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The map label for this gene is mmgC [H]

Identifier: 119774499

GI number: 119774499

Start: 1652157

End: 1653326

Strand: Reverse

Name: mmgC [H]

Synonym: Sama_1362

Alternate gene names: 119774499

Gene position: 1653326-1652157 (Counterclockwise)

Preceding gene: 119774500

Following gene: 119774498

Centisome position: 38.39

GC content: 56.92

Gene sequence:

>1170_bases
ATGAGCCACCTGTACTCTACTCTCAACTTCGGACTCGGTGAAGACGTGGATATGCTGCGGGACGCGGTATACGAATTTGC
CAAGGGTGAAATTGCGCCGCTGGCGGAAAAGGTTGACCGCGACAACGCCTTCCCCAACGAGCTGTGGGCCAAGTTCGGTG
ACATGGGCCTGCTTGGCGTGACCGTGGCCGAAGAATACGGCGGCGTGAACATGGGTTACCTCGCCCACGTGGTGGCCATG
GAAGAAATCAGCCGCGCCTCGGCCTCCATTGGCCTGTCTTACGGCGCTCACTCCAACCTGTGCGTTAACCAAATCTATCG
CAACGGCAATGAGGCCCAGCGTGCCAAGTACCTGCCCAAGCTCATCAGCGGTGAGCACATTGGCGCCCTGGCCATGAGCG
AGCCCAATGCCGGCTCCGACGTGGTATCCATGAAGCTGCATGCCCGCAAGGAAGGCGACCGCTATATCCTCAATGGCAAC
AAGATGTGGATCACCAATGGCCCCGATGCCCACACCTATGTGATTTATGCCAAGACTGACCTCGACAAGGGACCACACGG
CATCACCGCCTTTATCGTTGAGCGTGGATTCAAGGGTTTCTCCCAGGCGCAAAAGCTCGACAAGCTGGGTATGCGCGGCT
CCAACACCTGTGAGCTGGTGTTTGAAGACTGTGAAGTACCGGAAGAAAACATCTTAGGCGGCCTCAACAACGGCGTGAAA
GTGCTGATGAGTGGCCTCGATTACGAGCGCGTGGTGCTCTCCGGTGGCCCACTGGGCATCATGACAGCCTGTATGGATAT
AGTCGTGCCTTATGTGCACGAGCGGGTGCAGTTTGGCAAGTCTATTGGTGAATTCCAACTGGTGCAGGGCAAGCTTGCCG
ACATGTACACCGGCATGAATGCGGCCAAGTCTTACGTTTACAACGTGGCCCGTGCCTGTGACAGAGGCGAAACCACCCGT
AAAGATGCCGCCGGTGTCATCCTATACGCCGCCGAATTGGCAACCAAGATGGCGCTGGACGCCATTCAGCTGCTGGGCGG
TAACGGTTATGTGAATGAATATGCCACCGGCCGTTTGCTGCGGGATGCCAAGCTGTATGAAATCGGCGCAGGCACCTCGG
AAATCCGCCGCATGCTGATTGGCCGCGAGCTGTTTAACGAGACTAAATAA

Upstream 100 bases:

>100_bases
ATCCAGGAGTTCCTGAACTGACGCCAACGCCCAGACTGAAACCAGACCGACACAATAACAAAGATAACAAGACAACAAGC
AGATTTAAGGACACAAGCAC

Downstream 100 bases:

>100_bases
GCAAAGCCGATAAGTCAGGCGGATAAGCCCTACTCTTCACATCCACTCCCCGGCGAAGTGCCGGGGCAAAGGGACACTGC
GGCAGGCAATACGCCTGCCC

Product: isovaleryl-CoA dehydrogenase

Products: 3-methylbut-2-enoyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 389; Mature: 388

Protein sequence:

