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The map label for this gene is yngE [H]

Identifier: 119774498

GI number: 119774498

Start: 1650432

End: 1652039

Strand: Reverse

Name: yngE [H]

Synonym: Sama_1361

Alternate gene names: 119774498

Gene position: 1652039-1650432 (Counterclockwise)

Preceding gene: 119774499

Following gene: 119774497

Centisome position: 38.36

GC content: 58.21

Gene sequence:

>1608_bases
GTGACTCAACTTACCTCCCGCGTGAATCCACGCAGCGACGAATTCAAACAAAAACACGATGCCATGGCGGCCCTGGTGGC
TGACCTCAAGGATAAGCTCGCCCATATCGAACAGGGCGGCGGCCTGGTGGCCATGGAGCGCCACTTATCCCGTGGCAAGC
TCGCCCCCCGCGCCCGGGTGGAAAAACTCTTAGACCCCGGTTCGCCCTTTTTGGAGCTCAGCCAATTTGCCGCGTTCGAA
GTCTACGATGAAGACGTACCGGCAGCAGGCATCATTGCCGGTATCGGCCGGGTCAGCGGCGTCGAGTGCATGATTATTGC
CAACGATGCCACCGTAAAAGGCGGTACCTACTACCCCATCACGGTGAAAAAGCACCTGCGCGCCCAGGCCATTGCCGAGC
GCTGCCATCTGCCCTGCATCTATCTGGTAGACTCAGGCGGCGCCAACCTGCCCCGTCAGGACGAAGTCTTCCCCGACCGT
GACCACTTCGGCCGCATCTTCTTCAATCAGGCACGTATGTCCGCCAAGGGCATTCCGCAAATCGCGGTGGTAATGGGTCT
GTGTACCGCAGGCGGCGCCTATGTGCCTGCCATGGCGGATGAATCCATTATTGTGCGCGAACAGGGCACCATCTTTTTGG
CAGGCCCGCCTCTTGTGAAAGCGGCCACCGGCGAAGAAGTCAGCGCCGAGGAGCTTGGCGGCGGCGATGTACACACCAAA
ATCAGTGGCGTGGCCGATCATCTGGCGCAAAACGATGAGCACGCGCTGGAGCTCGCCCGCAAGGCAGTATCGCGCCTTAA
TCATCAAAAGCAGGTTGAGCTGCAACTTTCGAAAGTGAAACCGCCCAAGTACGACATCAACGAACTGTACGGCATAGTCG
GTACCGACCTTAAAAAGCCCTTCGATGTGAAGGAAGTGATTGCCCGCATCGTGGATGACTCCGACTTTGACGAGTTCAAG
GCCAACTACGGCACCACCCTGGTGTGCGGATTTGCCCGTATCCATGGGTATCCGGTGGGGATTGTAGCCAACAACGGCAT
CCTGTTTTCAGAGTCGGCCCAAAAAGGCGCCCACTTTATTGAGCTGTGCTGCCAGCGCAAAATCCCGCTGGTGTTTTTGC
AAAACATCACCGGCTTTATGGTGGGTAAAAAATACGAGCACGAAGGCATTGCAAAGCACGGTGCCAAGATGGTGACTGCG
GTTTCCTGCGCCACTGTGCCCAAATTCACCGTGCTGATTGGCGGCAGCTACGGCGCCGGTAACTACGGCATGTGTGGCCG
CGCCTTTGAGCCTACCCTGATGTGGATGTGGCCCAATGCCCGCATTTCAGTGATGGGCGGAGAGCAGGCCGCTGGTGTGC
TCGCCACTGTGCGTAAAGATGGTCTGGCCCGCAAAGGCGAAACCATGAGCGCCGAAGAAGAAGCCAAATTCAAGGCGCCC
ATCATCGCCCAGTACGATAAAGAAGGTCATCCATACCATGCCAGCGCCCGCCTGTGGGATGACGGCATTATCGACCCGGC
GCAAACCCGTGACGTACTGGGGCTGGCCATATCCGCCGCCCTCAATGCCCCCATCGAAGAGACCCGCTTCGGCGTGTTCC
GCATGTAA

Upstream 100 bases:

>100_bases
GGCGGATAAGCCCTACTCTTCACATCCACTCCCCGGCGAAGTGCCGGGGCAAAGGGACACTGCGGCAGGCAATACGCCTG
CCCCTTGGAGGACACAAGAC

Downstream 100 bases:

>100_bases
GGAGAAGGCTATGACAACCATGACTTCCATTGCCGAGCTGTCTGCCTCCTTCAGCCGCATCCGCCTGGAGCTTAACGGCA
GGGTGGGGTATCTCATCTTA

Product: propionyl-CoA carboxylase

Products: ADP; phosphate; 3-methylglutaconyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 535; Mature: 534

Protein sequence:

>535_residues
MTQLTSRVNPRSDEFKQKHDAMAALVADLKDKLAHIEQGGGLVAMERHLSRGKLAPRARVEKLLDPGSPFLELSQFAAFE
VYDEDVPAAGIIAGIGRVSGVECMIIANDATVKGGTYYPITVKKHLRAQAIAERCHLPCIYLVDSGGANLPRQDEVFPDR
DHFGRIFFNQARMSAKGIPQIAVVMGLCTAGGAYVPAMADESIIVREQGTIFLAGPPLVKAATGEEVSAEELGGGDVHTK
ISGVADHLAQNDEHALELARKAVSRLNHQKQVELQLSKVKPPKYDINELYGIVGTDLKKPFDVKEVIARIVDDSDFDEFK
ANYGTTLVCGFARIHGYPVGIVANNGILFSESAQKGAHFIELCCQRKIPLVFLQNITGFMVGKKYEHEGIAKHGAKMVTA
VSCATVPKFTVLIGGSYGAGNYGMCGRAFEPTLMWMWPNARISVMGGEQAAGVLATVRKDGLARKGETMSAEEEAKFKAP
IIAQYDKEGHPYHASARLWDDGIIDPAQTRDVLGLAISAALNAPIEETRFGVFRM

Sequences:

>Translated_535_residues
MTQLTSRVNPRSDEFKQKHDAMAALVADLKDKLAHIEQGGGLVAMERHLSRGKLAPRARVEKLLDPGSPFLELSQFAAFE
VYDEDVPAAGIIAGIGRVSGVECMIIANDATVKGGTYYPITVKKHLRAQAIAERCHLPCIYLVDSGGANLPRQDEVFPDR
DHFGRIFFNQARMSAKGIPQIAVVMGLCTAGGAYVPAMADESIIVREQGTIFLAGPPLVKAATGEEVSAEELGGGDVHTK
ISGVADHLAQNDEHALELARKAVSRLNHQKQVELQLSKVKPPKYDINELYGIVGTDLKKPFDVKEVIARIVDDSDFDEFK
ANYGTTLVCGFARIHGYPVGIVANNGILFSESAQKGAHFIELCCQRKIPLVFLQNITGFMVGKKYEHEGIAKHGAKMVTA
VSCATVPKFTVLIGGSYGAGNYGMCGRAFEPTLMWMWPNARISVMGGEQAAGVLATVRKDGLARKGETMSAEEEAKFKAP
IIAQYDKEGHPYHASARLWDDGIIDPAQTRDVLGLAISAALNAPIEETRFGVFRM
>Mature_534_residues
TQLTSRVNPRSDEFKQKHDAMAALVADLKDKLAHIEQGGGLVAMERHLSRGKLAPRARVEKLLDPGSPFLELSQFAAFEV
YDEDVPAAGIIAGIGRVSGVECMIIANDATVKGGTYYPITVKKHLRAQAIAERCHLPCIYLVDSGGANLPRQDEVFPDRD
HFGRIFFNQARMSAKGIPQIAVVMGLCTAGGAYVPAMADESIIVREQGTIFLAGPPLVKAATGEEVSAEELGGGDVHTKI
SGVADHLAQNDEHALELARKAVSRLNHQKQVELQLSKVKPPKYDINELYGIVGTDLKKPFDVKEVIARIVDDSDFDEFKA
NYGTTLVCGFARIHGYPVGIVANNGILFSESAQKGAHFIELCCQRKIPLVFLQNITGFMVGKKYEHEGIAKHGAKMVTAV
SCATVPKFTVLIGGSYGAGNYGMCGRAFEPTLMWMWPNARISVMGGEQAAGVLATVRKDGLARKGETMSAEEEAKFKAPI
IAQYDKEGHPYHASARLWDDGIIDPAQTRDVLGLAISAALNAPIEETRFGVFRM

Specific function: Unknown

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI11545863, Length=522, Percent_Identity=69.5402298850575, Blast_Score=748, Evalue=0.0,
Organism=Homo sapiens, GI119943100, Length=485, Percent_Identity=32.5773195876289, Blast_Score=232, Evalue=6e-61,
Organism=Homo sapiens, GI295821216, Length=505, Percent_Identity=31.4851485148515, Blast_Score=222, Evalue=8e-58,
Organism=Homo sapiens, GI310133460, Length=132, Percent_Identity=63.6363636363636, Blast_Score=159, Evalue=5e-39,
Organism=Caenorhabditis elegans, GI17552936, Length=533, Percent_Identity=62.4765478424015, Blast_Score=693, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25147359, Length=484, Percent_Identity=33.0578512396694, Blast_Score=237, Evalue=1e-62,
Organism=Caenorhabditis elegans, GI25147362, Length=484, Percent_Identity=33.0578512396694, Blast_Score=237, Evalue=1e-62,
Organism=Drosophila melanogaster, GI24586065, Length=549, Percent_Identity=66.3023679417122, Blast_Score=748, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: 6.4.1.4

Molecular weight: Translated: 57988; Mature: 57857

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQLTSRVNPRSDEFKQKHDAMAALVADLKDKLAHIEQGGGLVAMERHLSRGKLAPRARV
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHCCCCCHHHHH
EKLLDPGSPFLELSQFAAFEVYDEDVPAAGIIAGIGRVSGVECMIIANDATVKGGTYYPI
HHHHCCCCCHHHHHHHHEEEEECCCCCHHHHHHHHHCCCCEEEEEEECCCEECCCEEEEE
TVKKHLRAQAIAERCHLPCIYLVDSGGANLPRQDEVFPDRDHFGRIFFNQARMSAKGIPQ
EHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHEEHHHHHCCCCCCH
IAVVMGLCTAGGAYVPAMADESIIVREQGTIFLAGPPLVKAATGEEVSAEELGGGDVHTK
HHHHHHHHHCCCEEEECCCCCEEEEEECCEEEEECCCEEEECCCCCCCHHHCCCCCHHHH
ISGVADHLAQNDEHALELARKAVSRLNHQKQVELQLSKVKPPKYDINELYGIVGTDLKKP
HHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHCCCCCCC
FDVKEVIARIVDDSDFDEFKANYGTTLVCGFARIHGYPVGIVANNGILFSESAQKGAHFI
CCHHHHHHHHHCCCCHHHHHHCCCCEEEEEHHHHCCEEEEEEECCCEEEECCHHHHHHHH
ELCCQRKIPLVFLQNITGFMVGKKYEHEGIAKHGAKMVTAVSCATVPKFTVLIGGSYGAG
HHHHCCCCCEEEECCCHHHHCCCCCCCCCHHHHCCHHEEEEHHCCCCEEEEEEECCCCCC
NYGMCGRAFEPTLMWMWPNARISVMGGEQAAGVLATVRKDGLARKGETMSAEEEAKFKAP
CCCCCCCCCCCEEEEECCCCEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHCCCC
IIAQYDKEGHPYHASARLWDDGIIDPAQTRDVLGLAISAALNAPIEETRFGVFRM
EEEEECCCCCCEECCCEECCCCCCCCHHHHHHHHHHHHHHHCCCHHHHCCCEECC
>Mature Secondary Structure 
TQLTSRVNPRSDEFKQKHDAMAALVADLKDKLAHIEQGGGLVAMERHLSRGKLAPRARV
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHCCCCCHHHHH
EKLLDPGSPFLELSQFAAFEVYDEDVPAAGIIAGIGRVSGVECMIIANDATVKGGTYYPI
HHHHCCCCCHHHHHHHHEEEEECCCCCHHHHHHHHHCCCCEEEEEEECCCEECCCEEEEE
TVKKHLRAQAIAERCHLPCIYLVDSGGANLPRQDEVFPDRDHFGRIFFNQARMSAKGIPQ
EHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHEEHHHHHCCCCCCH
IAVVMGLCTAGGAYVPAMADESIIVREQGTIFLAGPPLVKAATGEEVSAEELGGGDVHTK
HHHHHHHHHCCCEEEECCCCCEEEEEECCEEEEECCCEEEECCCCCCCHHHCCCCCHHHH
ISGVADHLAQNDEHALELARKAVSRLNHQKQVELQLSKVKPPKYDINELYGIVGTDLKKP
HHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHCCCCCCC
FDVKEVIARIVDDSDFDEFKANYGTTLVCGFARIHGYPVGIVANNGILFSESAQKGAHFI
CCHHHHHHHHHCCCCHHHHHHCCCCEEEEEHHHHCCEEEEEEECCCEEEECCHHHHHHHH
ELCCQRKIPLVFLQNITGFMVGKKYEHEGIAKHGAKMVTAVSCATVPKFTVLIGGSYGAG
HHHHCCCCCEEEECCCHHHHCCCCCCCCCHHHHCCHHEEEEHHCCCCEEEEEEECCCCCC
NYGMCGRAFEPTLMWMWPNARISVMGGEQAAGVLATVRKDGLARKGETMSAEEEAKFKAP
CCCCCCCCCCCEEEEECCCCEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHCCCC
IIAQYDKEGHPYHASARLWDDGIIDPAQTRDVLGLAISAALNAPIEETRFGVFRM
EEEEECCCCCCEECCCEECCCCCCCCHHHHHHHHHHHHHHHCCCHHHHCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; 3-methylcrotonoyl-CoA; HCO3-

Specific reaction: ATP + 3-methylcrotonoyl-CoA + HCO3- = ADP + phosphate + 3-methylglutaconyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 9387222 [H]