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The map label for this gene is gcvR [H]

Identifier: 119775044

GI number: 119775044

Start: 2337549

End: 2338076

Strand: Direct

Name: gcvR [H]

Synonym: Sama_1909

Alternate gene names: 119775044

Gene position: 2337549-2338076 (Clockwise)

Preceding gene: 119775039

Following gene: 119775045

Centisome position: 54.28

GC content: 53.98

Gene sequence:

>528_bases
ATGACCAATTACCTGGTCGTCACCGCCATGGGATCCGATCGTCCCGGTATCGTCAGCAAGCTCGCCCGTCTGGCCAGTGA
CTGTGATTGTGATATCGTCGACAGCCGCATGGCGCTTTTCGGCAATGAATTTACCTTGATCATGATGGTGTCCGGCTCCT
GGGCCGCCATCACCAAAATTGAAGCCGCCCTGCCCCCATTGTCGGTGGAAATGGAACTGCTGACCGTGATGAAGCGCACC
TCGCGCCACACCCCACAAAACTATGTGTCGCGAATTGAGGTGGAATTCCACGGAAAGGACCAGCGCGGCACCATGAAGCG
CATCACTCAGTTTTTGGCCGACCGTTCGCTGGATTTGGCGGCGGTGCGCTCAAACGCCGAGGAAACGGCAGCAGGCGAAT
CTATTCAGCACGTGTTCCTCGCCATCAATATTCCTGAAAAAGTTGAACTGGATAAGCTCGAAAAGAGTATTCATGAACTG
GCAAGCGACATGTCGCTGGCATGCCAGATTAAGAGAATGCAAAGCTAA

Upstream 100 bases:

>100_bases
TCTCAAAAGGATTTGTTTGTGGTAGCATTGGCGCGCGTCAAAACCACTGCCGATGTGGTTAAAAAGACGCCATGACAACG
ACACAATAAGAGGAACCTAC

Downstream 100 bases:

>100_bases
CCCGGTGTTAACCAAAAGGACGACTAATGAATACCTTAAAAGCAGGCGATAAAGCCCCGCATTTTACCTTGCCCAATCAA
AATGGTGAGATGATTTCCCT

Product: glycine cleavage system transcriptional repressor

Products: NA

Alternate protein names: Gcv operon repressor [H]

Number of amino acids: Translated: 175; Mature: 174

Protein sequence:

>175_residues
MTNYLVVTAMGSDRPGIVSKLARLASDCDCDIVDSRMALFGNEFTLIMMVSGSWAAITKIEAALPPLSVEMELLTVMKRT
SRHTPQNYVSRIEVEFHGKDQRGTMKRITQFLADRSLDLAAVRSNAEETAAGESIQHVFLAINIPEKVELDKLEKSIHEL
ASDMSLACQIKRMQS

Sequences:

>Translated_175_residues
MTNYLVVTAMGSDRPGIVSKLARLASDCDCDIVDSRMALFGNEFTLIMMVSGSWAAITKIEAALPPLSVEMELLTVMKRT
SRHTPQNYVSRIEVEFHGKDQRGTMKRITQFLADRSLDLAAVRSNAEETAAGESIQHVFLAINIPEKVELDKLEKSIHEL
ASDMSLACQIKRMQS
>Mature_174_residues
TNYLVVTAMGSDRPGIVSKLARLASDCDCDIVDSRMALFGNEFTLIMMVSGSWAAITKIEAALPPLSVEMELLTVMKRTS
RHTPQNYVSRIEVEFHGKDQRGTMKRITQFLADRSLDLAAVRSNAEETAAGESIQHVFLAINIPEKVELDKLEKSIHELA
SDMSLACQIKRMQS

Specific function: Negative transcriptional regulator of the glycine cleavage system operon (GCV). Does not autoregulate its own expression. It is not yet known how gcvR acts as a repressor. It does not seem to bind DNA. It could interact with gcvA and suppress its activato

COG id: COG2716

COG function: function code E; Glycine cleavage system regulatory protein

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI87082113, Length=164, Percent_Identity=34.7560975609756, Blast_Score=110, Evalue=4e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR016867 [H]

Pfam domain/function: PF01842 ACT [H]

EC number: NA

Molecular weight: Translated: 19446; Mature: 19315

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
5.7 %Met     (Translated Protein)
7.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
6.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNYLVVTAMGSDRPGIVSKLARLASDCDCDIVDSRMALFGNEFTLIMMVSGSWAAITKI
CCCEEEEEEECCCCCCHHHHHHHHHCCCCCCHHHHHHHHHCCCEEEEEEECCCCHHHHHH
EAALPPLSVEMELLTVMKRTSRHTPQNYVSRIEVEFHGKDQRGTMKRITQFLADRSLDLA
HHHCCCCCHHHHHHHHHHHHCCCCCHHHHHEEEEEECCCCCCCHHHHHHHHHHCCCCCHH
AVRSNAEETAAGESIQHVFLAINIPEKVELDKLEKSIHELASDMSLACQIKRMQS
HHHCCCHHHHCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TNYLVVTAMGSDRPGIVSKLARLASDCDCDIVDSRMALFGNEFTLIMMVSGSWAAITKI
CCEEEEEEECCCCCCHHHHHHHHHCCCCCCHHHHHHHHHCCCEEEEEEECCCCHHHHHH
EAALPPLSVEMELLTVMKRTSRHTPQNYVSRIEVEFHGKDQRGTMKRITQFLADRSLDLA
HHHCCCCCHHHHHHHHHHHHCCCCCHHHHHEEEEEECCCCCCCHHHHHHHHHHCCCCCHH
AVRSNAEETAAGESIQHVFLAINIPEKVELDKLEKSIHELASDMSLACQIKRMQS
HHHCCCHHHHCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537378; 9205837; 9278503; 2016588 [H]