>389_residues
MSHLYSTLNFGLGEDVDMLRDAVYEFAKGEIAPLAEKVDRDNAFPNELWAKFGDMGLLGVTVAEEYGGVNMGYLAHVVAM
EEISRASASIGLSYGAHSNLCVNQIYRNGNEAQRAKYLPKLISGEHIGALAMSEPNAGSDVVSMKLHARKEGDRYILNGN
KMWITNGPDAHTYVIYAKTDLDKGPHGITAFIVERGFKGFSQAQKLDKLGMRGSNTCELVFEDCEVPEENILGGLNNGVK
VLMSGLDYERVVLSGGPLGIMTACMDIVVPYVHERVQFGKSIGEFQLVQGKLADMYTGMNAAKSYVYNVARACDRGETTR
KDAAGVILYAAELATKMALDAIQLLGGNGYVNEYATGRLLRDAKLYEIGAGTSEIRRMLIGRELFNETK

Sequences:

>Translated_389_residues
MSHLYSTLNFGLGEDVDMLRDAVYEFAKGEIAPLAEKVDRDNAFPNELWAKFGDMGLLGVTVAEEYGGVNMGYLAHVVAM
EEISRASASIGLSYGAHSNLCVNQIYRNGNEAQRAKYLPKLISGEHIGALAMSEPNAGSDVVSMKLHARKEGDRYILNGN
KMWITNGPDAHTYVIYAKTDLDKGPHGITAFIVERGFKGFSQAQKLDKLGMRGSNTCELVFEDCEVPEENILGGLNNGVK
VLMSGLDYERVVLSGGPLGIMTACMDIVVPYVHERVQFGKSIGEFQLVQGKLADMYTGMNAAKSYVYNVARACDRGETTR
KDAAGVILYAAELATKMALDAIQLLGGNGYVNEYATGRLLRDAKLYEIGAGTSEIRRMLIGRELFNETK
>Mature_388_residues
SHLYSTLNFGLGEDVDMLRDAVYEFAKGEIAPLAEKVDRDNAFPNELWAKFGDMGLLGVTVAEEYGGVNMGYLAHVVAME
EISRASASIGLSYGAHSNLCVNQIYRNGNEAQRAKYLPKLISGEHIGALAMSEPNAGSDVVSMKLHARKEGDRYILNGNK
MWITNGPDAHTYVIYAKTDLDKGPHGITAFIVERGFKGFSQAQKLDKLGMRGSNTCELVFEDCEVPEENILGGLNNGVKV
LMSGLDYERVVLSGGPLGIMTACMDIVVPYVHERVQFGKSIGEFQLVQGKLADMYTGMNAAKSYVYNVARACDRGETTRK
DAAGVILYAAELATKMALDAIQLLGGNGYVNEYATGRLLRDAKLYEIGAGTSEIRRMLIGRELFNETK

