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The map label for this gene is dhmA2 [H]

Identifier: 119774320

GI number: 119774320

Start: 1446466

End: 1447398

Strand: Direct

Name: dhmA2 [H]

Synonym: Sama_1183

Alternate gene names: 119774320

Gene position: 1446466-1447398 (Clockwise)

Preceding gene: 119774319

Following gene: 119774321

Centisome position: 33.59

GC content: 53.59

Gene sequence:

>933_bases
ATGGATAATCATAAAATGCTGGATAGCCTGCTGCCTTTCAAACGCCGTTTTTTCAATCACGGCGGCCATAATATTCACTT
TATCGATGAGGGACCAGAGGGCGACGTGGCACCGAAAGGCACTGTTGTTATGGTGCACGGTAACCCGAGCTGGACCCTGT
ATTACCGTAATCTGATTCGCGCCCTGAAAGGCGAGTATCGCTGCATTGCCATGGATAACGTAGGTTGCGGTTTGTCGGAT
AAACCCGATGACAGCCGTTACCATTACACCCTGACAAGCCGGATAGGCGATCTCGAAGCCTTGCTCGCTTCGCTCAATGT
GACAGAAAAAGTCACCCTGGTGGTACACGACTGGGGTGGCATGATTGGCATGGGCTGGGCGACCAAATATCCAGATGCCA
TTGAAAGACTGGTCATTTTGAACACAGCGGCATTCCACTTGCCTGCCACTAAACCCTTGCCATTGCGGCTTAAAATCTGC
CGTGACACCTGGCTCGGTACCTTGCTGGTGCGTGGCTTTAATGCCTTTGCCGGTCTTGCCTCTGTGATTGGCTGCAAGCG
CAATCCTATGAATGCAGAGATGCGACGTGCCTACGTTGCCCCCTTTAACAGCTGGGCCAATCGTATTTCTACCCTGCGTT
TTGTGCAGGATATCCCCTTGAAGCCCGGCGATACCGCCTGGGATGAAGTGAGCCGGATTGAGCAGAGTCTGGCGCAATTT
ACCCGTGTGCCCACTCTCATCTGCTGGGGACTCAAAGACTTTGTGTTTGACCGGCATTTCCTCACCGTATGGCAAGAAAA
GTTGCCCCAGGCCGAGGTGCACGCCTTCGAAGACTGTGGTCACTACATCCTTGAGGATGCCAGCGACGAAGTGATAGCCC
ACATTGAGCGTTTTGTGGCGGCCTCTGCGCCTGCCGAGGCCCTTGCGTCATGA

Upstream 100 bases:

>100_bases
CCATTGCCCACGACCAGGGTTTTTTACGTCCGGGGGATCAGGTCAGCTTCCTCGGCATAGGTTCGGGGCTGAACTGCATG
ATGTTGGGGCTTCGCTGGTA

Downstream 100 bases:

>100_bases
ATGCCAACCTGTGCCGTCATTTGGTTTCGGCCGCACAGGCTCAGCCCCAGGGCTTGGCGGTGGCGGTACAAAGGCACAGA
TTCGGCAAGCCGCCGCGGGG

Product: alpha/beta fold family hydrolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 310; Mature: 310

Protein sequence:

>310_residues
MDNHKMLDSLLPFKRRFFNHGGHNIHFIDEGPEGDVAPKGTVVMVHGNPSWTLYYRNLIRALKGEYRCIAMDNVGCGLSD
KPDDSRYHYTLTSRIGDLEALLASLNVTEKVTLVVHDWGGMIGMGWATKYPDAIERLVILNTAAFHLPATKPLPLRLKIC
RDTWLGTLLVRGFNAFAGLASVIGCKRNPMNAEMRRAYVAPFNSWANRISTLRFVQDIPLKPGDTAWDEVSRIEQSLAQF
TRVPTLICWGLKDFVFDRHFLTVWQEKLPQAEVHAFEDCGHYILEDASDEVIAHIERFVAASAPAEALAS

Sequences:

>Translated_310_residues
MDNHKMLDSLLPFKRRFFNHGGHNIHFIDEGPEGDVAPKGTVVMVHGNPSWTLYYRNLIRALKGEYRCIAMDNVGCGLSD
KPDDSRYHYTLTSRIGDLEALLASLNVTEKVTLVVHDWGGMIGMGWATKYPDAIERLVILNTAAFHLPATKPLPLRLKIC
RDTWLGTLLVRGFNAFAGLASVIGCKRNPMNAEMRRAYVAPFNSWANRISTLRFVQDIPLKPGDTAWDEVSRIEQSLAQF
TRVPTLICWGLKDFVFDRHFLTVWQEKLPQAEVHAFEDCGHYILEDASDEVIAHIERFVAASAPAEALAS
>Mature_310_residues
MDNHKMLDSLLPFKRRFFNHGGHNIHFIDEGPEGDVAPKGTVVMVHGNPSWTLYYRNLIRALKGEYRCIAMDNVGCGLSD
KPDDSRYHYTLTSRIGDLEALLASLNVTEKVTLVVHDWGGMIGMGWATKYPDAIERLVILNTAAFHLPATKPLPLRLKIC
RDTWLGTLLVRGFNAFAGLASVIGCKRNPMNAEMRRAYVAPFNSWANRISTLRFVQDIPLKPGDTAWDEVSRIEQSLAQF
TRVPTLICWGLKDFVFDRHFLTVWQEKLPQAEVHAFEDCGHYILEDASDEVIAHIERFVAASAPAEALAS

Specific function: Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds, leading to the formation of the corresponding primary alcohols, halide ions and protons [H]

COG id: COG0596

COG function: function code R; Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the haloalkane dehalogenase family. Type 1 subfamily [H]

Homologues:

Organism=Homo sapiens, GI218777837, Length=121, Percent_Identity=34.7107438016529, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17554012, Length=300, Percent_Identity=22.3333333333333, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17562298, Length=307, Percent_Identity=23.1270358306189, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR000639 [H]

Pfam domain/function: PF00561 Abhydrolase_1 [H]

EC number: =3.8.1.5 [H]

Molecular weight: Translated: 34893; Mature: 34893

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDNHKMLDSLLPFKRRFFNHGGHNIHFIDEGPEGDVAPKGTVVMVHGNPSWTLYYRNLIR
CCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCEEEEECCCCEEHHHHHHHH
ALKGEYRCIAMDNVGCGLSDKPDDSRYHYTLTSRIGDLEALLASLNVTEKVTLVVHDWGG
HHCCCEEEEEECCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHCCCCEEEEEEEEECCC
MIGMGWATKYPDAIERLVILNTAAFHLPATKPLPLRLKICRDTWLGTLLVRGFNAFAGLA
EEECCCCCCCHHHHHHHHHHHHHHEECCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHH
SVIGCKRNPMNAEMRRAYVAPFNSWANRISTLRFVQDIPLKPGDTAWDEVSRIEQSLAQF
HHHCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
TRVPTLICWGLKDFVFDRHFLTVWQEKLPQAEVHAFEDCGHYILEDASDEVIAHIERFVA
HHCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCHHHHCCCCHHHHHHHHHHHH
ASAPAEALAS
CCCCHHHHCC
>Mature Secondary Structure
MDNHKMLDSLLPFKRRFFNHGGHNIHFIDEGPEGDVAPKGTVVMVHGNPSWTLYYRNLIR
CCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCEEEEECCCCEEHHHHHHHH
ALKGEYRCIAMDNVGCGLSDKPDDSRYHYTLTSRIGDLEALLASLNVTEKVTLVVHDWGG
HHCCCEEEEEECCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHCCCCEEEEEEEEECCC
MIGMGWATKYPDAIERLVILNTAAFHLPATKPLPLRLKICRDTWLGTLLVRGFNAFAGLA
EEECCCCCCCHHHHHHHHHHHHHHEECCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHH
SVIGCKRNPMNAEMRRAYVAPFNSWANRISTLRFVQDIPLKPGDTAWDEVSRIEQSLAQF
HHHCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
TRVPTLICWGLKDFVFDRHFLTVWQEKLPQAEVHAFEDCGHYILEDASDEVIAHIERFVA
HHCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCHHHHCCCCHHHHHHHHHHHH
ASAPAEALAS
CCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]