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The map label for this gene is phoP [H]

Identifier: 119774679

GI number: 119774679

Start: 1878698

End: 1879372

Strand: Reverse

Name: phoP [H]

Synonym: Sama_1542

Alternate gene names: 119774679

Gene position: 1879372-1878698 (Counterclockwise)

Preceding gene: 119774683

Following gene: 119774678

Centisome position: 43.64

GC content: 50.81

Gene sequence:

>675_bases
ATGAGAATTCTGGTTGTCGAAGACGATCCTTTATTGTCACATCACCTCAAAGTTCAATTGAGTGAACTGGGCAATCAGGT
CCAGGTTGCCAACACCGCACAGGAAGGCTTTTATCAGGCCACCAATTACCCGATTGACGTTGCCATCGTGGATCTGGGCT
TACCGGATCAGGACGGCATAGAACTTATCACTCGTTTGCGAGACGCCGAACTCAAGGCGCCTATCCTTATTCTGACCGCG
CGGGTGAACTGGCAGGACAAGGTCGAAGGACTCAATGCCGGCGCCGATGATTACCTGGTCAAACCTTTCCAGAAAGAAGA
GCTGGTTGCCCGTTTGGATGCCTTGGTGCGCCGCAGTGCGGGCTTTGTGAAACCCCGGATCACGTCAGGATCGCTGGAAC
TGGATCTGGCCGCCAAACAGGTTACGCTCGACTCAGAAGTACTTGAAATCACAGCATTTGAATATCTTATTTTGGAATAC
CTGATGCGACACAGCCATGAAGTGGTAGCCAAACAAAGACTGCTGGATGTGATTTATGGCGATAAAGAGGGTGATCCGAA
CACCATCGAAGTCATGGTCAGTCGGCTGCGTAAAAAACTGACCCGGGATGGTATGGATAACCCCATAGTGACCATTCGCG
GCCAGGGTTATAAATTCAACCTGCCCTGTAGCTGA

Upstream 100 bases:

>100_bases
GGTCAGCGTTGATTAAGAATATTCGTCATAGAATCGGGTAAAATTTTTACAGTCAATTCGTTAGCGCGTACACTGACCCA
AATTTCTTCGGGAGTTATTC

Downstream 100 bases:

>100_bases
TGATGCGCTTTAAGTTAAAACCCAAACGTCGCCTGCTGACGAGGATGTATTTGACATCCCTGTCAATTATTACCTTGGTG
GGTTTTGGCTTGGCATGGAT

Product: response regulator receiver protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 224; Mature: 224

Protein sequence:

>224_residues
MRILVVEDDPLLSHHLKVQLSELGNQVQVANTAQEGFYQATNYPIDVAIVDLGLPDQDGIELITRLRDAELKAPILILTA
RVNWQDKVEGLNAGADDYLVKPFQKEELVARLDALVRRSAGFVKPRITSGSLELDLAAKQVTLDSEVLEITAFEYLILEY
LMRHSHEVVAKQRLLDVIYGDKEGDPNTIEVMVSRLRKKLTRDGMDNPIVTIRGQGYKFNLPCS

Sequences:

>Translated_224_residues
MRILVVEDDPLLSHHLKVQLSELGNQVQVANTAQEGFYQATNYPIDVAIVDLGLPDQDGIELITRLRDAELKAPILILTA
RVNWQDKVEGLNAGADDYLVKPFQKEELVARLDALVRRSAGFVKPRITSGSLELDLAAKQVTLDSEVLEITAFEYLILEY
LMRHSHEVVAKQRLLDVIYGDKEGDPNTIEVMVSRLRKKLTRDGMDNPIVTIRGQGYKFNLPCS
>Mature_224_residues
MRILVVEDDPLLSHHLKVQLSELGNQVQVANTAQEGFYQATNYPIDVAIVDLGLPDQDGIELITRLRDAELKAPILILTA
RVNWQDKVEGLNAGADDYLVKPFQKEELVARLDALVRRSAGFVKPRITSGSLELDLAAKQVTLDSEVLEITAFEYLILEY
LMRHSHEVVAKQRLLDVIYGDKEGDPNTIEVMVSRLRKKLTRDGMDNPIVTIRGQGYKFNLPCS

Specific function: Member of the two-component regulatory system phoQ/phoP which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1787375, Length=222, Percent_Identity=48.6486486486487, Blast_Score=211, Evalue=2e-56,
Organism=Escherichia coli, GI1786784, Length=224, Percent_Identity=35.7142857142857, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI1789402, Length=221, Percent_Identity=38.0090497737557, Blast_Score=138, Evalue=3e-34,
Organism=Escherichia coli, GI1790552, Length=220, Percent_Identity=40, Blast_Score=136, Evalue=1e-33,
Organism=Escherichia coli, GI1786911, Length=228, Percent_Identity=35.0877192982456, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1786599, Length=223, Percent_Identity=34.9775784753363, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI87082012, Length=220, Percent_Identity=33.6363636363636, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1790860, Length=222, Percent_Identity=34.2342342342342, Blast_Score=114, Evalue=4e-27,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=32.15859030837, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI2367329, Length=227, Percent_Identity=32.5991189427313, Blast_Score=96, Evalue=1e-21,
Organism=Escherichia coli, GI1787229, Length=224, Percent_Identity=29.0178571428571, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1788394, Length=223, Percent_Identity=28.6995515695067, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1790863, Length=230, Percent_Identity=30.4347826086957, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=30.8411214953271, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI145693157, Length=102, Percent_Identity=34.3137254901961, Blast_Score=61, Evalue=5e-11,
Organism=Escherichia coli, GI145693140, Length=234, Percent_Identity=26.0683760683761, Blast_Score=61, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25165; Mature: 25165

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRILVVEDDPLLSHHLKVQLSELGNQVQVANTAQEGFYQATNYPIDVAIVDLGLPDQDGI
CEEEEECCCCCHHHHHEEEHHHCCCEEEEEHHHHHCCEECCCCCEEEEEEEECCCCCHHH
ELITRLRDAELKAPILILTARVNWQDKVEGLNAGADDYLVKPFQKEELVARLDALVRRSA
HHHHHHHCCCCCCCEEEEEEECCCHHHHCCCCCCCCCHHCCCCCHHHHHHHHHHHHHHCC
GFVKPRITSGSLELDLAAKQVTLDSEVLEITAFEYLILEYLMRHSHEVVAKQRLLDVIYG
CCCCCEECCCCEEEEEEHEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DKEGDPNTIEVMVSRLRKKLTRDGMDNPIVTIRGQGYKFNLPCS
CCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCEEEECCCC
>Mature Secondary Structure
MRILVVEDDPLLSHHLKVQLSELGNQVQVANTAQEGFYQATNYPIDVAIVDLGLPDQDGI
CEEEEECCCCCHHHHHEEEHHHCCCEEEEEHHHHHCCEECCCCCEEEEEEEECCCCCHHH
ELITRLRDAELKAPILILTARVNWQDKVEGLNAGADDYLVKPFQKEELVARLDALVRRSA
HHHHHHHCCCCCCCEEEEEEECCCHHHHCCCCCCCCCHHCCCCCHHHHHHHHHHHHHHCC
GFVKPRITSGSLELDLAAKQVTLDSEVLEITAFEYLILEYLMRHSHEVVAKQRLLDVIYG
CCCCCEECCCCEEEEEEHEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DKEGDPNTIEVMVSRLRKKLTRDGMDNPIVTIRGQGYKFNLPCS
CCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA