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The map label for this gene is phoQ [H]

Identifier: 119774678

GI number: 119774678

Start: 1877346

End: 1878698

Strand: Reverse

Name: phoQ [H]

Synonym: Sama_1541

Alternate gene names: 119774678

Gene position: 1878698-1877346 (Counterclockwise)

Preceding gene: 119774679

Following gene: 119774676

Centisome position: 43.63

GC content: 52.25

Gene sequence:

>1353_bases
ATGATGCGCTTTAAGTTAAAACCCAAACGTCGCCTGCTGACGAGGATGTATTTGACATCCCTGTCAATTATTACCTTGGT
GGGTTTTGGCTTGGCATGGATGGTGAACATTCTGCATGCCCAAAACTCTTATAACGAAGAAACTGCACAGCTGATTGCGG
AAATCCCCCAGGTTGCAGCAGAACTTCGTGAGCATGATCTCATCCCTGATACCAGCGCCTGGCTTGAAGAAAACCGCAAA
GGCGAGCGCTATGTAATGGCAAGCTGTGATGACAGATTCAAGCAGGTGTGGACTTCGGCCATGGCAGTAGACAGAGGCCT
GTTTGATACCTGCGAGCGTTTTGCCGACATAAAGAACGACTCCCCGCCCTATTACCTGACCCTATCTGACACTCGTGGCT
ACTACATCTACATGCTGTCGGTGGAAATCGCCAAAGTTCATTACAATCTGCTGGTGATGAAGGACGCCGAAAAACTGGAG
CAGGAATACGATAAGTTCAGCCGTCGCACCTATTTCCGCCTCGCCCTGGTGCTGGTCCTGGCTCTGATCCTGCTTGTCAG
TGCGGCCTACTGGGGGATGCGCCCTCTGGTGCGAATGCGCGAAGAGCTCAAGTCCATTGCCGATGGCAAGGCGAAATCAC
TGTCTGATGGTTATCCGGTAGAGCTCGAAGGGGTAACTCAGGCACTGAACCAATTGCTGCAGCAATCTTCTGCCCAGCAG
GAGCGTTACCAGAATGCGATGAACGACCTGGCGCACAGCCTGAAAACCCGTCTCGCCGCGGTGCATGCCATATTGGATGA
CAAGGCATTGCATCAACAGGAGGTGAGCGAGAAAGTGATGGAACAAGTGAGCCAGATGGATCATCTGGTGAAGTATCAAT
TAAAACGGGCCATGCTGGGACGTAAAGGCCTGAAACAGGAACAGACTCAGCTGCTGCCATTGGTCAATCAGCTGTCGCAA
ATGCTGTTCAAAATCTATCGTGACAAAGACGTCCAGTTTTCGACGCGGATCCTGCCGTTATTGCAATTCCCGGGAGACAA
AGGGGATCTGATGGAGCTCTGTGGCAACCTGATGGAGAACGCATTCAGGCTCTGTATTTCGACTGTACGCGTGAGCGCTG
AAATCAACGACAAAGGCGAATTTGAACTCAGGGTTGAAGATGACGGCCCGGGCGTCGCAGAAAGCCTCAGGCAAAAAATC
CTTGAGCGGGGAGTACGGGCCGATACCCATAGCCCGGGCCAGGGTATCGGTCTTGCGGTATGCCACGAGATTGTCCAAAG
CTACAATGGCACCCTGACGATTGAAGAGTCCAACCTTGAGGGCGCCATGTTCAGGATCCGTATCCCACTGTAA

Upstream 100 bases:

>100_bases
TGGTCAGTCGGCTGCGTAAAAAACTGACCCGGGATGGTATGGATAACCCCATAGTGACCATTCGCGGCCAGGGTTATAAA
TTCAACCTGCCCTGTAGCTG

Downstream 100 bases:

>100_bases
AGACGTGGATCTGAGTTCTGAGCTTTTTATCCCACGACGTAGAGCTGCTCAGCACGGTTGAACATAACCCATGAGGTGGC
GATATATTTATCGCCACTGA

Product: sensor protein PhoQ

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 450; Mature: 450

Protein sequence:

>450_residues
MMRFKLKPKRRLLTRMYLTSLSIITLVGFGLAWMVNILHAQNSYNEETAQLIAEIPQVAAELREHDLIPDTSAWLEENRK
GERYVMASCDDRFKQVWTSAMAVDRGLFDTCERFADIKNDSPPYYLTLSDTRGYYIYMLSVEIAKVHYNLLVMKDAEKLE
QEYDKFSRRTYFRLALVLVLALILLVSAAYWGMRPLVRMREELKSIADGKAKSLSDGYPVELEGVTQALNQLLQQSSAQQ
ERYQNAMNDLAHSLKTRLAAVHAILDDKALHQQEVSEKVMEQVSQMDHLVKYQLKRAMLGRKGLKQEQTQLLPLVNQLSQ
MLFKIYRDKDVQFSTRILPLLQFPGDKGDLMELCGNLMENAFRLCISTVRVSAEINDKGEFELRVEDDGPGVAESLRQKI
LERGVRADTHSPGQGIGLAVCHEIVQSYNGTLTIEESNLEGAMFRIRIPL

Sequences:

>Translated_450_residues
MMRFKLKPKRRLLTRMYLTSLSIITLVGFGLAWMVNILHAQNSYNEETAQLIAEIPQVAAELREHDLIPDTSAWLEENRK
GERYVMASCDDRFKQVWTSAMAVDRGLFDTCERFADIKNDSPPYYLTLSDTRGYYIYMLSVEIAKVHYNLLVMKDAEKLE
QEYDKFSRRTYFRLALVLVLALILLVSAAYWGMRPLVRMREELKSIADGKAKSLSDGYPVELEGVTQALNQLLQQSSAQQ
ERYQNAMNDLAHSLKTRLAAVHAILDDKALHQQEVSEKVMEQVSQMDHLVKYQLKRAMLGRKGLKQEQTQLLPLVNQLSQ
MLFKIYRDKDVQFSTRILPLLQFPGDKGDLMELCGNLMENAFRLCISTVRVSAEINDKGEFELRVEDDGPGVAESLRQKI
LERGVRADTHSPGQGIGLAVCHEIVQSYNGTLTIEESNLEGAMFRIRIPL
>Mature_450_residues
MMRFKLKPKRRLLTRMYLTSLSIITLVGFGLAWMVNILHAQNSYNEETAQLIAEIPQVAAELREHDLIPDTSAWLEENRK
GERYVMASCDDRFKQVWTSAMAVDRGLFDTCERFADIKNDSPPYYLTLSDTRGYYIYMLSVEIAKVHYNLLVMKDAEKLE
QEYDKFSRRTYFRLALVLVLALILLVSAAYWGMRPLVRMREELKSIADGKAKSLSDGYPVELEGVTQALNQLLQQSSAQQ
ERYQNAMNDLAHSLKTRLAAVHAILDDKALHQQEVSEKVMEQVSQMDHLVKYQLKRAMLGRKGLKQEQTQLLPLVNQLSQ
MLFKIYRDKDVQFSTRILPLLQFPGDKGDLMELCGNLMENAFRLCISTVRVSAEINDKGEFELRVEDDGPGVAESLRQKI
LERGVRADTHSPGQGIGLAVCHEIVQSYNGTLTIEESNLEGAMFRIRIPL

Specific function: Member of the two-component regulatory system phoQ/phoP which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides. In presence of low periplasmic Mg(2+) concentrations, phoQ functions as a membrane

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1787374, Length=293, Percent_Identity=35.8361774744027, Blast_Score=171, Evalue=8e-44,
Organism=Escherichia coli, GI1788393, Length=242, Percent_Identity=27.6859504132231, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1787894, Length=296, Percent_Identity=30.0675675675676, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1790551, Length=265, Percent_Identity=29.4339622641509, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI1786837, Length=166, Percent_Identity=32.5301204819277, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1790861, Length=302, Percent_Identity=25.4966887417219, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1786912, Length=243, Percent_Identity=27.5720164609054, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1790346, Length=274, Percent_Identity=23.3576642335766, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR015014
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF08918 PhoQ_Sensor [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 51476; Mature: 51476

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMRFKLKPKRRLLTRMYLTSLSIITLVGFGLAWMVNILHAQNSYNEETAQLIAEIPQVAA
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
ELREHDLIPDTSAWLEENRKGERYVMASCDDRFKQVWTSAMAVDRGLFDTCERFADIKND
HHHHCCCCCCCHHHHHCCCCCCEEEEECHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCC
SPPYYLTLSDTRGYYIYMLSVEIAKVHYNLLVMKDAEKLEQEYDKFSRRTYFRLALVLVL
CCCEEEEEECCCCEEEEEEEEEEEHHHHHHEEECCHHHHHHHHHHHHHHHHHHHHHHHHH
ALILLVSAAYWGMRPLVRMREELKSIADGKAKSLSDGYPVELEGVTQALNQLLQQSSAQQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHH
ERYQNAMNDLAHSLKTRLAAVHAILDDKALHQQEVSEKVMEQVSQMDHLVKYQLKRAMLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RKGLKQEQTQLLPLVNQLSQMLFKIYRDKDVQFSTRILPLLQFPGDKGDLMELCGNLMEN
HCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHH
AFRLCISTVRVSAEINDKGEFELRVEDDGPGVAESLRQKILERGVRADTHSPGQGIGLAV
HHHHHHHHHHHEEEECCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHH
CHEIVQSYNGTLTIEESNLEGAMFRIRIPL
HHHHHHHCCCEEEEEECCCCCEEEEEECCC
>Mature Secondary Structure
MMRFKLKPKRRLLTRMYLTSLSIITLVGFGLAWMVNILHAQNSYNEETAQLIAEIPQVAA
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
ELREHDLIPDTSAWLEENRKGERYVMASCDDRFKQVWTSAMAVDRGLFDTCERFADIKND
HHHHCCCCCCCHHHHHCCCCCCEEEEECHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCC
SPPYYLTLSDTRGYYIYMLSVEIAKVHYNLLVMKDAEKLEQEYDKFSRRTYFRLALVLVL
CCCEEEEEECCCCEEEEEEEEEEEHHHHHHEEECCHHHHHHHHHHHHHHHHHHHHHHHHH
ALILLVSAAYWGMRPLVRMREELKSIADGKAKSLSDGYPVELEGVTQALNQLLQQSSAQQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHH
ERYQNAMNDLAHSLKTRLAAVHAILDDKALHQQEVSEKVMEQVSQMDHLVKYQLKRAMLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RKGLKQEQTQLLPLVNQLSQMLFKIYRDKDVQFSTRILPLLQFPGDKGDLMELCGNLMEN
HCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHH
AFRLCISTVRVSAEINDKGEFELRVEDDGPGVAESLRQKILERGVRADTHSPGQGIGLAV
HHHHHHHHHHHEEEECCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHH
CHEIVQSYNGTLTIEESNLEGAMFRIRIPL
HHHHHHHCCCEEEEEECCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA