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The map label for this gene is lon [H]

Identifier: 119774363

GI number: 119774363

Start: 1508471

End: 1510828

Strand: Direct

Name: lon [H]

Synonym: Sama_1226

Alternate gene names: 119774363

Gene position: 1508471-1510828 (Clockwise)

Preceding gene: 119774362

Following gene: 119774364

Centisome position: 35.03

GC content: 54.03

Gene sequence:

>2358_bases
ATGTCCCAAGAGCGTGAAGCGCATTTCGAATTGCCGGTATTACCCCTGCGAGATGTGGTGGTGTACCCCCATATGGTCAT
TCCGTTATTTGTGGGTCGTGAAAAGTCTATTCGCTGCCTGGAAACGGCCATGGCCCAAGATAAGCAGATCATGCTTGTCG
CTCAGCGAGATGCCGATCTGGATGAGCCCGGTGCTGACGACATTTTTGAGGTGGGGACCATCGCCTCCATTCTGCAGCTG
CTCAAACTGCCTGACGGCACAGTTAAAGTGCTGGTTGAGGGGGGGCGCCGTGCCCGCGTTGCCCGTTACACCCAGGAAGA
GCCTTTCTTCATCGGCCGCATCGAAGAGCTGCCTTCGGCGCCGTTGGAAGACAAGGAAGAAGAGGTGTTGGTGCGCAGTG
CCATCGCCCAGTTTGAAGGCTACATCAAGCTCAATAAAAAAATTCCACCCGAAGTGCTCACCTCCATGTCCGGCATCGAC
GAGGCTGCTCGCCTTGCCGATACCATGGCGGCCCATATGCCACTCAAGCTCGAAGACAAACAGTCTGTGCTTGAAATGGT
GAATGTGGGTGAGCGCCTCGAGTACCTGATGGCCATGATGGAAGGCGAAATCGATTTGTTGCAGGTGGAGAAGCGCATCC
GCTCCCGCGTGAAAAAGCAAATGGAAAAGAGCCAACGCGAGTACTACCTGAATGAGCAAATGAAAGCCATTCAGAAGGAG
CTTGGCGATCTTGATGAAGGCCATGATGAATTTGAGACTCTCAATCGTAAGATTGAAGAGGCCAAGATGCCGGCTGACGC
CAAAGACAAGGCCCAGGCTGAGCTGAACAAGTTACGTATGATGTCTCCCATGTCAGCAGAGGCCACTGTGGTGCGCTCCT
ATGTTGATTGGATGACTTCAGTGCCTTGGTTTGAGCGCTCCAAAATCAAGCGTGACCTCTCCAAGGCCGAGCAGGTACTT
AATGCAGACCACTATGGTCTGGAAAAAGTCAAAGAGCGTATCCTTGAGTATTTGGCGGTTCAGACCCGGGTGAAACAGCT
TAAAGGCCCAATCCTGTGTCTGGTAGGCCCACCAGGTGTGGGTAAAACCTCGCTCGGTCAGTCAATTGCCAAGGCAACCG
GCCGTAAATATGTGCGGGTGGCGCTCGGTGGTGTGCGCGATGAAGCGGAAATCCGCGGCCATCGCCGTACTTACATCGGC
TCTATGCCGGGCAAAATCATTCAGAAGATGGCCAAGGTTGGGGTGAAAAACCCGCTGTTCCTGTTGGATGAAATCGACAA
GATGAGTTCCGACATGCGCGGCGACCCGGCTTCAGCCCTGCTGGAAGTTTTGGACCCAGAGCAGAACGCCACCTTTAACG
ATCACTATCTGGAAGTCGATTATGACCTGTCCGATGTGATGTTTGTGGCCACCAGTAACTCCATGGATATTCCAGGCCCG
CTGTTGGACCGTATGGAAGTGATTCGTCTGTCGGGTTACACCGAAGACGAAAAGCTCAACATCGCCAAGCAGCACTTACT
GCCAAAGCAGGTAGAGCGCAACGGCCTTAAGCCACAGGAAATCAGCGTCGATGATGGTGCAATTCTCGGCATTATCCGTT
ACTACACCCGTGAGGCAGGCGTCCGTGCCCTTGAGCGTGAGCTGTCGAAGATTTGCCGTAAAGTCGTGAAGCAAATACTG
CTGGATAAAGCGGTGAAACACGTGGATGTGACAGGTGAAAACCTTAAATCATTCCTGGGTGTCCAGCGTCATGACTATGG
TAAGGCTGAGTCCAACAATCAGGTAGGTCAGGTAACAGGTCTTGCCTGGACTCAGGTTGGCGGCGATCTCCTGACCATTG
AAGCCACTTCCGTGGCGGGTAAGGGCAAGCTGACATACACGGGCTCTCTGGGTGATGTGATGCAGGAGTCGATTCAGGCC
GCGATGACAGTGGTTCGGGCGCGCGCCGAGCAGCTGGGTATCAACCCTGACTTCTATGAAAAGCGCGATATCCATGTGCA
CGTGCCTGAAGGTGCGACGCCAAAGGATGGTCCATCAGCCGGTGCCGCCATGTGTACCGCACTGGTTTCAACCTTAACGG
GTAATCCTGTTCGCGCTGACGTGGCCATGACAGGTGAGATTACTTTGCGCGGTGAAGTGCTGCCCATCGGTGGTCTCAAG
GAGAAACTGCTGGCGGCTCACCGTGGTGGCATCAAGCATGTGCTTATCCCCAAGGAAAACGAACGTGACCTTGAAGAAAT
CCCCGCTAACGTGGTGGCAGATCTGCAAATTCACCCGGTTCGTTGGGTGGACGAAGTGCTGAAATTGGCGCTGGAGCGCC
CGGTTGAAGGCTTCGAAGTGGTCAAAAACGCCGGATAA

Upstream 100 bases:

>100_bases
AAGGAGTCCAATTGGGCTCCTTTTTTACATTTATGCCATTGAAAGGGCCGAAACAGCCCCAATATACTCGAATATAGTCC
ATCTGATACGGAATCGAATT

Downstream 100 bases:

>100_bases
GGCAAAAAAGTGCGCTACAGGCTTAAAAAAAGTGAAAAAAGGGGCTTAACAAACCCTTGACCTGTGGTAGCCTAGGTTCG
TGGAGAGCCAGTACCTCCCA

Product: endopeptidase La

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 785; Mature: 784

Protein sequence:

>785_residues
MSQEREAHFELPVLPLRDVVVYPHMVIPLFVGREKSIRCLETAMAQDKQIMLVAQRDADLDEPGADDIFEVGTIASILQL
LKLPDGTVKVLVEGGRRARVARYTQEEPFFIGRIEELPSAPLEDKEEEVLVRSAIAQFEGYIKLNKKIPPEVLTSMSGID
EAARLADTMAAHMPLKLEDKQSVLEMVNVGERLEYLMAMMEGEIDLLQVEKRIRSRVKKQMEKSQREYYLNEQMKAIQKE
LGDLDEGHDEFETLNRKIEEAKMPADAKDKAQAELNKLRMMSPMSAEATVVRSYVDWMTSVPWFERSKIKRDLSKAEQVL
NADHYGLEKVKERILEYLAVQTRVKQLKGPILCLVGPPGVGKTSLGQSIAKATGRKYVRVALGGVRDEAEIRGHRRTYIG
SMPGKIIQKMAKVGVKNPLFLLDEIDKMSSDMRGDPASALLEVLDPEQNATFNDHYLEVDYDLSDVMFVATSNSMDIPGP
LLDRMEVIRLSGYTEDEKLNIAKQHLLPKQVERNGLKPQEISVDDGAILGIIRYYTREAGVRALERELSKICRKVVKQIL
LDKAVKHVDVTGENLKSFLGVQRHDYGKAESNNQVGQVTGLAWTQVGGDLLTIEATSVAGKGKLTYTGSLGDVMQESIQA
AMTVVRARAEQLGINPDFYEKRDIHVHVPEGATPKDGPSAGAAMCTALVSTLTGNPVRADVAMTGEITLRGEVLPIGGLK
EKLLAAHRGGIKHVLIPKENERDLEEIPANVVADLQIHPVRWVDEVLKLALERPVEGFEVVKNAG

Sequences:

>Translated_785_residues
MSQEREAHFELPVLPLRDVVVYPHMVIPLFVGREKSIRCLETAMAQDKQIMLVAQRDADLDEPGADDIFEVGTIASILQL
LKLPDGTVKVLVEGGRRARVARYTQEEPFFIGRIEELPSAPLEDKEEEVLVRSAIAQFEGYIKLNKKIPPEVLTSMSGID
EAARLADTMAAHMPLKLEDKQSVLEMVNVGERLEYLMAMMEGEIDLLQVEKRIRSRVKKQMEKSQREYYLNEQMKAIQKE
LGDLDEGHDEFETLNRKIEEAKMPADAKDKAQAELNKLRMMSPMSAEATVVRSYVDWMTSVPWFERSKIKRDLSKAEQVL
NADHYGLEKVKERILEYLAVQTRVKQLKGPILCLVGPPGVGKTSLGQSIAKATGRKYVRVALGGVRDEAEIRGHRRTYIG
SMPGKIIQKMAKVGVKNPLFLLDEIDKMSSDMRGDPASALLEVLDPEQNATFNDHYLEVDYDLSDVMFVATSNSMDIPGP
LLDRMEVIRLSGYTEDEKLNIAKQHLLPKQVERNGLKPQEISVDDGAILGIIRYYTREAGVRALERELSKICRKVVKQIL
LDKAVKHVDVTGENLKSFLGVQRHDYGKAESNNQVGQVTGLAWTQVGGDLLTIEATSVAGKGKLTYTGSLGDVMQESIQA
AMTVVRARAEQLGINPDFYEKRDIHVHVPEGATPKDGPSAGAAMCTALVSTLTGNPVRADVAMTGEITLRGEVLPIGGLK
EKLLAAHRGGIKHVLIPKENERDLEEIPANVVADLQIHPVRWVDEVLKLALERPVEGFEVVKNAG
>Mature_784_residues
SQEREAHFELPVLPLRDVVVYPHMVIPLFVGREKSIRCLETAMAQDKQIMLVAQRDADLDEPGADDIFEVGTIASILQLL
KLPDGTVKVLVEGGRRARVARYTQEEPFFIGRIEELPSAPLEDKEEEVLVRSAIAQFEGYIKLNKKIPPEVLTSMSGIDE
AARLADTMAAHMPLKLEDKQSVLEMVNVGERLEYLMAMMEGEIDLLQVEKRIRSRVKKQMEKSQREYYLNEQMKAIQKEL
GDLDEGHDEFETLNRKIEEAKMPADAKDKAQAELNKLRMMSPMSAEATVVRSYVDWMTSVPWFERSKIKRDLSKAEQVLN
ADHYGLEKVKERILEYLAVQTRVKQLKGPILCLVGPPGVGKTSLGQSIAKATGRKYVRVALGGVRDEAEIRGHRRTYIGS
MPGKIIQKMAKVGVKNPLFLLDEIDKMSSDMRGDPASALLEVLDPEQNATFNDHYLEVDYDLSDVMFVATSNSMDIPGPL
LDRMEVIRLSGYTEDEKLNIAKQHLLPKQVERNGLKPQEISVDDGAILGIIRYYTREAGVRALERELSKICRKVVKQILL
DKAVKHVDVTGENLKSFLGVQRHDYGKAESNNQVGQVTGLAWTQVGGDLLTIEATSVAGKGKLTYTGSLGDVMQESIQAA
MTVVRARAEQLGINPDFYEKRDIHVHVPEGATPKDGPSAGAAMCTALVSTLTGNPVRADVAMTGEITLRGEVLPIGGLKE
KLLAAHRGGIKHVLIPKENERDLEEIPANVVADLQIHPVRWVDEVLKLALERPVEGFEVVKNAG

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=780, Percent_Identity=38.974358974359, Blast_Score=526, Evalue=1e-149,
Organism=Homo sapiens, GI21396489, Length=827, Percent_Identity=36.7593712212817, Blast_Score=508, Evalue=1e-144,
Organism=Escherichia coli, GI1786643, Length=781, Percent_Identity=79.1293213828425, Blast_Score=1271, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=657, Percent_Identity=40.9436834094368, Blast_Score=493, Evalue=1e-139,
Organism=Caenorhabditis elegans, GI17556486, Length=764, Percent_Identity=34.4240837696335, Blast_Score=424, Evalue=1e-119,
Organism=Saccharomyces cerevisiae, GI6319449, Length=701, Percent_Identity=38.5164051355207, Blast_Score=491, Evalue=1e-139,
Organism=Drosophila melanogaster, GI221513036, Length=631, Percent_Identity=44.2155309033281, Blast_Score=526, Evalue=1e-149,
Organism=Drosophila melanogaster, GI24666867, Length=622, Percent_Identity=44.5337620578778, Blast_Score=526, Evalue=1e-149,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 87395; Mature: 87264

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQEREAHFELPVLPLRDVVVYPHMVIPLFVGREKSIRCLETAMAQDKQIMLVAQRDADL
CCCCCCCCCCCCCCCHHHHHHCCHHHHHHHCCCCCHHHHHHHHHCCCCEEEEEEECCCCC
DEPGADDIFEVGTIASILQLLKLPDGTVKVLVEGGRRARVARYTQEEPFFIGRIEELPSA
CCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHCCCCCCEEEEEHHHCCCC
PLEDKEEEVLVRSAIAQFEGYIKLNKKIPPEVLTSMSGIDEAARLADTMAAHMPLKLEDK
CCCCCHHHHHHHHHHHHHHCCEEECCCCCHHHHHHHHCHHHHHHHHHHHHHHCCCEECHH
QSVLEMVNVGERLEYLMAMMEGEIDLLQVEKRIRSRVKKQMEKSQREYYLNEQMKAIQKE
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGDLDEGHDEFETLNRKIEEAKMPADAKDKAQAELNKLRMMSPMSAEATVVRSYVDWMTS
HCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHC
VPWFERSKIKRDLSKAEQVLNADHYGLEKVKERILEYLAVQTRVKQLKGPILCLVGPPGV
CCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCC
GKTSLGQSIAKATGRKYVRVALGGVRDEAEIRGHRRTYIGSMPGKIIQKMAKVGVKNPLF
CHHHHHHHHHHHCCCCEEEEECCCCCCHHHHCCCHHHHCCCCCHHHHHHHHHCCCCCCHH
LLDEIDKMSSDMRGDPASALLEVLDPEQNATFNDHYLEVDYDLSDVMFVATSNSMDIPGP
HHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCEEEEECCCCCEEEEEECCCCCCCCH
LLDRMEVIRLSGYTEDEKLNIAKQHLLPKQVERNGLKPQEISVDDGAILGIIRYYTREAG
HHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHCCCCCCEECCCCCHHHHHHHHHHHHHH
VRALERELSKICRKVVKQILLDKAVKHVDVTGENLKSFLGVQRHDYGKAESNNQVGQVTG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHCCCCCCCCCCCCEEEEC
LAWTQVGGDLLTIEATSVAGKGKLTYTGSLGDVMQESIQAAMTVVRARAEQLGINPDFYE
EEHHHCCCCEEEEEEECCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
KRDIHVHVPEGATPKDGPSAGAAMCTALVSTLTGNPVRADVAMTGEITLRGEVLPIGGLK
CCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEECEEEEECEEEECCCHH
EKLLAAHRGGIKHVLIPKENERDLEEIPANVVADLQIHPVRWVDEVLKLALERPVEGFEV
HHHHHHHCCCCEEEECCCCCCCCHHHCCHHHEECCEECCHHHHHHHHHHHHHCCCHHHHH
VKNAG
HHCCC
>Mature Secondary Structure 
SQEREAHFELPVLPLRDVVVYPHMVIPLFVGREKSIRCLETAMAQDKQIMLVAQRDADL
CCCCCCCCCCCCCCHHHHHHCCHHHHHHHCCCCCHHHHHHHHHCCCCEEEEEEECCCCC
DEPGADDIFEVGTIASILQLLKLPDGTVKVLVEGGRRARVARYTQEEPFFIGRIEELPSA
CCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHCCCCCCEEEEEHHHCCCC
PLEDKEEEVLVRSAIAQFEGYIKLNKKIPPEVLTSMSGIDEAARLADTMAAHMPLKLEDK
CCCCCHHHHHHHHHHHHHHCCEEECCCCCHHHHHHHHCHHHHHHHHHHHHHHCCCEECHH
QSVLEMVNVGERLEYLMAMMEGEIDLLQVEKRIRSRVKKQMEKSQREYYLNEQMKAIQKE
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGDLDEGHDEFETLNRKIEEAKMPADAKDKAQAELNKLRMMSPMSAEATVVRSYVDWMTS
HCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHC
VPWFERSKIKRDLSKAEQVLNADHYGLEKVKERILEYLAVQTRVKQLKGPILCLVGPPGV
CCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCC
GKTSLGQSIAKATGRKYVRVALGGVRDEAEIRGHRRTYIGSMPGKIIQKMAKVGVKNPLF
CHHHHHHHHHHHCCCCEEEEECCCCCCHHHHCCCHHHHCCCCCHHHHHHHHHCCCCCCHH
LLDEIDKMSSDMRGDPASALLEVLDPEQNATFNDHYLEVDYDLSDVMFVATSNSMDIPGP
HHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCEEEEECCCCCEEEEEECCCCCCCCH
LLDRMEVIRLSGYTEDEKLNIAKQHLLPKQVERNGLKPQEISVDDGAILGIIRYYTREAG
HHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHCCCCCCEECCCCCHHHHHHHHHHHHHH
VRALERELSKICRKVVKQILLDKAVKHVDVTGENLKSFLGVQRHDYGKAESNNQVGQVTG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHCCCCCCCCCCCCEEEEC
LAWTQVGGDLLTIEATSVAGKGKLTYTGSLGDVMQESIQAAMTVVRARAEQLGINPDFYE
EEHHHCCCCEEEEEEECCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
KRDIHVHVPEGATPKDGPSAGAAMCTALVSTLTGNPVRADVAMTGEITLRGEVLPIGGLK
CCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEECEEEEECEEEECCCHH
EKLLAAHRGGIKHVLIPKENERDLEEIPANVVADLQIHPVRWVDEVLKLALERPVEGFEV
HHHHHHHCCCCEEEECCCCCCCCHHHCCHHHEECCEECCHHHHHHHHHHHHHCCCHHHHH
VKNAG
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8981986; 12620739 [H]