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The map label for this gene is 119774706

Identifier: 119774706

GI number: 119774706

Start: 1913337

End: 1914497

Strand: Reverse

Name: 119774706

Synonym: Sama_1569

Alternate gene names: NA

Gene position: 1914497-1913337 (Counterclockwise)

Preceding gene: 119774709

Following gene: 119774705

Centisome position: 44.46

GC content: 54.01

Gene sequence:

>1161_bases
ATGCCATTTTATGTGAAGCAAGGTCAGATCCCGCACAAGCGCCATATCGCGTTTGCCAAGGAAAATGGAGAGCTTTACCG
CGAAGAGCTGTTCTCTACCCACGGGTTTTCGAACATCTATTCCAATAAGTACCACCACAATATGCCCACCAAGGCGCTGG
AAGTGGCCCCTATGTCACTGACCCACGGCGACACCTGGGTCGATTCGCTGGTACAGAACTATAAGCTGGACTCACGTCTG
GCCGATGGTGAAGGCAATTTCTTCTCTGCCCGCAACAAGATTTTCTTTAACGCAGATGTCGCGCTCTACACCGCCAAGGT
GACTGCCGACACCGACGAGTTTTACCGTAACGCCTATGCCGATGAAGTGGTGTTTGTACACGAAGGCGACGGCGTGCTCT
TGTCTGAATACGGCGAGCTTGAAGTCAAGAAGTGGGACTATCTGGTCATTCCGCGCGGCACGACTTATCAGCTGAAGTTC
AACGATTACAGCAATGTACGCCTGTTCGTGATTGAATCTTTCACCATGGTGGAGATCCCTAAGCATTTCCGTAACGAATA
CGGTCAGCTACTGGAATCTGCCCCTTACTGCGAGCGCGATATCCGCGTCCCCGAGCTAAAAGACGCCGTGGTTGAGCGCG
GAAACTTCCCGCTGGTGTGTAAGTTTGGCGATAAGTACCAACTGACTCAGCTGGAGTGGCATCCCTTTGATTTGGTGGGC
TGGGACGGTTTTGTCTATCCCTGGGCCTTCAACATCACCGAATACGCGCCCAAGGTGGGTAAAATCCACCTGCCGCCGTC
GGATCACCTGCTGTTTGTGGCCAGAAACTTCGTTATCTGCAACTTTGTACCGCGCCCCTATGATTTCCACCCGCAGGCGA
TCCCGGCCCCGTACTACCATAACAACATCGACAGTGACGAAGTGCTCTATTACGTCGACGGTGATTTTATGAGCCGCACC
GGCATTGAAGCCGGTTACATCACCCTGCACCAGAAAGGCGTGGCCCACGGCCCGCAACCCGGCCGCACCGAGGCCTCCAT
AGGCAAGAAGGACACCTACGAGTACGCCGTGATGGTAGACACCTTTGCGCCACTGCAGCTGACCGAACACGTGAAAAACT
GCATGGCACCCGATTACAACCGCTCCTGGCTCGAAGACTAA

Upstream 100 bases:

>100_bases
TTTTTGTACAAGTCGGCAACTAAATTGATACCCAGATCACATATAGCGCCAATTCGGCGGGTAAATGGGCCACTGCGAGC
CCAATAGAGGATAAAAACAA

Downstream 100 bases:

>100_bases
TCACAACAATTCCAGGCAGCAATCCATTGAAAGAGGACAAGACAATGGCAAGCGAAACCAATCCACTGGGCCTGCTCGGC
ATCGAATTTACCGAGTTTGC

Product: homogentisate 1,2-dioxygenase

Products: 4-maleylacetoacetate

Alternate protein names: NA

Number of amino acids: Translated: 386; Mature: 385

Protein sequence:

>386_residues
MPFYVKQGQIPHKRHIAFAKENGELYREELFSTHGFSNIYSNKYHHNMPTKALEVAPMSLTHGDTWVDSLVQNYKLDSRL
ADGEGNFFSARNKIFFNADVALYTAKVTADTDEFYRNAYADEVVFVHEGDGVLLSEYGELEVKKWDYLVIPRGTTYQLKF
NDYSNVRLFVIESFTMVEIPKHFRNEYGQLLESAPYCERDIRVPELKDAVVERGNFPLVCKFGDKYQLTQLEWHPFDLVG
WDGFVYPWAFNITEYAPKVGKIHLPPSDHLLFVARNFVICNFVPRPYDFHPQAIPAPYYHNNIDSDEVLYYVDGDFMSRT
GIEAGYITLHQKGVAHGPQPGRTEASIGKKDTYEYAVMVDTFAPLQLTEHVKNCMAPDYNRSWLED

Sequences:

>Translated_386_residues
MPFYVKQGQIPHKRHIAFAKENGELYREELFSTHGFSNIYSNKYHHNMPTKALEVAPMSLTHGDTWVDSLVQNYKLDSRL
ADGEGNFFSARNKIFFNADVALYTAKVTADTDEFYRNAYADEVVFVHEGDGVLLSEYGELEVKKWDYLVIPRGTTYQLKF
NDYSNVRLFVIESFTMVEIPKHFRNEYGQLLESAPYCERDIRVPELKDAVVERGNFPLVCKFGDKYQLTQLEWHPFDLVG
WDGFVYPWAFNITEYAPKVGKIHLPPSDHLLFVARNFVICNFVPRPYDFHPQAIPAPYYHNNIDSDEVLYYVDGDFMSRT
GIEAGYITLHQKGVAHGPQPGRTEASIGKKDTYEYAVMVDTFAPLQLTEHVKNCMAPDYNRSWLED
>Mature_385_residues
PFYVKQGQIPHKRHIAFAKENGELYREELFSTHGFSNIYSNKYHHNMPTKALEVAPMSLTHGDTWVDSLVQNYKLDSRLA
DGEGNFFSARNKIFFNADVALYTAKVTADTDEFYRNAYADEVVFVHEGDGVLLSEYGELEVKKWDYLVIPRGTTYQLKFN
DYSNVRLFVIESFTMVEIPKHFRNEYGQLLESAPYCERDIRVPELKDAVVERGNFPLVCKFGDKYQLTQLEWHPFDLVGW
DGFVYPWAFNITEYAPKVGKIHLPPSDHLLFVARNFVICNFVPRPYDFHPQAIPAPYYHNNIDSDEVLYYVDGDFMSRTG
IEAGYITLHQKGVAHGPQPGRTEASIGKKDTYEYAVMVDTFAPLQLTEHVKNCMAPDYNRSWLED

Specific function: Unknown

COG id: COG3508

COG function: function code Q; Homogentisate 1,2-dioxygenase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the homogentisate dioxygenase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR005708
- InterPro:   IPR014710 [H]

Pfam domain/function: PF04209 HgmA [H]

EC number: 1.13.11.5

Molecular weight: Translated: 44645; Mature: 44513

Theoretical pI: Translated: 5.53; Mature: 5.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPFYVKQGQIPHKRHIAFAKENGELYREELFSTHGFSNIYSNKYHHNMPTKALEVAPMSL
CCEEECCCCCCHHHEEEEEECCCHHHHHHHHHHCCCHHHHCCCCCCCCCCCCEEEEEEEE
THGDTWVDSLVQNYKLDSRLADGEGNFFSARNKIFFNADVALYTAKVTADTDEFYRNAYA
CCCHHHHHHHHHHCCCCCEEECCCCCEEECCCEEEEECCEEEEEEEEECCHHHHHHHCCC
DEVVFVHEGDGVLLSEYGELEVKKWDYLVIPRGTTYQLKFNDYSNVRLFVIESFTMVEIP
CCEEEEECCCCEEEECCCCEEEEEEEEEEEECCCEEEEEECCCCCEEEEEEECCEEEECH
KHFRNEYGQLLESAPYCERDIRVPELKDAVVERGNFPLVCKFGDKYQLTQLEWHPFDLVG
HHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCEEEEECCCEEEEEEECCCEEEEC
WDGFVYPWAFNITEYAPKVGKIHLPPSDHLLFVARNFVICNFVPRPYDFHPQAIPAPYYH
CCCEEEEEEECHHHHCCCCCEEECCCCCCEEEEEECEEEEEECCCCCCCCCCCCCCCCCC
NNIDSDEVLYYVDGDFMSRTGIEAGYITLHQKGVAHGPQPGRTEASIGKKDTYEYAVMVD
CCCCCCCEEEEECCCCHHCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEEEE
TFAPLQLTEHVKNCMAPDYNRSWLED
CCCCHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
PFYVKQGQIPHKRHIAFAKENGELYREELFSTHGFSNIYSNKYHHNMPTKALEVAPMSL
CEEECCCCCCHHHEEEEEECCCHHHHHHHHHHCCCHHHHCCCCCCCCCCCCEEEEEEEE
THGDTWVDSLVQNYKLDSRLADGEGNFFSARNKIFFNADVALYTAKVTADTDEFYRNAYA
CCCHHHHHHHHHHCCCCCEEECCCCCEEECCCEEEEECCEEEEEEEEECCHHHHHHHCCC
DEVVFVHEGDGVLLSEYGELEVKKWDYLVIPRGTTYQLKFNDYSNVRLFVIESFTMVEIP
CCEEEEECCCCEEEECCCCEEEEEEEEEEEECCCEEEEEECCCCCEEEEEEECCEEEECH
KHFRNEYGQLLESAPYCERDIRVPELKDAVVERGNFPLVCKFGDKYQLTQLEWHPFDLVG
HHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCEEEEECCCEEEEEEECCCEEEEC
WDGFVYPWAFNITEYAPKVGKIHLPPSDHLLFVARNFVICNFVPRPYDFHPQAIPAPYYH
CCCEEEEEEECHHHHCCCCCEEECCCCCCEEEEEECEEEEEECCCCCCCCCCCCCCCCCC
NNIDSDEVLYYVDGDFMSRTGIEAGYITLHQKGVAHGPQPGRTEASIGKKDTYEYAVMVD
CCCCCCCEEEEECCCCHHCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEEEE
TFAPLQLTEHVKNCMAPDYNRSWLED
CCCCHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: homogentisate; O2

Specific reaction: homogentisate + O2 = 4-maleylacetoacetate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11427726 [H]