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The map label for this gene is gltT [H]

Identifier: 119774456

GI number: 119774456

Start: 1603255

End: 1604568

Strand: Reverse

Name: gltT [H]

Synonym: Sama_1319

Alternate gene names: 119774456

Gene position: 1604568-1603255 (Counterclockwise)

Preceding gene: 119774458

Following gene: 119774440

Centisome position: 37.26

GC content: 51.98

Gene sequence:

>1314_bases
ATGGCTGCTGCACAATCCAGTAAAATTGGCCTGACAGGCAAGATCTTAATCGGCATGGGCGCCGGTATTTTGATAGGTTT
GCTCCTTCGTAACTTTTTCGGCGGCAGTGAATGGGTTCAGGACTACATCACCGAGGGTTTTTTCCATGTGATAGGCACTA
TATTTATCAACAGTCTCAAGATGTTGGTTGTGCCTCTTGTCTTTATTTCACTGGTCTGTGGAACCTGTTCTCTGAGTGAA
CCTTCCAAGTTAGGCCGACTGGGCGGTAAAACCCTCGCGTTTTATCTGTTTACCACCGCTATCGCACTGGTCGTGGCAAT
CTCTGCTGCGGTACTTGTCCAGCCCGGCAATGCCTCTCTGGCATCTGAAAGCATGCAGTATTCGGCCAAGGAAGCCCCCA
GTCTGGCGGATGTGCTGATCAACATAGTGCCATCCAACCCAATGAAGGCGCTGAGCGAAGGAAATATGCTGCAAATAATT
ATTTTTGCAGTAATTTTCGGTTTTGCCATATCACACATTGGTGAGCGCGGACGCCGTGTGGCGGCCCTGTTTGATGACCT
CAACGAAGTCATCATGCGCGTGGTAACCCTCATTATGCAGCTGGCTCCCTACGGTGTGTTTGCCCTGATGGGGAAACTCG
CACTGACCTTGGGTATGGAAACCCTTGAGAGCGTGATTAAGTACTTTATGCTGGTGTTGGTGGTGCTGCTGTTCCACGGA
TTTGTGGTGTATCCAACCCTGCTTAAATTGTTCTCCGGCCTGAGTCCACTGATGTTCATCCGTAAGATGCGTGATGTGCA
GCTGTTTGCCTTTAGTACGGCCAGCTCTAACGCAACCCTGCCTGTCACCATGGAAGCATCTGAGCACCGTCTGGGCGCCG
ATAACAAAGTTGCCTCTTTCACCCTGCCACTGGGCGCCACCATCAACATGGATGGCACTGCTATTATGCAGGGCGTAGCG
ACTGTGTTTATTGCTCAGGTATTTGGTATCGACCTGACCATCACCGACTATGCCATGGTCGTGATGACAGCCACACTGGC
TTCCATCGGTACTGCGGGCGTGCCTGGCGTTGGCCTGGTGATGCTGGCCATGGTGCTCAATCAGGTTGGCTTGCCGGTAG
AAGGCATTGCGCTCATTTTGGGTGTGGATCGTATGCTCGATATGGTTCGCACTGCGGTAAACGTCACGGGTGATACAGTC
GCCACTGTGGTGATTGCCAAGTCTGAAGGCGCCCTCAACGAAGCCGTCTTTAATGACCCCAAGGCAGGTAAAACCGCAGG
CAGTTTTGATGCTGAGGTTCACCGCGGCGAATAA

Upstream 100 bases:

>100_bases
CCAGAAAACTTTAGTTAATTGCCCGTTTCCTCGGCACCGCTTTCTTGCTAGGCTTTTGTGCGCCAAAACACAAAAGCACA
AAAAATAAACAGGAAAATCT

Downstream 100 bases:

>100_bases
GCGCATTTTGAGAAAATGTGTCGGGTGAGTAATTCGCCCCTTTGCTTTTTAGTTAAAACCCCTGTTCCCCGCTAAACCCA
AAATGTAAAAATCCACCTGC

Product: sodium:dicarboxylate symporter

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 437; Mature: 436

Protein sequence:

