Click here to switch to the map view.

The map label for this gene is clpA [H]

Identifier: 119775191

GI number: 119775191

Start: 2490792

End: 2493053

Strand: Reverse

Name: clpA [H]

Synonym: Sama_2056

Alternate gene names: 119775191

Gene position: 2493053-2490792 (Counterclockwise)

Preceding gene: 119775192

Following gene: 119775187

Centisome position: 57.9

GC content: 53.45

Gene sequence:

>2262_bases
ATGCTGAACAAAGATCTTGAAGTGACGTTGAATCTGGCGTTTCAGCAGGCAAGGGATGCCCGCCATGAATACATGACAGT
AGAGCACTTACTGCTGGCACTTATCGATAATCCATCAGCCCAGGATGCCTTGGTTGCCTGCGGCGCCAACATAGATAAGC
TCAGGGAAGAAGTCGCCACCTTTATTTCTCAAACCACGCCGGTCATTACCGATCCCGATGATGATAGGGAAACCCAGCCT
ACACTCGGGTTCCAACGGGTGCTGCAACGGGCGGTGTTTCATGTGCAGTCCTCCGGTCGCAACGAAGTCACAGGTGCCAA
TGTCCTGGTGGCCATTTTCAGTGAGCAAGAATCCCAAGCTGTGTATTTACTTCGTCGCAGCGATATTACCCGCCTCGACG
TGGTCAATTACATCTCCCATGGGTTTTCAAAGAGTGAAGATGCACCTCAGGAATCTGAGCAGGAGCGCATCGAAGATCAT
TCAGAGCAGGGCGAAGAGCAGCGCAGCATGCTGTCTCAGTTTGCGGCCAACCTGAATTTATTGGCCGCACAGGGAGTGAT
TGACCCGCTTATCGGCCGTGACAACGAAATCGAGCGCTCAATCCAAATCCTCTGCCGCCGCCGGAAAAATAACCCCTTGC
TCGTGGGTGAGGCAGGCGTTGGGAAAACCGCTATTGCCGAAGGTTTGGCGTATCGCATCGTCAATGACGACGTGCCCGAA
GTCATGCGTGATGCCACCGTATATTCACTGGATCTTGGCGCGCTGCTTGCGGGTACCAAGTATCGTGGGGATTTTGAAAA
GCGGTTTAAGAGCCTGCTTAAAGAGCTCACAGCAGATAAGCACGCGATTCTCTTCATTGATGAAATACATACCATTATAG
GTGCGGGTGCTGCCTCCGGTGGGGTGATGGATGCCTCCAACCTGCTCAAACCGCTTCTTTCAAGTGGCACCTTGCGCTGC
ATGGGCTCCACTACCTTTCAGGAATACCAGAGTATTTTTGAGAAAGACCGTGCACTGGCGCGTCGCTTCCAGAAGATAGA
TATCAACGAGCCGTCGGTGGCCGAAACCACCAAGATTTTGATGGGGCTCAAGAGCAAGTACGAAGAACACCATGGGGTAC
GTTACACCCAGGCAGCCCTTGCCTGCGCGGCAGAGCTCAGCGCCAAACACATTAATGACCGGCATTTGCCGGACAAGGCT
ATTGATGTGATAGACGAAGCTGGCGCCCGCATGGCAATGCAACCGGCCAGTAAACGCAGAAAAACCATAGGCCAGGCGGA
AATTGAGGCCATTATCGCCAAAATCGCCCGTATTCCTGAAAAGTCTGTGTCCACCTCAGATAAGGACATGCTCAAGAACC
TTGAGCGTAACCTCAAGATGGTGGTCTTTGGCCAGGACAAAGCCATTGAGAGCTTGAGTGCCGCTATCCGTTTGTCCCGC
AGCGGATTGGGCGCCGACAACAAACCTGTGGGCAGTTTCCTCTTTGCCGGGCCAACCGGTGTGGGTAAAACCGAGGTCAC
CAATCAGCTTGCCAAATGCTTGGGGCTAAAGCTGGTACGCTTTGACATGTCTGAGTACATGGAGGCGCACACAGTATCGC
GTCTCATCGGCGCCCCTCCTGGCTACGTGGGCTACGATCAGGGCGGTTTGCTGACCGATGCCGTGATTAAGCAGCCCCAC
TGTGTGGTGCTGCTGGATGAAATCGAAAAGGCCCATCCGGATGTTTATAACTTGCTGCTGCAGGTGATGGATCACGGTAC
CCTGACCGATAACAACGGCCGCAAGGCGGACTTCCGCCATGTGACTCTGGTCATGACCACCAACGCGGGTGTGCAGGAGA
CTGTGCGTAAATCCATTGGCTTTAAACAGCAGGATCACAGCCACGATGCCATGTCGGAAATCAACCGGGTATTCTCACCC
GAATTCCGTAACCGTCTCGACTCCATCATTTGGTTTAACCACCTGGATTTAACCATTATTGCCAAGGTGGTGGACAAGTT
CCTGACCGAGTTGCAGGCGCAGCTCGATGCCAAACGGGTAACGCTGATGGTCAGTGATGAAGCCAGAACCCTGCTCGCAG
AGAAGGGTTACGACAAAGCTATGGGCGCCAGACCCATGGCCAGGGTGGTCAAAGACTTGATTAAACGACCTCTGGCCGAT
GAAATCCTCTTTGGCGAACTTGAGCATGGCGGCATGGCGCACGTCGATGCCAAAGACGGGGAAATCGTGATTTCTGCTGA
GCGTTTGGAGAAGGTTACCTGA