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI226958412, Length=376, Percent_Identity=65.4255319148936, Blast_Score=518, Evalue=1e-147,
Organism=Homo sapiens, GI226958414, Length=343, Percent_Identity=68.2215743440233, Blast_Score=494, Evalue=1e-140,
Organism=Homo sapiens, GI4557233, Length=375, Percent_Identity=40, Blast_Score=280, Evalue=2e-75,
Organism=Homo sapiens, GI4501859, Length=367, Percent_Identity=35.9673024523161, Blast_Score=257, Evalue=1e-68,
Organism=Homo sapiens, GI21361497, Length=355, Percent_Identity=38.5915492957746, Blast_Score=236, Evalue=4e-62,
Organism=Homo sapiens, GI4501857, Length=373, Percent_Identity=34.3163538873995, Blast_Score=228, Evalue=7e-60,
Organism=Homo sapiens, GI187960098, Length=385, Percent_Identity=34.8051948051948, Blast_Score=228, Evalue=1e-59,
Organism=Homo sapiens, GI4557231, Length=385, Percent_Identity=34.8051948051948, Blast_Score=227, Evalue=1e-59,
Organism=Homo sapiens, GI76496475, Length=340, Percent_Identity=35, Blast_Score=209, Evalue=3e-54,
Organism=Homo sapiens, GI4557235, Length=340, Percent_Identity=35, Blast_Score=209, Evalue=3e-54,
Organism=Homo sapiens, GI7656849, Length=383, Percent_Identity=32.3759791122715, Blast_Score=208, Evalue=6e-54,
Organism=Homo sapiens, GI4503943, Length=375, Percent_Identity=29.8666666666667, Blast_Score=175, Evalue=7e-44,
Organism=Homo sapiens, GI7669494, Length=371, Percent_Identity=30.4582210242588, Blast_Score=169, Evalue=3e-42,
Organism=Homo sapiens, GI48976061, Length=286, Percent_Identity=25.5244755244755, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI211971008, Length=286, Percent_Identity=25.5244755244755, Blast_Score=91, Evalue=3e-18,
Organism=Escherichia coli, GI1786223, Length=384, Percent_Identity=28.3854166666667, Blast_Score=172, Evalue=2e-44,
Organism=Escherichia coli, GI87081958, Length=384, Percent_Identity=29.4270833333333, Blast_Score=163, Evalue=2e-41,
Organism=Escherichia coli, GI87082384, Length=259, Percent_Identity=26.6409266409266, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI87081702, Length=333, Percent_Identity=24.3243243243243, Blast_Score=72, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17538396, Length=380, Percent_Identity=64.7368421052632, Blast_Score=521, Evalue=1e-148,
Organism=Caenorhabditis elegans, GI17506239, Length=378, Percent_Identity=34.1269841269841, Blast_Score=243, Evalue=2e-64,
Organism=Caenorhabditis elegans, GI17569725, Length=381, Percent_Identity=36.745406824147, Blast_Score=241, Evalue=5e-64,
Organism=Caenorhabditis elegans, GI17508101, Length=380, Percent_Identity=33.1578947368421, Blast_Score=231, Evalue=5e-61,
Organism=Caenorhabditis elegans, GI17534899, Length=382, Percent_Identity=34.8167539267016, Blast_Score=228, Evalue=3e-60,
Organism=Caenorhabditis elegans, GI17570075, Length=395, Percent_Identity=32.1518987341772, Blast_Score=217, Evalue=6e-57,
Organism=Caenorhabditis elegans, GI71990804, Length=276, Percent_Identity=39.1304347826087, Blast_Score=211, Evalue=6e-55,
Organism=Caenorhabditis elegans, GI71985184, Length=354, Percent_Identity=34.7457627118644, Blast_Score=204, Evalue=9e-53,
Organism=Caenorhabditis elegans, GI17533517, Length=379, Percent_Identity=31.3984168865435, Blast_Score=203, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI17505929, Length=356, Percent_Identity=32.3033707865169, Blast_Score=179, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17551932, Length=367, Percent_Identity=30.2452316076294, Blast_Score=178, Evalue=4e-45,
Organism=Caenorhabditis elegans, GI32563615, Length=231, Percent_Identity=35.9307359307359, Blast_Score=175, Evalue=4e-44,
Organism=Caenorhabditis elegans, GI71985192, Length=288, Percent_Identity=34.7222222222222, Blast_Score=174, Evalue=6e-44,
Organism=Caenorhabditis elegans, GI71982178, Length=274, Percent_Identity=34.3065693430657, Blast_Score=173, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI17534353, Length=375, Percent_Identity=29.6, Blast_Score=172, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI17531909, Length=246, Percent_Identity=31.3008130081301, Blast_Score=115, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17531913, Length=183, Percent_Identity=28.4153005464481, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI86563381, Length=279, Percent_Identity=25.8064516129032, Blast_Score=66, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI86563383, Length=279, Percent_Identity=25.8064516129032, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI21355753, Length=384, Percent_Identity=61.71875, Blast_Score=488, Evalue=1e-138,
Organism=Drosophila melanogaster, GI21356377, Length=377, Percent_Identity=40.053050397878, Blast_Score=293, Evalue=2e-79,
Organism=Drosophila melanogaster, GI24646207, Length=376, Percent_Identity=37.7659574468085, Blast_Score=268, Evalue=5e-72,
Organism=Drosophila melanogaster, GI24666513, Length=380, Percent_Identity=35.5263157894737, Blast_Score=249, Evalue=3e-66,
Organism=Drosophila melanogaster, GI24660351, Length=393, Percent_Identity=35.1145038167939, Blast_Score=241, Evalue=5e-64,
Organism=Drosophila melanogaster, GI281363737, Length=354, Percent_Identity=33.3333333333333, Blast_Score=196, Evalue=2e-50,
Organism=Drosophila melanogaster, GI19920834, Length=388, Percent_Identity=29.1237113402062, Blast_Score=160, Evalue=1e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.10

