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The map label for this gene is trpE [H]

Identifier: 119775264

GI number: 119775264

Start: 2574098

End: 2575681

Strand: Direct

Name: trpE [H]

Synonym: Sama_2129

Alternate gene names: 119775264

Gene position: 2574098-2575681 (Clockwise)

Preceding gene: 119775257

Following gene: 119775265

Centisome position: 59.78

GC content: 55.24

Gene sequence:

>1584_bases
ATGACACAACAGGCGTTTGATGCCAAGGCAGAGGGAAAGCTGGCCACAGGCAAATTGACCAAGCAGCCCTTGCCTTACCA
GGATGACCCGCTGGCCCTCTACGAGAGCCTGACTCAGGATGCCCACCACACACTTTTGCTGGAATCGGCTGAAATCGACA
GCAAAGAGAACCTGAAAAGCATCATCATGACCCACGCGGCCCTGAAAATTGCAGCCCAGGGCTATCGGTTGGAGTTTACC
GCGCTGGACGACAATGGCCGGGTGCTGCTGCCTGCCATCGCCGGTTTTTTTAACTGCGAACTGACTGAAACCAATTACCT
TGCCGTGACCTTAACACGCGACACCGGTCTACTGGATGAAGATGCCAGGCTAAAATCCACCTCGCCTCTGGATGGCCTGC
GGGCACTACTCAAACATATCCATGTGGGTGAAAAGGTTGCCTTTGAGGATCTTTTCCTCGGTGGCGTACTGGCATACGAT
TTGATTGATACCGTTGAGCCACTTCCCAAAGCAAGGGACGGCGCCAATACCTGCCCGGATTATCTCTTTTATCTCGCCGA
CACCCTGGTGCTTGTGGACCACAAGGCCAAACAGGCCGAGTTGGTCTTGTCGACCTTTTCCGCGGACGGGCAAATATCCC
CCTTCATAGAAGATGAACTCAAGCGCCGCGCCAAGGTGATCGAGGCCATCGCCAATCGTCCCCGCCCGGTTAAAGCCCTC
AAACCGGTGAATGTCGAGGCCAGCGTCAGCATCAGTGACGAAGACTTTAAAGACGCGGTGAACGCCCTGAAAGAGCACAT
CATCGCCGGCGATATTTTTCAGGTGGTGCCTTCAAGAAGCTTCAGTCTGCCTTGCCCCAATACCCTTGGCGCTTATAGAG
CACTGCGTAAAACCAATCCCAGCCCCTACATGTTTTATTTTCGCAGCAGCGATTTCACCCTCTTTGGCGCCTCACCTGAA
AGCGCGCTCAAATACGATGCTGACAGTAATCAGGTGGAAGTCTACCCCATCGCCGGTACCCGTAAGCGCGGCAAAGATGC
CAGTGGCAACATAGATCACGACCTGGATGGCCGTATCGAGCTGGAGCTGCGCCTCGATAAAAAGGAACTCTCTGAGCACC
TGATGCTGGTCGATTTGGCCCGAAATGATATAGCCCGTATCAGCCAAAGCGGCACCCGCAAGGTAGCAGAGCTGTTGAAA
GTTGACCGCTACAGCCACGTGATGCATCTGGTCAGCCGGGTCACAGGTCAACTGAGGCAGGATCTCGACGCCCTCCATGC
TTATCAGGCCTGCATGAATATGGGCACGCTCACAGGCGCACCCAAGGTCAGGGCTTCCCAGCTTATCCGCGAAACGGAAA
AGACACGCAGGGGCAGCTATGGCGGCGCCGTGGGTTACCTTTCCGCCACCGGTGACATGGATACCTGTATCGTTATTCGT
TCGGCCTTTGTGAAAGACGGCCTTGCCCATATCCAGGCCGGTGCCGGTGTGGTGTATGACTCAGATCCCCAGGCAGAGGC
AGACGAAACCCGTCAAAAAGCACAGGCAGTGATCTCTGCCATCAAACTGGGAGGTGGCCTGTGA

Upstream 100 bases:

>100_bases
CGTTTAACAGACACAAGATTCATCGAAAAGGCCCGCACTACGCGGGCCTTTTTGCATCTGGCCCGGTGAAAAGCGGCACA
AAAACTTGAAGGATAACCGG

Downstream 100 bases:

