Click here to switch to the map view.

The map label for this gene is zwf [H]

Identifier: 119774947

GI number: 119774947

Start: 2205565

End: 2207037

Strand: Reverse

Name: zwf [H]

Synonym: Sama_1812

Alternate gene names: 119774947

Gene position: 2207037-2205565 (Counterclockwise)

Preceding gene: 119774950

Following gene: 119774946

Centisome position: 51.25

GC content: 49.97

Gene sequence:

>1473_bases
ATGGGCAATACAACATCAGGGGCAAAAGCTTGTGATTTTGTCCTTTTCGGTACCAAAGGTGACCTGGCGAGGCGCAAACT
GCTTCCCTCTTTATACCAATTGGATAAGGCAACACTGCTTCACAACGACACCAAGATCATCGGTGTTGCCAAAGATGCAT
TCTCTACTGAAGAATTTCGTGAGCTGGTTAAGACGGCACTGACCACCTTCGTTAAAGATCCCCTCTGCGAAACCACTATC
GAAAGATTCGTCAGCCGCTGCCATTATGTCGGTACCAATTTCACCGAGTCAGAAGGGTACAGTGCATTCCATGAGCTGCT
TGAACCTGAAAAGCGGGTCATGGTTAATTACTTTGCTACTCCTCCTGCCATTTTCGGCGATATCTGCCGCTGTCTGCACG
AACAAAATCTGATTTTCCCCGATACCCGCGTTGTCCTAGAAAAGCCAATTGGCTCAGATCTCGAATCTTCCCGAGTTATC
AATAACCAGGTATCTCAATACTTCAATGAGAACCAGGTTTATCGCATCGACCATTACCTGGGTAAAGAAACGGTACAAAA
CCTGATTGCACTGCGTTTTGCCAACTCACTCTTTGCGTCCAAATGGGATAACCGCACTATCGATCATGTGCAGATTACCG
TTGCAGAAGAAGTGGGTATTGAAGGTCGTTGGGGTTATTTCGATAAAGCCGGCCAGATGCGGGACATGATCCAAAACCAC
CTGTTACAGGTGCTAACACTGGTCGCCATGGATCCACCCGTAAACCTGGATGCCGACTCTATCCGTGATGAAAAGGTAAA
GGTGCTTAAGTCGCTGCGCCCAATCAACATGGATAACGTCAACGAAAACACGGTACGTGGCCAATACTCTGCGGGTTTCC
TGAAGGGCAGCCCGGTTCCAGGCTATCTCGAGGAAGAAGGCGCAAACGTTAATTCCAATACCGAGACCTTTGTGGCACTG
CGTGTGGATATTGACAACTGGCGCTGGGCCGGTGTGCCATTTTATCTGCGCAGTGGCAAACGTATGCCGTTCAAAAGTTC
AGAAATTGTGGTGCATTTTAAAAATCCACCGCACAACCTGTATCGCTCCAGTTACCGTAATCTGCCACCGAACAAATTGA
CCATTCGTCTGCAACCCCATGAAGGTGTTGAAATTCAGATGATGAACAAGGTGCCGGGTCTGGAGCAAAAGACGCGTCTG
CAAACCACCAAGTTAGATCTCAGCTTCTCTGACACCTTTAAAAACGAGCGCATTGCCGATGCGTACGAACGTCTGCTGCT
GGAAGCCATGCTCGGTAACCAGGCGCTGTTCGTTCGCCGCGACGAAGTAGAGCAGGCCTGGACCTGGGTTGATGGCATCA
TTCAGGCGTGGGAAGCGGGTAACGAAAGACCGAAAGCCTATCCTGCGGGCACCTGGGGGCCGGTGGCCTCGGTAGCGCTC
ATCACCAAAGATGGGCGTTCCTGGGATGAATAA

Upstream 100 bases:

>100_bases
ATATGGATGCATAAATCAGATTCTGTTGTTATATTACAACAAAAGGGCTTCTGGCCGTCCAGCATACGGCGAAGCCGATT
ACAAAGGAGAGCTTGCAGCA

Downstream 100 bases:

>100_bases
GGAGGCCAAGGTGCTGAAAGAAGCGGTATTCAAATCATTCGATAACACTGATTCGCTGGAAACCCAGTTGGCAGACCGTA
TCGCGCGCCAACTGCAGGAT

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 490; Mature: 489

Protein sequence:

>490_residues
MGNTTSGAKACDFVLFGTKGDLARRKLLPSLYQLDKATLLHNDTKIIGVAKDAFSTEEFRELVKTALTTFVKDPLCETTI
ERFVSRCHYVGTNFTESEGYSAFHELLEPEKRVMVNYFATPPAIFGDICRCLHEQNLIFPDTRVVLEKPIGSDLESSRVI
NNQVSQYFNENQVYRIDHYLGKETVQNLIALRFANSLFASKWDNRTIDHVQITVAEEVGIEGRWGYFDKAGQMRDMIQNH
LLQVLTLVAMDPPVNLDADSIRDEKVKVLKSLRPINMDNVNENTVRGQYSAGFLKGSPVPGYLEEEGANVNSNTETFVAL
RVDIDNWRWAGVPFYLRSGKRMPFKSSEIVVHFKNPPHNLYRSSYRNLPPNKLTIRLQPHEGVEIQMMNKVPGLEQKTRL
QTTKLDLSFSDTFKNERIADAYERLLLEAMLGNQALFVRRDEVEQAWTWVDGIIQAWEAGNERPKAYPAGTWGPVASVAL
ITKDGRSWDE

Sequences:

>Translated_490_residues
MGNTTSGAKACDFVLFGTKGDLARRKLLPSLYQLDKATLLHNDTKIIGVAKDAFSTEEFRELVKTALTTFVKDPLCETTI
ERFVSRCHYVGTNFTESEGYSAFHELLEPEKRVMVNYFATPPAIFGDICRCLHEQNLIFPDTRVVLEKPIGSDLESSRVI
NNQVSQYFNENQVYRIDHYLGKETVQNLIALRFANSLFASKWDNRTIDHVQITVAEEVGIEGRWGYFDKAGQMRDMIQNH
LLQVLTLVAMDPPVNLDADSIRDEKVKVLKSLRPINMDNVNENTVRGQYSAGFLKGSPVPGYLEEEGANVNSNTETFVAL
RVDIDNWRWAGVPFYLRSGKRMPFKSSEIVVHFKNPPHNLYRSSYRNLPPNKLTIRLQPHEGVEIQMMNKVPGLEQKTRL
QTTKLDLSFSDTFKNERIADAYERLLLEAMLGNQALFVRRDEVEQAWTWVDGIIQAWEAGNERPKAYPAGTWGPVASVAL
ITKDGRSWDE
>Mature_489_residues
GNTTSGAKACDFVLFGTKGDLARRKLLPSLYQLDKATLLHNDTKIIGVAKDAFSTEEFRELVKTALTTFVKDPLCETTIE
RFVSRCHYVGTNFTESEGYSAFHELLEPEKRVMVNYFATPPAIFGDICRCLHEQNLIFPDTRVVLEKPIGSDLESSRVIN
NQVSQYFNENQVYRIDHYLGKETVQNLIALRFANSLFASKWDNRTIDHVQITVAEEVGIEGRWGYFDKAGQMRDMIQNHL
LQVLTLVAMDPPVNLDADSIRDEKVKVLKSLRPINMDNVNENTVRGQYSAGFLKGSPVPGYLEEEGANVNSNTETFVALR
VDIDNWRWAGVPFYLRSGKRMPFKSSEIVVHFKNPPHNLYRSSYRNLPPNKLTIRLQPHEGVEIQMMNKVPGLEQKTRLQ
TTKLDLSFSDTFKNERIADAYERLLLEAMLGNQALFVRRDEVEQAWTWVDGIIQAWEAGNERPKAYPAGTWGPVASVALI
TKDGRSWDE

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI108773793, Length=483, Percent_Identity=36.231884057971, Blast_Score=313, Evalue=2e-85,
Organism=Homo sapiens, GI109389365, Length=483, Percent_Identity=36.231884057971, Blast_Score=313, Evalue=2e-85,
Organism=Homo sapiens, GI52145310, Length=500, Percent_Identity=28.2, Blast_Score=162, Evalue=6e-40,
Organism=Escherichia coli, GI1788158, Length=486, Percent_Identity=64.6090534979424, Blast_Score=664, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17538218, Length=484, Percent_Identity=38.0165289256198, Blast_Score=328, Evalue=4e-90,
Organism=Saccharomyces cerevisiae, GI6324088, Length=475, Percent_Identity=36.8421052631579, Blast_Score=306, Evalue=6e-84,
Organism=Drosophila melanogaster, GI24643350, Length=481, Percent_Identity=36.7983367983368, Blast_Score=311, Evalue=7e-85,
Organism=Drosophila melanogaster, GI24643352, Length=481, Percent_Identity=36.7983367983368, Blast_Score=311, Evalue=9e-85,
Organism=Drosophila melanogaster, GI221513548, Length=484, Percent_Identity=28.3057851239669, Blast_Score=192, Evalue=6e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 55777; Mature: 55646

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGNTTSGAKACDFVLFGTKGDLARRKLLPSLYQLDKATLLHNDTKIIGVAKDAFSTEEFR
CCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHEEECCCEEEEEEHHHCCHHHHH
ELVKTALTTFVKDPLCETTIERFVSRCHYVGTNFTESEGYSAFHELLEPEKRVMVNYFAT
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCHHEEEEEECC
PPAIFGDICRCLHEQNLIFPDTRVVLEKPIGSDLESSRVINNQVSQYFNENQVYRIDHYL
CHHHHHHHHHHHHHCCCCCCCCHHEEECCCCCCCHHHHHHHHHHHHHHCCCCEEEHHHHH
GKETVQNLIALRFANSLFASKWDNRTIDHVQITVAEEVGIEGRWGYFDKAGQMRDMIQNH
CHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEHHCCCCCCCCCCCCCHHHHHHHHHH
LLQVLTLVAMDPPVNLDADSIRDEKVKVLKSLRPINMDNVNENTVRGQYSAGFLKGSPVP
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
GYLEEEGANVNSNTETFVALRVDIDNWRWAGVPFYLRSGKRMPFKSSEIVVHFKNPPHNL
CCHHHCCCCCCCCCEEEEEEEEECCCCEECCCCCEECCCCCCCCCCCCEEEEECCCCHHH
YRSSYRNLPPNKLTIRLQPHEGVEIQMMNKVPGLEQKTRLQTTKLDLSFSDTFKNERIAD
HHHHHCCCCCCEEEEEECCCCCCEEEEECCCCCCCHHHHCEEEEEEEEEHHHHCCCHHHH
AYERLLLEAMLGNQALFVRRDEVEQAWTWVDGIIQAWEAGNERPKAYPAGTWGPVASVAL
HHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHEEEE
ITKDGRSWDE
EEECCCCCCC
>Mature Secondary Structure 
GNTTSGAKACDFVLFGTKGDLARRKLLPSLYQLDKATLLHNDTKIIGVAKDAFSTEEFR
CCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHEEECCCEEEEEEHHHCCHHHHH
ELVKTALTTFVKDPLCETTIERFVSRCHYVGTNFTESEGYSAFHELLEPEKRVMVNYFAT
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCHHEEEEEECC
PPAIFGDICRCLHEQNLIFPDTRVVLEKPIGSDLESSRVINNQVSQYFNENQVYRIDHYL
CHHHHHHHHHHHHHCCCCCCCCHHEEECCCCCCCHHHHHHHHHHHHHHCCCCEEEHHHHH
GKETVQNLIALRFANSLFASKWDNRTIDHVQITVAEEVGIEGRWGYFDKAGQMRDMIQNH
CHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEHHCCCCCCCCCCCCCHHHHHHHHHH
LLQVLTLVAMDPPVNLDADSIRDEKVKVLKSLRPINMDNVNENTVRGQYSAGFLKGSPVP
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
GYLEEEGANVNSNTETFVALRVDIDNWRWAGVPFYLRSGKRMPFKSSEIVVHFKNPPHNL
CCHHHCCCCCCCCCEEEEEEEEECCCCEECCCCCEECCCCCCCCCCCCEEEEECCCCHHH
YRSSYRNLPPNKLTIRLQPHEGVEIQMMNKVPGLEQKTRLQTTKLDLSFSDTFKNERIAD
HHHHHCCCCCCEEEEEECCCCCCEEEEECCCCCCCHHHHCEEEEEEEEEHHHHCCCHHHH
AYERLLLEAMLGNQALFVRRDEVEQAWTWVDGIIQAWEAGNERPKAYPAGTWGPVASVAL
HHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHEEEE
ITKDGRSWDE
EEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8145647 [H]