Molecular weight: Translated: 42457; Mature: 42326

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHLYSTLNFGLGEDVDMLRDAVYEFAKGEIAPLAEKVDRDNAFPNELWAKFGDMGLLGV
CCCHHHHHHCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHCCCCEEEE
TVAEEYGGVNMGYLAHVVAMEEISRASASIGLSYGAHSNLCVNQIYRNGNEAQRAKYLPK
EEHHHHCCCCHHHHHHHHHHHHHHHHHHHHCEECCCCCCHHHHHHHHCCCHHHHHHHHHH
LISGEHIGALAMSEPNAGSDVVSMKLHARKEGDRYILNGNKMWITNGPDAHTYVIYAKTD
HHCCCCCCEEEECCCCCCCCEEEEEEECCCCCCEEEECCCEEEEECCCCCEEEEEEEECC
LDKGPHGITAFIVERGFKGFSQAQKLDKLGMRGSNTCELVFEDCEVPEENILGGLNNGVK
CCCCCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHCCCCCCCHH
VLMSGLDYERVVLSGGPLGIMTACMDIVVPYVHERVQFGKSIGEFQLVQGKLADMYTGMN
HHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCHH
AAKSYVYNVARACDRGETTRKDAAGVILYAAELATKMALDAIQLLGGNGYVNEYATGRLL
HHHHHHHHHHHHHCCCCCCHHHHCCCEEHHHHHHHHHHHHHHHHHCCCCCCCHHHHCHHH
RDAKLYEIGAGTSEIRRMLIGRELFNETK
HCCCEEEECCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SHLYSTLNFGLGEDVDMLRDAVYEFAKGEIAPLAEKVDRDNAFPNELWAKFGDMGLLGV
CCHHHHHHCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHCCCCEEEE
TVAEEYGGVNMGYLAHVVAMEEISRASASIGLSYGAHSNLCVNQIYRNGNEAQRAKYLPK
EEHHHHCCCCHHHHHHHHHHHHHHHHHHHHCEECCCCCCHHHHHHHHCCCHHHHHHHHHH
LISGEHIGALAMSEPNAGSDVVSMKLHARKEGDRYILNGNKMWITNGPDAHTYVIYAKTD
HHCCCCCCEEEECCCCCCCCEEEEEEECCCCCCEEEECCCEEEEECCCCCEEEEEEEECC
LDKGPHGITAFIVERGFKGFSQAQKLDKLGMRGSNTCELVFEDCEVPEENILGGLNNGVK
CCCCCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHCCCCCCCHH
VLMSGLDYERVVLSGGPLGIMTACMDIVVPYVHERVQFGKSIGEFQLVQGKLADMYTGMN
HHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCHH
AAKSYVYNVARACDRGETTRKDAAGVILYAAELATKMALDAIQLLGGNGYVNEYATGRLL
HHHHHHHHHHHHHCCCCCCHHHHCCCEEHHHHHHHHHHHHHHHHHCCCCCCCHHHHCHHH
RDAKLYEIGAGTSEIRRMLIGRELFNETK
HCCCEEEECCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 3-methylbutanoyl-CoA; acceptor

Specific reaction: 3-methylbutanoyl-CoA + acceptor = 3-methylbut-2-enoyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]