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The map label for this gene is cpxA [H]

Identifier: 119775001

GI number: 119775001

Start: 2275054

End: 2276460

Strand: Direct

Name: cpxA [H]

Synonym: Sama_1866

Alternate gene names: 119775001

Gene position: 2275054-2276460 (Clockwise)

Preceding gene: 119774997

Following gene: 119775002

Centisome position: 52.83

GC content: 56.22

Gene sequence:

>1407_bases
ATGAAGTTGTCCCGCCATCACCCCTTTGCCCGCCTGCAATGGCGCCTGTTTGGCTATTTCGGTTCCTCCTTGTTGGTGAT
TTTGTTATTGGCCAGTCTGATCGAAGCCATGGTGCTGCACCAACTGTTGGTGTTGCCCAAAGAGACCAAGGCAAAGCTGT
CGATGCTTGCTCAAGAGGCCGAAGCTCTCATTAAACAGGGCTCCCCCCAGGCGATTGCCCAGTGGGAGGCGGCGCAGTCG
TTCCGCTTGCATGTGATTAACAGCCGTCTAGAAGGCGTCAGCGGCCGCCCCATTCATCCGCACTTTGAATTTAAGCTGGG
ATTTATGCTTGGACCGGATCAGGCGCTGGGGGATCGGGTGCAAAAGCCCATCATCGGCTTGCCGATTTATGCCACCTTAG
ATGGCAGCGGACCTCTGCTTTTGGCAGTGCAGCTTAATGCCGATCTTCATCCGGCCAAGGATCTCAGTTACAGCCTGTGG
GCCATTCGGTTAACCGTGGGATTATTTGTGCTATGGCTTTTCAGTCGCCTGCTGGGACATTACCTCATCAAACCGCTGGC
GACGTTGCAACAGGGCACCCGCGCCTTGGCAAGCGGTAAACTCAGTACCCGCATCGGCGAGCACTTTTCGGCGGCTGAAC
CTGAGTTTTATCAGCTCGGTCACGACTTTGATGAAATGGCGGATGTGATTGAACGCACCCTCACCACCCAGGAGCGCCTG
ATCCGCGACGTGTCCCATGAACTGCGCACCCCGCTTGCCCGGCAAAAGCTGGCCGCTGAATTGCTGGAGAGCGACCTGGC
AGACACCTCGCCTTACCTTAAGCGGATCCACGCTGAAAACAGCGAACTCAGCCGCCTGATAGACACACTTCTGGGTTACA
GCCGCCTCGCCAGTGGTTATCAGGCCGCGCGCAGCACATCATTTACCCTGCACGAGCTGGCTTGCTCACTTCTGGGGGAT
TGCCGCTTTGAAGCGGCGCCAACACAAAGTATCGAGTGGCAGGCTTTGAGCGCCTGCAAGTATATCGCCCTTGAAACCGA
TCAAAGTCTGCTGCTGCGGGCGCTGGAAAACCTGGTGCGCAACAGCCTTAAATACGCAGGAACTGAATGTCATATTCAGA
TAAGCAGCCACTGCGATGATAGCTGGCTCACTATCACAGTGGAGGATGATGGTCCGGGTATAGATGACACCAAACTCGAG
ACCCTGTTTCATCCCTTTACCCGCTTTGATGAGGCCCGTCATGCCAGTCAGGGCGGCTTTGGGCTGGGGCTTGCCATAGT
GCGGGAGTGTATGCGTCTGCTCGGCGGCGATGTCTCGGCCGGGCGAAGTGAACTTGGTGGGTTGGAAGTTAAGCTGTTGC
TGCCGATGCGGCTTAAAAGGCTGGCCGCTACCGACAAGGCAATTTAG

Upstream 100 bases:

>100_bases
TACAGTATAACAATTATGACAAACTTGCCAATCCTCTGGGATCTGAAAAGACAAGGTGTATAATGCGAATCATTTTTATT
TATGAGTCTGTGCGATTGTC

Downstream 100 bases:

>100_bases
TATAGGTGCATGAATTGCTTTTGGAAGGTGCGCGGATGTCCAGCCTGAGTCCAAGCCGGATTTGGCATATAGTGACCCTC
ATTCCCGAGGGCAAGGTGCT

Product: putative two-component system sensor kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 468; Mature: 468

Protein sequence:

>468_residues
MKLSRHHPFARLQWRLFGYFGSSLLVILLLASLIEAMVLHQLLVLPKETKAKLSMLAQEAEALIKQGSPQAIAQWEAAQS
FRLHVINSRLEGVSGRPIHPHFEFKLGFMLGPDQALGDRVQKPIIGLPIYATLDGSGPLLLAVQLNADLHPAKDLSYSLW
AIRLTVGLFVLWLFSRLLGHYLIKPLATLQQGTRALASGKLSTRIGEHFSAAEPEFYQLGHDFDEMADVIERTLTTQERL
IRDVSHELRTPLARQKLAAELLESDLADTSPYLKRIHAENSELSRLIDTLLGYSRLASGYQAARSTSFTLHELACSLLGD
CRFEAAPTQSIEWQALSACKYIALETDQSLLLRALENLVRNSLKYAGTECHIQISSHCDDSWLTITVEDDGPGIDDTKLE
TLFHPFTRFDEARHASQGGFGLGLAIVRECMRLLGGDVSAGRSELGGLEVKLLLPMRLKRLAATDKAI

Sequences:

>Translated_468_residues
MKLSRHHPFARLQWRLFGYFGSSLLVILLLASLIEAMVLHQLLVLPKETKAKLSMLAQEAEALIKQGSPQAIAQWEAAQS
FRLHVINSRLEGVSGRPIHPHFEFKLGFMLGPDQALGDRVQKPIIGLPIYATLDGSGPLLLAVQLNADLHPAKDLSYSLW
AIRLTVGLFVLWLFSRLLGHYLIKPLATLQQGTRALASGKLSTRIGEHFSAAEPEFYQLGHDFDEMADVIERTLTTQERL
IRDVSHELRTPLARQKLAAELLESDLADTSPYLKRIHAENSELSRLIDTLLGYSRLASGYQAARSTSFTLHELACSLLGD
CRFEAAPTQSIEWQALSACKYIALETDQSLLLRALENLVRNSLKYAGTECHIQISSHCDDSWLTITVEDDGPGIDDTKLE
TLFHPFTRFDEARHASQGGFGLGLAIVRECMRLLGGDVSAGRSELGGLEVKLLLPMRLKRLAATDKAI
>Mature_468_residues
MKLSRHHPFARLQWRLFGYFGSSLLVILLLASLIEAMVLHQLLVLPKETKAKLSMLAQEAEALIKQGSPQAIAQWEAAQS
FRLHVINSRLEGVSGRPIHPHFEFKLGFMLGPDQALGDRVQKPIIGLPIYATLDGSGPLLLAVQLNADLHPAKDLSYSLW
AIRLTVGLFVLWLFSRLLGHYLIKPLATLQQGTRALASGKLSTRIGEHFSAAEPEFYQLGHDFDEMADVIERTLTTQERL
IRDVSHELRTPLARQKLAAELLESDLADTSPYLKRIHAENSELSRLIDTLLGYSRLASGYQAARSTSFTLHELACSLLGD
CRFEAAPTQSIEWQALSACKYIALETDQSLLLRALENLVRNSLKYAGTECHIQISSHCDDSWLTITVEDDGPGIDDTKLE
TLFHPFTRFDEARHASQGGFGLGLAIVRECMRLLGGDVSAGRSELGGLEVKLLLPMRLKRLAATDKAI

Specific function: This protein is involved in several diverse cellular processes, such as the functioning of acetohydroxyacid synthetase I, in the biosynthesis of isoleucine and valine, the TraJ protein activation activity for tra gene expression in F plasmid, and the synt

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790346, Length=273, Percent_Identity=36.996336996337, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI1787894, Length=270, Percent_Identity=34.8148148148148, Blast_Score=129, Evalue=3e-31,
Organism=Escherichia coli, GI1788393, Length=279, Percent_Identity=30.8243727598566, Blast_Score=122, Evalue=4e-29,
Organism=Escherichia coli, GI1789808, Length=311, Percent_Identity=27.9742765273312, Blast_Score=101, Evalue=9e-23,
Organism=Escherichia coli, GI1786912, Length=225, Percent_Identity=33.3333333333333, Blast_Score=93, Evalue=4e-20,
Organism=Escherichia coli, GI1790551, Length=304, Percent_Identity=28.9473684210526, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1786783, Length=338, Percent_Identity=25.4437869822485, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI87082128, Length=279, Percent_Identity=25.089605734767, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI145693157, Length=241, Percent_Identity=24.4813278008299, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1790861, Length=227, Percent_Identity=28.1938325991189, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1788279, Length=307, Percent_Identity=27.3615635179153, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1789403, Length=224, Percent_Identity=27.6785714285714, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI87081816, Length=340, Percent_Identity=26.1764705882353, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1787374, Length=219, Percent_Identity=28.7671232876712, Blast_Score=66, Evalue=6e-12,
Organism=Escherichia coli, GI1786600, Length=219, Percent_Identity=25.1141552511416, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 51945; Mature: 51945

Theoretical pI: Translated: 6.87; Mature: 6.87

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLSRHHPFARLQWRLFGYFGSSLLVILLLASLIEAMVLHQLLVLPKETKAKLSMLAQEA
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
EALIKQGSPQAIAQWEAAQSFRLHVINSRLEGVSGRPIHPHFEFKLGFMLGPDQALGDRV
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEECCCHHHHHHH
QKPIIGLPIYATLDGSGPLLLAVQLNADLHPAKDLSYSLWAIRLTVGLFVLWLFSRLLGH
HCCEECCCEEEEECCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
YLIKPLATLQQGTRALASGKLSTRIGEHFSAAEPEFYQLGHDFDEMADVIERTLTTQERL
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHH
IRDVSHELRTPLARQKLAAELLESDLADTSPYLKRIHAENSELSRLIDTLLGYSRLASGY
HHHHHHHHHCHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
QAARSTSFTLHELACSLLGDCRFEAAPTQSIEWQALSACKYIALETDQSLLLRALENLVR
HHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHEEECCCHHHHHHHHHHHHH
NSLKYAGTECHIQISSHCDDSWLTITVEDDGPGIDDTKLETLFHPFTRFDEARHASQGGF
HHHHHCCCEEEEEECCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCC
GLGLAIVRECMRLLGGDVSAGRSELGGLEVKLLLPMRLKRLAATDKAI
HHHHHHHHHHHHHHCCCCCCCHHHHCCEEEEEECHHHHHHHHHHCCCC
>Mature Secondary Structure
MKLSRHHPFARLQWRLFGYFGSSLLVILLLASLIEAMVLHQLLVLPKETKAKLSMLAQEA
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
EALIKQGSPQAIAQWEAAQSFRLHVINSRLEGVSGRPIHPHFEFKLGFMLGPDQALGDRV
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEECCCHHHHHHH
QKPIIGLPIYATLDGSGPLLLAVQLNADLHPAKDLSYSLWAIRLTVGLFVLWLFSRLLGH
HCCEECCCEEEEECCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
YLIKPLATLQQGTRALASGKLSTRIGEHFSAAEPEFYQLGHDFDEMADVIERTLTTQERL
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHH
IRDVSHELRTPLARQKLAAELLESDLADTSPYLKRIHAENSELSRLIDTLLGYSRLASGY
HHHHHHHHHCHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
QAARSTSFTLHELACSLLGDCRFEAAPTQSIEWQALSACKYIALETDQSLLLRALENLVR
HHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHEEECCCHHHHHHHHHHHHH
NSLKYAGTECHIQISSHCDDSWLTITVEDDGPGIDDTKLETLFHPFTRFDEARHASQGGF
HHHHHCCCEEEEEECCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCC
GLGLAIVRECMRLLGGDVSAGRSELGGLEVKLLLPMRLKRLAATDKAI
HHHHHHHHHHHHHHCCCCCCCHHHHCCEEEEEECHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]