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The map label for this gene is edd [H]

Identifier: 119774945

GI number: 119774945

Start: 2203018

End: 2204844

Strand: Reverse

Name: edd [H]

Synonym: Sama_1810

Alternate gene names: 119774945

Gene position: 2204844-2203018 (Counterclockwise)

Preceding gene: 119774946

Following gene: 119774944

Centisome position: 51.2

GC content: 55.17

Gene sequence:

>1827_bases
ATGCACCCCGTAGTCAAATCGGTGACCGACAGGATCATCGAACGCAGTAAAGAAAGTCGCAGTGCTTATCTGGCCGCGCT
GCAGGAAGCCCGCAGTGGAAAGGTTCATCGCTCTGCCTTGAGTTGCGGCAACCTGGCCCATGGTTTCGCCGCCTGTGGCG
CAGAAGATAAACAGTCGCTGCGCCAACTCACCAAGGTCAATATTGGCATTGTGACTGCGTTTAACGACATGTTGTCTGCC
CATCAGCCTTATGAACATTATCCTGAGCTGCTCAAAGCCGCCTGTAATGAAGTAGGCAGTGTTGCCCAGGTGGCCGGTGG
CGTACCCGCCATGTGTGACGGTGTAACTCAGGGCCAACCCGGGATGGAGCTGTCGCTGCTGTCCCGTGAGGTGATAGCCA
TGGCGACCGCCGTAGGCTTATCCCACAACATGTTTGATGGCGCGCTGCTGCTTGGGGTGTGTGACAAAATCGTGCCCGGC
TTGCTGATTGGTGCAATGAGTTTTGGCCACCTTCCAATGCTGTTTGTACCTGCGGGGCCCATGCGCTCAGGCATTCCCAA
TAAGGAAAAAGCCCGTGTGCGTCAAAAATTCGCTGAGGGTAAGGTGGACCGCGAAGCCTTGCTCGAAGCCGAGGCAAGCT
CTTATCACAGTGCCGGTACCTGTACCTTCTATGGTACTGCCAACTCCAATCAACTGGTGCTCGAGGTGATGGGGCTGCAA
CTGCCAGGCTCATCCTTTGTGAACCCGGACGACCCACTGCGAACCGAACTCAGCAAAATGGCCGCCAAGCAGGTTTGTCG
CCTGACCGAAAACGGGCTGCAGTATTCACCCATAGGTGAGATAGTCAACGAAAAATCCGTGGTTAACGGCATAGTTGCGC
TGCTTGCCACCGGAGGTTCAACCAACCTGACCATGCACATAGTGGCTGCGGCCAGGGCCGCCGGTATCATCATCAACTGG
GATGACTTTTCCGAGCTGTCTGATGCCGTTCCTCTGCTGGCCCGTGTTTATCCCAACGGTCACGCGGATATCAATCACTT
CCATGCGGCGGGCGGTATGGCCTTCCTGATGAAAGAACTGCTGGATGCAGGTCTTATCCACGAAGATGTCAATACAGTGG
CAGGCTACGGTCTGCGCCGTTACACCCAGGAGCCAAGACTCATTGATGGTCAGCTCACCTGGGTTGATGGTCCTGTTACC
AGTCTGGACCAAGAGGTACTGCGCGGTGTTGCAGAGCCATTCCAGTCAAATGGCGGCCTTAAACTGATGAAAGGCAACCT
TGGTCGCGCCGTTATCAAAGTCTCGGCAGTCCAGGAGCAGCATCGTATCGTCGAAGCCCCAGCGGTGGTCATTGATGATC
AGAACAAACTGGATGCCCTCTTTAAAGCCGGTGAGCTTGATAGAGACTGTGTGGTTGTGGTGAAAGGTCAGGGACCCAAA
GCTAATGGCATGCCTGAGCTGCACAAACTAACCCCCATCCTGGGTACCTTGCAGGACCGCGGTTTTAAAGTGGCGTTGAT
GACCGATGGTCGTATGTCCGGTGCATCAGGCAAAGTACCTGCGGCAATCCACCTTACGCCTGAGGCTCTGGATGGCGGTC
TTATCGCCAAGGTTCAGGACGGTGACCTTATCCGTATCAATGCCATTACCGGTGAACTGTCCTTGCTGGTCTCGGCTCCC
GAGCTTGAAAGCCGCACTGCCGCACCGGTGGAATTAAGAAAGTCCCGTTATGGCATGGGCAGGGAACTTTTCGGCGCGCT
CAGACAAAATCTCAGCAGTCCCGAAACCGGTGCCCGTTGCACCGAAGCAATCGATGAACTTTATTGA

Upstream 100 bases:

>100_bases
CGCTCGAAAGCGACGATATAAAAGCGATGCCAATTCGAGTGGTATTGGGTCAACACAAAACCCCGGTCGACGTGTATTGG
AGCGCTTAAGGAGGCAAGTT

Downstream 100 bases:

>100_bases
GCCTGAAAGGATACAACCGATGTCTGAGAATAACTGGTCTTTACAACCACAAGATATTTTTAAGCGCAGTCCGATTGTGC
CTGTTATGGTGATCAATAAG

Product: phosphogluconate dehydratase

Products: NA

Alternate protein names: 6-phosphogluconate dehydratase [H]

Number of amino acids: Translated: 608; Mature: 608

Protein sequence:

>608_residues
MHPVVKSVTDRIIERSKESRSAYLAALQEARSGKVHRSALSCGNLAHGFAACGAEDKQSLRQLTKVNIGIVTAFNDMLSA
HQPYEHYPELLKAACNEVGSVAQVAGGVPAMCDGVTQGQPGMELSLLSREVIAMATAVGLSHNMFDGALLLGVCDKIVPG
LLIGAMSFGHLPMLFVPAGPMRSGIPNKEKARVRQKFAEGKVDREALLEAEASSYHSAGTCTFYGTANSNQLVLEVMGLQ
LPGSSFVNPDDPLRTELSKMAAKQVCRLTENGLQYSPIGEIVNEKSVVNGIVALLATGGSTNLTMHIVAAARAAGIIINW
DDFSELSDAVPLLARVYPNGHADINHFHAAGGMAFLMKELLDAGLIHEDVNTVAGYGLRRYTQEPRLIDGQLTWVDGPVT
SLDQEVLRGVAEPFQSNGGLKLMKGNLGRAVIKVSAVQEQHRIVEAPAVVIDDQNKLDALFKAGELDRDCVVVVKGQGPK
ANGMPELHKLTPILGTLQDRGFKVALMTDGRMSGASGKVPAAIHLTPEALDGGLIAKVQDGDLIRINAITGELSLLVSAP
ELESRTAAPVELRKSRYGMGRELFGALRQNLSSPETGARCTEAIDELY

Sequences:

>Translated_608_residues
MHPVVKSVTDRIIERSKESRSAYLAALQEARSGKVHRSALSCGNLAHGFAACGAEDKQSLRQLTKVNIGIVTAFNDMLSA
HQPYEHYPELLKAACNEVGSVAQVAGGVPAMCDGVTQGQPGMELSLLSREVIAMATAVGLSHNMFDGALLLGVCDKIVPG
LLIGAMSFGHLPMLFVPAGPMRSGIPNKEKARVRQKFAEGKVDREALLEAEASSYHSAGTCTFYGTANSNQLVLEVMGLQ
LPGSSFVNPDDPLRTELSKMAAKQVCRLTENGLQYSPIGEIVNEKSVVNGIVALLATGGSTNLTMHIVAAARAAGIIINW
DDFSELSDAVPLLARVYPNGHADINHFHAAGGMAFLMKELLDAGLIHEDVNTVAGYGLRRYTQEPRLIDGQLTWVDGPVT
SLDQEVLRGVAEPFQSNGGLKLMKGNLGRAVIKVSAVQEQHRIVEAPAVVIDDQNKLDALFKAGELDRDCVVVVKGQGPK
ANGMPELHKLTPILGTLQDRGFKVALMTDGRMSGASGKVPAAIHLTPEALDGGLIAKVQDGDLIRINAITGELSLLVSAP
ELESRTAAPVELRKSRYGMGRELFGALRQNLSSPETGARCTEAIDELY
>Mature_608_residues
MHPVVKSVTDRIIERSKESRSAYLAALQEARSGKVHRSALSCGNLAHGFAACGAEDKQSLRQLTKVNIGIVTAFNDMLSA
HQPYEHYPELLKAACNEVGSVAQVAGGVPAMCDGVTQGQPGMELSLLSREVIAMATAVGLSHNMFDGALLLGVCDKIVPG
LLIGAMSFGHLPMLFVPAGPMRSGIPNKEKARVRQKFAEGKVDREALLEAEASSYHSAGTCTFYGTANSNQLVLEVMGLQ
LPGSSFVNPDDPLRTELSKMAAKQVCRLTENGLQYSPIGEIVNEKSVVNGIVALLATGGSTNLTMHIVAAARAAGIIINW
DDFSELSDAVPLLARVYPNGHADINHFHAAGGMAFLMKELLDAGLIHEDVNTVAGYGLRRYTQEPRLIDGQLTWVDGPVT
SLDQEVLRGVAEPFQSNGGLKLMKGNLGRAVIKVSAVQEQHRIVEAPAVVIDDQNKLDALFKAGELDRDCVVVVKGQGPK
ANGMPELHKLTPILGTLQDRGFKVALMTDGRMSGASGKVPAAIHLTPEALDGGLIAKVQDGDLIRINAITGELSLLVSAP
ELESRTAAPVELRKSRYGMGRELFGALRQNLSSPETGARCTEAIDELY