>437_residues
MAAAQSSKIGLTGKILIGMGAGILIGLLLRNFFGGSEWVQDYITEGFFHVIGTIFINSLKMLVVPLVFISLVCGTCSLSE
PSKLGRLGGKTLAFYLFTTAIALVVAISAAVLVQPGNASLASESMQYSAKEAPSLADVLINIVPSNPMKALSEGNMLQII
IFAVIFGFAISHIGERGRRVAALFDDLNEVIMRVVTLIMQLAPYGVFALMGKLALTLGMETLESVIKYFMLVLVVLLFHG
FVVYPTLLKLFSGLSPLMFIRKMRDVQLFAFSTASSNATLPVTMEASEHRLGADNKVASFTLPLGATINMDGTAIMQGVA
TVFIAQVFGIDLTITDYAMVVMTATLASIGTAGVPGVGLVMLAMVLNQVGLPVEGIALILGVDRMLDMVRTAVNVTGDTV
ATVVIAKSEGALNEAVFNDPKAGKTAGSFDAEVHRGE

Sequences:

>Translated_437_residues
MAAAQSSKIGLTGKILIGMGAGILIGLLLRNFFGGSEWVQDYITEGFFHVIGTIFINSLKMLVVPLVFISLVCGTCSLSE
PSKLGRLGGKTLAFYLFTTAIALVVAISAAVLVQPGNASLASESMQYSAKEAPSLADVLINIVPSNPMKALSEGNMLQII
IFAVIFGFAISHIGERGRRVAALFDDLNEVIMRVVTLIMQLAPYGVFALMGKLALTLGMETLESVIKYFMLVLVVLLFHG
FVVYPTLLKLFSGLSPLMFIRKMRDVQLFAFSTASSNATLPVTMEASEHRLGADNKVASFTLPLGATINMDGTAIMQGVA
TVFIAQVFGIDLTITDYAMVVMTATLASIGTAGVPGVGLVMLAMVLNQVGLPVEGIALILGVDRMLDMVRTAVNVTGDTV
ATVVIAKSEGALNEAVFNDPKAGKTAGSFDAEVHRGE
>Mature_436_residues
AAAQSSKIGLTGKILIGMGAGILIGLLLRNFFGGSEWVQDYITEGFFHVIGTIFINSLKMLVVPLVFISLVCGTCSLSEP
SKLGRLGGKTLAFYLFTTAIALVVAISAAVLVQPGNASLASESMQYSAKEAPSLADVLINIVPSNPMKALSEGNMLQIII
FAVIFGFAISHIGERGRRVAALFDDLNEVIMRVVTLIMQLAPYGVFALMGKLALTLGMETLESVIKYFMLVLVVLLFHGF
VVYPTLLKLFSGLSPLMFIRKMRDVQLFAFSTASSNATLPVTMEASEHRLGADNKVASFTLPLGATINMDGTAIMQGVAT
VFIAQVFGIDLTITDYAMVVMTATLASIGTAGVPGVGLVMLAMVLNQVGLPVEGIALILGVDRMLDMVRTAVNVTGDTVA
TVVIAKSEGALNEAVFNDPKAGKTAGSFDAEVHRGE

Specific function: This carrier protein is part of the Na(+)-dependent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI169790839, Length=438, Percent_Identity=33.3333333333333, Blast_Score=205, Evalue=8e-53,
Organism=Homo sapiens, GI194239697, Length=457, Percent_Identity=31.5098468271335, Blast_Score=193, Evalue=3e-49,
Organism=Homo sapiens, GI4827012, Length=283, Percent_Identity=40.2826855123675, Blast_Score=192, Evalue=7e-49,
Organism=Homo sapiens, GI21314632, Length=390, Percent_Identity=32.8205128205128, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI40254478, Length=450, Percent_Identity=31.3333333333333, Blast_Score=189, Evalue=4e-48,
Organism=Homo sapiens, GI66773030, Length=440, Percent_Identity=31.1363636363636, Blast_Score=186, Evalue=5e-47,
Organism=Homo sapiens, GI5032093, Length=376, Percent_Identity=36.436170212766, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI223468564, Length=246, Percent_Identity=38.2113821138211, Blast_Score=162, Evalue=6e-40,
Organism=Homo sapiens, GI223468566, Length=255, Percent_Identity=38.0392156862745, Blast_Score=162, Evalue=7e-40,
Organism=Homo sapiens, GI262359914, Length=380, Percent_Identity=31.0526315789474, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI301601644, Length=170, Percent_Identity=40, Blast_Score=114, Evalue=1e-25,
Organism=Escherichia coli, GI1790514, Length=441, Percent_Identity=35.6009070294785, Blast_Score=248, Evalue=5e-67,
Organism=Escherichia coli, GI1789947, Length=397, Percent_Identity=31.7380352644836, Blast_Score=195, Evalue=5e-51,
Organism=Escherichia coli, GI1788024, Length=449, Percent_Identity=32.293986636971, Blast_Score=165, Evalue=7e-42,
Organism=Escherichia coli, GI1789473, Length=386, Percent_Identity=28.7564766839378, Blast_Score=117, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI71983106, Length=411, Percent_Identity=33.5766423357664, Blast_Score=219, Evalue=2e-57,
Organism=Caenorhabditis elegans, GI71983099, Length=411, Percent_Identity=33.5766423357664, Blast_Score=219, Evalue=2e-57,
Organism=Caenorhabditis elegans, GI71996953, Length=446, Percent_Identity=32.0627802690583, Blast_Score=211, Evalue=4e-55,
Organism=Caenorhabditis elegans, GI193206505, Length=425, Percent_Identity=33.4117647058824, Blast_Score=206, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI17537407, Length=414, Percent_Identity=34.0579710144928, Blast_Score=204, Evalue=5e-53,
Organism=Caenorhabditis elegans, GI193206654, Length=434, Percent_Identity=31.7972350230415, Blast_Score=192, Evalue=3e-49,
Organism=Caenorhabditis elegans, GI17541374, Length=392, Percent_Identity=32.3979591836735, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI24583025, Length=437, Percent_Identity=32.4942791762014, Blast_Score=196, Evalue=3e-50,
Organism=Drosophila melanogaster, GI17137668, Length=437, Percent_Identity=32.4942791762014, Blast_Score=196, Evalue=3e-50,
Organism=Drosophila melanogaster, GI24583023, Length=437, Percent_Identity=32.4942791762014, Blast_Score=196, Evalue=3e-50,
Organism=Drosophila melanogaster, GI281360481, Length=452, Percent_Identity=28.9823008849558, Blast_Score=134, Evalue=8e-32,
Organism=Drosophila melanogaster, GI281360483, Length=452, Percent_Identity=28.9823008849558, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI17137666, Length=452, Percent_Identity=28.9823008849558, Blast_Score=134, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 46213; Mature: 46081

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AAAQSSKIGLTGKILIGMGAGILIGLLLRNFFGGSEWVQDYITEGFFHVIGTIFINSLK
CCCCCCCCCCCEEHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
MLVVPLVFISLVCGTCSLSEPSKLGRLGGKTLAFYLFTTAIALVVAISAAVLVQPGNASL
HHHHHHHHHHHHHCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHEECCCCCHH
ASESMQYSAKEAPSLADVLINIVPSNPMKALSEGNMLQIIIFAVIFGFAISHIGERGRRV
HHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCHHH
AALFDDLNEVIMRVVTLIMQLAPYGVFALMGKLALTLGMETLESVIKYFMLVLVVLLFHG
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FVVYPTLLKLFSGLSPLMFIRKMRDVQLFAFSTASSNATLPVTMEASEHRLGADNKVASF
HHHHHHHHHHHCCCCHHHHHHHHCCCEEEEEEECCCCCEEEEEECCCCCCCCCCCCEEEE
TLPLGATINMDGTAIMQGVATVFIAQVFGIDLTITDYAMVVMTATLASIGTAGVPGVGLV
EECCCCEECCCHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHCCCCCCHHHHH
MLAMVLNQVGLPVEGIALILGVDRMLDMVRTAVNVTGDTVATVVIAKSEGALNEAVFNDP
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHCCCC
KAGKTAGSFDAEVHRGE
CCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]