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The map label for this gene is purM [H]

Identifier: 119775232

GI number: 119775232

Start: 2541383

End: 2542420

Strand: Direct

Name: purM [H]

Synonym: Sama_2097

Alternate gene names: 119775232

Gene position: 2541383-2542420 (Clockwise)

Preceding gene: 119775230

Following gene: 119775233

Centisome position: 59.02

GC content: 55.78

Gene sequence:

>1038_bases
GTGAGCACTCCTACCCCACTGAGCTATAAAGACGCCGGTGTCGATATCGATGCAGGCAACGCACTGGTGCAAAACATCAA
GTCTGCCGTTAAGCGCACCCGCCGCCCTGAAGTGATGGGCAACCTGGGTGGTTTTGGTGCCCTGTGTGAACTGCCGACCA
AATACAAGCACCCAGTGCTGGTATCCGGTACCGACGGCGTGGGAACCAAGCTGCGTCTGGCCATTGACTTCAAGAGCCAC
GACACCGTGGGTATTGATCTGGTCGCCATGTGTGTGAACGACCTGATTGTGCAGGGCGCTGAGCCACTGTTCTTCCTCGA
CTACTATGCCACCGGCAAGCTGGACGTAGAGACAGCCACCTCTGTAGTAAATGGTATTGGTGAAGGCTGTTTCCAGTCAG
GTTGCGCCCTGATTGGTGGTGAAACCGCCGAAATGCCCGGCATGTACGAAGGCGAAGACTACGACCTGGCCGGTTTCTGC
GTAGGTGTGGTTGAAAAGGCCGACATCATCGACGGCACCAAGGTAAAAGCCGGTGATGCGCTGATTGCACTCGCCTCAAG
TGGTCCTCACTCAAACGGTTATTCTCTTATCCGTAAGGTACTGGAAGTGAGCAAGGCCGATCCTCAAATGGATCTGAACG
GCAAGCCGCTCATCAAGCACCTGCTGGAACCCACCAAGATTTATGTCAAATCACTGCTGAAGCTGATTGCCGAAAGCGAC
GTACACGCCATGGCGCACATCACCGGCGGTGGTTTCTGGGAAAACATCCCACGCGTACTGCCTGACAACTGCAAAGCCGT
GGTTCAGGGCGATTCCTGGCAGTGGCCTGTGGTATTCGACTGGCTGCAAACTGCCGGCAATATCGAAACCTACGAAATGT
ACCGCACCTTTAACTGCGGCGTGGGCATGATTGTTGCCCTGCCCGCCGACAAGGTTGACGCGGCCCTTGAACTCCTTAAG
GCCGAAGGTGAAAACGCCTGGCACATCGGCCATATCGCCGCGCGTAATGGCGATGAAGAGCAGGTGGAGATCCTCTGA

Upstream 100 bases:

>100_bases
CACATTTGATAGTCAAAACTACCCTTTCGACACCCCTCACAAACTGCTAGAATACGGCCCCAATAAAAACCACTCGATGT
ACCCTACTAGAGGATCCTCC

Downstream 100 bases:

>100_bases
TGAGTTGTCGCGTCGTTGTCCTTATCTCCGGCAGTGGCAGTAATCTGCAGGCCATTATCGACCAGTGTCAGGGCCGTAGC
GGCGTTGAACTGGTTGGCGT

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 345; Mature: 344

Protein sequence:

>345_residues
MSTPTPLSYKDAGVDIDAGNALVQNIKSAVKRTRRPEVMGNLGGFGALCELPTKYKHPVLVSGTDGVGTKLRLAIDFKSH
DTVGIDLVAMCVNDLIVQGAEPLFFLDYYATGKLDVETATSVVNGIGEGCFQSGCALIGGETAEMPGMYEGEDYDLAGFC
VGVVEKADIIDGTKVKAGDALIALASSGPHSNGYSLIRKVLEVSKADPQMDLNGKPLIKHLLEPTKIYVKSLLKLIAESD
VHAMAHITGGGFWENIPRVLPDNCKAVVQGDSWQWPVVFDWLQTAGNIETYEMYRTFNCGVGMIVALPADKVDAALELLK
AEGENAWHIGHIAARNGDEEQVEIL

Sequences:

>Translated_345_residues
MSTPTPLSYKDAGVDIDAGNALVQNIKSAVKRTRRPEVMGNLGGFGALCELPTKYKHPVLVSGTDGVGTKLRLAIDFKSH
DTVGIDLVAMCVNDLIVQGAEPLFFLDYYATGKLDVETATSVVNGIGEGCFQSGCALIGGETAEMPGMYEGEDYDLAGFC
VGVVEKADIIDGTKVKAGDALIALASSGPHSNGYSLIRKVLEVSKADPQMDLNGKPLIKHLLEPTKIYVKSLLKLIAESD
VHAMAHITGGGFWENIPRVLPDNCKAVVQGDSWQWPVVFDWLQTAGNIETYEMYRTFNCGVGMIVALPADKVDAALELLK
AEGENAWHIGHIAARNGDEEQVEIL
>Mature_344_residues
STPTPLSYKDAGVDIDAGNALVQNIKSAVKRTRRPEVMGNLGGFGALCELPTKYKHPVLVSGTDGVGTKLRLAIDFKSHD
TVGIDLVAMCVNDLIVQGAEPLFFLDYYATGKLDVETATSVVNGIGEGCFQSGCALIGGETAEMPGMYEGEDYDLAGFCV
GVVEKADIIDGTKVKAGDALIALASSGPHSNGYSLIRKVLEVSKADPQMDLNGKPLIKHLLEPTKIYVKSLLKLIAESDV
HAMAHITGGGFWENIPRVLPDNCKAVVQGDSWQWPVVFDWLQTAGNIETYEMYRTFNCGVGMIVALPADKVDAALELLKA
EGENAWHIGHIAARNGDEEQVEIL

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=350, Percent_Identity=47.1428571428571, Blast_Score=318, Evalue=4e-87,
Organism=Homo sapiens, GI209869995, Length=350, Percent_Identity=47.1428571428571, Blast_Score=318, Evalue=4e-87,
Organism=Homo sapiens, GI209869993, Length=350, Percent_Identity=47.1428571428571, Blast_Score=318, Evalue=4e-87,
Organism=Escherichia coli, GI1788845, Length=343, Percent_Identity=75.5102040816327, Blast_Score=545, Evalue=1e-156,
Organism=Caenorhabditis elegans, GI17567511, Length=348, Percent_Identity=42.2413793103448, Blast_Score=257, Evalue=7e-69,
Organism=Saccharomyces cerevisiae, GI6321203, Length=345, Percent_Identity=48.9855072463768, Blast_Score=318, Evalue=5e-88,
Organism=Drosophila melanogaster, GI24582400, Length=310, Percent_Identity=42.9032258064516, Blast_Score=236, Evalue=2e-62,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 37009; Mature: 36878

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTPTPLSYKDAGVDIDAGNALVQNIKSAVKRTRRPEVMGNLGGFGALCELPTKYKHPVL
CCCCCCCCCCCCCCEECCCHHHHHHHHHHHHHCCCCHHHHCCCCCCHHHCCCCCCCCCEE
VSGTDGVGTKLRLAIDFKSHDTVGIDLVAMCVNDLIVQGAEPLFFLDYYATGKLDVETAT
EECCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEEECCCEEHHHHH
SVVNGIGEGCFQSGCALIGGETAEMPGMYEGEDYDLAGFCVGVVEKADIIDGTKVKAGDA
HHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEECCCE
LIALASSGPHSNGYSLIRKVLEVSKADPQMDLNGKPLIKHLLEPTKIYVKSLLKLIAESD
EEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHCCC
VHAMAHITGGGFWENIPRVLPDNCKAVVQGDSWQWPVVFDWLQTAGNIETYEMYRTFNCG
CCEEEEECCCCHHHHCCCCCCCCCEEEEECCCCCCCHHHHHHHHCCCCEEEEEEEEECCC
VGMIVALPADKVDAALELLKAEGENAWHIGHIAARNGDEEQVEIL
CEEEEEECCHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCEEEEC
>Mature Secondary Structure 
STPTPLSYKDAGVDIDAGNALVQNIKSAVKRTRRPEVMGNLGGFGALCELPTKYKHPVL
CCCCCCCCCCCCCEECCCHHHHHHHHHHHHHCCCCHHHHCCCCCCHHHCCCCCCCCCEE
VSGTDGVGTKLRLAIDFKSHDTVGIDLVAMCVNDLIVQGAEPLFFLDYYATGKLDVETAT
EECCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEEECCCEEHHHHH
SVVNGIGEGCFQSGCALIGGETAEMPGMYEGEDYDLAGFCVGVVEKADIIDGTKVKAGDA
HHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEECCCE
LIALASSGPHSNGYSLIRKVLEVSKADPQMDLNGKPLIKHLLEPTKIYVKSLLKLIAESD
EEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHCCC
VHAMAHITGGGFWENIPRVLPDNCKAVVQGDSWQWPVVFDWLQTAGNIETYEMYRTFNCG
CCEEEEECCCCHHHHCCCCCCCCCEEEEECCCCCCCHHHHHHHHCCCCEEEEEEEEECCC
VGMIVALPADKVDAALELLKAEGENAWHIGHIAARNGDEEQVEIL
CEEEEEECCHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA