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The map label for this gene is fabF [H]

Identifier: 119775113

GI number: 119775113

Start: 2406797

End: 2408035

Strand: Reverse

Name: fabF [H]

Synonym: Sama_1978

Alternate gene names: 119775113

Gene position: 2408035-2406797 (Counterclockwise)

Preceding gene: 119775114

Following gene: 119775112

Centisome position: 55.92

GC content: 57.14

Gene sequence:

>1239_bases
GTGACAAAACGTCGCGTAGTGATAACCGGTCTGGGACTGGTAACCCCGGTCGGTAATGATGTTGATTCCACCTGGAAGGC
TTTGCTTGCCGGTCAGAGTGGTGTGGCGCCCATCACCAAGTTTGACGCCAGTGAATTTGCGACCCGCTTCAGCGCGTCGG
TAAAAGATTTCGACGTTGAGCAGTATCTGTCCAAAAAAGATGCACGCAAGATGGACCTCTTTATCCAATACGGCATGGCT
GCTGGCATTCAGGCCATTCGCGATGCTGGCCTTGACATGGAAAAAGAAGACCCCACCCGCGTAGGTACCGCCATCGGTGC
CGGTATGGGCGGTATGTGGCTGATTGAAGCCGGTCACTCAGCGCTGATGGCCGGTGGCCCCCGTAAGATCTCCCCCTTCT
TCGTACCCAGCACCATCATCAACATGATTGCCGGTCACCTGTCGATCATGTATGGCATGCGCGGCCCCAACTTTGCCGTA
ACCACTGCCTGTACCACGGGCGTACACAATATCGGTTTTGCCGCTCGCTCTATTGCCTATGGCGATGCTGACGTAATGGT
GGCCGGTGGCGCTGAAGATGTGACCTGTCCGCTGGGTGTGGGTGGCTTTAACGCTGCCAAGGCGCTCTCGACCCGCAATG
ACGACCCACAAGCGGCAAGTCGCCCATGGGATCGTGACCGCGATGGTTTTGTGATTGGTGACGGCGCTGGTGTACTGGTG
ATGGAAGAGTACGAGCACGCCAAAGCCCGTGGCGCCAAGATTTACGCCGAACTGGTTGGTTTTGGTATGAGCGGTGACGC
TTTCCATATGACGTCGCCTCCGGAAGATGGCGCCGGTGCGGCGCTGGCAATGACCAATGCTCTCAAAGACAGCGGTCTCT
CGCTGGAGTCCATTGGTTACATTAACGCCCACGGTACCTCAACGCCAGCCGGTGACAAGGCCGAAGCCGCCGCGGTGAAG
TCCGTGTTTGGTGACCACGCCTACAAGCTGATGGTGAGCTCCACCAAGTCCATGACAGGCCATTTGCTGGGCGCGGCCGG
TGCGGTGGAAGCTATTTTTACCATTCTGGCGCTGAAAGATGGCGCTGTGCCGCCAACCATCAACCTGGATAATCCGGATG
AAGGTTGCGATCTTGACTTCGTGCCCCACGAGGCGCGTCAGACCAGCTTCGAGTATGCCCTGTGTAACTCCTTCGGCTTT
GGCGGCACCAACGGCTCGCTGTTACTTAAAAAGATGTGA

Upstream 100 bases:

>100_bases
TTTCTGCTGGTTGTACCAGCCTCCTTTTGGATTGCCATCTGGCACAATCCGGCGCAATTTGGGCTTTTAGCCTCAAATAC
AGTTATGAAAGGTGACTCCT

Downstream 100 bases:

>100_bases
TCAGGCAGTTTGATTGTTTGATGAAGGCGCCGGGACGTTTCGTTCTGGCGCCTTTTCTTTTTGTCGGTGCATTCACGTGC
TTATGCTTTTGGCGTAAGCT

Product: 3-oxoacyl-(acyl-carrier-protein) synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 412; Mature: 411

Protein sequence:

>412_residues
MTKRRVVITGLGLVTPVGNDVDSTWKALLAGQSGVAPITKFDASEFATRFSASVKDFDVEQYLSKKDARKMDLFIQYGMA
AGIQAIRDAGLDMEKEDPTRVGTAIGAGMGGMWLIEAGHSALMAGGPRKISPFFVPSTIINMIAGHLSIMYGMRGPNFAV
TTACTTGVHNIGFAARSIAYGDADVMVAGGAEDVTCPLGVGGFNAAKALSTRNDDPQAASRPWDRDRDGFVIGDGAGVLV
MEEYEHAKARGAKIYAELVGFGMSGDAFHMTSPPEDGAGAALAMTNALKDSGLSLESIGYINAHGTSTPAGDKAEAAAVK
SVFGDHAYKLMVSSTKSMTGHLLGAAGAVEAIFTILALKDGAVPPTINLDNPDEGCDLDFVPHEARQTSFEYALCNSFGF
GGTNGSLLLKKM

Sequences:

>Translated_412_residues
MTKRRVVITGLGLVTPVGNDVDSTWKALLAGQSGVAPITKFDASEFATRFSASVKDFDVEQYLSKKDARKMDLFIQYGMA
AGIQAIRDAGLDMEKEDPTRVGTAIGAGMGGMWLIEAGHSALMAGGPRKISPFFVPSTIINMIAGHLSIMYGMRGPNFAV
TTACTTGVHNIGFAARSIAYGDADVMVAGGAEDVTCPLGVGGFNAAKALSTRNDDPQAASRPWDRDRDGFVIGDGAGVLV
MEEYEHAKARGAKIYAELVGFGMSGDAFHMTSPPEDGAGAALAMTNALKDSGLSLESIGYINAHGTSTPAGDKAEAAAVK
SVFGDHAYKLMVSSTKSMTGHLLGAAGAVEAIFTILALKDGAVPPTINLDNPDEGCDLDFVPHEARQTSFEYALCNSFGF
GGTNGSLLLKKM
>Mature_411_residues
TKRRVVITGLGLVTPVGNDVDSTWKALLAGQSGVAPITKFDASEFATRFSASVKDFDVEQYLSKKDARKMDLFIQYGMAA
GIQAIRDAGLDMEKEDPTRVGTAIGAGMGGMWLIEAGHSALMAGGPRKISPFFVPSTIINMIAGHLSIMYGMRGPNFAVT
TACTTGVHNIGFAARSIAYGDADVMVAGGAEDVTCPLGVGGFNAAKALSTRNDDPQAASRPWDRDRDGFVIGDGAGVLVM
EEYEHAKARGAKIYAELVGFGMSGDAFHMTSPPEDGAGAALAMTNALKDSGLSLESIGYINAHGTSTPAGDKAEAAAVKS
VFGDHAYKLMVSSTKSMTGHLLGAAGAVEAIFTILALKDGAVPPTINLDNPDEGCDLDFVPHEARQTSFEYALCNSFGFG
GTNGSLLLKKM

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthes

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=416, Percent_Identity=48.5576923076923, Blast_Score=375, Evalue=1e-104,
Organism=Homo sapiens, GI223972627, Length=152, Percent_Identity=55.2631578947368, Blast_Score=155, Evalue=6e-38,
Organism=Homo sapiens, GI41872631, Length=422, Percent_Identity=25.3554502369668, Blast_Score=96, Evalue=8e-20,
Organism=Escherichia coli, GI1787337, Length=413, Percent_Identity=73.6077481840194, Blast_Score=609, Evalue=1e-175,
Organism=Escherichia coli, GI1788663, Length=414, Percent_Identity=38.1642512077295, Blast_Score=253, Evalue=2e-68,
Organism=Caenorhabditis elegans, GI71983541, Length=412, Percent_Identity=39.8058252427184, Blast_Score=281, Evalue=3e-76,
Organism=Caenorhabditis elegans, GI71983535, Length=265, Percent_Identity=45.2830188679245, Blast_Score=226, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI212642053, Length=361, Percent_Identity=23.8227146814404, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17550940, Length=355, Percent_Identity=24.2253521126761, Blast_Score=98, Evalue=7e-21,
Organism=Saccharomyces cerevisiae, GI6320904, Length=448, Percent_Identity=40.625, Blast_Score=295, Evalue=7e-81,
Organism=Drosophila melanogaster, GI24644341, Length=417, Percent_Identity=43.6450839328537, Blast_Score=348, Evalue=3e-96,
Organism=Drosophila melanogaster, GI24581345, Length=428, Percent_Identity=24.0654205607477, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI221330659, Length=378, Percent_Identity=24.3386243386243, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI19920632, Length=378, Percent_Identity=24.3386243386243, Blast_Score=102, Evalue=5e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 42995; Mature: 42864

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKRRVVITGLGLVTPVGNDVDSTWKALLAGQSGVAPITKFDASEFATRFSASVKDFDVE
CCCCEEEEEECCEECCCCCCHHHHHHHHHCCCCCCCCCEECCHHHHHHHHHCCCCCCCHH
QYLSKKDARKMDLFIQYGMAAGIQAIRDAGLDMEKEDPTRVGTAIGAGMGGMWLIEAGHS
HHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCEEEEECCCC
ALMAGGPRKISPFFVPSTIINMIAGHLSIMYGMRGPNFAVTTACTTGVHNIGFAARSIAY
EEECCCCCCCCCEECHHHHHHHHHHHHHHEECCCCCCEEEEEEHHCCCHHHCHHHHHEEE
GDADVMVAGGAEDVTCPLGVGGFNAAKALSTRNDDPQAASRPWDRDRDGFVIGDGAGVLV
CCCCEEEECCCCCCEECCCCCCCHHHHHHHCCCCCCCHHCCCCCCCCCCEEEECCCCEEE
MEEYEHAKARGAKIYAELVGFGMSGDAFHMTSPPEDGAGAALAMTNALKDSGLSLESIGY
EECHHHHHHCCHHEEEHHHCCCCCCCEEECCCCCCCCCCCCHHHHHHHHHCCCCHHHCEE
INAHGTSTPAGDKAEAAAVKSVFGDHAYKLMVSSTKSMTGHLLGAAGAVEAIFTILALKD
EECCCCCCCCCCCHHHHHHHHHHCCHHEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCC
GAVPPTINLDNPDEGCDLDFVPHEARQTSFEYALCNSFGFGGTNGSLLLKKM
CCCCCEEECCCCCCCCCCCCCCCHHHHCCHHEEECCCCCCCCCCCCEEEEEC
>Mature Secondary Structure 
TKRRVVITGLGLVTPVGNDVDSTWKALLAGQSGVAPITKFDASEFATRFSASVKDFDVE
CCCEEEEEECCEECCCCCCHHHHHHHHHCCCCCCCCCEECCHHHHHHHHHCCCCCCCHH
QYLSKKDARKMDLFIQYGMAAGIQAIRDAGLDMEKEDPTRVGTAIGAGMGGMWLIEAGHS
HHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCEEEEECCCC
ALMAGGPRKISPFFVPSTIINMIAGHLSIMYGMRGPNFAVTTACTTGVHNIGFAARSIAY
EEECCCCCCCCCEECHHHHHHHHHHHHHHEECCCCCCEEEEEEHHCCCHHHCHHHHHEEE
GDADVMVAGGAEDVTCPLGVGGFNAAKALSTRNDDPQAASRPWDRDRDGFVIGDGAGVLV
CCCCEEEECCCCCCEECCCCCCCHHHHHHHCCCCCCCHHCCCCCCCCCCEEEECCCCEEE
MEEYEHAKARGAKIYAELVGFGMSGDAFHMTSPPEDGAGAALAMTNALKDSGLSLESIGY
EECHHHHHHCCHHEEEHHHCCCCCCCEEECCCCCCCCCCCCHHHHHHHHHCCCCHHHCEE
INAHGTSTPAGDKAEAAAVKSVFGDHAYKLMVSSTKSMTGHLLGAAGAVEAIFTILALKD
EECCCCCCCCCCCHHHHHHHHHHCCHHEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCC
GAVPPTINLDNPDEGCDLDFVPHEARQTSFEYALCNSFGFGGTNGSLLLKKM
CCCCCEEECCCCCCCCCCCCCCCHHHHCCHHEEECCCCCCCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8550484 [H]