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The map label for this gene is mdtE [H]

Identifier: 119774850

GI number: 119774850

Start: 2097037

End: 2098110

Strand: Direct

Name: mdtE [H]

Synonym: Sama_1715

Alternate gene names: 119774850

Gene position: 2097037-2098110 (Clockwise)

Preceding gene: 119774849

Following gene: 119774851

Centisome position: 48.7

GC content: 56.33

Gene sequence:

>1074_bases
ATGACACTGCGACAACATTACCGCCATGCACTGGTCTTTTCGGCACTCACCATCGGCCTGCTTGGCTGCGAACAGGCGCC
GGTTGAAGTCAAAGCAACCGGCGACATCTCTCGGCCAGCCATGATAGTGACATTGCAGCCGCAGGGCATATCGCAAACCC
AGTTTACCGGCGTTGTCCGCAGCGCTGAGCGGGCGGAGCTGGCCTTTAAACAGTCGGGCAAGCTTGCCAGCATGACGGTG
CAGGAAGGTGATAAGGTCAGCCGGGGGCAAACACTGGCCACTCTGGATGATGCGGAGCTGAAAACCGCGCTCAATTCTGC
CAATGTTGAATTTAAGCAGGCGCAAACCGATTTTGACCGTGGCAATAAAATTTTCTCGACCAGTCAGGCTATCTCGCGCA
GCGATTTGGATCAGCTTAAAGTTAAGCGCGATCTGGCCGCCAACAAGGTTGCCAAGGCGCAGCAGGATTTGGCCAACGCC
AGTCTCAACGCCCCCTTTGATGGCACAGTGGCACAAAAGCTGGTGAATAACTTTGCCACGGTGCAGCCCAATCAGCCGGT
TTACGTTGTGCACAATCCTGCCAATCTGGAAGTGATGATCAATGTGCCCGGCAAACTGTTTCTTGAGCCCAATGCCGGTC
AGCGGGCGGTGGCAGAAATCGAAGGCCTGGCCGGGCAGCGTTTTGGCCTGACCTATCGCTACTACGCCGCCGATGCCGAC
CCGGTATCGCAAACCTATCAGGTCGTGCTGGGCTTTGATGACCCAAGCGCCGCCAATCTGTTGCCGGGCATGAGCGCCAA
GGTGTATCCGGTGATGGACAGCGCCGCGCAAAACCAGCATCTGCTGGTGCCTGTGGATGCGGTGGTGCCTTCAAATACCG
GCAGCCAGTTTGTCTGGTTGGTGAATGCCGACAGCAGTGTTGCCAAGCGCAGCATCCGTGTTGGCAATATTTTGGGTAAC
CAAATTCAGGTGACCGAGGGTTTAAGCCCGGGTGATAAAATTGTCGTGGCAGGCGTTCACGCCCTGGCAGAAGGAATGAA
GGTTCACCCAATGCAGTCGGGGGAGTCTAACTGA

Upstream 100 bases:

>100_bases
GTGTCCACCGCGTAGTATGCGTGTTGGACACTTAAATACGTTGTTATACAGGCAGCATCAAAGCGCATTATCCAATAGCA
CTTACTTAGGGGTACAGGGA

Downstream 100 bases:

>100_bases
TGGATATCGCCCGTTATTCGATTGCCAAACGCACCAGCGTTTGGGTGATCATCTGTTTGCTGCTGCTTGGGGGCTACCTT
AGCTACCAACAACTGGGGCG

Product: acriflavin resistance periplasmic protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 357; Mature: 356

Protein sequence:

>357_residues
MTLRQHYRHALVFSALTIGLLGCEQAPVEVKATGDISRPAMIVTLQPQGISQTQFTGVVRSAERAELAFKQSGKLASMTV
QEGDKVSRGQTLATLDDAELKTALNSANVEFKQAQTDFDRGNKIFSTSQAISRSDLDQLKVKRDLAANKVAKAQQDLANA
SLNAPFDGTVAQKLVNNFATVQPNQPVYVVHNPANLEVMINVPGKLFLEPNAGQRAVAEIEGLAGQRFGLTYRYYAADAD
PVSQTYQVVLGFDDPSAANLLPGMSAKVYPVMDSAAQNQHLLVPVDAVVPSNTGSQFVWLVNADSSVAKRSIRVGNILGN
QIQVTEGLSPGDKIVVAGVHALAEGMKVHPMQSGESN

Sequences:

