEAIYSLLMMENGFIAASANVENVDPQAADMPIVTQCRDAELTTVMSNSFGFGGTNATLVMR
KYR

Sequences:

>Translated_403_residues
MKRVVITGIGIVSSIGNNKQEVTESLKAGRSGITHSAQFEEMQLRSHVWGDIKLDPAEHIDRKALRFMGDAAAYAYLAMQ
EAISDANLTEEQYSNPRVGLVVGTGGASSSNQVQAADTLREKGVKRVGPYIVPRIMASTASACLATPFKIKGFNYSISSA
CATSAHCIGHAAELIQMGKQDMVFAGGAEELDWTLTMGFDAMGALSTKYNETPEKASRTYDADRDGFVISGGGGIVIVEE
LEHALARGAKIYAEVIGYGASSDGYDMVAPSGEGAMRCMQMALTDVDTPIDYINTHGTSTPVGDVRELEAIREVFKDQVP
PIASTKSLTGHALGAAGVHEAIYSLLMMENGFIAASANVENVDPQAADMPIVTQCRDAELTTVMSNSFGFGGTNATLVMR
KYR
>Mature_403_residues
MKRVVITGIGIVSSIGNNKQEVTESLKAGRSGITHSAQFEEMQLRSHVWGDIKLDPAEHIDRKALRFMGDAAAYAYLAMQ
EAISDANLTEEQYSNPRVGLVVGTGGASSSNQVQAADTLREKGVKRVGPYIVPRIMASTASACLATPFKIKGFNYSISSA
CATSAHCIGHAAELIQMGKQDMVFAGGAEELDWTLTMGFDAMGALSTKYNETPEKASRTYDADRDGFVISGGGGIVIVEE
LEHALARGAKIYAEVIGYGASSDGYDMVAPSGEGAMRCMQMALTDVDTPIDYINTHGTSTPVGDVRELEAIREVFKDQVP
PIASTKSLTGHALGAAGVHEAIYSLLMMENGFIAASANVENVDPQAADMPIVTQCRDAELTTVMSNSFGFGGTNATLVMR
KYR

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=417, Percent_Identity=35.2517985611511, Blast_Score=226, Evalue=2e-59,
Organism=Homo sapiens, GI223972627, Length=138, Percent_Identity=43.4782608695652, Blast_Score=99, Evalue=8e-21,
Organism=Homo sapiens, GI41872631, Length=335, Percent_Identity=27.7611940298507, Blast_Score=93, Evalue=4e-19,
Organism=Escherichia coli, GI1788663, Length=405, Percent_Identity=70.3703703703704, Blast_Score=591, Evalue=1e-170,
Organism=Escherichia coli, GI1787337, Length=413, Percent_Identity=37.2881355932203, Blast_Score=243, Evalue=2e-65,
Organism=Caenorhabditis elegans, GI71983541, Length=417, Percent_Identity=34.7721822541966, Blast_Score=209, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI71983535, Length=264, Percent_Identity=39.3939393939394, Blast_Score=161, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI212642053, Length=354, Percent_Identity=26.5536723163842, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17550940, Length=356, Percent_Identity=24.7191011235955, Blast_Score=90, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6320904, Length=448, Percent_Identity=30.5803571428571, Blast_Score=186, Evalue=5e-48,
Organism=Drosophila melanogaster, GI24644341, Length=420, Percent_Identity=38.3333333333333, Blast_Score=256, Evalue=1e-68,
Organism=Drosophila melanogaster, GI221330659, Length=336, Percent_Identity=27.3809523809524, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI19920632, Length=336, Percent_Identity=27.3809523809524, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24581345, Length=339, Percent_Identity=23.3038348082596, Blast_Score=86, Evalue=4e-17,

Paralogues:

None

Copy number: 24024 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 30,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.41 [H]

Molecular weight: Translated: 42902; Mature: 42902

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS00606 B_KETOACYL_SYNTHASE ; PS00639 THIOL_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRVVITGIGIVSSIGNNKQEVTESLKAGRSGITHSAQFEEMQLRSHVWGDIKLDPAEHI
CCEEEEECCHHHHHCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCEEECHHHHH
DRKALRFMGDAAAYAYLAMQEAISDANLTEEQYSNPRVGLVVGTGGASSSNQVQAADTLR
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCEEEEEECCCCCCCCCCHHHHHHH
EKGVKRVGPYIVPRIMASTASACLATPFKIKGFNYSISSACATSAHCIGHAAELIQMGKQ
HCCHHHHCCHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCC
DMVFAGGAEELDWTLTMGFDAMGALSTKYNETPEKASRTYDADRDGFVISGGGGIVIVEE
CEEEECCCCCCEEEEEECCCHHHHHHCCCCCCHHHHHHCCCCCCCCEEEECCCCEEEHHH
LEHALARGAKIYAEVIGYGASSDGYDMVAPSGEGAMRCMQMALTDVDTPIDYINTHGTST
HHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCHHHHHHHHHHHHHCCCCHHHHHCCCCCC
PVGDVRELEAIREVFKDQVPPIASTKSLTGHALGAAGVHEAIYSLLMMENGFIAASANVE
CCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHCHHHHHHHHHHHHHHCCCCEEEECCCC
NVDPQAADMPIVTQCRDAELTTVMSNSFGFGGTNATLVMRKYR
CCCCCCCCCCHHCCCCCCHHEEEECCCCCCCCCCEEEEEEECC
>Mature Secondary Structure
MKRVVITGIGIVSSIGNNKQEVTESLKAGRSGITHSAQFEEMQLRSHVWGDIKLDPAEHI
CCEEEEECCHHHHHCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCEEECHHHHH
DRKALRFMGDAAAYAYLAMQEAISDANLTEEQYSNPRVGLVVGTGGASSSNQVQAADTLR
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCEEEEEECCCCCCCCCCHHHHHHH
EKGVKRVGPYIVPRIMASTASACLATPFKIKGFNYSISSACATSAHCIGHAAELIQMGKQ
HCCHHHHCCHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCC
DMVFAGGAEELDWTLTMGFDAMGALSTKYNETPEKASRTYDADRDGFVISGGGGIVIVEE
CEEEECCCCCCEEEEEECCCHHHHHHCCCCCCHHHHHHCCCCCCCCEEEECCCCEEEHHH
LEHALARGAKIYAEVIGYGASSDGYDMVAPSGEGAMRCMQMALTDVDTPIDYINTHGTST
HHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCHHHHHHHHHHHHHCCCCHHHHHCCCCCC
PVGDVRELEAIREVFKDQVPPIASTKSLTGHALGAAGVHEAIYSLLMMENGFIAASANVE
CCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHCHHHHHHHHHHHHHHCCCCEEEECCCC
NVDPQAADMPIVTQCRDAELTTVMSNSFGFGGTNATLVMRKYR
CCCCCCCCCCHHCCCCCCHHEEEECCCCCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]