Upstream 100 bases:

>100_bases
ATTTGCCAGACAAAACCAACATCCATTACTGTGTTCTTTGGAGAAAGCCTAAAGCATCAAGTCTTTCCGTGCGCTTTAGC
AGCAGTTTTAGGGGGTATTT

Downstream 100 bases:

>100_bases
GGTGGCCTTGGCCTCTGAGAACAACAAAAAAACCCGGATGTTCCGGGTTTTTTATTTTGAAGGGCAAATCAGCGAGCGCG
GAAGACGATACGACCCTTGG

Product: ATP-dependent Clp protease, ATP-binding subunit ClpA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 753; Mature: 753

Protein sequence:

>753_residues
MLNKDLEVTLNLAFQQARDARHEYMTVEHLLLALIDNPSAQDALVACGANIDKLREEVATFISQTTPVITDPDDDRETQP
TLGFQRVLQRAVFHVQSSGRNEVTGANVLVAIFSEQESQAVYLLRRSDITRLDVVNYISHGFSKSEDAPQESEQERIEDH
SEQGEEQRSMLSQFAANLNLLAAQGVIDPLIGRDNEIERSIQILCRRRKNNPLLVGEAGVGKTAIAEGLAYRIVNDDVPE
VMRDATVYSLDLGALLAGTKYRGDFEKRFKSLLKELTADKHAILFIDEIHTIIGAGAASGGVMDASNLLKPLLSSGTLRC
MGSTTFQEYQSIFEKDRALARRFQKIDINEPSVAETTKILMGLKSKYEEHHGVRYTQAALACAAELSAKHINDRHLPDKA
IDVIDEAGARMAMQPASKRRKTIGQAEIEAIIAKIARIPEKSVSTSDKDMLKNLERNLKMVVFGQDKAIESLSAAIRLSR
SGLGADNKPVGSFLFAGPTGVGKTEVTNQLAKCLGLKLVRFDMSEYMEAHTVSRLIGAPPGYVGYDQGGLLTDAVIKQPH
CVVLLDEIEKAHPDVYNLLLQVMDHGTLTDNNGRKADFRHVTLVMTTNAGVQETVRKSIGFKQQDHSHDAMSEINRVFSP
EFRNRLDSIIWFNHLDLTIIAKVVDKFLTELQAQLDAKRVTLMVSDEARTLLAEKGYDKAMGARPMARVVKDLIKRPLAD
EILFGELEHGGMAHVDAKDGEIVISAERLEKVT

Sequences:

>Translated_753_residues
MLNKDLEVTLNLAFQQARDARHEYMTVEHLLLALIDNPSAQDALVACGANIDKLREEVATFISQTTPVITDPDDDRETQP
TLGFQRVLQRAVFHVQSSGRNEVTGANVLVAIFSEQESQAVYLLRRSDITRLDVVNYISHGFSKSEDAPQESEQERIEDH
SEQGEEQRSMLSQFAANLNLLAAQGVIDPLIGRDNEIERSIQILCRRRKNNPLLVGEAGVGKTAIAEGLAYRIVNDDVPE
VMRDATVYSLDLGALLAGTKYRGDFEKRFKSLLKELTADKHAILFIDEIHTIIGAGAASGGVMDASNLLKPLLSSGTLRC
MGSTTFQEYQSIFEKDRALARRFQKIDINEPSVAETTKILMGLKSKYEEHHGVRYTQAALACAAELSAKHINDRHLPDKA
IDVIDEAGARMAMQPASKRRKTIGQAEIEAIIAKIARIPEKSVSTSDKDMLKNLERNLKMVVFGQDKAIESLSAAIRLSR
SGLGADNKPVGSFLFAGPTGVGKTEVTNQLAKCLGLKLVRFDMSEYMEAHTVSRLIGAPPGYVGYDQGGLLTDAVIKQPH
CVVLLDEIEKAHPDVYNLLLQVMDHGTLTDNNGRKADFRHVTLVMTTNAGVQETVRKSIGFKQQDHSHDAMSEINRVFSP
EFRNRLDSIIWFNHLDLTIIAKVVDKFLTELQAQLDAKRVTLMVSDEARTLLAEKGYDKAMGARPMARVVKDLIKRPLAD
EILFGELEHGGMAHVDAKDGEIVISAERLEKVT
>Mature_753_residues
MLNKDLEVTLNLAFQQARDARHEYMTVEHLLLALIDNPSAQDALVACGANIDKLREEVATFISQTTPVITDPDDDRETQP
TLGFQRVLQRAVFHVQSSGRNEVTGANVLVAIFSEQESQAVYLLRRSDITRLDVVNYISHGFSKSEDAPQESEQERIEDH
SEQGEEQRSMLSQFAANLNLLAAQGVIDPLIGRDNEIERSIQILCRRRKNNPLLVGEAGVGKTAIAEGLAYRIVNDDVPE
VMRDATVYSLDLGALLAGTKYRGDFEKRFKSLLKELTADKHAILFIDEIHTIIGAGAASGGVMDASNLLKPLLSSGTLRC
MGSTTFQEYQSIFEKDRALARRFQKIDINEPSVAETTKILMGLKSKYEEHHGVRYTQAALACAAELSAKHINDRHLPDKA
IDVIDEAGARMAMQPASKRRKTIGQAEIEAIIAKIARIPEKSVSTSDKDMLKNLERNLKMVVFGQDKAIESLSAAIRLSR
SGLGADNKPVGSFLFAGPTGVGKTEVTNQLAKCLGLKLVRFDMSEYMEAHTVSRLIGAPPGYVGYDQGGLLTDAVIKQPH
CVVLLDEIEKAHPDVYNLLLQVMDHGTLTDNNGRKADFRHVTLVMTTNAGVQETVRKSIGFKQQDHSHDAMSEINRVFSP
EFRNRLDSIIWFNHLDLTIIAKVVDKFLTELQAQLDAKRVTLMVSDEARTLLAEKGYDKAMGARPMARVVKDLIKRPLAD
EILFGELEHGGMAHVDAKDGEIVISAERLEKVT

Specific function: ATP-dependent specificity component of the ClpP protease. It directs the protease to specific substrates. The primary function of the ClpA-ClpP complex appears to be the degradation of unfolded or abnormal proteins [H]

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=300, Percent_Identity=32.6666666666667, Blast_Score=151, Evalue=2e-36,
Organism=Escherichia coli, GI1787109, Length=737, Percent_Identity=70.6919945725916, Blast_Score=1083, Evalue=0.0,
Organism=Escherichia coli, GI1788943, Length=416, Percent_Identity=42.5480769230769, Blast_Score=291, Evalue=9e-80,
Organism=Saccharomyces cerevisiae, GI6320464, Length=261, Percent_Identity=55.1724137931034, Blast_Score=277, Evalue=3e-75,
Organism=Saccharomyces cerevisiae, GI6323002, Length=442, Percent_Identity=38.6877828054299, Blast_Score=269, Evalue=1e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR013461
- InterPro:   IPR023150 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 83326; Mature: 83326

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNKDLEVTLNLAFQQARDARHEYMTVEHLLLALIDNPSAQDALVACGANIDKLREEVAT
CCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCHHHHHHHHHH
FISQTTPVITDPDDDRETQPTLGFQRVLQRAVFHVQSSGRNEVTGANVLVAIFSEQESQA
HHHCCCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCE
VYLLRRSDITRLDVVNYISHGFSKSEDAPQESEQERIEDHSEQGEEQRSMLSQFAANLNL
EEEEECCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCHH
LAAQGVIDPLIGRDNEIERSIQILCRRRKNNPLLVGEAGVGKTAIAEGLAYRIVNDDVPE
HHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHEECCCCHHH
VMRDATVYSLDLGALLAGTKYRGDFEKRFKSLLKELTADKHAILFIDEIHTIIGAGAASG
HHHCCCEEEEEHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHCCCCCC
GVMDASNLLKPLLSSGTLRCMGSTTFQEYQSIFEKDRALARRFQKIDINEPSVAETTKIL
CCCCHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
MGLKSKYEEHHGVRYTQAALACAAELSAKHINDRHLPDKAIDVIDEAGARMAMQPASKRR
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHHCCCHHHHH
KTIGQAEIEAIIAKIARIPEKSVSTSDKDMLKNLERNLKMVVFGQDKAIESLSAAIRLSR
HHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHH
SGLGADNKPVGSFLFAGPTGVGKTEVTNQLAKCLGLKLVRFDMSEYMEAHTVSRLIGAPP
CCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCC
GYVGYDQGGLLTDAVIKQPHCVVLLDEIEKAHPDVYNLLLQVMDHGTLTDNNGRKADFRH
CCCCCCCCCCHHHHHHCCCCEEEEHHHHHHHCCHHHHHHHHHHHCCCEECCCCCCCCCEE
VTLVMTTNAGVQETVRKSIGFKQQDHSHDAMSEINRVFSPEFRNRLDSIIWFNHLDLTII
EEEEEECCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHH
AKVVDKFLTELQAQLDAKRVTLMVSDEARTLLAEKGYDKAMGARPMARVVKDLIKRPLAD
HHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHCCCCHHHCCCHHHHHHHHHHHCCCHH
EILFGELEHGGMAHVDAKDGEIVISAERLEKVT
HHHHHHHCCCCEEEEECCCCCEEEEHHHHHCCC
>Mature Secondary Structure
MLNKDLEVTLNLAFQQARDARHEYMTVEHLLLALIDNPSAQDALVACGANIDKLREEVAT
CCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCHHHHHHHHHH
FISQTTPVITDPDDDRETQPTLGFQRVLQRAVFHVQSSGRNEVTGANVLVAIFSEQESQA
HHHCCCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCE
VYLLRRSDITRLDVVNYISHGFSKSEDAPQESEQERIEDHSEQGEEQRSMLSQFAANLNL
EEEEECCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCHH
LAAQGVIDPLIGRDNEIERSIQILCRRRKNNPLLVGEAGVGKTAIAEGLAYRIVNDDVPE
HHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHEECCCCHHH
VMRDATVYSLDLGALLAGTKYRGDFEKRFKSLLKELTADKHAILFIDEIHTIIGAGAASG
HHHCCCEEEEEHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHCCCCCC
GVMDASNLLKPLLSSGTLRCMGSTTFQEYQSIFEKDRALARRFQKIDINEPSVAETTKIL
CCCCHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
MGLKSKYEEHHGVRYTQAALACAAELSAKHINDRHLPDKAIDVIDEAGARMAMQPASKRR
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHHCCCHHHHH
KTIGQAEIEAIIAKIARIPEKSVSTSDKDMLKNLERNLKMVVFGQDKAIESLSAAIRLSR
HHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHH
SGLGADNKPVGSFLFAGPTGVGKTEVTNQLAKCLGLKLVRFDMSEYMEAHTVSRLIGAPP
CCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCC
GYVGYDQGGLLTDAVIKQPHCVVLLDEIEKAHPDVYNLLLQVMDHGTLTDNNGRKADFRH
CCCCCCCCCCHHHHHHCCCCEEEEHHHHHHHCCHHHHHHHHHHHCCCEECCCCCCCCCEE
VTLVMTTNAGVQETVRKSIGFKQQDHSHDAMSEINRVFSPEFRNRLDSIIWFNHLDLTII
EEEEEECCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHH
AKVVDKFLTELQAQLDAKRVTLMVSDEARTLLAEKGYDKAMGARPMARVVKDLIKRPLAD
HHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHCCCCHHHCCCHHHHHHHHHHHCCCHH
EILFGELEHGGMAHVDAKDGEIVISAERLEKVT
HHHHHHHCCCCEEEEECCCCCEEEEHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]