>Translated_357_residues
MTLRQHYRHALVFSALTIGLLGCEQAPVEVKATGDISRPAMIVTLQPQGISQTQFTGVVRSAERAELAFKQSGKLASMTV
QEGDKVSRGQTLATLDDAELKTALNSANVEFKQAQTDFDRGNKIFSTSQAISRSDLDQLKVKRDLAANKVAKAQQDLANA
SLNAPFDGTVAQKLVNNFATVQPNQPVYVVHNPANLEVMINVPGKLFLEPNAGQRAVAEIEGLAGQRFGLTYRYYAADAD
PVSQTYQVVLGFDDPSAANLLPGMSAKVYPVMDSAAQNQHLLVPVDAVVPSNTGSQFVWLVNADSSVAKRSIRVGNILGN
QIQVTEGLSPGDKIVVAGVHALAEGMKVHPMQSGESN
>Mature_356_residues
TLRQHYRHALVFSALTIGLLGCEQAPVEVKATGDISRPAMIVTLQPQGISQTQFTGVVRSAERAELAFKQSGKLASMTVQ
EGDKVSRGQTLATLDDAELKTALNSANVEFKQAQTDFDRGNKIFSTSQAISRSDLDQLKVKRDLAANKVAKAQQDLANAS
LNAPFDGTVAQKLVNNFATVQPNQPVYVVHNPANLEVMINVPGKLFLEPNAGQRAVAEIEGLAGQRFGLTYRYYAADADP
VSQTYQVVLGFDDPSAANLLPGMSAKVYPVMDSAAQNQHLLVPVDAVVPSNTGSQFVWLVNADSSVAKRSIRVGNILGNQ
IQVTEGLSPGDKIVVAGVHALAEGMKVHPMQSGESN

Specific function: Part of a multidrug resistance efflux system that confers resistance to compounds such as rhodamine 6G, erythromycin, doxorubicin, ethidium bromide, TPP, SDS, deoxycholate, crystal violet and benzalkonium [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Lipid-anchor (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1789929, Length=383, Percent_Identity=25.065274151436, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1789665, Length=380, Percent_Identity=25, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI87082036, Length=321, Percent_Identity=23.98753894081, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI1786668, Length=364, Percent_Identity=24.4505494505494, Blast_Score=65, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 38195; Mature: 38064

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLRQHYRHALVFSALTIGLLGCEQAPVEVKATGDISRPAMIVTLQPQGISQTQFTGVVR
CCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCEEEEEECCCCCCHHHHHHHHH
SAERAELAFKQSGKLASMTVQEGDKVSRGQTLATLDDAELKTALNSANVEFKQAQTDFDR
CCHHHHHHHHCCCCEEEEEECCCCCCCCCCEEEEECCHHHHHHHHCCCEEEEHHHCCHHC
GNKIFSTSQAISRSDLDQLKVKRDLAANKVAKAQQDLANASLNAPFDGTVAQKLVNNFAT
CCEEEEHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHEE
VQPNQPVYVVHNPANLEVMINVPGKLFLEPNAGQRAVAEIEGLAGQRFGLTYRYYAADAD
ECCCCCEEEEECCCCEEEEEECCCEEEECCCCCCHHHHHHHHCCCCEECEEEEEEECCCC
PVSQTYQVVLGFDDPSAANLLPGMSAKVYPVMDSAAQNQHLLVPVDAVVPSNTGSQFVWL
CCCCEEEEEEECCCCCHHHHCCCCCCEEEEEECCCCCCCEEEEEEHHCCCCCCCCEEEEE
VNADSSVAKRSIRVGNILGNQIQVTEGLSPGDKIVVAGVHALAEGMKVHPMQSGESN
EECCCHHHHHHEEECCCCCCEEEEECCCCCCCEEEEEEHHHHHCCCEEEECCCCCCC
>Mature Secondary Structure 
TLRQHYRHALVFSALTIGLLGCEQAPVEVKATGDISRPAMIVTLQPQGISQTQFTGVVR
CHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCEEEEEECCCCCCHHHHHHHHH
SAERAELAFKQSGKLASMTVQEGDKVSRGQTLATLDDAELKTALNSANVEFKQAQTDFDR
CCHHHHHHHHCCCCEEEEEECCCCCCCCCCEEEEECCHHHHHHHHCCCEEEEHHHCCHHC
GNKIFSTSQAISRSDLDQLKVKRDLAANKVAKAQQDLANASLNAPFDGTVAQKLVNNFAT
CCEEEEHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHEE
VQPNQPVYVVHNPANLEVMINVPGKLFLEPNAGQRAVAEIEGLAGQRFGLTYRYYAADAD
ECCCCCEEEEECCCCEEEEEECCCEEEECCCCCCHHHHHHHHCCCCEECEEEEEEECCCC
PVSQTYQVVLGFDDPSAANLLPGMSAKVYPVMDSAAQNQHLLVPVDAVVPSNTGSQFVWL
CCCCEEEEEEECCCCCHHHHCCCCCCEEEEEECCCCCCCEEEEEEHHCCCCCCCCEEEEE
VNADSSVAKRSIRVGNILGNQIQVTEGLSPGDKIVVAGVHALAEGMKVHPMQSGESN
EECCCHHHHHHEEECCCCCCEEEEECCCCCCCEEEEEEHHHHHCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]