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The map label for this gene is mdh [H]

Identifier: 119774776

GI number: 119774776

Start: 2005890

End: 2006960

Strand: Reverse

Name: mdh [H]

Synonym: Sama_1640

Alternate gene names: 119774776

Gene position: 2006960-2005890 (Counterclockwise)

Preceding gene: 119774777

Following gene: 119774775

Centisome position: 46.61

GC content: 53.69

Gene sequence:

>1071_bases
ATGAAGTTCAGAAATTTCAAAGCTGTACCTAAGATGATCTTCGGTCGCGGCGCATTCAACCAGCTCGACGAAGTACTGGC
CGCCGAGCGCAAGAACGATGACGATTTCGTGGTATTTCTGGTGGACGACGTGCACCAGGGCAAACCACTGGAAAGCCGTA
TTCCGGTCAAGCCACAAGACAAGCTGATTTGGGTAAACGTGGACGATGAGCCTTCAACCGAACAGGTTGATGCCCTCACC
GAGGAAGTACAGGCCTTCAACAGCAAGCTGCCCGTCAGCGTAGTGGGTCTGGGTGGCGGTTCTACCATGGATTTGGCCAA
GGCCGTATCCCTGATGCTGACCAACCCAGGTGGCTCTGCCATGTACCAGGGCTGGGATCTGATTAAGGTGGCTGCCGTTC
ATCACATTGGTATTCCTACCATTTCCGGTACCGGTGCCGAAGCCTCACGTACTGCGGTACTGTGCGGCCCTGAGCGCAAG
CTGGGTCTTAACTCAGACTTCACCGTATTCGACCAGATCATCATGGATCCCGAGCTGATTGCCGGTGTACCTGTTGATCA
GTGGTTCTACACAGGGATGGATTGCTACATCCACTGCATCGAGTCGCTGGAAGGCACTTACCTGAACGAATATTCCAAGG
CCTTCGGTGAAAAATCACTGGAGCTGTGCCGTCAAGTGTACCTGGATGACCACCCAGAAAAAGACGACAAGCTGATGATG
GCCTCATACATGGGCGGCATGTCCATCGCGTACAGCCAGGTGGGTGCCTGTCACGCCCTGTCTTATGGCCTGGGTTACGT
GCTGGGCTACCACCACGGTATCGGCAACTGTATCGCCTTTAACGTGCTGGAAGAGTTCTACCCAGAGGGTGTGGCCGAAT
TCCGCACCATGATGGAAAAACACAATATCACCCTGCCAAAAGACATCTGCAAAGATTTGCCAGATGAAACCATTGCTCGT
ATGGTTAAAGTGGCCAAGAGCCTCGGCCCACTGTGGCACAACGTGTACGGCGACGGTTGGGAAGAAAAAGTGACCGACGA
GATGCTGACCAAACTGTACCGTCGCATCTAG

Upstream 100 bases:

>100_bases
TCCATGCTCATCAAGCTCAGCTGGACTGAAGAACAGATCCAGGAACGTATTGCCAACATCAAGAAGGCCTTTGCCCAATA
ATAGACGGGAGTCTTTTGCA

Downstream 100 bases:

>100_bases
TCTTGTTTCCGGGCTCCTTCGGGAGCCCGCTTTGTTAGAGTCCAGGAATTTTTTGATGAACGTGACCCTGTTGATCCCTG
CCCGCTACGGCTCCAGCCGT

Product: alcohol dehydrogenase, iron-containing

Products: NA

Alternate protein names: MEDH [H]

Number of amino acids: Translated: 356; Mature: 356

Protein sequence:

>356_residues
MKFRNFKAVPKMIFGRGAFNQLDEVLAAERKNDDDFVVFLVDDVHQGKPLESRIPVKPQDKLIWVNVDDEPSTEQVDALT
EEVQAFNSKLPVSVVGLGGGSTMDLAKAVSLMLTNPGGSAMYQGWDLIKVAAVHHIGIPTISGTGAEASRTAVLCGPERK
LGLNSDFTVFDQIIMDPELIAGVPVDQWFYTGMDCYIHCIESLEGTYLNEYSKAFGEKSLELCRQVYLDDHPEKDDKLMM
ASYMGGMSIAYSQVGACHALSYGLGYVLGYHHGIGNCIAFNVLEEFYPEGVAEFRTMMEKHNITLPKDICKDLPDETIAR
MVKVAKSLGPLWHNVYGDGWEEKVTDEMLTKLYRRI

Sequences:

>Translated_356_residues
MKFRNFKAVPKMIFGRGAFNQLDEVLAAERKNDDDFVVFLVDDVHQGKPLESRIPVKPQDKLIWVNVDDEPSTEQVDALT
EEVQAFNSKLPVSVVGLGGGSTMDLAKAVSLMLTNPGGSAMYQGWDLIKVAAVHHIGIPTISGTGAEASRTAVLCGPERK
LGLNSDFTVFDQIIMDPELIAGVPVDQWFYTGMDCYIHCIESLEGTYLNEYSKAFGEKSLELCRQVYLDDHPEKDDKLMM
ASYMGGMSIAYSQVGACHALSYGLGYVLGYHHGIGNCIAFNVLEEFYPEGVAEFRTMMEKHNITLPKDICKDLPDETIAR
MVKVAKSLGPLWHNVYGDGWEEKVTDEMLTKLYRRI
>Mature_356_residues
MKFRNFKAVPKMIFGRGAFNQLDEVLAAERKNDDDFVVFLVDDVHQGKPLESRIPVKPQDKLIWVNVDDEPSTEQVDALT
EEVQAFNSKLPVSVVGLGGGSTMDLAKAVSLMLTNPGGSAMYQGWDLIKVAAVHHIGIPTISGTGAEASRTAVLCGPERK
LGLNSDFTVFDQIIMDPELIAGVPVDQWFYTGMDCYIHCIESLEGTYLNEYSKAFGEKSLELCRQVYLDDHPEKDDKLMM
ASYMGGMSIAYSQVGACHALSYGLGYVLGYHHGIGNCIAFNVLEEFYPEGVAEFRTMMEKHNITLPKDICKDLPDETIAR
MVKVAKSLGPLWHNVYGDGWEEKVTDEMLTKLYRRI

Specific function: May Act On The Acetaldehyde Produced From The Degradation Of Ethanolamine. [C]

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Integral Membrane Protein [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI87082107, Length=295, Percent_Identity=25.7627118644068, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI48994951, Length=225, Percent_Identity=25.3333333333333, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1789163, Length=279, Percent_Identity=23.6559139784946, Blast_Score=62, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6321181, Length=288, Percent_Identity=27.7777777777778, Blast_Score=97, Evalue=6e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.244 [H]

Molecular weight: Translated: 39622; Mature: 39622

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFRNFKAVPKMIFGRGAFNQLDEVLAAERKNDDDFVVFLVDDVHQGKPLESRIPVKPQD
CCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCC
KLIWVNVDDEPSTEQVDALTEEVQAFNSKLPVSVVGLGGGSTMDLAKAVSLMLTNPGGSA
CEEEEECCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHEECCCCCC
MYQGWDLIKVAAVHHIGIPTISGTGAEASRTAVLCGPERKLGLNSDFTVFDQIIMDPELI
HHCCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHCCHHHH
AGVPVDQWFYTGMDCYIHCIESLEGTYLNEYSKAFGEKSLELCRQVYLDDHPEKDDKLMM
CCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCHHHHH
ASYMGGMSIAYSQVGACHALSYGLGYVLGYHHGIGNCIAFNVLEEFYPEGVAEFRTMMEK
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHH
HNITLPKDICKDLPDETIARMVKVAKSLGPLWHNVYGDGWEEKVTDEMLTKLYRRI
CCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKFRNFKAVPKMIFGRGAFNQLDEVLAAERKNDDDFVVFLVDDVHQGKPLESRIPVKPQD
CCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCC
KLIWVNVDDEPSTEQVDALTEEVQAFNSKLPVSVVGLGGGSTMDLAKAVSLMLTNPGGSA
CEEEEECCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHEECCCCCC
MYQGWDLIKVAAVHHIGIPTISGTGAEASRTAVLCGPERKLGLNSDFTVFDQIIMDPELI
HHCCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHCCHHHH
AGVPVDQWFYTGMDCYIHCIESLEGTYLNEYSKAFGEKSLELCRQVYLDDHPEKDDKLMM
CCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCHHHHH
ASYMGGMSIAYSQVGACHALSYGLGYVLGYHHGIGNCIAFNVLEEFYPEGVAEFRTMMEK
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHH
HNITLPKDICKDLPDETIARMVKVAKSLGPLWHNVYGDGWEEKVTDEMLTKLYRRI
CCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1644761; 1995642 [H]