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The map label for this gene is pepP [H]

Identifier: 119774671

GI number: 119774671

Start: 1865108

End: 1866433

Strand: Reverse

Name: pepP [H]

Synonym: Sama_1534

Alternate gene names: 119774671

Gene position: 1866433-1865108 (Counterclockwise)

Preceding gene: 119774675

Following gene: 119774668

Centisome position: 43.34

GC content: 53.85

Gene sequence:

>1326_bases
ATGGCCACCTCCACCGACATCACTCTGTATACAGCCCGTCGCAGTGCACTCCTGGACCGCTTACCACCAGCGAGCCTGAT
AGTGCTTGCCGGATACCAACAAAAAGTACGCAGCAAAAACATCAAGTACCATTTCCGTCAGGACAACGATTTTTTATATT
TGACCGGGTTCGCAGAACCTGATGCCCTGGCCCTCATCTATCGAGAAGGTAATCGCGACTACCTAACGCTTTTTTGTCGC
CCCCGCGACCAGGCCGCCGAAGTCAGTTTTGGTCAGCGAGCGGGCCCCGAAGGCGCCATTGCCAAATATGGCGCCGACTA
CGCGTTTGCAATCGATGAGTTTGAGCCAAGGTTGCTAGAGGCACTTAAAGGCAAGACCCAGGTTTTTGTCAGCGATGAGC
TAAACCGCCTGCCAACTCTGTGGCAGCTCATTAATCGCGAAAGATTTCACACTCCGTTCGACGTTCCCAAGGCCTACCGG
CAACTATCAGCCTTGGGCGCTGTGCTGCACCCGATGCGGGTAATTAAGTCTGAATCCGAAATTGCCCTTATCCGCCACGC
AGTCAATGCCTCCATCTCGGGGCATAAGGCGCTGATGCGAACCACTACTCCCGGCATCCATGAAGGGCTGCTCGCGGCCA
CCTTTATGCTGGAAATAGCCAAACATGGCTGTGTCGATGTGGGCTACCCCAATATAGTTGCCAGTGGCAACAATGCCTGC
TGTCTGCATTACGAAGACAACTGCTGCGAAATTAAGGCGGGGGAGCTGGTACTGGTCGATGCCGGCGCTGAGTATGACCA
TTACAGCGCCGACATTACCCGCACCTTTCCCGCGACTGGCCACTTCAGCGCTGCACAGCGACAGATCCACAACCTTGTAT
TGTCAGCGCTCGATGCCGCCATTGCCAGGGTACGCCCCGGCGCACGCTGGAATGAGATCTATCAGACCTGCATGGAAGTG
ATGGCAAGGGGTCTTATTGAGCTTGGCTTACTTGATGGCTCTTTTGACGACGTAATGGCAAGCGAACGCTACAAGCGTTT
TACGGTACATAAAACCGGTCACTGGTTGGGAATGGACGTGCACGATGTTGGCCCCTATCAGGATGAAACCGGAGATTGGC
GCATATTTGAACCCGGGATGGTGTTTACCATAGAGCCCGGCATCTATATCCCTGTTGATGCTCTGGATGTACCAAGCCAA
TATCGGGGGATGGGTGTACGAATTGAGGATGATATTCTGGTTACCCAGCAAGGCTGTGAGAATCTCTCTGCTGCCTGCCC
ACGCAGCAGCGATGAGATAGAAGCCTTCATGGCCGCCAATAGATAA

Upstream 100 bases:

>100_bases
ACTTGGCGACAGCACGCATGTTTTTCACTTGTTTTGGATATTGCATGCAAATATCCTGTTAACCATGCTCCCCCTATCAG
CTCGCAAAGAATAGAAGAAT

Downstream 100 bases:

>100_bases
ATACTGCCGGGGTAAAAGAAGGATTAGAAAGGCGGTCCACTAGCCGCCTTTTTTCGTGCTTTACCAATGCCCGCCTCAAA
CTCAGTCGAACCGCTTCACA

Product: xaa-pro aminopeptidase

Products: NA

Alternate protein names: Aminoacylproline aminopeptidase; Aminopeptidase P II; APP-II; X-Pro aminopeptidase [H]

Number of amino acids: Translated: 441; Mature: 440

Protein sequence:

>441_residues
MATSTDITLYTARRSALLDRLPPASLIVLAGYQQKVRSKNIKYHFRQDNDFLYLTGFAEPDALALIYREGNRDYLTLFCR
PRDQAAEVSFGQRAGPEGAIAKYGADYAFAIDEFEPRLLEALKGKTQVFVSDELNRLPTLWQLINRERFHTPFDVPKAYR
QLSALGAVLHPMRVIKSESEIALIRHAVNASISGHKALMRTTTPGIHEGLLAATFMLEIAKHGCVDVGYPNIVASGNNAC
CLHYEDNCCEIKAGELVLVDAGAEYDHYSADITRTFPATGHFSAAQRQIHNLVLSALDAAIARVRPGARWNEIYQTCMEV
MARGLIELGLLDGSFDDVMASERYKRFTVHKTGHWLGMDVHDVGPYQDETGDWRIFEPGMVFTIEPGIYIPVDALDVPSQ
YRGMGVRIEDDILVTQQGCENLSAACPRSSDEIEAFMAANR

Sequences:

>Translated_441_residues
MATSTDITLYTARRSALLDRLPPASLIVLAGYQQKVRSKNIKYHFRQDNDFLYLTGFAEPDALALIYREGNRDYLTLFCR
PRDQAAEVSFGQRAGPEGAIAKYGADYAFAIDEFEPRLLEALKGKTQVFVSDELNRLPTLWQLINRERFHTPFDVPKAYR
QLSALGAVLHPMRVIKSESEIALIRHAVNASISGHKALMRTTTPGIHEGLLAATFMLEIAKHGCVDVGYPNIVASGNNAC
CLHYEDNCCEIKAGELVLVDAGAEYDHYSADITRTFPATGHFSAAQRQIHNLVLSALDAAIARVRPGARWNEIYQTCMEV
MARGLIELGLLDGSFDDVMASERYKRFTVHKTGHWLGMDVHDVGPYQDETGDWRIFEPGMVFTIEPGIYIPVDALDVPSQ
YRGMGVRIEDDILVTQQGCENLSAACPRSSDEIEAFMAANR
>Mature_440_residues
ATSTDITLYTARRSALLDRLPPASLIVLAGYQQKVRSKNIKYHFRQDNDFLYLTGFAEPDALALIYREGNRDYLTLFCRP
RDQAAEVSFGQRAGPEGAIAKYGADYAFAIDEFEPRLLEALKGKTQVFVSDELNRLPTLWQLINRERFHTPFDVPKAYRQ
LSALGAVLHPMRVIKSESEIALIRHAVNASISGHKALMRTTTPGIHEGLLAATFMLEIAKHGCVDVGYPNIVASGNNACC
LHYEDNCCEIKAGELVLVDAGAEYDHYSADITRTFPATGHFSAAQRQIHNLVLSALDAAIARVRPGARWNEIYQTCMEVM
ARGLIELGLLDGSFDDVMASERYKRFTVHKTGHWLGMDVHDVGPYQDETGDWRIFEPGMVFTIEPGIYIPVDALDVPSQY
RGMGVRIEDDILVTQQGCENLSAACPRSSDEIEAFMAANR

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=407, Percent_Identity=35.1351351351351, Blast_Score=241, Evalue=1e-63,
Organism=Homo sapiens, GI149589008, Length=482, Percent_Identity=30.9128630705394, Blast_Score=171, Evalue=9e-43,
Organism=Homo sapiens, GI260593665, Length=313, Percent_Identity=34.185303514377, Blast_Score=158, Evalue=1e-38,
Organism=Homo sapiens, GI260593663, Length=478, Percent_Identity=29.0794979079498, Blast_Score=142, Evalue=5e-34,
Organism=Escherichia coli, GI1789275, Length=446, Percent_Identity=39.9103139013453, Blast_Score=322, Evalue=3e-89,
Organism=Escherichia coli, GI1788728, Length=322, Percent_Identity=30.7453416149068, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1790282, Length=292, Percent_Identity=31.8493150684932, Blast_Score=107, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17508215, Length=477, Percent_Identity=29.769392033543, Blast_Score=172, Evalue=4e-43,
Organism=Caenorhabditis elegans, GI71989583, Length=271, Percent_Identity=31.7343173431734, Blast_Score=132, Evalue=5e-31,
Organism=Saccharomyces cerevisiae, GI6320922, Length=439, Percent_Identity=28.246013667426, Blast_Score=172, Evalue=6e-44,
Organism=Saccharomyces cerevisiae, GI6321118, Length=457, Percent_Identity=30.6345733041575, Blast_Score=164, Evalue=4e-41,
Organism=Drosophila melanogaster, GI19920384, Length=418, Percent_Identity=36.6028708133971, Blast_Score=230, Evalue=2e-60,
Organism=Drosophila melanogaster, GI21357079, Length=489, Percent_Identity=30.2658486707566, Blast_Score=177, Evalue=1e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR007865
- InterPro:   IPR001131 [H]

Pfam domain/function: PF05195 AMP_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.11.9 [H]

Molecular weight: Translated: 49140; Mature: 49009

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATSTDITLYTARRSALLDRLPPASLIVLAGYQQKVRSKNIKYHFRQDNDFLYLTGFAEP
CCCCCEEEEEECHHHHHHHHCCCCEEEEEECCHHHHHCCCCEEEEECCCCEEEEEECCCC
DALALIYREGNRDYLTLFCRPRDQAAEVSFGQRAGPEGAIAKYGADYAFAIDEFEPRLLE
CEEEEEEEECCCCEEEEEECCCCCCCCCCCCCCCCCCCCHHHCCCCEEEEECCCCHHHHH
ALKGKTQVFVSDELNRLPTLWQLINRERFHTPFDVPKAYRQLSALGAVLHPMRVIKSESE
HHCCCEEEEECCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCH
IALIRHAVNASISGHKALMRTTTPGIHEGLLAATFMLEIAKHGCVDVGYPNIVASGNNAC
HHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCEECCCCCEEECCCCEE
CLHYEDNCCEIKAGELVLVDAGAEYDHYSADITRTFPATGHFSAAQRQIHNLVLSALDAA
EEEECCCCEEEECCCEEEEECCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHH
IARVRPGARWNEIYQTCMEVMARGLIELGLLDGSFDDVMASERYKRFTVHKTGHWLGMDV
HHHCCCCCHHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHEEEEEECCCEEECCH
HDVGPYQDETGDWRIFEPGMVFTIEPGIYIPVDALDVPSQYRGMGVRIEDDILVTQQGCE
HCCCCCCCCCCCEEEECCCEEEEECCCEEEEECCCCCCHHHCCCCEEEECCEEEEHHCCC
NLSAACPRSSDEIEAFMAANR
HHHHCCCCCCHHHHHHHHCCC
>Mature Secondary Structure 
ATSTDITLYTARRSALLDRLPPASLIVLAGYQQKVRSKNIKYHFRQDNDFLYLTGFAEP
CCCCEEEEEECHHHHHHHHCCCCEEEEEECCHHHHHCCCCEEEEECCCCEEEEEECCCC
DALALIYREGNRDYLTLFCRPRDQAAEVSFGQRAGPEGAIAKYGADYAFAIDEFEPRLLE
CEEEEEEEECCCCEEEEEECCCCCCCCCCCCCCCCCCCCHHHCCCCEEEEECCCCHHHHH
ALKGKTQVFVSDELNRLPTLWQLINRERFHTPFDVPKAYRQLSALGAVLHPMRVIKSESE
HHCCCEEEEECCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCH
IALIRHAVNASISGHKALMRTTTPGIHEGLLAATFMLEIAKHGCVDVGYPNIVASGNNAC
HHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCEECCCCCEEECCCCEE
CLHYEDNCCEIKAGELVLVDAGAEYDHYSADITRTFPATGHFSAAQRQIHNLVLSALDAA
EEEECCCCEEEECCCEEEEECCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHH
IARVRPGARWNEIYQTCMEVMARGLIELGLLDGSFDDVMASERYKRFTVHKTGHWLGMDV
HHHCCCCCHHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHEEEEEECCCEEECCH
HDVGPYQDETGDWRIFEPGMVFTIEPGIYIPVDALDVPSQYRGMGVRIEDDILVTQQGCE
HCCCCCCCCCCCEEEECCCEEEEECCCEEEEECCCCCCHHHCCCCEEEECCEEEEHHCCC
NLSAACPRSSDEIEAFMAANR
HHHHCCCCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2659585; 1339425; 9278503; 9520390 [H]