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The map label for this gene is fabH [H]

Identifier: 119775117

GI number: 119775117

Start: 2410331

End: 2411290

Strand: Reverse

Name: fabH [H]

Synonym: Sama_1982

Alternate gene names: 119775117

Gene position: 2411290-2410331 (Counterclockwise)

Preceding gene: 119775118

Following gene: 119775116

Centisome position: 56.0

GC content: 53.65

Gene sequence:

>960_bases
ATGCATACAAAAATTCTTGGAACTGGCAGTTACCTGCCGGCTCAGGTGCGTAGCAATCTCGATCTGGAAAAAATGGTGGA
TACCAGTGACCAGTGGATTGTTGAACGCACAGGTATTTCCGAACGTCGCATCGCTGCCATGGACGAGACTGTTTCTACCA
TGGGTTACCAGGCCGCATTGAAAGCCCTCGAGATGGCGGGTATTCAAGCACAAGAGCTGGACATGATCATTTGTGGTACC
ACCAGTGCTGCCAATGCATTTCCCGCCGCCGCCTGTGAAGTTCAGGCACTCCTGGGGGTTCACACCATTCCTGCATTTGA
TGTTGCCGCTGCCTGCTCCGGTTTCGTTTATGCCCTGTCGGTTGCCGATCAGTTCGTCAAAACCGGCGCTGCCAAAAAAG
TGCTTGTGATTGGTGCCGATGTGCTCTCTCGCCTGTGTGAACCCGAAGACCGCACCACCATTATTCTCTTTGGTGATGGC
GCCGGTGCCGCTGTAGTCGGTGCCAGTGAAGAGCCGGGGATCATCAATACTCACATCTATGCAGATGGCCGTCAGGGCGA
CCTGCTCAAATGTGCCTTCCCACCACGTCTGGGTGAATCTTCAGAAGCCGTGGGCTTTATGCAGATGAAGGGCAACGATG
TGTTCAAGGTTGCCGTGACTCAGCTGTCCCATGTCGTGGAAGAAACCCTGCGCCTCAATAATGTGGACAAGGCAGAGATT
GACTGGCTGGTACCCCACCAGGCGAACTTCCGTATTATCAATGCCACTGCAAAGAAGCTCGACATGAGTTTAGATAAAGT
GGTGTTGACGCTTGCCAAACACGGTAACACTTCCGCTGCCTCTGTGCCGATTGCCCTGGATGAAGCTGTGCGTGATGGAC
GTATTCAGCGGGGACAATTGCTGCTTTTGGAAGCCTTTGGCGCCGGTTTTGCCTGGGGTAGTGCGCTGGTGCGCTTCTAA

Upstream 100 bases:

>100_bases
GTCTTGCCTACACCGAGGCAAAACGTCGACTTCCAGAGATGATCAAAGATCGTCTTGAGTCGATTCTTTTAGATATCAAT
AGCTGATTTCTCCTTAAACT

Downstream 100 bases:

>100_bases
TTTCCCCGGGAATTCTGCTAGGCTTTTTACGCTTTTACTCAAAAAGGTTTAATAACAATGGATAAATTTGCCTTTGTATT
TCCAGGGCAGGGCTCGCAGG

Product: 3-oxoacyl-(acyl carrier protein) synthase III

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase III; Beta-ketoacyl-ACP synthase III; KAS III [H]

Number of amino acids: Translated: 319; Mature: 319

Protein sequence:

>319_residues
MHTKILGTGSYLPAQVRSNLDLEKMVDTSDQWIVERTGISERRIAAMDETVSTMGYQAALKALEMAGIQAQELDMIICGT
TSAANAFPAAACEVQALLGVHTIPAFDVAAACSGFVYALSVADQFVKTGAAKKVLVIGADVLSRLCEPEDRTTIILFGDG
AGAAVVGASEEPGIINTHIYADGRQGDLLKCAFPPRLGESSEAVGFMQMKGNDVFKVAVTQLSHVVEETLRLNNVDKAEI
DWLVPHQANFRIINATAKKLDMSLDKVVLTLAKHGNTSAASVPIALDEAVRDGRIQRGQLLLLEAFGAGFAWGSALVRF

Sequences:

>Translated_319_residues
MHTKILGTGSYLPAQVRSNLDLEKMVDTSDQWIVERTGISERRIAAMDETVSTMGYQAALKALEMAGIQAQELDMIICGT
TSAANAFPAAACEVQALLGVHTIPAFDVAAACSGFVYALSVADQFVKTGAAKKVLVIGADVLSRLCEPEDRTTIILFGDG
AGAAVVGASEEPGIINTHIYADGRQGDLLKCAFPPRLGESSEAVGFMQMKGNDVFKVAVTQLSHVVEETLRLNNVDKAEI
DWLVPHQANFRIINATAKKLDMSLDKVVLTLAKHGNTSAASVPIALDEAVRDGRIQRGQLLLLEAFGAGFAWGSALVRF
>Mature_319_residues
MHTKILGTGSYLPAQVRSNLDLEKMVDTSDQWIVERTGISERRIAAMDETVSTMGYQAALKALEMAGIQAQELDMIICGT
TSAANAFPAAACEVQALLGVHTIPAFDVAAACSGFVYALSVADQFVKTGAAKKVLVIGADVLSRLCEPEDRTTIILFGDG
AGAAVVGASEEPGIINTHIYADGRQGDLLKCAFPPRLGESSEAVGFMQMKGNDVFKVAVTQLSHVVEETLRLNNVDKAEI
DWLVPHQANFRIINATAKKLDMSLDKVVLTLAKHGNTSAASVPIALDEAVRDGRIQRGQLLLLEAFGAGFAWGSALVRF

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the

COG id: COG0332

COG function: function code I; 3-oxoacyl-[acyl-carrier-protein] synthase III

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabH family [H]

Homologues:

Organism=Escherichia coli, GI1787333, Length=319, Percent_Identity=67.398119122257, Blast_Score=453, Evalue=1e-129,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013751
- InterPro:   IPR013747
- InterPro:   IPR004655
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF08545 ACP_syn_III; PF08541 ACP_syn_III_C [H]

EC number: =2.3.1.180 [H]

Molecular weight: Translated: 33989; Mature: 33989

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS00435 PEROXIDASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHTKILGTGSYLPAQVRSNLDLEKMVDTSDQWIVERTGISERRIAAMDETVSTMGYQAAL
CCCEEEECCCCCHHHHHCCCCHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHH
KALEMAGIQAQELDMIICGTTSAANAFPAAACEVQALLGVHTIPAFDVAAACSGFVYALS
HHHHHCCCCHHHCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
VADQFVKTGAAKKVLVIGADVLSRLCEPEDRTTIILFGDGAGAAVVGASEEPGIINTHIY
HHHHHHHCCCCCEEEEECHHHHHHHCCCCCCEEEEEEECCCCEEEEECCCCCCEEEEEEE
ADGRQGDLLKCAFPPRLGESSEAVGFMQMKGNDVFKVAVTQLSHVVEETLRLNNVDKAEI
ECCCCCCEEEEECCCCCCCCCCCEEEEEECCCCEEHHHHHHHHHHHHHHHHCCCCCCCCE
DWLVPHQANFRIINATAKKLDMSLDKVVLTLAKHGNTSAASVPIALDEAVRDGRIQRGQL
EEECCCCCCEEEEECHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEHHHHHHCCCCCCCCE
LLLEAFGAGFAWGSALVRF
EEEEECCCCHHHHHHHHCC
>Mature Secondary Structure
MHTKILGTGSYLPAQVRSNLDLEKMVDTSDQWIVERTGISERRIAAMDETVSTMGYQAAL
CCCEEEECCCCCHHHHHCCCCHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHH
KALEMAGIQAQELDMIICGTTSAANAFPAAACEVQALLGVHTIPAFDVAAACSGFVYALS
HHHHHCCCCHHHCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
VADQFVKTGAAKKVLVIGADVLSRLCEPEDRTTIILFGDGAGAAVVGASEEPGIINTHIY
HHHHHHHCCCCCEEEEECHHHHHHHCCCCCCEEEEEEECCCCEEEEECCCCCCEEEEEEE
ADGRQGDLLKCAFPPRLGESSEAVGFMQMKGNDVFKVAVTQLSHVVEETLRLNNVDKAEI
ECCCCCCEEEEECCCCCCCCCCCEEEEEECCCCEEHHHHHHHHHHHHHHHHCCCCCCCCE
DWLVPHQANFRIINATAKKLDMSLDKVVLTLAKHGNTSAASVPIALDEAVRDGRIQRGQL
EEECCCCCCEEEEECHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEHHHHHHCCCCCCCCE
LLLEAFGAGFAWGSALVRF
EEEEECCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]