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The map label for this gene is thrS

Identifier: 119774900

GI number: 119774900

Start: 2159575

End: 2161503

Strand: Direct

Name: thrS

Synonym: Sama_1765

Alternate gene names: 119774900

Gene position: 2159575-2161503 (Clockwise)

Preceding gene: 119774897

Following gene: 119774901

Centisome position: 50.15

GC content: 52.26

Gene sequence:

>1929_bases
ATGCCTGTAATTACGCTTCCTGACGGCAGCCAACGTGTGTTTGCCAATCCCGTCTCCACTATGGACGTCGCTGCCGATAT
CGGCCCTGGGCTTGCCAAGGCCTGTATTGCCGGCCGTGTAAACGGTGAGCTGAAAGATGCCTGCGACCTCATCCATGAAG
ACGCCAGCCTGTCTATCATCACTGCCCGTGATGAAGAAGGCTTGGAAATTCTGCGTCACTCCTGTGCACACTTGCTTGGT
CATGCCATCAAGCAGCTTTGGCCACAAACCAAAATGGCCATTGGTCCGGTTATCGATAACGGCTTCTACTACGATGTGGA
TCTTGAGCACAAGCTGACTGCCGATGACATCGCTGCGCTGGAAAAGCGCATGCTGGAGCTGGCCAAAACCGATTATGACG
TGGTGAAACGCGTTGTGAGCTGGCAGGAAGCCCGCGATACCTTTGAAGGTCGCGGAGAAAGCTACAAGATGGCGATTCTT
GATGAAAACATTGCCAAGGACGCCACCCCGGCGTTGTATCATCACGAAGAATACACTGACATGTGTCGTGGCCCACACGT
GCCCAACATGCGTTTTTGCCATCACTTCAAACTGATGAGCGTTGCCGGTGCCTACTGGCGTGGTGATTCCAACAACAAGA
TGCTGCAGCGCATCTACGGTACTGCCTGGGGTGATAAGAAAGCCCTGAATACCCACCTGGCGCGTCTCGAAGAAGCCGCC
AAGCGTGACCACCGTAAAATAGGCAAGCAACTCGACCTGTATCATATGCAGGAAGAAGCGCCAGGTATGGTGTTCTGGCA
TAACGATGGCTGGAGCATCTTCCGTGAGCTGGAAACCTTTATCCGCCACAAGCTGTCTGAGTACGATTATCAGGAAGTGA
AAGGTCCATTCATGATGGACCGCGTATTGTGGGAACGCTCAGGTCATTGGGATAAGTACGCCGATGCCATGTTCACCACG
GCCAGTGAAAACCGTGAATACGCTATCAAACCGATGAACTGCCCAGGTCACGTGCAAATCTTCAACCAGGGCCTCAAGTC
GTATCGCGATTTGCCACTGCGTATGGCCGAGTTCGGTTGCTGTCACCGTAATGAGCCATCGGGTTCGCTGCATGGCCTGA
TGCGCGTACGCGGCTTTACCCAGGACGATGCCCATATCTTCTGTACCGAAGAACAGGTACAGGAAGAGGTAAGTGCATGT
ATCAGAATGGTGTATGACACATACTCGACCTTCGGTTTCGAAAATATTGTGGTGAAGCTGTCTACCCGACCCGAGAAGCG
TATCGGTGACGACGACATGTGGGACCGCGCAGAATCCGCTCTGATTGAAGCCCTGAATGCCAACGGCATTGCCTTTGAAA
TTCTGCCTGGCGAAGGTGCCTTTTACGGTCCGAAAATTGAGTTCACCCTGCATGACTGTCTCGACCGTGCATGGCAGTGC
GGAACCGTTCAGCTCGACTACGCCTTGCCTGGCCGTTTGGGTGCGACCTATGTGGCCGAAGATAACGCCCGTCAGACCCC
GGTGATGATCCACCGCGCCATTTTGGGCTCTTTGGAGCGTTTCATCGGTATTCTTATTGAAGAATACGCCGGACGCTTCC
CCGCATGGCTGGCTCCAGTGCAGGCTGTCGTGATGAACATCACCGACAAACAGGCTGATTATGTTGAAGAATTAGTCAAA
TTCTTCAAAGAACAAGGTATTCGCGCTTCTCAAGACTTGAGGAATGAGAAAATTGGCTTTAAAATACGCGAGCACACCTT
AAGGCGTGTCCCTTATCTATTGGTTGTTGGCGACCAGGAAATGGAGAACAGGGAAATCGCGGTGCGTACCCGTGACGGTA
AAGATTTGGGCAAGATGTCCATCGATGCTTTCGTTGCGAGCGTAAAAGAACAAATTTCGCACCGTAGTCTAAAACTGTTG
GAGGAATAG

