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The map label for this gene is uvrB [H]

Identifier: 119774963

GI number: 119774963

Start: 2224267

End: 2226285

Strand: Reverse

Name: uvrB [H]

Synonym: Sama_1828

Alternate gene names: 119774963

Gene position: 2226285-2224267 (Counterclockwise)

Preceding gene: 119774973

Following gene: 119774960

Centisome position: 51.7

GC content: 53.84

Gene sequence:

>2019_bases
GTGTCTGAGCAAGTTTTTCAACTTTCTTCCCACTATTCACCCGCAGGTGACCAGCCTACAGCTATCGCCAAACTGATTGA
TGGGCTTGAGTCAGGGCTCGCCTGTCAGACTTTGCTCGGGGTAACAGGCTCTGGCAAGACCTTTACCGTGGCCAATGTTA
TTGCCACCCTGGGGCGCCCGACCATTATCATGGCGCCCAATAAGACACTGGCGGCGCAGCTCTATGGGGAGATGAAAGAA
TTCTTTCCCAATAATGCGGTGGAATACTTCGTTTCTTACTATGACTACTATCAGCCGGAAGCCTATGTGCCGGCATCCAA
TACCTTTATTGAGAAAGATGCCTCGGTAAACGCCCATATCGAACAAATGCGTCTGTCGGCGACCAAGGCCTTACTTGAAC
GCCGTGATGTCATCATTGTCGCGTCTGTGTCCGCGATTTATGGTTTGGGTGATCCAGACTCTTATATGAAGATGTTGCTG
CATTTGCGCCAGGGTGACTTTATGGGCCAGCGCGACATCTTAAGACGCCTCAGTGAACTGCAATACAGCCGTAACGACAT
CGACTTGCAGCGGGGCACCTTTAGGGTGCGTGGAGAGGTCATTGATATCTTTCCGGCGGATTCGGAGCGGGATGCCATCC
GGGTTGAATTGTTCGACGATGAGATTGAGCGCATCAGCGAATTTGACCCACTCACGGGGCAGGTCACCAAACGTCTGGCT
CGTGCCACCGTGTACCCAAAAACCCACTATGTGACGCCGCGTGAGAAAATCCTCGAAGCCATTGACCAGATTAAAGACGA
ACTGAGGGTGCGCAAACAGCAGTTTTTGGATAACCACAAACTCATTGAAGCTCAGCGTATTACCGAGCGGGTTCAGTATG
ATGTGGAAATGATGACAGAGTTGGGATACTGCTCGGGGATTGAAAACTACTCCCGTTATCTGTCGGGCCGTGCCGAAGGG
GAAGGGCCGCCAACCCTGCTGGACTATCTGCCTGCCGATGGTCTGATGATAATCGATGAATCCCACAACACTGTGCCGCA
GATTGGTGCCATGTATAAGGGTGACCGCTCTCGTAAAACCACCCTGGTGGAGTATGGTTTCCGTTTGCCCTCGGCACTGG
ATAACCGGCCCCTTAAGTTTGAAGAGTTTGAATCCCTGATGCCGCAGACGATTTTCGTTTCGGCCACGCCCGGGAAGTAT
GAGCTGGAGAAAAGCGGGGATGATATCGCCGAGCAGGTAGTGCGCCCTACTGGTCTGATTGACCCCGAGCTGGAAGTACG
CCCGGTGGCCATTCAGGTTGACGACCTACTCTCAGAAGTTGCCAAGCGGGTGGCAGTCAATGAACGGGTGCTGGTGACCA
CACTCACCAAGCGGATGGCAGAAGATCTCACCGATTACCTCGATGAACACGGCGTTAAAGTGCGCTATCTGCACTCGGAT
ATTGATACCGTGGAGCGGATGGAAATCATCCGCGATCTGCGGCTCGGGGTGTTCGATGTACTGGTAGGCATTAACCTGCT
CAGGGAAGGTCTCGACATGCCGGAAGTGTCTCTGGTGTGTATTCTCGATGCCGATAAAGAAGGCTTTTTGCGCTCCGAAC
GTTCGCTTATTCAGACCATAGGCCGCGCAGCCCGTAACGTGAATGGCAAAGTGATTCTCTACGCCGACCGTATTACTGAC
TCCATGGCCCGTGCCATGGCGGAAACGGAGCGGCGCCGCACCAAGCAGATGCAGTTCAACGAGGAGCACGGCATCATCCC
CCGCGGCGTGGTGAAGAAAATCACCGATGTGATGGACGTAGGTGAGAGGTCTGCGCCAAGCCGCGGCGCCGTCAAGGCAT
CAGGTCGAAGCAGGGATGTAGGTAAACCGTCGATGAGGCAAGACCCGCATCAGATTGCCGTAACCATAGATGCGCTTGAA
AAACAGATGCATCAGCACGCCCGGGATCTGGAATTTGAACAGGCTGCTGCGCTTCGGGATGAAATCCATGGGCTACGCCA
GCAGTTGCTGGAAGCTTGA

Upstream 100 bases:

>100_bases
TGTATTAGCTAAGGAGCATATCCTGCTGACCGAGTGCTGTTGGCGTCTAAGGTGCACTGGTTTACACTAGGTGCCCGGCT
TAACAAGGACAAACTTTTCT

Downstream 100 bases:

>100_bases
GCTTGCCGTCACCCCTGACGCAGCAGCCTGCACGTCCAACAATGGAAAACGCGCCTTGTGGCGCGTTTTCAGTATTAGAT
ACAAGCGGCATCCCGATTTA

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B [H]

Number of amino acids: Translated: 672; Mature: 671

Protein sequence:

>672_residues
MSEQVFQLSSHYSPAGDQPTAIAKLIDGLESGLACQTLLGVTGSGKTFTVANVIATLGRPTIIMAPNKTLAAQLYGEMKE
FFPNNAVEYFVSYYDYYQPEAYVPASNTFIEKDASVNAHIEQMRLSATKALLERRDVIIVASVSAIYGLGDPDSYMKMLL
HLRQGDFMGQRDILRRLSELQYSRNDIDLQRGTFRVRGEVIDIFPADSERDAIRVELFDDEIERISEFDPLTGQVTKRLA
RATVYPKTHYVTPREKILEAIDQIKDELRVRKQQFLDNHKLIEAQRITERVQYDVEMMTELGYCSGIENYSRYLSGRAEG
EGPPTLLDYLPADGLMIIDESHNTVPQIGAMYKGDRSRKTTLVEYGFRLPSALDNRPLKFEEFESLMPQTIFVSATPGKY
ELEKSGDDIAEQVVRPTGLIDPELEVRPVAIQVDDLLSEVAKRVAVNERVLVTTLTKRMAEDLTDYLDEHGVKVRYLHSD
IDTVERMEIIRDLRLGVFDVLVGINLLREGLDMPEVSLVCILDADKEGFLRSERSLIQTIGRAARNVNGKVILYADRITD
SMARAMAETERRRTKQMQFNEEHGIIPRGVVKKITDVMDVGERSAPSRGAVKASGRSRDVGKPSMRQDPHQIAVTIDALE
KQMHQHARDLEFEQAAALRDEIHGLRQQLLEA

Sequences:

>Translated_672_residues
MSEQVFQLSSHYSPAGDQPTAIAKLIDGLESGLACQTLLGVTGSGKTFTVANVIATLGRPTIIMAPNKTLAAQLYGEMKE
FFPNNAVEYFVSYYDYYQPEAYVPASNTFIEKDASVNAHIEQMRLSATKALLERRDVIIVASVSAIYGLGDPDSYMKMLL
HLRQGDFMGQRDILRRLSELQYSRNDIDLQRGTFRVRGEVIDIFPADSERDAIRVELFDDEIERISEFDPLTGQVTKRLA
RATVYPKTHYVTPREKILEAIDQIKDELRVRKQQFLDNHKLIEAQRITERVQYDVEMMTELGYCSGIENYSRYLSGRAEG
EGPPTLLDYLPADGLMIIDESHNTVPQIGAMYKGDRSRKTTLVEYGFRLPSALDNRPLKFEEFESLMPQTIFVSATPGKY
ELEKSGDDIAEQVVRPTGLIDPELEVRPVAIQVDDLLSEVAKRVAVNERVLVTTLTKRMAEDLTDYLDEHGVKVRYLHSD
IDTVERMEIIRDLRLGVFDVLVGINLLREGLDMPEVSLVCILDADKEGFLRSERSLIQTIGRAARNVNGKVILYADRITD
SMARAMAETERRRTKQMQFNEEHGIIPRGVVKKITDVMDVGERSAPSRGAVKASGRSRDVGKPSMRQDPHQIAVTIDALE
KQMHQHARDLEFEQAAALRDEIHGLRQQLLEA
>Mature_671_residues
SEQVFQLSSHYSPAGDQPTAIAKLIDGLESGLACQTLLGVTGSGKTFTVANVIATLGRPTIIMAPNKTLAAQLYGEMKEF
FPNNAVEYFVSYYDYYQPEAYVPASNTFIEKDASVNAHIEQMRLSATKALLERRDVIIVASVSAIYGLGDPDSYMKMLLH
LRQGDFMGQRDILRRLSELQYSRNDIDLQRGTFRVRGEVIDIFPADSERDAIRVELFDDEIERISEFDPLTGQVTKRLAR
ATVYPKTHYVTPREKILEAIDQIKDELRVRKQQFLDNHKLIEAQRITERVQYDVEMMTELGYCSGIENYSRYLSGRAEGE
GPPTLLDYLPADGLMIIDESHNTVPQIGAMYKGDRSRKTTLVEYGFRLPSALDNRPLKFEEFESLMPQTIFVSATPGKYE
LEKSGDDIAEQVVRPTGLIDPELEVRPVAIQVDDLLSEVAKRVAVNERVLVTTLTKRMAEDLTDYLDEHGVKVRYLHSDI
DTVERMEIIRDLRLGVFDVLVGINLLREGLDMPEVSLVCILDADKEGFLRSERSLIQTIGRAARNVNGKVILYADRITDS
MARAMAETERRRTKQMQFNEEHGIIPRGVVKKITDVMDVGERSAPSRGAVKASGRSRDVGKPSMRQDPHQIAVTIDALEK
QMHQHARDLEFEQAAALRDEIHGLRQQLLEA

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI1786996, Length=670, Percent_Identity=72.2388059701493, Blast_Score=993, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055 [H]

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 75922; Mature: 75790

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEQVFQLSSHYSPAGDQPTAIAKLIDGLESGLACQTLLGVTGSGKTFTVANVIATLGRP
CCCHHHHHHHCCCCCCCCHHHHHHHHHHHHCCHHHHHHHCCCCCCCEEHHHHHHHHCCCC
TIIMAPNKTLAAQLYGEMKEFFPNNAVEYFVSYYDYYQPEAYVPASNTFIEKDASVNAHI
EEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEECCCCCCEECCCCCCHHHH
EQMRLSATKALLERRDVIIVASVSAIYGLGDPDSYMKMLLHLRQGDFMGQRDILRRLSEL
HHHHHHHHHHHHHHCCEEEEEEHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHH
QYSRNDIDLQRGTFRVRGEVIDIFPADSERDAIRVELFDDEIERISEFDPLTGQVTKRLA
HHCCCCCCCCCCEEEEECEEEEEECCCCCCCEEEEEEEHHHHHHHHHCCCCHHHHHHHHH
RATVYPKTHYVTPREKILEAIDQIKDELRVRKQQFLDNHKLIEAQRITERVQYDVEMMTE
HHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
LGYCSGIENYSRYLSGRAEGEGPPTLLDYLPADGLMIIDESHNTVPQIGAMYKGDRSRKT
HHHHCCHHHHHHHHCCCCCCCCCCHHHHHCCCCCEEEEECCCCCCHHHHHHHCCCCCCCH
TLVEYGFRLPSALDNRPLKFEEFESLMPQTIFVSATPGKYELEKSGDDIAEQVVRPTGLI
HHHHHCCCCCHHHCCCCCCHHHHHHCCCCEEEEEECCCCEEECCCCHHHHHHHHCCCCCC
DPELEVRPVAIQVDDLLSEVAKRVAVNERVLVTTLTKRMAEDLTDYLDEHGVKVRYLHSD
CCCCCEEEEEEEHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCC
IDTVERMEIIRDLRLGVFDVLVGINLLREGLDMPEVSLVCILDADKEGFLRSERSLIQTI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCHHHHHHHHHHHHHH
GRAARNVNGKVILYADRITDSMARAMAETERRRTKQMQFNEEHGIIPRGVVKKITDVMDV
HHHHHCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHC
GERSAPSRGAVKASGRSRDVGKPSMRQDPHQIAVTIDALEKQMHQHARDLEFEQAAALRD
CCCCCCCCCCEECCCCCCCCCCCCCCCCCHHEEEEHHHHHHHHHHHHHCCCHHHHHHHHH
EIHGLRQQLLEA
HHHHHHHHHHCC
>Mature Secondary Structure 
SEQVFQLSSHYSPAGDQPTAIAKLIDGLESGLACQTLLGVTGSGKTFTVANVIATLGRP
CCHHHHHHHCCCCCCCCHHHHHHHHHHHHCCHHHHHHHCCCCCCCEEHHHHHHHHCCCC
TIIMAPNKTLAAQLYGEMKEFFPNNAVEYFVSYYDYYQPEAYVPASNTFIEKDASVNAHI
EEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEECCCCCCEECCCCCCHHHH
EQMRLSATKALLERRDVIIVASVSAIYGLGDPDSYMKMLLHLRQGDFMGQRDILRRLSEL
HHHHHHHHHHHHHHCCEEEEEEHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHH
QYSRNDIDLQRGTFRVRGEVIDIFPADSERDAIRVELFDDEIERISEFDPLTGQVTKRLA
HHCCCCCCCCCCEEEEECEEEEEECCCCCCCEEEEEEEHHHHHHHHHCCCCHHHHHHHHH
RATVYPKTHYVTPREKILEAIDQIKDELRVRKQQFLDNHKLIEAQRITERVQYDVEMMTE
HHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
LGYCSGIENYSRYLSGRAEGEGPPTLLDYLPADGLMIIDESHNTVPQIGAMYKGDRSRKT
HHHHCCHHHHHHHHCCCCCCCCCCHHHHHCCCCCEEEEECCCCCCHHHHHHHCCCCCCCH
TLVEYGFRLPSALDNRPLKFEEFESLMPQTIFVSATPGKYELEKSGDDIAEQVVRPTGLI
HHHHHCCCCCHHHCCCCCCHHHHHHCCCCEEEEEECCCCEEECCCCHHHHHHHHCCCCCC
DPELEVRPVAIQVDDLLSEVAKRVAVNERVLVTTLTKRMAEDLTDYLDEHGVKVRYLHSD
CCCCCEEEEEEEHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCC
IDTVERMEIIRDLRLGVFDVLVGINLLREGLDMPEVSLVCILDADKEGFLRSERSLIQTI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCHHHHHHHHHHHHHH
GRAARNVNGKVILYADRITDSMARAMAETERRRTKQMQFNEEHGIIPRGVVKKITDVMDV
HHHHHCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHC
GERSAPSRGAVKASGRSRDVGKPSMRQDPHQIAVTIDALEKQMHQHARDLEFEQAAALRD
CCCCCCCCCCEECCCCCCCCCCCCCCCCCHHEEEEHHHHHHHHHHHHHCCCHHHHHHHHH
EIHGLRQQLLEA
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA