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The map label for this gene is melA [H]

Identifier: 119774705

GI number: 119774705

Start: 1912255

End: 1913292

Strand: Reverse

Name: melA [H]

Synonym: Sama_1568

Alternate gene names: 119774705

Gene position: 1913292-1912255 (Counterclockwise)

Preceding gene: 119774706

Following gene: 119774704

Centisome position: 44.43

GC content: 51.54

Gene sequence:

>1038_bases
ATGGCAAGCGAAACCAATCCACTGGGCCTGCTCGGCATCGAATTTACCGAGTTTGCCACCCCAGATAACGACTTCATGCA
CAAGGTTTTTCTGGACTTTGGCTTTTCCATGCTGAAAAAGCACAAGGAAAAAGACATCTACTACTACCAGCAAAACGACA
TCAACTTTTTGATGAACCGTGACCGCGCCGGTTTCTCGGCCGGTTTTGCCAAGTCTCACGGCCCGGCCATCACCTCCATG
GGCTGGCGCGTGGAAGATGCCGAATATGCCTACAAGCACGCGGTTGAACGTGGCGCCAAGGCCGCCCCGGATGACGTGAA
AGACCTGCCCTACCCAGCCATTTACGGCATTGGTGACAGCCTGATTTACTTCATCGACCGTTTCGGTGATGACAACATCT
ACGCCACCGATTTTGTTGATCTGGATGAGCCTGTGATTGTGCAGGAAAAAGGCTTTATGGAAGTCGACCATCTGACCAAC
AACGTCTACAAGGGCACCATGGAACAGTGGTCAAACTTCTATAAAGACGTTTTTGGCTTTACCGAAGTGCGCTACTTCGA
CATCAAGGGCTCCCAGACTGCACTGATTTCTTACGCGCTGCGTTCACCGGATGGCAGCTTCTGTATCCCTATCAACGAAG
GTAAAGGCGACGATCGTAACCAGATTGACGAATACCTGCGTGAATACAATGGCCCGGGCGTTCAGCACCTGGCGTTCCGC
AGCCGTGACATAGTTGCCTCGCTGGATGCAATGGAAGGCTCGTCCATTGCGACACTGGACATTATCCCTGAATACTACGA
CACCATCTTCGAAAAACTGCCCCAGGTGACCGAAGACCGTGAGCGCATCAAGCATCACCAAATTCTGGTGGATGGCGATG
AAAACGGCTACCTGCTGCAGATTTTCACCAAGAACCTGTTTGGTCCTATCTTTATCGAAATCATCCAGCGTAAGAACAAC
CTGGGTTTCGGTGAAGGTAACTTCAAGGCGCTGTTTGAATCTATCGAGCGCGATCAGGTCCGCCGCGGCGTGCTTTAA

Upstream 100 bases:

>100_bases
AACACGTGAAAAACTGCATGGCACCCGATTACAACCGCTCCTGGCTCGAAGACTAATCACAACAATTCCAGGCAGCAATC
CATTGAAAGAGGACAAGACA

Downstream 100 bases:

>100_bases
ATCATCCTCGTTGCCAAGGTTTTATATATAAAAAGGCCGCCCTGTGCGGCCTTTTTGCTTACCTGAGAACTGAAACCATT
GCCTGGCGTCCCCGGCCCTT

Product: 4-hydroxyphenylpyruvate dioxygenase

Products: homogentisate; CO2

Alternate protein names: NA

Number of amino acids: Translated: 345; Mature: 344

Protein sequence:

>345_residues
MASETNPLGLLGIEFTEFATPDNDFMHKVFLDFGFSMLKKHKEKDIYYYQQNDINFLMNRDRAGFSAGFAKSHGPAITSM
GWRVEDAEYAYKHAVERGAKAAPDDVKDLPYPAIYGIGDSLIYFIDRFGDDNIYATDFVDLDEPVIVQEKGFMEVDHLTN
NVYKGTMEQWSNFYKDVFGFTEVRYFDIKGSQTALISYALRSPDGSFCIPINEGKGDDRNQIDEYLREYNGPGVQHLAFR
SRDIVASLDAMEGSSIATLDIIPEYYDTIFEKLPQVTEDRERIKHHQILVDGDENGYLLQIFTKNLFGPIFIEIIQRKNN
LGFGEGNFKALFESIERDQVRRGVL

Sequences:

>Translated_345_residues
MASETNPLGLLGIEFTEFATPDNDFMHKVFLDFGFSMLKKHKEKDIYYYQQNDINFLMNRDRAGFSAGFAKSHGPAITSM
GWRVEDAEYAYKHAVERGAKAAPDDVKDLPYPAIYGIGDSLIYFIDRFGDDNIYATDFVDLDEPVIVQEKGFMEVDHLTN
NVYKGTMEQWSNFYKDVFGFTEVRYFDIKGSQTALISYALRSPDGSFCIPINEGKGDDRNQIDEYLREYNGPGVQHLAFR
SRDIVASLDAMEGSSIATLDIIPEYYDTIFEKLPQVTEDRERIKHHQILVDGDENGYLLQIFTKNLFGPIFIEIIQRKNN
LGFGEGNFKALFESIERDQVRRGVL
>Mature_344_residues
ASETNPLGLLGIEFTEFATPDNDFMHKVFLDFGFSMLKKHKEKDIYYYQQNDINFLMNRDRAGFSAGFAKSHGPAITSMG
WRVEDAEYAYKHAVERGAKAAPDDVKDLPYPAIYGIGDSLIYFIDRFGDDNIYATDFVDLDEPVIVQEKGFMEVDHLTNN
VYKGTMEQWSNFYKDVFGFTEVRYFDIKGSQTALISYALRSPDGSFCIPINEGKGDDRNQIDEYLREYNGPGVQHLAFRS
RDIVASLDAMEGSSIATLDIIPEYYDTIFEKLPQVTEDRERIKHHQILVDGDENGYLLQIFTKNLFGPIFIEIIQRKNNL
GFGEGNFKALFESIERDQVRRGVL

Specific function: Unknown

COG id: COG3185

COG function: function code ER; 4-hydroxyphenylpyruvate dioxygenase and related hemolysins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 4HPPD family [H]

Homologues:

Organism=Homo sapiens, GI4504477, Length=296, Percent_Identity=30.7432432432432, Blast_Score=122, Evalue=4e-28,
Organism=Homo sapiens, GI285002264, Length=296, Percent_Identity=30.7432432432432, Blast_Score=122, Evalue=4e-28,
Organism=Homo sapiens, GI14249394, Length=348, Percent_Identity=24.7126436781609, Blast_Score=90, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17555220, Length=295, Percent_Identity=33.2203389830508, Blast_Score=138, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI17550752, Length=202, Percent_Identity=39.1089108910891, Blast_Score=128, Evalue=5e-30,
Organism=Drosophila melanogaster, GI21356105, Length=298, Percent_Identity=34.5637583892617, Blast_Score=145, Evalue=6e-35,
Organism=Drosophila melanogaster, GI24667510, Length=298, Percent_Identity=34.5637583892617, Blast_Score=144, Evalue=6e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005956
- InterPro:   IPR004360 [H]

Pfam domain/function: PF00903 Glyoxalase [H]

EC number: 1.13.11.27

Molecular weight: Translated: 39513; Mature: 39382

Theoretical pI: Translated: 4.52; Mature: 4.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASETNPLGLLGIEFTEFATPDNDFMHKVFLDFGFSMLKKHKEKDIYYYQQNDINFLMNR
CCCCCCCCEEEEEEHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEECC
DRAGFSAGFAKSHGPAITSMGWRVEDAEYAYKHAVERGAKAAPDDVKDLPYPAIYGIGDS
CCCCCCCCCCCCCCCEECCCCCEECHHHHHHHHHHHHCCCCCCCCHHHCCCCEEECCCHH
LIYFIDRFGDDNIYATDFVDLDEPVIVQEKGFMEVDHLTNNVYKGTMEQWSNFYKDVFGF
HHHHHHHCCCCCEEEEEEECCCCCEEEECCCCEEHHHHHHHHHHHHHHHHHHHHHHHHCC
TEVRYFDIKGSQTALISYALRSPDGSFCIPINEGKGDDRNQIDEYLREYNGPGVQHLAFR
CEEEEEECCCCCEEEEEEEEECCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCHHHHHHC
SRDIVASLDAMEGSSIATLDIIPEYYDTIFEKLPQVTEDRERIKHHQILVDGDENGYLLQ
CCHHHHHHHCCCCCCEEEEECCHHHHHHHHHHCCCHHHHHHHHHHCEEEEECCCCCEEEE
IFTKNLFGPIFIEIIQRKNNLGFGEGNFKALFESIERDQVRRGVL
EEHHHCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ASETNPLGLLGIEFTEFATPDNDFMHKVFLDFGFSMLKKHKEKDIYYYQQNDINFLMNR
CCCCCCCEEEEEEHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEECC
DRAGFSAGFAKSHGPAITSMGWRVEDAEYAYKHAVERGAKAAPDDVKDLPYPAIYGIGDS
CCCCCCCCCCCCCCCEECCCCCEECHHHHHHHHHHHHCCCCCCCCHHHCCCCEEECCCHH
LIYFIDRFGDDNIYATDFVDLDEPVIVQEKGFMEVDHLTNNVYKGTMEQWSNFYKDVFGF
HHHHHHHCCCCCEEEEEEECCCCCEEEECCCCEEHHHHHHHHHHHHHHHHHHHHHHHHCC
TEVRYFDIKGSQTALISYALRSPDGSFCIPINEGKGDDRNQIDEYLREYNGPGVQHLAFR
CEEEEEECCCCCEEEEEEEEECCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCHHHHHHC
SRDIVASLDAMEGSSIATLDIIPEYYDTIFEKLPQVTEDRERIKHHQILVDGDENGYLLQ
CCHHHHHHHCCCCCCEEEEECCHHHHHHHHHHCCCHHHHHHHHHHCEEEEECCCCCEEEE
IFTKNLFGPIFIEIIQRKNNLGFGEGNFKALFESIERDQVRRGVL
EEHHHCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 4-hydroxyphenylpyruvate; O2

Specific reaction: 4-hydroxyphenylpyruvate + O2 = homogentisate + CO2

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1756973 [H]