>100_bases
AACTCTATTTACTCGATAACTTCGACTCTTTTACTTACAACCTGGTCGACCAATTCCGCGCGCTGGGCTTTGAGGTAGTG
ATTTACCGTAACGACGTTGA

Product: anthranilate synthase component I

Products: NA

Alternate protein names: Anthranilate synthase component I [H]

Number of amino acids: Translated: 527; Mature: 526

Protein sequence:

>527_residues
MTQQAFDAKAEGKLATGKLTKQPLPYQDDPLALYESLTQDAHHTLLLESAEIDSKENLKSIIMTHAALKIAAQGYRLEFT
ALDDNGRVLLPAIAGFFNCELTETNYLAVTLTRDTGLLDEDARLKSTSPLDGLRALLKHIHVGEKVAFEDLFLGGVLAYD
LIDTVEPLPKARDGANTCPDYLFYLADTLVLVDHKAKQAELVLSTFSADGQISPFIEDELKRRAKVIEAIANRPRPVKAL
KPVNVEASVSISDEDFKDAVNALKEHIIAGDIFQVVPSRSFSLPCPNTLGAYRALRKTNPSPYMFYFRSSDFTLFGASPE
SALKYDADSNQVEVYPIAGTRKRGKDASGNIDHDLDGRIELELRLDKKELSEHLMLVDLARNDIARISQSGTRKVAELLK
VDRYSHVMHLVSRVTGQLRQDLDALHAYQACMNMGTLTGAPKVRASQLIRETEKTRRGSYGGAVGYLSATGDMDTCIVIR
SAFVKDGLAHIQAGAGVVYDSDPQAEADETRQKAQAVISAIKLGGGL

Sequences:

>Translated_527_residues
MTQQAFDAKAEGKLATGKLTKQPLPYQDDPLALYESLTQDAHHTLLLESAEIDSKENLKSIIMTHAALKIAAQGYRLEFT
ALDDNGRVLLPAIAGFFNCELTETNYLAVTLTRDTGLLDEDARLKSTSPLDGLRALLKHIHVGEKVAFEDLFLGGVLAYD
LIDTVEPLPKARDGANTCPDYLFYLADTLVLVDHKAKQAELVLSTFSADGQISPFIEDELKRRAKVIEAIANRPRPVKAL
KPVNVEASVSISDEDFKDAVNALKEHIIAGDIFQVVPSRSFSLPCPNTLGAYRALRKTNPSPYMFYFRSSDFTLFGASPE
SALKYDADSNQVEVYPIAGTRKRGKDASGNIDHDLDGRIELELRLDKKELSEHLMLVDLARNDIARISQSGTRKVAELLK
VDRYSHVMHLVSRVTGQLRQDLDALHAYQACMNMGTLTGAPKVRASQLIRETEKTRRGSYGGAVGYLSATGDMDTCIVIR
SAFVKDGLAHIQAGAGVVYDSDPQAEADETRQKAQAVISAIKLGGGL
>Mature_526_residues
TQQAFDAKAEGKLATGKLTKQPLPYQDDPLALYESLTQDAHHTLLLESAEIDSKENLKSIIMTHAALKIAAQGYRLEFTA
LDDNGRVLLPAIAGFFNCELTETNYLAVTLTRDTGLLDEDARLKSTSPLDGLRALLKHIHVGEKVAFEDLFLGGVLAYDL
IDTVEPLPKARDGANTCPDYLFYLADTLVLVDHKAKQAELVLSTFSADGQISPFIEDELKRRAKVIEAIANRPRPVKALK
PVNVEASVSISDEDFKDAVNALKEHIIAGDIFQVVPSRSFSLPCPNTLGAYRALRKTNPSPYMFYFRSSDFTLFGASPES
ALKYDADSNQVEVYPIAGTRKRGKDASGNIDHDLDGRIELELRLDKKELSEHLMLVDLARNDIARISQSGTRKVAELLKV
DRYSHVMHLVSRVTGQLRQDLDALHAYQACMNMGTLTGAPKVRASQLIRETEKTRRGSYGGAVGYLSATGDMDTCIVIRS
AFVKDGLAHIQAGAGVVYDSDPQAEADETRQKAQAVISAIKLGGGL

Specific function: Tryptophan biosynthesis; first step. [C]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1787518, Length=500, Percent_Identity=55, Blast_Score=513, Evalue=1e-146,
Organism=Escherichia coli, GI1788114, Length=432, Percent_Identity=28.9351851851852, Blast_Score=166, Evalue=4e-42,
Organism=Escherichia coli, GI1786809, Length=228, Percent_Identity=29.3859649122807, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI87082077, Length=265, Percent_Identity=27.5471698113208, Blast_Score=69, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6320935, Length=409, Percent_Identity=37.4083129584352, Blast_Score=237, Evalue=3e-63,
Organism=Saccharomyces cerevisiae, GI6324361, Length=384, Percent_Identity=24.21875, Blast_Score=95, Evalue=3e-20,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR005257
- InterPro:   IPR015890 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =4.1.3.27 [H]

Molecular weight: Translated: 57720; Mature: 57589

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQQAFDAKAEGKLATGKLTKQPLPYQDDPLALYESLTQDAHHTLLLESAEIDSKENLKS
CCCCCCCCCCCCCEEECCCCCCCCCCCCCHHHHHHHHHHCCHHEEEEECCCCCCHHHHHH
IIMTHAALKIAAQGYRLEFTALDDNGRVLLPAIAGFFNCELTETNYLAVTLTRDTGLLDE
HHHHHHHHHHHCCCEEEEEEEECCCCCEEHHHHHHHHEEEEECCCEEEEEEECCCCCCCC
DARLKSTSPLDGLRALLKHIHVGEKVAFEDLFLGGVLAYDLIDTVEPLPKARDGANTCPD
CCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHH
YLFYLADTLVLVDHKAKQAELVLSTFSADGQISPFIEDELKRRAKVIEAIANRPRPVKAL
HHHHHHHHHHEECCCCHHHHHHHEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCC
KPVNVEASVSISDEDFKDAVNALKEHIIAGDIFQVVPSRSFSLPCPNTLGAYRALRKTNP
CCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCC
SPYMFYFRSSDFTLFGASPESALKYDADSNQVEVYPIAGTRKRGKDASGNIDHDLDGRIE
CCEEEEEECCCEEEECCCCCHHEEECCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCEEE
LELRLDKKELSEHLMLVDLARNDIARISQSGTRKVAELLKVDRYSHVMHLVSRVTGQLRQ
EEEEECHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLDALHAYQACMNMGTLTGAPKVRASQLIRETEKTRRGSYGGAVGYLSATGDMDTCIVIR
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHH
SAFVKDGLAHIQAGAGVVYDSDPQAEADETRQKAQAVISAIKLGGGL
HHHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TQQAFDAKAEGKLATGKLTKQPLPYQDDPLALYESLTQDAHHTLLLESAEIDSKENLKS
CCCCCCCCCCCCEEECCCCCCCCCCCCCHHHHHHHHHHCCHHEEEEECCCCCCHHHHHH
IIMTHAALKIAAQGYRLEFTALDDNGRVLLPAIAGFFNCELTETNYLAVTLTRDTGLLDE
HHHHHHHHHHHCCCEEEEEEEECCCCCEEHHHHHHHHEEEEECCCEEEEEEECCCCCCCC
DARLKSTSPLDGLRALLKHIHVGEKVAFEDLFLGGVLAYDLIDTVEPLPKARDGANTCPD
CCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHH
YLFYLADTLVLVDHKAKQAELVLSTFSADGQISPFIEDELKRRAKVIEAIANRPRPVKAL
HHHHHHHHHHEECCCCHHHHHHHEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCC
KPVNVEASVSISDEDFKDAVNALKEHIIAGDIFQVVPSRSFSLPCPNTLGAYRALRKTNP
CCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCC
SPYMFYFRSSDFTLFGASPESALKYDADSNQVEVYPIAGTRKRGKDASGNIDHDLDGRIE
CCEEEEEECCCEEEECCCCCHHEEECCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCEEE
LELRLDKKELSEHLMLVDLARNDIARISQSGTRKVAELLKVDRYSHVMHLVSRVTGQLRQ
EEEEECHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLDALHAYQACMNMGTLTGAPKVRASQLIRETEKTRRGSYGGAVGYLSATGDMDTCIVIR
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHH
SAFVKDGLAHIQAGAGVVYDSDPQAEADETRQKAQAVISAIKLGGGL
HHHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]