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The map label for this gene is zitB [H]

Identifier: 119774890

GI number: 119774890

Start: 2146324

End: 2147421

Strand: Direct

Name: zitB [H]

Synonym: Sama_1755

Alternate gene names: 119774890

Gene position: 2146324-2147421 (Clockwise)

Preceding gene: 119774885

Following gene: 119774891

Centisome position: 49.84

GC content: 53.64

Gene sequence:

>1098_bases
ATGCCATCGTCTATGAATGCCAAACCCTTTCACTCTGTTGCCCATTGGCAGCACAGTCATGACTTTTTTAAACACAACGA
TGCTGGTGAACGCAGTACCCGGATAGTCCTGGTGCTGACACTGGTGACCATGGTGGCCGAGATCCTCGCTGGCACCGTGT
ATGGCTCCATGGCCTTACTGGCGGACGGTTGGCATATGGGCACCCACGCCGCAGCTTTCCTTATCACCCTGTTTGCTTAC
CGCTATGCACTGAAACATAAAGATGACCCGGCATTTGCCTTCGGAACAGGCAAGGTAAGTGTGCTCGGCGGCTTTGCCAG
TGCGGTTGCGCTGGGCTTAGTTGCGCTGATTATGGTGATAGAATCTGCGGTACGCCTGATATCGCCCCATCAAATTGCCT
TTGATGAGGCCATACTGGTGGCGATTATTGGCCTGTCGGTCAACCTGCTCAGTGCGTTTCTATTGAAAGACCACCATCAC
CATCATCATCACCACCACGGGCACCATCATGAAGAGGATGACCATGAAACCCATTTGCATCATCATGAAGAAGGCAACTG
CCATCATGATCACAGTCAAGTTGGTGCGGATCACCACAGCCATGAGCATCATGATCATGACCACGATCACCAGCATCATC
ACGGGCATCACGACCACAACCTGCGTGCTGCCTATTTGCACGTACTGGCCGATGCATTGACGTCCGTGCTCGCCATTGGT
GCCTTGCTTGCGGGTAAATTCTTTGGTCTGGGCTGGCTCGACCCGCTAATCGGGATACTCGGCGCCATCATCATCGGCCG
CTGGGCAGTAGGGCTTGTTAAAGACACGGGCCCCTTGCTGCTCGACGCTGACAACAACGAGAAATTACGGAAAAACGTGA
TTCGTCTGGTGGCAAGCGTGCCGGATCACGGGGTGTCCGATCTGCATCTGTGGCGTATCAGTGCCGATCATCGTGCCTGT
ATCCTGGGTGTTGTGAGCCATCAACCCAAGTCCAGTGACTACTTCGTAAAAAGGCTCAAGGACGAGTTGGGTCTGCACCA
TGTCACTGTTGAAGTACATTGCTGTGACTGCGAAGTCAGGCCCTCATCGCAGGACTGA

Upstream 100 bases:

>100_bases
TTACGAATTGCTGGTTAATTCACATTTCAAATAGTTTGAAGTTCAAACTAATTTAATTCACACTGAAAACACGCTAACGT
TCATCCATCAATTACTCAAC

Downstream 100 bases:

>100_bases
AACCGAACCAGAACGTATGGTGCCGCGCCCACTATCAAGATTTCGGCGCAGCGCCGTGACAAGAAGGAAGCCTTAACCAC
ATGGATATCAATCAGGATTT

Product: cation efflux family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 365; Mature: 364

Protein sequence:

>365_residues
MPSSMNAKPFHSVAHWQHSHDFFKHNDAGERSTRIVLVLTLVTMVAEILAGTVYGSMALLADGWHMGTHAAAFLITLFAY
RYALKHKDDPAFAFGTGKVSVLGGFASAVALGLVALIMVIESAVRLISPHQIAFDEAILVAIIGLSVNLLSAFLLKDHHH
HHHHHHGHHHEEDDHETHLHHHEEGNCHHDHSQVGADHHSHEHHDHDHDHQHHHGHHDHNLRAAYLHVLADALTSVLAIG
ALLAGKFFGLGWLDPLIGILGAIIIGRWAVGLVKDTGPLLLDADNNEKLRKNVIRLVASVPDHGVSDLHLWRISADHRAC
ILGVVSHQPKSSDYFVKRLKDELGLHHVTVEVHCCDCEVRPSSQD

Sequences:

>Translated_365_residues
MPSSMNAKPFHSVAHWQHSHDFFKHNDAGERSTRIVLVLTLVTMVAEILAGTVYGSMALLADGWHMGTHAAAFLITLFAY
RYALKHKDDPAFAFGTGKVSVLGGFASAVALGLVALIMVIESAVRLISPHQIAFDEAILVAIIGLSVNLLSAFLLKDHHH
HHHHHHGHHHEEDDHETHLHHHEEGNCHHDHSQVGADHHSHEHHDHDHDHQHHHGHHDHNLRAAYLHVLADALTSVLAIG
ALLAGKFFGLGWLDPLIGILGAIIIGRWAVGLVKDTGPLLLDADNNEKLRKNVIRLVASVPDHGVSDLHLWRISADHRAC
ILGVVSHQPKSSDYFVKRLKDELGLHHVTVEVHCCDCEVRPSSQD
>Mature_364_residues
PSSMNAKPFHSVAHWQHSHDFFKHNDAGERSTRIVLVLTLVTMVAEILAGTVYGSMALLADGWHMGTHAAAFLITLFAYR
YALKHKDDPAFAFGTGKVSVLGGFASAVALGLVALIMVIESAVRLISPHQIAFDEAILVAIIGLSVNLLSAFLLKDHHHH
HHHHHGHHHEEDDHETHLHHHEEGNCHHDHSQVGADHHSHEHHDHDHDHQHHHGHHDHNLRAAYLHVLADALTSVLAIGA
LLAGKFFGLGWLDPLIGILGAIIIGRWAVGLVKDTGPLLLDADNNEKLRKNVIRLVASVPDHGVSDLHLWRISADHRACI
LGVVSHQPKSSDYFVKRLKDELGLHHVTVEVHCCDCEVRPSSQD

Specific function: Involved in zinc efflux across the cytoplasmic membrane, thus reducing zinc accumulation in the cytoplasm and rendering bacteria more resistant to zinc. It may contribute to zinc homeostasis at low concentrations of zinc [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI222080086, Length=344, Percent_Identity=27.6162790697674, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI40255009, Length=344, Percent_Identity=27.6162790697674, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI20070323, Length=338, Percent_Identity=28.1065088757396, Blast_Score=88, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17555794, Length=352, Percent_Identity=24.1477272727273, Blast_Score=66, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI32564488, Length=112, Percent_Identity=36.6071428571429, Blast_Score=66, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17555796, Length=345, Percent_Identity=23.768115942029, Blast_Score=65, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI193210990, Length=133, Percent_Identity=32.3308270676692, Blast_Score=64, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6323899, Length=366, Percent_Identity=27.0491803278689, Blast_Score=96, Evalue=9e-21,
Organism=Saccharomyces cerevisiae, GI6324892, Length=400, Percent_Identity=22, Blast_Score=67, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24645863, Length=280, Percent_Identity=28.2142857142857, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24585900, Length=345, Percent_Identity=23.768115942029, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24585898, Length=345, Percent_Identity=23.768115942029, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24585896, Length=345, Percent_Identity=23.768115942029, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI19921672, Length=345, Percent_Identity=23.768115942029, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24656728, Length=297, Percent_Identity=26.2626262626263, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24656724, Length=297, Percent_Identity=26.2626262626263, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24656720, Length=297, Percent_Identity=26.2626262626263, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24656715, Length=297, Percent_Identity=26.2626262626263, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI21357035, Length=297, Percent_Identity=26.2626262626263, Blast_Score=69, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 40375; Mature: 40244

Theoretical pI: Translated: 6.84; Mature: 6.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSSMNAKPFHSVAHWQHSHDFFKHNDAGERSTRIVLVLTLVTMVAEILAGTVYGSMALL
CCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ADGWHMGTHAAAFLITLFAYRYALKHKDDPAFAFGTGKVSVLGGFASAVALGLVALIMVI
HCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCEEEHHHHHHHHHHHHHHHHHHH
ESAVRLISPHQIAFDEAILVAIIGLSVNLLSAFLLKDHHHHHHHHHGHHHEEDDHETHLH
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHCC
HHEEGNCHHDHSQVGADHHSHEHHDHDHDHQHHHGHHDHNLRAAYLHVLADALTSVLAIG
CCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
ALLAGKFFGLGWLDPLIGILGAIIIGRWAVGLVKDTGPLLLDADNNEKLRKNVIRLVASV
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHEECCCCEEEECCCCHHHHHHHHHHHHHC
PDHGVSDLHLWRISADHRACILGVVSHQPKSSDYFVKRLKDELGLHHVTVEVHCCDCEVR
CCCCCCCEEEEEECCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCEEEEEEEEEECCCCC
PSSQD
CCCCC
>Mature Secondary Structure 
PSSMNAKPFHSVAHWQHSHDFFKHNDAGERSTRIVLVLTLVTMVAEILAGTVYGSMALL
CCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ADGWHMGTHAAAFLITLFAYRYALKHKDDPAFAFGTGKVSVLGGFASAVALGLVALIMVI
HCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCEEEHHHHHHHHHHHHHHHHHHH
ESAVRLISPHQIAFDEAILVAIIGLSVNLLSAFLLKDHHHHHHHHHGHHHEEDDHETHLH
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHCC
HHEEGNCHHDHSQVGADHHSHEHHDHDHDHQHHHGHHDHNLRAAYLHVLADALTSVLAIG
CCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
ALLAGKFFGLGWLDPLIGILGAIIIGRWAVGLVKDTGPLLLDADNNEKLRKNVIRLVASV
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHEECCCCEEEECCCCHHHHHHHHHHHHHC
PDHGVSDLHLWRISADHRACILGVVSHQPKSSDYFVKRLKDELGLHHVTVEVHCCDCEVR
CCCCCCCEEEEEECCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCEEEEEEEEEECCCCC
PSSQD
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]