Specific function: KEY ENZYME IN THE ENTNER-DOUDOROFF PATHWAY. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI1788157, Length=600, Percent_Identity=67.5, Blast_Score=849, Evalue=0.0,
Organism=Escherichia coli, GI48994964, Length=542, Percent_Identity=28.7822878228782, Blast_Score=180, Evalue=3e-46,
Organism=Escherichia coli, GI2367371, Length=478, Percent_Identity=33.0543933054393, Blast_Score=169, Evalue=5e-43,
Organism=Escherichia coli, GI1786464, Length=490, Percent_Identity=29.7959183673469, Blast_Score=144, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6322476, Length=476, Percent_Identity=29.8319327731092, Blast_Score=174, Evalue=5e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004786
- InterPro:   IPR015928
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.12 [H]

Molecular weight: Translated: 64801; Mature: 64801

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHPVVKSVTDRIIERSKESRSAYLAALQEARSGKVHRSALSCGNLAHGFAACGAEDKQSL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHCCCHHHHHH
RQLTKVNIGIVTAFNDMLSAHQPYEHYPELLKAACNEVGSVAQVAGGVPAMCDGVTQGQP
HHHHHCCCEEEEHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCC
GMELSLLSREVIAMATAVGLSHNMFDGALLLGVCDKIVPGLLIGAMSFGHLPMLFVPAGP
CCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCH
MRSGIPNKEKARVRQKFAEGKVDREALLEAEASSYHSAGTCTFYGTANSNQLVLEVMGLQ
HHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCEEEEEEECCC
LPGSSFVNPDDPLRTELSKMAAKQVCRLTENGLQYSPIGEIVNEKSVVNGIVALLATGGS
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
TNLTMHIVAAARAAGIIINWDDFSELSDAVPLLARVYPNGHADINHFHAAGGMAFLMKEL
CCEEEEEEEHHHHCEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCHHHHHHHH
LDAGLIHEDVNTVAGYGLRRYTQEPRLIDGQLTWVDGPVTSLDQEVLRGVAEPFQSNGGL
HHCCCHHHHHHHHHHCCHHHHCCCCCEECCEEEEECCCHHHHHHHHHHHHHHHHHCCCCE
KLMKGNLGRAVIKVSAVQEQHRIVEAPAVVIDDQNKLDALFKAGELDRDCVVVVKGQGPK
EEEECCCCCCCEEHHHHHHHHHHHHCCEEEECCCHHHHHHHHCCCCCCCEEEEEECCCCC
ANGMPELHKLTPILGTLQDRGFKVALMTDGRMSGASGKVPAAIHLTPEALDGGLIAKVQD
CCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCEEEEECHHHCCCCEEEEECC
GDLIRINAITGELSLLVSAPELESRTAAPVELRKSRYGMGRELFGALRQNLSSPETGARC
CCEEEEEEECCEEEEEEECCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHCCCCCCCCHHH
TEAIDELY
HHHHHHCC
>Mature Secondary Structure
MHPVVKSVTDRIIERSKESRSAYLAALQEARSGKVHRSALSCGNLAHGFAACGAEDKQSL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHCCCHHHHHH
RQLTKVNIGIVTAFNDMLSAHQPYEHYPELLKAACNEVGSVAQVAGGVPAMCDGVTQGQP
HHHHHCCCEEEEHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCC
GMELSLLSREVIAMATAVGLSHNMFDGALLLGVCDKIVPGLLIGAMSFGHLPMLFVPAGP
CCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCH
MRSGIPNKEKARVRQKFAEGKVDREALLEAEASSYHSAGTCTFYGTANSNQLVLEVMGLQ
HHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCEEEEEEECCC
LPGSSFVNPDDPLRTELSKMAAKQVCRLTENGLQYSPIGEIVNEKSVVNGIVALLATGGS
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
TNLTMHIVAAARAAGIIINWDDFSELSDAVPLLARVYPNGHADINHFHAAGGMAFLMKEL
CCEEEEEEEHHHHCEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCHHHHHHHH
LDAGLIHEDVNTVAGYGLRRYTQEPRLIDGQLTWVDGPVTSLDQEVLRGVAEPFQSNGGL
HHCCCHHHHHHHHHHCCHHHHCCCCCEECCEEEEECCCHHHHHHHHHHHHHHHHHCCCCE
KLMKGNLGRAVIKVSAVQEQHRIVEAPAVVIDDQNKLDALFKAGELDRDCVVVVKGQGPK
EEEECCCCCCCEEHHHHHHHHHHHHCCEEEECCCHHHHHHHHCCCCCCCEEEEEECCCCC
ANGMPELHKLTPILGTLQDRGFKVALMTDGRMSGASGKVPAAIHLTPEALDGGLIAKVQD
CCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCEEEEECHHHCCCCEEEEECC
GDLIRINAITGELSLLVSAPELESRTAAPVELRKSRYGMGRELFGALRQNLSSPETGARC
CCEEEEEEECCEEEEEEECCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHCCCCCCCCHHH
TEAIDELY
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]