Upstream 100 bases:

>100_bases
ATGAGGCTCAAGGCTCCTGTACTGTCTTACCCTCCGCGCGTTTCTTTTTATTTATGCCAAGTGGCCCTTGGTGTGGGTCA
CCACTGGATAAGGAAATATC

Downstream 100 bases:

>100_bases
GTCATAAAGATCAAGAAAGCAGGGCGTCAGCCGGCCCCAAACCGTATCAACGATGAAATCACCGGTGTTCCACAGGTACG
TTTAACCGGATTGGATGGAG

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS

Number of amino acids: Translated: 642; Mature: 641

Protein sequence:

>642_residues
MPVITLPDGSQRVFANPVSTMDVAADIGPGLAKACIAGRVNGELKDACDLIHEDASLSIITARDEEGLEILRHSCAHLLG
HAIKQLWPQTKMAIGPVIDNGFYYDVDLEHKLTADDIAALEKRMLELAKTDYDVVKRVVSWQEARDTFEGRGESYKMAIL
DENIAKDATPALYHHEEYTDMCRGPHVPNMRFCHHFKLMSVAGAYWRGDSNNKMLQRIYGTAWGDKKALNTHLARLEEAA
KRDHRKIGKQLDLYHMQEEAPGMVFWHNDGWSIFRELETFIRHKLSEYDYQEVKGPFMMDRVLWERSGHWDKYADAMFTT
ASENREYAIKPMNCPGHVQIFNQGLKSYRDLPLRMAEFGCCHRNEPSGSLHGLMRVRGFTQDDAHIFCTEEQVQEEVSAC
IRMVYDTYSTFGFENIVVKLSTRPEKRIGDDDMWDRAESALIEALNANGIAFEILPGEGAFYGPKIEFTLHDCLDRAWQC
GTVQLDYALPGRLGATYVAEDNARQTPVMIHRAILGSLERFIGILIEEYAGRFPAWLAPVQAVVMNITDKQADYVEELVK
FFKEQGIRASQDLRNEKIGFKIREHTLRRVPYLLVVGDQEMENREIAVRTRDGKDLGKMSIDAFVASVKEQISHRSLKLL
EE

Sequences:

>Translated_642_residues
MPVITLPDGSQRVFANPVSTMDVAADIGPGLAKACIAGRVNGELKDACDLIHEDASLSIITARDEEGLEILRHSCAHLLG
HAIKQLWPQTKMAIGPVIDNGFYYDVDLEHKLTADDIAALEKRMLELAKTDYDVVKRVVSWQEARDTFEGRGESYKMAIL
DENIAKDATPALYHHEEYTDMCRGPHVPNMRFCHHFKLMSVAGAYWRGDSNNKMLQRIYGTAWGDKKALNTHLARLEEAA
KRDHRKIGKQLDLYHMQEEAPGMVFWHNDGWSIFRELETFIRHKLSEYDYQEVKGPFMMDRVLWERSGHWDKYADAMFTT
ASENREYAIKPMNCPGHVQIFNQGLKSYRDLPLRMAEFGCCHRNEPSGSLHGLMRVRGFTQDDAHIFCTEEQVQEEVSAC
IRMVYDTYSTFGFENIVVKLSTRPEKRIGDDDMWDRAESALIEALNANGIAFEILPGEGAFYGPKIEFTLHDCLDRAWQC
GTVQLDYALPGRLGATYVAEDNARQTPVMIHRAILGSLERFIGILIEEYAGRFPAWLAPVQAVVMNITDKQADYVEELVK
FFKEQGIRASQDLRNEKIGFKIREHTLRRVPYLLVVGDQEMENREIAVRTRDGKDLGKMSIDAFVASVKEQISHRSLKLL
EE
>Mature_641_residues
PVITLPDGSQRVFANPVSTMDVAADIGPGLAKACIAGRVNGELKDACDLIHEDASLSIITARDEEGLEILRHSCAHLLGH
AIKQLWPQTKMAIGPVIDNGFYYDVDLEHKLTADDIAALEKRMLELAKTDYDVVKRVVSWQEARDTFEGRGESYKMAILD
ENIAKDATPALYHHEEYTDMCRGPHVPNMRFCHHFKLMSVAGAYWRGDSNNKMLQRIYGTAWGDKKALNTHLARLEEAAK
RDHRKIGKQLDLYHMQEEAPGMVFWHNDGWSIFRELETFIRHKLSEYDYQEVKGPFMMDRVLWERSGHWDKYADAMFTTA
SENREYAIKPMNCPGHVQIFNQGLKSYRDLPLRMAEFGCCHRNEPSGSLHGLMRVRGFTQDDAHIFCTEEQVQEEVSACI
RMVYDTYSTFGFENIVVKLSTRPEKRIGDDDMWDRAESALIEALNANGIAFEILPGEGAFYGPKIEFTLHDCLDRAWQCG
TVQLDYALPGRLGATYVAEDNARQTPVMIHRAILGSLERFIGILIEEYAGRFPAWLAPVQAVVMNITDKQADYVEELVKF
FKEQGIRASQDLRNEKIGFKIREHTLRRVPYLLVVGDQEMENREIAVRTRDGKDLGKMSIDAFVASVKEQISHRSLKLLE
E

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI38570111, Length=618, Percent_Identity=39.6440129449838, Blast_Score=453, Evalue=1e-127,
Organism=Homo sapiens, GI38202255, Length=653, Percent_Identity=37.9785604900459, Blast_Score=443, Evalue=1e-124,
Organism=Homo sapiens, GI20070344, Length=649, Percent_Identity=34.8228043143297, Blast_Score=380, Evalue=1e-105,
Organism=Escherichia coli, GI1788013, Length=642, Percent_Identity=78.816199376947, Blast_Score=1088, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71984192, Length=631, Percent_Identity=37.7179080824089, Blast_Score=442, Evalue=1e-124,
Organism=Caenorhabditis elegans, GI71984184, Length=631, Percent_Identity=37.7179080824089, Blast_Score=442, Evalue=1e-124,
Organism=Saccharomyces cerevisiae, GI6322112, Length=628, Percent_Identity=37.1019108280255, Blast_Score=427, Evalue=1e-120,
Organism=Saccharomyces cerevisiae, GI6322654, Length=398, Percent_Identity=38.1909547738693, Blast_Score=303, Evalue=8e-83,
Organism=Drosophila melanogaster, GI24583842, Length=631, Percent_Identity=38.9857369255151, Blast_Score=466, Evalue=1e-131,
Organism=Drosophila melanogaster, GI28574141, Length=631, Percent_Identity=38.9857369255151, Blast_Score=466, Evalue=1e-131,
Organism=Drosophila melanogaster, GI24583839, Length=631, Percent_Identity=38.9857369255151, Blast_Score=466, Evalue=1e-131,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYT_SHEAM (A1S6G4)

Other databases:

- EMBL:   CP000507
- RefSeq:   YP_927640.1
- ProteinModelPortal:   A1S6G4
- SMR:   A1S6G4
- STRING:   A1S6G4
- GeneID:   4604015
- GenomeReviews:   CP000507_GR
- KEGG:   saz:Sama_1765
- NMPDR:   fig|326297.7.peg.1666
- eggNOG:   COG0441
- HOGENOM:   HBG352811
- OMA:   GFEYEVE
- PhylomeDB:   A1S6G4
- ProtClustDB:   PRK00413
- GO:   GO:0005737
- HAMAP:   MF_00184_B
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR012675
- InterPro:   IPR004095
- InterPro:   IPR012676
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947
- Gene3D:   G3DSA:3.40.50.800
- Gene3D:   G3DSA:3.10.20.30
- PRINTS:   PR01047
- SMART:   SM00863
- TIGRFAMs:   TIGR00418

Pfam domain/function: PF03129 HGTP_anticodon; PF02824 TGS; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD; SSF52954 Anticodon_bd; SSF81271 TGS-like; SSF55186 Thr/Ala-tRNA-synth_IIc_edit

EC number: =6.1.1.3

Molecular weight: Translated: 73231; Mature: 73100

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVITLPDGSQRVFANPVSTMDVAADIGPGLAKACIAGRVNGELKDACDLIHEDASLSII
CCEEECCCCCCEEECCCCCHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEE
TARDEEGLEILRHSCAHLLGHAIKQLWPQTKMAIGPVIDNGFYYDVDLEHKLTADDIAAL
EECCCHHHHHHHHHHHHHHHHHHHHHCCHHHHEECCEECCCEEEEEECCCCCCHHHHHHH
EKRMLELAKTDYDVVKRVVSWQEARDTFEGRGESYKMAILDENIAKDATPALYHHEEYTD
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCHHCCCCCCHHHCCHHHHH
MCRGPHVPNMRFCHHFKLMSVAGAYWRGDSNNKMLQRIYGTAWGDKKALNTHLARLEEAA
HHCCCCCCCCHHHHHHHHHHHCCHHCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
KRDHRKIGKQLDLYHMQEEAPGMVFWHNDGWSIFRELETFIRHKLSEYDYQEVKGPFMMD
HHHHHHHCCHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCHHHHCCCHHHH
RVLWERSGHWDKYADAMFTTASENREYAIKPMNCPGHVQIFNQGLKSYRDLPLRMAEFGC
HHHHHCCCCCHHHHHHHHEECCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCHHHHHHCC
CHRNEPSGSLHGLMRVRGFTQDDAHIFCTEEQVQEEVSACIRMVYDTYSTFGFENIVVKL
CCCCCCCHHHHHHHHHCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEE
STRPEKRIGDDDMWDRAESALIEALNANGIAFEILPGEGAFYGPKIEFTLHDCLDRAWQC
ECCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCEECCEEEEEHHHHHHHHHCC
GTVQLDYALPGRLGATYVAEDNARQTPVMIHRAILGSLERFIGILIEEYAGRFPAWLAPV
CCEEEEEECCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
QAVVMNITDKQADYVEELVKFFKEQGIRASQDLRNEKIGFKIREHTLRRVPYLLVVGDQE
HHHHHHCCCCHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCHHHHHHHHCCEEEEECCCC
MENREIAVRTRDGKDLGKMSIDAFVASVKEQISHRSLKLLEE
CCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PVITLPDGSQRVFANPVSTMDVAADIGPGLAKACIAGRVNGELKDACDLIHEDASLSII
CEEECCCCCCEEECCCCCHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEE
TARDEEGLEILRHSCAHLLGHAIKQLWPQTKMAIGPVIDNGFYYDVDLEHKLTADDIAAL
EECCCHHHHHHHHHHHHHHHHHHHHHCCHHHHEECCEECCCEEEEEECCCCCCHHHHHHH
EKRMLELAKTDYDVVKRVVSWQEARDTFEGRGESYKMAILDENIAKDATPALYHHEEYTD
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCHHCCCCCCHHHCCHHHHH
MCRGPHVPNMRFCHHFKLMSVAGAYWRGDSNNKMLQRIYGTAWGDKKALNTHLARLEEAA
HHCCCCCCCCHHHHHHHHHHHCCHHCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
KRDHRKIGKQLDLYHMQEEAPGMVFWHNDGWSIFRELETFIRHKLSEYDYQEVKGPFMMD
HHHHHHHCCHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCHHHHCCCHHHH
RVLWERSGHWDKYADAMFTTASENREYAIKPMNCPGHVQIFNQGLKSYRDLPLRMAEFGC
HHHHHCCCCCHHHHHHHHEECCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCHHHHHHCC
CHRNEPSGSLHGLMRVRGFTQDDAHIFCTEEQVQEEVSACIRMVYDTYSTFGFENIVVKL
CCCCCCCHHHHHHHHHCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEE
STRPEKRIGDDDMWDRAESALIEALNANGIAFEILPGEGAFYGPKIEFTLHDCLDRAWQC
ECCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCEECCEEEEEHHHHHHHHHCC
GTVQLDYALPGRLGATYVAEDNARQTPVMIHRAILGSLERFIGILIEEYAGRFPAWLAPV
CCEEEEEECCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
QAVVMNITDKQADYVEELVKFFKEQGIRASQDLRNEKIGFKIREHTLRRVPYLLVVGDQE
HHHHHHCCCCHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCHHHHHHHHCCEEEEECCCC
MENREIAVRTRDGKDLGKMSIDAFVASVKEQISHRSLKLLEE
CCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA